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Artificial Intelligence in Gastroenterology 2024年第1期5卷 1-8页

作者： Wei zhang Li-Ning Song Yun-Fei You Feng-Nan Qi Xiao-Hong Cui Ming-Xun Yi Guang Zhu Ren-An Chang hai-jian zhang Research Center of Clinical Medicine and Department of General Surgery The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of General Surgery Shanghai Electric Power HospitalShanghai 200050China Division of Life Science The Hong Kong University of Science and TechnologyHong KongChina Research Center of Clinical Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

Artificial Intelligence(AI)has increased as a potent tool in medicine,with promising oncology applications.The emergence of immunotherapy has transformed the treatment terrain for hepatocellular carcinoma(HCC),offering new hope to patients with this challenging malignancy.This article examines the role and future of AI in forecasting the effectiveness of immunotherapy in HCC.We highlight the potential of AI to revolutionize the prediction of therapy response,thus improving patient selection and clinical outcomes.The article further outlines the challenges and future research directions in this emerging field.

关键词： Artificial intelligence Hepatocellular carcinoma Immunotherapy Predictive modeling

Expression characteristics and diagnostic value of annexin A2 in hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第41期18卷 5897-5904页

作者： hai-jian zhang Deng-Fu Yao Min Yao Hua Huang Wei Wu Mei-Juan Yan Xiao-Di Yan Jie Chen Research Center of Clinical Medicine Affiliated Hospital of Nantong University Nantong 226001 Jiangsu Province China Min Yao Mei-Juan Yah Medical School of Nantong University Nantong 226001 Jiangsu Province China Medical School of Nantong University Nantong 226001 Jiangsu Province China Departments of Pathology Affiliated Hospital ofNantong University Nantong 226001 Jiangsu Province China

AIM:To investigate the characteristics and diagnostic value of annexin A2(ANXA2) expression in cancerous tissues and sera of patients with hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC).METHODS:Levels of liver ANXA2 gene transcription or protein expression were analyzed in HCC-,their selfcontrolled precancerous-,and distant cancerous-tissues from 30 HCC.Serum levels of ANXA2 expression in 115 patients with HCC,25 with metastatic liver can-cer,35 with chronic hepatitis,28 with acute hepatitis,38 with cirrhosis,and 30 healthy controls were determined.Clinicopathological characteristics of circulating ANXA2 expression were analyzed,and its diagnostic efficiency and clinical values in HCC were evaluated.RESULTS:ANXA2 expression was localized in both cell membrane and cytoplasm in HCC tissue,mainly in the cytoplasm of matched adjacent cancerous tissue,and there was almost no positive staining in matched distant cancerous tissue.Abnormal expression of liver ANXA2 was present in HCC tissues compared with self-controlled adjacent-and distant-cancerous tissues at protein or mRNA level.Circulating ANXA2 in HCC patients was significantly higher than that of other liver diseases(P < 0.01) except metastatic liver cancer.If the diagnostic cutoff value of ANXA2 level was more than 18 ng/mL,the incidence of serum ANXA2 was 86.96% in the HCC group,80% in the metastatic liver cancer group,31.58% in the liver cirrhosis group,none in the chronic hepatitis or acute hepatitis or normal control group,respectively.Serum ANXA2 expression in HCC patients was correlated with HBV infection(27.38 ± 5.67 ng/mL vs 18.58 ± 7.83 ng/mL,P < 0.01),extrahepatic metastasis(26.11 ± 5.43 ng/mL vs 22.79 ± 5.64 ng/mL,P < 0.01),and portal vein thrombus(26.03 ± 5.99 ng/mL vs 23.06 ± 5.03 ng/mL,P < 0.01),and was significantly higher(P < 0.01) in the moderately-(26.19 ± 5.34 ng/mL) or the poorly-differentiated group(27.05 ± 5.13 ng/mL) than in the well differentiated group(20.43 ± 4.97 ng/mL),and in the tumor node metastasis stages ⅢⅣ(P < 0.01)

关键词：肝细胞癌诊断价值膜联蛋白癌组织特征和乙型肝炎病毒 mRNA水平工作特性曲线

Expression of hepatic Wnt5a and its clinicopathological features in patients with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 227-232页

