检索结果-南通市图书馆

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

引用

Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Survey of traditional Dai medicine reveals species confusion and potential safety concerns: a case study on Radix Clerodendri Japonicum

引用

Chinese Journal of Natural Medicines 2017年第6期15卷 417-426页

作者： DUAN Bao-Zhong FANG hai-Lan LI Xi-Wen huang lin-Fang WANG Ping CHEN Shi-lin College of Pharmaceutical Sciences Hubei University of Chinese Medicine Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences College of Pharmaceutical Sciences Dali University Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College

The adulteration of herbal products is a threat to consumer safety. In the present study, we surveyed the species composition of commercial Radix Clerodendri Japonicum products using DNA barcoding as a supervisory method. A reference database for plant-material DNA-barcode was successfully constructed with 48 voucher samples from 12 Clerodendrum species. The database was used to identify 27 Radix Clerodendri Japonicum decoction piece samples purchased from drug stores and hospitals. The DNA sequencing results revealed that only 1 decoction piece(3.70%) was authentic C. japonicum, as recorded in the Dai Pharmacopeia, whereas the other samples were all adulterants, indicating a potential safety issue. The results indicate that decoction pieces that are available in the market have complex origins and that DNA barcoding is a suitable tool for regulation of Dai medicines.

关键词： Dai medicine DNA barcode Radix Clerodendri Japonicum Adulterants ITS 2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PET/PA6米字型复合纤维的纺制

引用

化纤与纺织技术 2017年第3期46卷 1-4页

作者：李雪梅林海黄洁希王增喜郑建华广东省化学纤维研究所广东广州510245

分析探讨了纺制PET/PA6米字型POY复合纤维的生产工艺,组分质量比PET∶PA6为82∶18,结果表明,当纺丝温度PET为285~295℃,PA6为260~270℃,箱体温度为265~292℃,纺丝速度为2 900~3 200 m/min,侧吹风速为0.40~0.65 m/min,风温为18~22℃时,可纺制出性能较好的POY用于后道加工,所得纤维的规格为285 dtex/72 f,断裂强度(2.3±0.2)c N/dtex,断裂伸长率(135±5)%。

关键词：涤锦复合纤维聚酯聚酰胺米字型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interannual variability of the sea surface salinity and its related freshwater flux in the tropical Pacific:A comparison of CMIP5 and CMIP6

引用

Atmospheric and Oceanic Science Letters 2022年第4期15卷 6-12页

作者： hai Zhi Yu huang Pengfei lin Shiwei Shi Meng Dong College of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjingChina State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric Physics(IAP)Chinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

This paper assesses the interannual variabilities of simulated sea surface salinity(SSS)and freshwater flux(FWF)in the tropical Pacific from phases 5 and 6 of the Coupled Model Intercomparison Project(CMIP5 and CMIP6).The authors focus on comparing the simulated SSS and FWF responses to El Nino–Southern Oscillation(ENSO)from two generations of models developed by the same *** results show that CMIP5 and CMIP6 models can perform well in simulating the spatial distributions of the SSS and FWF responses associated with ENSO,as well as their *** is found that most CMIP6 models have improved in simulating the geographical distribution of the SSS and FWF interannual variability in the tropical Pacific compared to CMIP5 *** particular,CMIP6 models have corrected the underestimation of the spatial relationship of the FWF and SSS variability with ENSO in the central-western *** addition,CMIP6 models outperform CMIP5 models in simulating the FWF interannual variability(spatial distribution and intensity)in the tropical ***,as a whole,CMIP6 models do not show improved skill scores for SSS interannual variability,which is due to their overestimation of the intensity in some *** uncertainties exist in simulating the interannual variability of SSS among CMIP5 and CMIP6 models and some improvements with respect to physical processes are needed.

关键词： Interannual variability Sea surface salinity Sea surface temperature Coupled model intercomparison project

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison Between Performances of PbO_2 and F^--doped PbO_2 Anodes for Electrochemical Degradation of Aniline

引用

Chemical Research in Chinese Universities 2010年第6期26卷 991-995页

作者： WANG Xuan huang Wei-min LI Hui-ting ZHANG Xue-na LU hai-yan lin hai-bo College of Chemistry Jilin University Changchun 130012 P. R. China Suzhou Nistar Chemical Technology Co. Ltd. Suzhou 215123 P. R. China

The paper deals with the influence of anode material on the efficiency of degradation for organic pollutants in water *** electrochemical performance of fluorine ion doped lead dioxide（F--PbO2） electrode for the degradation of aniline was compared with that of undoped lead dioxide（PbO2） electrode by ultraviolet-visible（UV-Vis） spectroscopy,linear voltammetry and other analytical methods,such as the measurement by chemical oxygen demand analyzer,high performance liquid chromatography and scanning electron *** was shown that both PbO2 electrode and F--PbO2 electrode could make aniline be mineralized completely and have the same degradation course,but F--PbO2 electrode has much higher electrocatalytic activity than undoped PbO2 electrode for the electrochemical degradation of *** experimental results confirm that F--PbO2 electrode has much higher potential for oxygen evolution than undoped PbO2 electrode.

