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MicroRNA-125b regulates Th17/Treg cell differentiation and is associated with juvenile idiopathic arthritis

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World Journal of Pediatrics 2020年第1期16卷 99-110页

作者： Zhi-Dan Fan Qian Cao Na Huang Le Ma Hui-Hui Ma Ya-yuan Zhang hai-guo yu guo-Ping Zhou Department of Pediatrics The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Rheumatology and Immunology Children's Hospital of Nanjing Medical UniversityNanjing 210008China

Background Juvenile idiopathic arthritis(JIA)is the most common rheumatic disease in childhood driven by aberrant pathways of T-cell activation.T helper 17(Th17)/regulatory T cell(Treg)imbalance plays critical roles in the pathogenesis of ***-125b(miR-125b)was upregulated after the activation of the initial CD4^+T cells,and could regulate the differentiation of CD4^+T ***,the effects of miR-125b on Th17/Treg imbalance and differentiation of Th 17/Treg cells remain *** In this study,we evaluated the expression of miR-125b in the peripheral blood mononuclear cells(PBMCs)of children with JIA,and the relationship of miR-125b with Th17/Treg ***,we used lentivirus vector-mediated overexpression technology to investigate the regulatory function of miR-125b in CD4^+T cells or dendritic cell/CD4^+T co-culture *** Decreased miR-125b expression in PBMCs and CD4^+T cells of JIA patients was negatively correlated with the ratio of Th17/Treg *** also correlated negatively with retinoic acid receptor-related orphan receptorγt but positively with Forkhead box protein 3 at transcriptional ***,we found that miR-125b overexpression inhibited Th17 cell differentiation,whereas facilitated the differentiation of Treg ***-125b upregulation led to the decrease of Th 17-secreting cytokines but the increase of the Treg-secreting *** Our results demonstrate that miR-125b participated in regulating Thl7/Treg cell differentiation and imbalance in JIA *** findings provide novel insight into the critical role of miR-125b in the Th17/Treg imbalance of JIA,and raise the distinct possibility that miR-125b may prove to be a potential therapeutic target for JIA.

关键词： CD4^+T-cell differentiation Juvenile idiopathic arthritis MicroRNA-125b Th17cells Treg cells

Clinical and laboratory features,treatment,and outcomes of macrophage activation syndrome in 80 children:a multi-center study in China

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World Journal of Pediatrics 2020年第1期16卷 89-98页

作者： Li-Xia Zou yun Zhu Li Sun Hui-Hui Ma Si-Rui Yang Hua-Song Zeng Ji-Hong Xiao hai-guo yu Li guo Yi-Ping Xu Mei-Ping Lu Department of Rheumatology Immunology and Allergy Children's HospitalZhejiang University School of Medicine57 Zhugan LaneHangzhou 310003China Department of Nephrology and Immunology Children's Hospital of Soochow University92 Zhongnan StreetSuzhou 215003China Department of Rheumatology Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China Department of Rheumatology and Immunology Children's Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China Department of Pediatric Rheumatology and Allergy The First Hospital of Jilin University71 Xinming StreetChangchun 130021China Pediatric Allergy Immunology and Rheumatology DepartmentGuangzhou Children's HospitalGuangzhou Women and Children's Medical CenterGuangzhou Medical University318 Renminzhong RoadGuangzhou 510120China Department of Pediatric The First Affiliated Hospital of Xiamen University55 Zhenhai RoadXiamen 361003China

Background Macrophage activation syndrome(MAS)is a major cause of morbidity and mortality in pediatric *** aimed to further understand the clinical features,treatment,and outcome of MAS in *** A multi-center cohort study was performed in seven hospitals in China from 2012 to *** patients with MAS were enrolled,including 53 cases with systemic juvenile idiopathic arthritis(SJIA-MAS),10 cases of Kawasaki disease(KD-MAS),and 17 cases of connective tissue disease(CTD-MAS).The clinical and laboratory data were collected before(pre-),at onset,and during full-blown stages of *** compared the data among the SJIA-MAS,KD-MAS,and CTD-MAS *** 51.2%of patients developed MAS when the underlying disease was first *** patients with SJIA,22.6%(12/53)were found to have hypotension before the onset of *** patients were also found to have significantly increased aspartate aminotransferase(AST)and lactate dehydrogenase(LDH),as well as decreased albumin(P<0.05),but no difference in alanine aminotransferase,ferdtin,and ratio of ferritin/erythrocyte sedimentation rate(ESR)at onset of MAS when compared to pre-MAS stages of the *** addition,ferritin and ratio of ferritin/ESR were significantly elevated in patients at full-blown stages of SJIA-MAS compared to pre-MAS *** increased ferritin and ratio of ferritin/ESR were also observed in patients with SJIA compared to in KD and ***-operating characteristic analysis showed that 12,217.5μg/L of ferritin and 267.5 of ferritin/ESR ratio had sensitivity(80.0%and 90.5%)and specificity(88.2%and 86.7%),respectively,for predicting full-blown *** majority of the patients received corticosteroids(79/80),while biologic agents were used in 12.5%(10/80)of *** was the most commonly selected biologic *** overall mortality rate was 7.5%.Conclusions About half of MAS occurred when the underlying autoimmune diseases(SJIA,KD,and CTD)were

关键词： Connective tissue disease Kawasaki disease Macrophage activation syndrome Systemic juvenile idiopathic arthritis

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无刷双馈电机自抗扰控制方法

控制与决策 2015年第12期30卷 2293-2297页

作者：夏超英郭海宇天津大学电气与自动化工程学院天津300072

针对无刷双馈电机非线性强耦合特性,提出一种实现其高性能控制的自抗扰控制方法.在控制电机同步坐标系下,设计磁链自抗扰控制器和转速自抗扰控制器,对系统内部的耦合影响和系统外部扰动进行观测和补偿,实现非线性系统线性化控制.该控制... 详细信息

针对无刷双馈电机非线性强耦合特性,提出一种实现其高性能控制的自抗扰控制方法.在控制电机同步坐标系下,设计磁链自抗扰控制器和转速自抗扰控制器,对系统内部的耦合影响和系统外部扰动进行观测和补偿,实现非线性系统线性化控制.该控制器具有较强的鲁棒性,且不依赖电机模型.仿真对比结果表明,自抗扰控制器能够准确地估计和补偿系统的内外扰动,控制精度高,抗扰能力强,能够实现磁链和电磁转矩的解耦,进而实现磁链和转速相互独立控制,是一种简单有效的高性能控制方法.

关键词：无刷双馈电机自抗扰控制器解耦控制

^(99m)Tc-AMD3100:A novel potential receptor-targeting radiopharmaceutical for tumor imaging

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Chinese Chemical Letters 2010年第4期21卷 461-463页

作者： Jin Ming Zhang~(a,),Jia He Tian~a,Tian Ran Li~a, hai yu guo~a,Li Shen~b a Department of Nuclear Medicine,The PLA General Hospital,Beijing,100853,China b Peking University Health Science Center,Beijing,100191,China Department of Nuclear Medicine The PLA General Hospital Beijing 100853 China Peking University Health Science Center Beijing 100191 China

The chemokine CXCR4 receptor is over-expressed in a wide variety of *** this study,AMD3100,which was a prototype non-peptide antagonist of CXCR4 receptor,was labeled with;Tc.;Tc-AMD3100 was verified by thin layer radio chromatography（TLRC）.The tumor-localizing properties of;Tc-AMD3100 were evaluated and proved in mice bearing Hep-G2 tumor xenograft.;Tc-AMD3100 was a promising,novel receptor-specific radiopharmaceutical with potential application in the imaging of human tumors.

关键词： ^(99m)Tc Chemokine CXCR4 AMD3100 Tumor imaging

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东北地区产业结构变迁及其经济效应分析

商业研究 2017年第10期 171-176页

作者：解海郭富康宇虹哈尔滨学院哈尔滨150001 哈尔滨工业大学经济与管理学院哈尔滨150001

产业结构变迁是区域经济发展的基础性特征,也是决定区域经济发展内生动力的重要方面。以东北地区为例分析产业结构演变及其合理化进程和高级化进程对长期经济增长和短期经济波动的影响,结果显示,产业结构的合理化和高度化对东北的经济... 详细信息