作者： Li Wang Min Yao Miao Fang Wen-Jie Zheng Zhi-Zhen Dong Liu-Hong Pan hai-jian zhang Deng-Fu Yao Department of Medical Informatics Medical College of Nantong University Research Center of Clinical Medicine Affiliated Hospital of Nantong University Department of Immunology Medical College of Nantong University

Backgroud： Wingless-type MMTV integration site family member 5a （Wnt5a） is involved in carcinogenesis.However, little data are available in Wnt5a signaling with hepatocellular carcinoma （HCC）. In thepresent study... 详细信息

关键词： Wnt5a signaling Hepatocellular carcinoma Clinical staging Tissue microarray Wnt/β-catenin pathway Wnt3a signaling

Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment

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World Journal of Gastroenterology 2020年第18期26卷 2126-2137页

作者： Li-Wei Qiu Yi-Fei Liu Xiao-Qing Cao Yan Wang Xiao-Hong Cui Xian Ye Shuo-Wen Huang Hong-Jun Xie hai-jian zhang Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Thoracic Surgery Beijing Chest HospitalCapital Medical University(Beijing Tuberculosis and Thoracic Tumor Research Institute)Beijing 101149China Emergency Department Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of General Surgery Shanghai Electric Power HospitalShanghai 200050China Medical School of Nantong University Nantong 226001Jiangsu ProvinceChina

Hepatocellular carcinoma(HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2(ANXA2), is found to promote cancer progression and therapeutic resistance.However, the underlining mechanisms of ANXA2 in immune escape of HCC remain poorly understood up to now. Herein, we summarized the molecular function of ANXA2 in HCC and its relationship with prognosis. Furthermore, we tentatively elucidated the underlying mechanism of ANXA2 immune escape of HCC by upregulating the proportion of regulatory T cells and the expression of several inhibitory molecules, and by downregulating the proportion of natural killer cells and dendritic cells and the expression of several inhibitory molecules or effector molecules. We expect a lot of in-depth studies to further reveal the underlying mechanism of ANXA2 in immune escape of HCC in the future.

关键词： Annexin A2 Hepatocellular carcinoma Immune microenvironment Overall survival Chemotherapy resistance Checkpoint

Values of circulating GPC-3 mRNA and alpha-fetoprotein in detecting patients with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2013年第2期12卷 171-179页

作者： Min Yao Deng-Fu Yao Yin-Zhu Bian Wei Wu Xiao-Di Yan Dan-Dan Yu Li-Wei Qiu Jun-Ling Yang hai-jian zhang Wen-Li Sai Jie Chen Department of Immunology Medical School of Nantong University Research Center of Clinical Medicine Affiliated Hospital of Nantong University Department of Oncology Affiliated Yancheng Hospital of Nantong University

BACKGROUND: The prognosis of hepatocellular carcinoma (HCC) is poor and its early diagnosis is of the utmost importance. This study aimed to investigate the values of glypican-3 (GPC-3) expression in the liver and sera and its gene transcription for diagnosis and monitoring of metastasis of HCC. METHODS: Liver GPC-3 was analyzed in HCC tissues from 36 patients by immunohistochemistry and Western blotting. GPC-3 mRNA from circulating peripheral blood mononuclear cells from 123 HCC patients or 246 patients with other diseases or 36 HCC tissues was amplified by RT-PCR, quantitative realtime PCR, and confirmed by DNA sequencing. Circulating GPC-3 level was detected by ELISA. RESULTS: The increasing expression of GPC-3 was observed from non-cancerous to cancerous tissues, with brown granule-like staining localized in tumor parts of atypical hyperplasia and HCC formation. The positive rate of GPC-3 was 80.6% in HCC, 41.7% in their paracancerous tissues, and none in distal cancerous tissues (P<0.001), with no significant difference in differentiation grade and tumor number except for size (Z=2.941, P=0.003). Serum GPC-3 was detected only in HCC (52.8%) and significant difference was found between GPC-3 and tumor size (χ2 =6.318, P=0.012) or HBV infection (χ2 =23.362, P<0.001). Circulating GPC-3 mRNA was detected in 70.7% of HCC tissues, with relation to TNM stage, periportal cancerous embolus, and extra-hepatic metastasis (P<0.001). The combination ofcirculating GPC-3, GPC-3 mRNA and alpha-fetoprotein is of complementary value for HCC diagnosis (94.3%). CONCLUSION: Both GPC-3 overexpression and GPC-3 mRNA abnormality could be used as markers for the diagnosis of HCC and monitoring its metastasis.

