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Modeling of Non-uniformly Sampled Systems by Support Vector Regression with Applications

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International Journal of Plant Engineering and Management 2010年第3期15卷 135-140页

作者： li Da-hai li Tian-shi School of Mechanical Engineering Xi'an Jiaotong University Xi'an 710049 P.R. China

This paper presents a modeling method for a non-uniformly sampled system bused on support vector regression （ SVR ）. First, a lifted discrete-time state-space model for a non-uniformly sampled system is derived by using the lifting technique to reduce the modeling difficulty caused by multirate sampling. Then, the system is divided into several parallel subsystems and their input-output model is presented to satisfy the SVR model. Finally, an on-line SVR technique is utilized to establish the models of all subsystems to deal with uncertainty. Furthermore, the presented method is applied in a multichannel electrohydraulic force servo synchronous loading system to predict the system outputs over the control sample interval and the prediction mean absolute percentage error reaches 0. 092%. The results demonstrate that the presented method has a high modeling precision and the subsystems have the same level of prediction error.

关键词： support vector regression multirate sampling non-uniformly sampled systems

Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： shi-shi Yu Xi Zheng Xiao-Sheng li Qian-Jie Xu Wei Zhang Zhong-li liao hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

Complete Nucleotide Sequence of a Mumps Virus SP Strain Isolated in China

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Virologica Sinica 2009年第1期24卷 28-36页

作者： Shao-hui MA Jian-sheng liU hai-jing shi li-chun WANG Jing-jing WANG Long-ding liU Qi-han li Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650118 China

The complete nucleotide sequence of the mumps virus SP, which was isolated in China, was determined. As with other mumps viruses, its genome was 15 384 nucleotides (nts) in length and encoded seven proteins. The full-length nucleotide sequence of the SP isolate differed from other strains by 4% –6.8% at the nucleotide sequence level. Due to variations of amino acids over the full genome (including the HN and N genes), this isolate exhibited significant variations in the antigenic sites. This report is the first to describe the full-length genome of a genotype F strain and provide an overview of the diversity of genetic characteristics of a circulating mumps virus.

关键词： Complete nucleotide sequence Genotype F Mumps virus

Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui Wan Yu-Xin Zhang Guan-Yue Shan Jun-Ya Cheng Duan-Rui Qiao Yi-Ying liu Wen-Na shi hai-Jun li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu hai-Feng Zhou Wei Yang Di Zhu Bi-Fei Wu hai-Bin shi Sheng liu Wei-Zhong Zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

Research of Hierarchical P2P Network based on Chord

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Research of Hierarchical P2P Network based on Chord

2009通信理论与技术新发展——第十四届全国青年通信学术会议

作者： MA hai-bo shi li ZHANG Jia-min (Software Institute Dalian Jiaotong University Dalian,liaoning Province,China)

Structured P2P model with Chord method can be used to quickly search the location of resources,which is an effective P2P routing *** article combined the unstructured and structured P2P model,saying that Hierarchical P2P Network based on Chord as the model of the HPNC. The method is composing the nodes not far from them into a group with unstructured P2P model,the group constitutes the lower network;the central node from lower network abstracts into super-node, becomes the upper network node using structured Chord model,the network improves the efficiency of resources *** P2P network with HPNC is fast and simple,resources search fast.

关键词： P2P Chord Network model Hierarchy

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车桥系统气动特性的节段模型风洞试验研究

铁道学报 2004年第3期26卷 71-75页

作者：李永乐廖海黎强士中西南交通大学桥梁及结构工程系四川成都610031

侧向风作用下的车桥耦合振动分析需要考虑相互气动影响的车辆和桥梁各自的气动参数。为考虑车辆和桥梁的相互气动影响,在常规桥梁节段模型三分力测试装置的基础上研制了一种三分力分离装置———交叉滑槽系统。该系统利用环形滑槽和直... 详细信息

侧向风作用下的车桥耦合振动分析需要考虑相互气动影响的车辆和桥梁各自的气动参数。为考虑车辆和桥梁的相互气动影响,在常规桥梁节段模型三分力测试装置的基础上研制了一种三分力分离装置———交叉滑槽系统。该系统利用环形滑槽和直线滑槽交叉点位置的变化来调整车辆和桥梁间的相对几何关系,并能实现车桥系统的同轴转动,从而方便地进行不同攻角情况下气动力的测试。利用交叉滑槽系统通过节段模型风洞试验对车桥系统的气动特性进行了多工况对比研究,讨论了车桥系统的雷诺数效应,分析了车桥间的相互气动作用,比较了车辆在桥上位置的影响。试验结果表明,基于交叉滑槽系统的节段模型风洞试验测试是可行的;车桥间的相互气动作用对车辆和桥梁的气动力有较明显的影响。

关键词：车桥系统气动特性节段模型风洞试验交叉滑槽系统雷诺数

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裸脚式稀土矿山原地浸矿渗流过程及边坡变形

稀土 2017年第3期38卷 35-46页

作者：王观石罗嗣海胡世丽洪本根邓旭江西理工大学工程研究院江西赣州341000 江西理工大学建筑与测绘工程学院江西赣州341000 中国科学院寒区旱区环境与工程研究所冻土工程国家重点实验室甘肃兰州730000

原地浸矿回收稀土资源时,因注液不当等原因,容易引发滑坡等地质灾害。选择陡坡开采矿块,现场实验研究裸脚式稀土矿山的原地浸矿渗流过程及其引起的边坡变形规律,得到如下结论。实验矿块的浸润面接近临界水位时,仍有26.5%的矿层处于非饱... 详细信息

原地浸矿回收稀土资源时,因注液不当等原因,容易引发滑坡等地质灾害。选择陡坡开采矿块,现场实验研究裸脚式稀土矿山的原地浸矿渗流过程及其引起的边坡变形规律,得到如下结论。实验矿块的浸润面接近临界水位时,仍有26.5%的矿层处于非饱和状态,因而影响了离子交换效率和资源回收率,是造成"复灌"回收龙南类型离子型稀土资源的一个主要原因。实验矿块矿层饱和体积比为65.0%时,原地浸矿的渗流场进入平衡期,在平衡期之前,注液强度增加6天后裂缝宽度才有明显变化;进入平衡期之后,裂缝宽度变化滞后注液强度增加3天,滞后注液强度减小2天。对于坡度均一的陡坡,如果原地浸矿前期注液强度过大,易引发推移式滑坡,剪出口出现在半山腰以上,后期注液强度过大,易引发牵引式滑坡,剪出口出现在山脚下;对于上陡下缓的陡坡,原地浸矿易引发推移式滑坡。

关键词：稀土矿山原地浸矿渗流规律边坡变形注液强度

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-li li Xiao-Ting Sun li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding hai-Yan shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors