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The effectiveness of the TAX 327 nomogram in predicting overall survival in Chinese patients with metastatic castration-resistant prostate cancer

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Asian Journal of Andrology 2013年第5期15卷 679-684页

作者： Xiao-Jie Bian Yao Zhu Yi-Jun Shen Jin-You Wang Chun-Guang Ma hai-liang zhan Bo Dai Shi-Lin zhang Xu-Dong Yao Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer Center Shanghai 200032 China Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China

Based on the results of TAX 327, a nomogram was developed to predict the overall survival of metastatic castration-resistant prostate cancer （mCRPC） after first-line chemotherapy. The nomogram, however, has not been validated in an independent dataset, especially in a series out of clinical trials. Thus, the objective of the current study was to validate the TAX 327 nomogram in a community setting in China. A total of 146 patients with mCRPC who received first-line chemotherapy （docetaxel or mitoxantrone） were identified. Because clinical trials are limited in China's Mainland, those patients did not receive investigational treatment after the failure of first-line chemotherapy. The predicted overall survival rate was calculated from the TAX 327 nomogram. The validity of the model was assessed with discrimination, calibration and decision curve analysis. The median survival of the cohort was 21 months （docetaxel） and 19 months （mitoxantrone） at last follow-up. The predictive c-index of the TAX 327 nomogram was 0.66 （95% CI： 0.54-0.70）. The calibration plot demonstrated that the 2-year survival rate was underestimated by the nomogram. Decision curve analysis showed a net benefit of the nomogram at a threshold probability greater than 30%. In conclusion, the present validation study did not confirm the predictive value of the TAX 327 nomogram in a contemporary community series of men in China, and further studies with a large sample size to develop or validate nomograms for predicting survival and selecting therapies in advanced prostate cancer are necessary.

关键词： castration-resistant chemotherapy nomogram prostate cancer validation studies

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu liang Ni-Hui zhang Zhi-Lai zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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An embedded electron current layer observed at the edge of the plasma sheet in the Earth’s magnetotail

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Earth and Planetary Physics 2025年第1期9卷 148-158页

作者： ChenChen zhan RongSheng Wang QuanMing Lu San Lu XinMin Li Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences(CAS)Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Anhui Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China

The formation of an embedded electron current sheet within the magnetotail plasma sheet has been poorly *** this article,we present an electron current layer detected at the edge of the magnetotail plasma *** ions were demagnetized inside the electron current layer,but the electrons were still frozen in with the magnetic field ***,this decoupling of ions and electrons gave rise to a strong Hall electric field,which could be the reason for the formation of the embedded thin current *** magnetized electrons,the absence of the nongyrotropic electron distribution,and negligible energy dissipation in the layer indicate that magnetic reconnection had not been triggered within the embedded thin current *** highly asymmetric plasma on the two sides of the current layer and low magnetic shear across it could suppress magnetic *** observations indicate that the embedded electric current layer,probably generated by the Hall electric field,even down to electron scale,is not a sufficient condition for magnetic reconnection.

关键词： magnetotail plasma sheet magnetic reconnection

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Binary Population Synthesis

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Research in Astronomy and Astrophysics 2020年第10期20卷 207-220页

作者： zhan-Wen Han Hong-Wei Ge Xue-Fei Chen hai-liang Chen Yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China University of the Chinese Academy of Sciences Beijing 100049China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100101China

Binary interactions lead to the formation of intriguing objects,such as compact binaries,supernovae,gamma ray bursts,X-ray binaries,pulsars,novae,cataclysmic variables,hot subdwarf stars,barium stars and blue *** study the evolution of binary populations and the consequent formation of these objects,many methods have been developed over the years,for which a robust approach named binary population synthesis(BPS)warrants special *** approach has seen widespread application in many areas of astrophysics,including but not limited to analyses of the stellar content of galaxies,research on galactic chemical evolution and studies concerning star formation and cosmic *** this review,we discuss the role of BPS,its general picture and the various components that comprise *** pay special attention to the stability criteria for mass transfer in binaries,as this stability largely determines the fate of binary *** conclude with our perspectives regarding the future of this field.