关键词： hepatocellular carcinoma glypican-3 immunohistochemistry quantitative real-time PCR gene expression sequencing

How variable progenitor clones construct a largely invariant neocortex

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National Science Review 2024年第1期11卷 129-144页

作者： Zhongfu Shen Jiajun Yang Qiangqiang zhang Kuiyu Wang Xiaohui Lv Xiaolin Hu jian Ma Song-hai Shi New Cornerstone Science Laboratory IDG/McG overn Institute for Brain Research Tsinghua-Peking Center for Life Sciences Beijing Frontier Research Center for Biological Structure School of Life Sciences Tsinghua University Department of Computer Sciences Tsinghua University College of Life Sciences Nankai University Chinese Institute for Brain Research

The neocortex contains a vast collection of diverse neurons organized into distinct layers. While nearly all neocortical neurons are generated by radial glial progenitors(RGPs), it remains largely unclear how a complex yet organized neocortex is constructed reliably and robustly. Here, we show that the division behavior and neuronal output of RGPs are highly constrained with patterned variabilities to support the reliable and robust construction of the mouse neocortex. The neurogenic process of RGPs can be well-approximated by a consistent Poisson-like process unfolding over time, producing deep to superficial layer neurons progressively. The exact neuronal outputs regarding layer occupation are variable; yet, this variability is constrained systematically to support all layer formation, largely reflecting the variable intermediate progenitor generation and RGP neurogenic entry and exit timing differences. Together, these results define the fundamental features of neocortical neurogenesis with a balanced reliability and variability for the construction of the complex neocortex.

关键词： neocortex radial glial progenitor intermediate progenitor neurogenesis clonal variability layer formation

Exponential synchronization of general chaotic delayed neural networks via hybrid feedback

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 262-270页

作者： Mei-qin LIU jian-hai zhang School of Electrical Engineering Zhejiang University Hangzhou 3 10027 China

This paper investigates the exponential synchronization problem of some chaotic delayed neural networks based on the proposed general neural network model,which is the interconnection of a linear delayed dynamic system and a bounded static nonlinear operator,and covers several well-known neural networks,such as Hopfield neural networks,cellular neural networks(CNNs),bidirectional associative memory(BAM)networks,recurrent multilayer perceptrons(RMLPs).By virtue of Lyapunov-Krasovskii stability theory and linear matrix inequality(LMI)technique,some exponential synchronization criteria are derived.Using the drive-response concept,hybrid feedback controllers are designed to synchronize two identical chaotic neural networks based on those synchronization criteria.Finally,detailed comparisons with existing results are made and numerical simulations are carried out to demonstrate the effectiveness of the established synchronization laws.

关键词：人工神经网络指数同步化线形分析计算机

Permanent lining castable with low bulk density and thermal conductivity:bauxite castable for tundish obtained by adding pearlescent sand

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Journal of Iron and Steel Research(International) 2024年第3期31卷 634-646页

作者： Yi Wang jian Yang Bao Wang hai-jun zhang Juan Han Pei-yan Pei Wen-long Lv jian-an Zhou The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina Wuhan Research Institute of Metallurgical Construction MCCWuhan 430081HubeiChina