关键词： Lead dioxide electrode Electrochemical oxidation Degradation Aniline

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of 1,3-benzothiazines by intramolecular dehydrogenative C–S cross-coupling in a flow electrolysis cell

引用

Science China Chemistry 2019年第11期62卷 1501-1503页

作者： Chong huang hai-Chao Xu State Key Laboratory of Physical Chemistry of Solid Surfaces Innovative Collaboration Center of Chemistry for Energy MaterialsKey Laboratory of Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering Xiamen University

Dehydrogenative cyclization of thioamides is an attractive approach for the synthesis of *** herein is an electrochemical dehydrogenative cyclization reaction of N-benzyl thioamides in a flow electrolysis *** continuous-flow electrosynthesis has addressed the limitations associated with previously reported methods for the cyclization of alkylthioamides and provide a transition metal-and oxidizing reagent-free access to various functionalized 1,3-benzothiazines in good yields.

关键词： C-H functionalization electrochemistry flow chemistry heterocycles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

引用

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 35-41页

作者： XIA haiyan huang Yin YANG Hua WANG Xintian SHI Jianping LIU Lixia FU Yacheng QUAN Changyun LI Suyuan Cofoe Medical Technology Company Limited Changsha 410000China Institute of New Energy Hexi UniversityZhangye 734000China Chemistry and Chemical Engineering Central South UniversityChangsha 410000China

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C(CuO/Ag-C)disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM^(-1)·cm^(-2),and a low limit of detection(0.68 mM)in a wide linear response range of 0.68 mM and 3 mM(signal/noise=3),*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

关键词： electrochemical sensor CuO nanoparticles glucose detection screen-printing technique

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of bonding filling on HER/OER/ORR multifunctional catalytic activity in transition-metals-doped PdPX(X=S,Se,Te)

引用

Rare Metals 2024年第10期43卷 5126-5140页

作者： hai-Hua huang Wei Li Cheng-Chao Hu Xue-Qin Sun lin-Guo Lu Xiao-Feng Fan School of Materials Science and Engineering Laboratory of Sensitive Materials and DevicesShandong Department of EducationLiaocheng UniversityLiaocheng 252059China School of Environmental and Material Engineering Yantai UniversityYantai 264005China Department of Physics University of Puerto RicoRio PiedrasSan Juan.PR00931USA Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationCollege of Materials Science and EngineeringJilin UniversityChangchun 130012China

The development of stable and highly efficien multifunctional electrocatalysts for the hydrogen evolution reaction(HER),oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)are essential for the efficient conversion and storage of renewable *** significant advantages of single-atom catalysts,such as strong metal slab interactions,unsaturated coordination and efficient atomic utilization,have opened new avenues for designing multifunctional ***,based on density functional theory,a single atom doped PdPX system was designed as a multifunctional electrocatalyst,which demonstrated the synergistic effect between defects and transition metal atoms and led to enhanced catalytic *** results showed that PdPS/PdPSe with P/X vacancy,PdPTe with P/Pd vacancy and Co/Rh/Ir@PdPX exhibited promising HER ***@PdPS(Se),with an overpotential of 0.56(0.44)V,was predicted to be a promising OER ***,Rh(Ir)@PdPS(Se)catalysts exhibited efficient catalytic properties for ORR Besides,Co@PdPS(Se),Rh(Ir)@PdPS~(V(S)),Co@PdP-Se~(V(Se))and Ir@PdPS~(V(S)-1)exihibited multifunctional catalytic performance with moderate ***,the origin of catalytic activity was revealed by using the crystal orbital Hamilton populations *** a strong adsorption system,proper filling of the anti-bonding state can increase the energy of the system,weaken the adsorption strength,and facilitate the desorption of intermediates Conversely,augmenting bonding states can enhance its adsorption *** findings provide theoretica guidance for the design and fabrication of novel multifunctional electrocatalysts in terms of filling of bondingstate.

关键词： Electrocatalyst Two-dimensional PdPX Water splitting Density functional theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

引用

Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai Bo Sun Huijun Wang Yi Zheng Siyu Zhou Huixin Li Yanyan huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design and feedforward control of large-rotation two-axis scan mirror assembly with MEMS sensor integration

引用

Chinese Journal of Aeronautics 2019年第8期32卷 1912-1922页

作者： hai huang Xintao ZHENG Weipeng LI School of Astronautics Beihang University

As a key component of electro-optical systems, a Two-axis Scan mirror AssemblY(TSAY) is usually used for line-of-Sight(LOS) precision pointing, tracking, scanning, and stabilizing. Therefore, it is necessary for a TSAY to have a large angular range, high dynamic characteristics, and small mirror surface distortion. Furthermore, vibration from carriers of electro-optical systems, such as spacecraft and airplanes, is inevitable, so it is critical to guarantee the control accuracy of a TSAY under vibration. In this paper, a TSAY prototype is designed and developed. To increase the control bandwidth, structural topology optimization is applied to the TSAY’s elliptical mirror to reduce the moment of inertia, meanwhile keeping surface flatness. A flexible hinge is adopted to achieve a large angular range. To suppress the angular perturbation caused by the base linear vibration, an adaptive feedforward loop with base-integrated Micro-Electro-Mechanical System(MEMS) accelerators is constructed to enhance the TSAY’s feedback loop. Simulation and experimental results show that the TSAY prototype’s two-axis mechanical angular ranges are more than ±3.2°, the mirror surface flatness Root Mean Square(RMS) value is better than 0.04 k, and the closed-loop bandwidth is beyond 330 Hz. These are suitable for most applications. Besides, the angular perturbation caused by the base vibration can be suppressed more than 37.7% with the addition of the adaptive feedforward loop.

关键词： Adaptive feedforward Micro-Electro-Mechanical System accelerator Scan mirror Topological optimization Vibration suppression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：