关键词： stars evolution-star binaries(including multiple) close-stars statistics-supernovae general-galaxies stellar content-methods numerical

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云多租数据库资源规划调度技术综述

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软件学报 2025年第1期36卷 446-468页

作者：刘海龙王硕侯舒峰徐海洋李战怀西北工业大学计算机学院大数据存储与管理工业和信息化部重点实验室(西北工业大学)

云多租数据库具有按需付费、按需扩展、免部署、高可用、自带运维能力、资源共享等诸多优势,可以大大降低用户使用数据库服务的成本.现在越来越多的企业和个人开始在数据库即服务(DaaS)平台托管他们的数据库服务. DaaS平台需要按照用户... 详细信息

云多租数据库具有按需付费、按需扩展、免部署、高可用、自带运维能力、资源共享等诸多优势,可以大大降低用户使用数据库服务的成本.现在越来越多的企业和个人开始在数据库即服务(DaaS)平台托管他们的数据库服务. DaaS平台需要按照用户服务水平协议(SLA)为诸多租户提供服务,同时也需要保障平台收益.但是,由于租户及其负载具有动态性、异构性和竞争性等特点,如何在遵循SLA的同时根据负载自适应规划调度资源同时兼顾平台收益对于DaaS平台来说是一件极具挑战性的工作.针对云多租数据库中比较常见的类型,如关系型数据库,详细分析了当前云多租数据库资源规划调度技术所面临的挑战,提炼了关键科学问题,给出了技术框架,然后从资源规划调度技术、资源预估技术、资源弹性伸缩技术以及数据库资源规划调度工具等4个方面对现有研究工作进行了总结和分析,并且展望了未来的研究方向.

关键词：多租户云数据库资源规划调度资源预估资源弹性伸缩关系数据库云原生多模数据库

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Few-layer WSe2 lateral homo-and hetero-junctions with superior optoelectronic performance by laser manufacturing

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Science China(Technological Sciences) 2020年第8期63卷 1531-1537页

作者： LI Yang YANG Jian zhan ZhaoYao WU Jumiati LI hai ZHEN liang HE QiYuan XU ChengYan School of Materials Science and Engineering MOE Key Laboratory of Micro-Systems and Micro-Structures ManufacturingHarbin Institute of TechnologyHarbin 150001China Center for Programmable Materials School of Materials Science and EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University(NanjingTech)Nanjing 211816China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China

Lateral hetero-junctions are considered as potential candidate for building blocks in modern electronics and optoelectronics,however,the construction of which remains a *** this work,by using a laser-assisted manufacture technique,WSe2/WO3-x hetero-junction and monolayer/trilayer WSe2 homo-junction with Schottky diode like behavior are fabricated,both of which present competitive performance for photodetection and power generation in a wide range of wavelengths from ultraviolet to infrared,with maximum photoresponsivity of 10 A/W,external quantum efficiency of 14%,and power conversion efficiency of 1.3%.Combined with Kelvin probe microscopy and electrical transport measurements,it is demonstrated that the barrier-induced built-in electric field at WSe2/WO3-x interface,and the energy band discontinuities at the monolayer/trilayer WSe2 interface facilitate the separation of photo-generated electron-hole *** work provides a solid step towards the controllable construction of lateral junctions by laser-assisted manufacture for exploiting van der Waals materials-based novel electronic and optoelectronic applications.

关键词： laser manufacture lateral heterostructure optoelectronic performance WSe2

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Investigation of migration of pollutant at the base of Suzhou Qizishan landfill without a liner system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第3期10卷 439-449页

作者： hai-jian XIE Yun-min CHEN liang-tong zhan Ren-peng CHEN Xiao-wu TANG Ru-hai CHEN Han KE MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang University Hangzhou 310058 China College of Civil Engineering and Architeeture Zhejiang University Hangzhou 310058 China

We investigated migration of pollutant at the base of the Suzhou landfill after it had been operated for 13 years. The investigation was carried out by performing chemical analyses on the soil samples taken from the silty clay deposit. Concentrations of chloride, chemical oxygen demand （COD） and the heavy metals in the soil samples were determined using the standard methods. The experimental data showed that the maximum migration depth of chloride was more than 10 m, while the maximum migration depth of COD varied between 1 and 3.5 m. It is believed that the difference is attributed to the variation in diffusion rate and leachate-soil interaction. The chloride profiles also indicated that adveetion may be the dominant contaminant transport mechanism at this site. The total contents ofCu, Pb and Cr are very close to the background levels and the concentration values of these metals mainly are lower than the threshold values specified by the Chinese soil quality standard and the European one. The water-extractable concentrations of COD in the surface of the silty clay generally exceed the limit value specified by the Chinese standard. The concentrations of copper and chromium in pore water are 1-2 orders of magnitude less than the total concentrations of these heavy metals within the soils, implying that heavy metals are mainly adsorbed by the soil particles. Finally, remediation methods were suggested for this landfill site.