The low thermal conductivity and light mass of castables for tundish permanent linings are crucial for minimizing the heat loss of molten steel.In consideration of the low bulk density and thermal conductivity of pearlescent sand,the thermal insulation performance of castables was attempted to be improved by adding pearlescent sand.Pearlescent sand was modified to prevent the strength of its porous structure from deteriorating.The modification mechanism of pearlescent sand and the effect of pearlescent sand on the performance of bauxite castables were studied.The results suggested that the addition of the modified pearlescent sand significantly raised the apparent porosity and decreased the bulk density of bauxite castable.At 1000℃,the bulk density of more than 60%of the modified pearlescent sand-bauxite castable was only 2.03 g/cm^(3).The mechanical properties and thermal shock resistance of the modified pearlescent sand-bauxite castable were inferior to those of conventional bauxite castable but were adequate to meet the use conditions of casta-bles for tundish permanent linings.At high temperatures of 200-800℃,the thermal conductivity of more than 60%of the modified pearlescent sand-bauxite castable was smaller than that of conventional bauxite castable.The addition of the modified pearlescent sand can greatly reduce the thermal conductivity and bulk density of bauxite castable.

关键词： Pearlescent sand-Hydrophobic modification Bauxite castable Thermal insulation performance Mechanical property

Distribution of pathogenic bacteria and antimicrobial sensitivity of eye infections in Suzhou

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 700-706页

作者： Li zhang hai-zhang You Guo-Hui Wang Wei Xu jian-Shan Li Qing-Liang Zhao Shu Du Department of Hospital-Acquired Infection Control Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Administrative Office Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Clinical Laboratory Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Pharmacy Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Corneal and Lacrimal Passage Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Fundus Diseases and Ocular Trauma Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina

AIM:To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial drugs.METHODS:The clinical data of 155 patients were retrospectively collected in this study,and the pathogenic bacteria species and drug resistance of each pathogenic bacteria were analyzed.RESULTS:Among the 155 patients(age from 12 to 87 years old,with an average age of 57,99 males and 56 females)with eye infections(160 eyes:74 in the left eye,76 in the right eye and 5 in both eyes,all of which were exogenous),71(45.81%)strains were gram-positive bacteria,23(14.84%)strains were gram-negative bacteria and 61(39.35%)strains were fungi.Gram-positive bacteria were highly resistant to penicillin and erythromycin(78.87%and 46.48%respectively),but least resistant to vancomycin at 0.Gram-negative bacteria were highly resistant to cefoxitin and compound sulfamethoxazole(100%and 95.65%respectively),but least resistant to meropenem at 0.Comparison of the resistance of gram-positive and gram-negative bacteria to some drugs revealed statistically significant differences(P<0.05)in the resistance of both to cefoxitin,cotrimoxazole,levofloxacin,cefuroxime,ceftriaxone and ceftazidime,and both had higher rates of resistance to gram-negative bacteria than to gram-positive bacteria.The distribution of bacterial infection strains showed that Staphylococcus epidermidis was the most common strain in the conjunctiva,cornea,aqueous humor or vitreous body and other eye parts.Besides,Fusarium and Pseudomonas aeruginosa were also among the most common strains of conjunctival and corneal infections.CONCLUSION:Gram-positive bacteria are the dominant bacteria in eye infections,followed by gram-negative bacteria and fungi.Considering the resistance of gramnegative bacteria to multiple drugs,monitoring of bacteria should be strengthened in eye bacterial infections for effective prevention and control to reduce complications caused by eye infections.

关键词： eye infection pathogenic bacteria drug resistance antimicrobial sensitivity test

Robust exponential stability analysis of a larger class of discrete-time recurrent neural networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1912-1920页

作者： zhang jian-hai zhang Sen-lin LIU Mei-qin Department of System Science ＆ Engineering School of Electrical Engineering Zhejiang University Hangzhou 310027 China

The robust exponential stability of a larger class of discrete-time recurrent neural networks (RNNs) is explored in this paper. A novel neural network model, named standard neural network model (SNNM), is introduced to provide a general framework for stability analysis of RNNs. Most of the existing RNNs can be transformed into SNNMs to be analyzed in a unified way. Applying Lyapunov stability theory method and S-Procedure technique, two useful criteria of robust exponential stability for the discrete-time SNNMs are derived. The conditions presented are formulated as linear matrix inequalities (LMIs) to be easily solved using existing efficient convex optimization techniques. An example is presented to demonstrate the transformation procedure and the effectiveness of the results.

关键词：人工神经网络指数稳定性分析标准技术