产业结构变迁是区域经济发展的基础性特征,也是决定区域经济发展内生动力的重要方面。以东北地区为例分析产业结构演变及其合理化进程和高级化进程对长期经济增长和短期经济波动的影响,结果显示,产业结构的合理化和高度化对东北的经济增长均具有显著的正向影响,二者相比较,产业结构的高级化具有更大的增长效应,但存在使经济面临更大波动风险的可能。因此,产业政策要做到内外关联和产业关联性的平衡,在经济增长和波动风险之间进行平衡,并构建一个合理的发展模式。

关键词：产业结构经济增长经济波动东北地区

Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang yu Jingxiao Zhao Xuelin Wang Hui guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

城镇职工基本养老保险收支测算及影响因素分析

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财经问题研究 2022年第3期 83-91页

作者：贺蕊莉郭海彧东北财经大学财政税务学院辽宁大连116025

人口老龄化是我国必须面对的现实问题。本文借鉴已有研究并选用相关统计数据,利用灰色模型预测人口老龄化背景下城镇职工基本养老保险收支状况,研究显示,城镇职工基本养老保险当期结余将于2022年出现负值,累计结余将于2025年开始减少并... 详细信息

人口老龄化是我国必须面对的现实问题。本文借鉴已有研究并选用相关统计数据,利用灰色模型预测人口老龄化背景下城镇职工基本养老保险收支状况,研究显示,城镇职工基本养老保险当期结余将于2022年出现负值,累计结余将于2025年开始减少并于2029年出现负值。本文还选取2015—2020年《中国统计年鉴》相关数据,利用随机森林模型对城镇职工基本养老保险收支影响因素进行经验研究,研究显示,人均GDP、老少比与老龄化率、养老保险基金收益率和政府财政能力都是保障基本养老保险制度良性可持续运转的重要因素。据此,本文提出深化改革、大力发展经济、改善人口结构和基本养老保险基金缴费人口结构、提高基本养老保险基金收益率等建议,并针对政府财政“兜底”责任问题,建议深化财政分权制度改革、提高养老保险统筹层次,以应对我国的人口老龄化问题。

关键词：人口老龄化养老保险收入养老保险支出财政责任

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城乡一体化低保老人养老担心度研究

财经问题研究 2019年第10期 95-102页

作者：刘艳茹郭海彧东北财经大学公共管理学院

本文以城乡低保老人为研究对象,分别采用模糊综合评价法、分类决策树算法和关联规则算法依次进行数据预处理、影响因素分析及关联性分析发现:城乡低保老人对养老困境均呈现出"比较担心"的共性特征;城乡低保老人的户籍状况、婚姻状况、... 详细信息

本文以城乡低保老人为研究对象,分别采用模糊综合评价法、分类决策树算法和关联规则算法依次进行数据预处理、影响因素分析及关联性分析发现:城乡低保老人对养老困境均呈现出"比较担心"的共性特征;城乡低保老人的户籍状况、婚姻状况、身体状况以及社会关系网成为影响养老担心度的重要因素;城乡低保老人养老担心度与低保制度满意度具有一定负向关联性.本文以城乡一体化低保制度为前提来测度低保老人养老担心度,对于实现精准扶贫具有重要意义.

关键词：城乡一体化低保老人养老担心度精准扶贫

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昨日赤壁今又来——评电影《赤壁》

电影评介 2008年第23期 20-21页

作者：史玉丰郭海玉山东大学威海分校新闻传播学院院山东大学威海分校新闻传播学院院

赤壁之战是中国历史上著名的以少胜多的战役,电影《赤壁》再现了这一历史事件的恢宏和壮大,但是却表现了迥异的特质,具体表现在对朋友之情的强调,对和平、自由、平等、团结等精神的弘扬和对人性英雄的塑造方面,这是吴宇森个人特色和中... 详细信息

赤壁之战是中国历史上著名的以少胜多的战役,电影《赤壁》再现了这一历史事件的恢宏和壮大,但是却表现了迥异的特质,具体表现在对朋友之情的强调,对和平、自由、平等、团结等精神的弘扬和对人性英雄的塑造方面,这是吴宇森个人特色和中华民族精神的一次成功的结合。

关键词：朋友精神人性英雄