关键词： Uncontrolled landfill Field investigation Contaminant migration Soil contamination Heavy metals Organic contaminants Chloride

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MDCFS: few-shot object detection with multilevel decoupled classifiers

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Optoelectronics Letters 2025年

作者： LI Chuanhui ZHOU Mian FENG Zhikun SUI Zezhou GAO zhan School of Computer Science and Engineering， Tianjin University of Technology

Few-shot object detection poses unique challenges as it requires effectively learning novel classes with limited labeled data. Current approaches often suffer from biases towards base classes during fine-tuning， leading to suboptimal performance on detecting novel classes. Additionally， in complex scenes， the confusion between foreground and background objects further affects the accuracy and robustness of the model. To address these issues， we propose the Multilevel Decoupling Classification Few-Shot Algorithm (MDCFS). we decouple the standard classifier into a parallel foreground classifier and a background classifier in the Few-Shot Object Detection (FSOD) setting. This decoupling enables the independent separation of positive samples from noisy negative samples， alleviating the foreground-background confusion problem commonly encountered in few-shot detectors. For Generalized Few-Shot Object Detection (G-FSOD)， where the few-shot dataset contains base classes， we further decouple the foreground classification head into a base class classification head and a novel class classification head. To ensure balance， we assign more weight to the novel class classification head， effectively addressing the bias towards base classes. Furthermore， we optimize the initial weights of the few-shot fine-tuning stage， significantly reducing training time and mitigating catastrophic forgetting in G-FSOD. Additionally， we incorporate metric learning into our model with minimal cost. Experimental results demonstrate the effectiveness of our approach. Compared to state-of-the-art few-shot object detection methods based on fine-tuning， MDCFS achieves performance improvements of up to 6.3% on the PASCAL VOC dataset and 1.5% on the COCO dataset.

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Generation of global 1-km daily top-of-atmosphere outgoing longwave radiation product from 2000 to 2021 using machine learning

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International Journal of Digital Earth 2023年第1期16卷 2002-2012页

作者： Chuan zhan Shunlin liang School of Resources and Environmental Engineering Wuhan University of Science and TechnologyWuhanPeople's Republic of China Department of Geography The University of Hong KongPokfulamPeople's Republic of China

Top-of-atmosphere(TOA)outgoing longwave radiation(OLR),a key component of the Earth’s energy budget,serves as a diagnostic of the Earth’s climate system response to incoming solar ***,existing products are typically estimated using broadband sensors with coarse spatial *** paper presents a machine learning method to estimate TOA OLR by directly linking Moderate Resolution Imaging Spectroradiometer(MODIS)TOA radiances with TOA OLR determined by Clouds and the Earth’s Radiant Energy System(CERES)and other information,such as the viewing geometry,land surface temperature and cloud top temperature determined by Modern-Era Retrospective analysis for Research and Applications,Version 2(MERRA-2).Models are built separately under clear-and cloudy-sky conditions using a gradient boosting regression *** test results show that the root mean square errors(RMSEs)of the clear-sky and cloudy-sky models for estimating instantaneous values are 4.1 and 7.8 W/m^(2),***-time conversion ratios derived from CERES daily and hourly OLR data are used to convert the instantaneous MODIS OLR to daily ***-comparisons of the daily results show that the RMSE of the estimated MODIS OLR is 8.9 W/m^(2) in East *** developed high resolution dataset will be beneficial in analyzing the regional energy budget.

关键词： TOA outgoing longwave radiation MODIS CERES machine learning Earth’s energy budget

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A Numerical-analytic Method for Quickly Predicting Springback of Numerical Control Bending of Thin-walled Tube

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Journal of Materials Science & Technology 2006年第5期22卷 713-720页

作者： Mei zhan He YANG liang HUANG College of Materials Science and Engineering Northwestern Polytechnical University Xi＇an 710072 China

Springback is one of important factors influencing the forming quality of numerical control （NC） bending of thin-walled tube. In this paper, a numerical-analytic method for springback angle prediction of the process was put forward. The method is based on springback angle model derived using analytic method and simulation results from three-dimensional （3D） rigid-plastic finite element method （FEM）. The method is validated through comparison with experimental results. The features of the method are as follows：（1） The method is high in efficiency because it combines advantages of rigid-plastic FEM and analytic method. （2） The method is satisfactory in accuracy, since the field variables used in the model is resulting from 3D rigid-plastic FEM solution, and the effects both of axial force and strain neutral axis shift have been included. （3） Research on multi-factor effects can be carried out using the method due to its advantage inheriting from rigid-plastic FEM. The method described here is also of general significance to other bending processes.

关键词： Thin-walled tube Numerical control bending Springback Numerical-analytic method 3D rigid-plastic FEM

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