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Solar energetic particles intensity variations associated with a tilted-dipole 3D corotating interaction region

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Earth and Planetary Physics 2024年第5期8卷 797-810页

作者： YuJi Zhu fang Shen Xi Luo yang Wang BoFeng Tang State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences Shandong Institute of Advanced Technology (SDIAT) College of Earth and Planetary Sciences University of Chinese Academy of Sciences School of Science Harbin Institute of Technology

The effect of a tilted-dipole three-dimensional corotating interaction region(CIR) on the transport and acceleration of solar energetic particles(SEPs) is *** this work,we discussed how the particle intensity longitudinal and radial dependence might be influenced by the background ***,we investigate how the spectral index distribution is modulated by the CIR structure We use the focused transport equation(FTE) to describe the propagation and acceleration of SEPs in a tilt-dipole 3D CIR,generated by the high-resolution 3D magnetohydrodynamic(MHD) *** forward stochastic differential method is used to solve the *** protons with theE～(-4.4)spectrum from 0.5 to 15 MeV are injected uniformly at the heliographic equator of 0.15 *** quantities are extracted along each interplanetary magnetic field(IMF) line to show the *** the tilted-dipole CIR background,if injected from the solar equator at the inner boundary,particles in the slow flow are transported to higher latitudes due to the extension of the IMF lines to higher *** longitudinal patterns of the particles are dominated by the density of IMF *** focusing effect modulates the longitudinal variation of the particle intensity and gives rise to new longitudinal intensity *** adiabatic effect largely increases the intensity fluctuation along the *** structure of the solar wind can also lead to the difference of the index α in the empirical functionI＿(max)=kR～(-α),describing the radial variation of peak intensity according to our *** the influence of the CIR structure,the index α varies from 1.9 to 3.4 at 0.3-1.0 *** variation of the solar wind speed should be considered when estimating the radial dependence of the SEP peak *** spectra indices rise near the CIR boundaries and drop near the stream interface(SI).The adiabatic effect makes the spatial variability of the spectral index *** spectral index could be sim

关键词： solar energetic particle (SEP) corotating interaction regions (CIR) magnetohydrodynamic (MHD)

Characterization of blueberry exosome-like nanoparticles and miRNAs with potential cross-kingdom human gene targets

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Food Science and Human Wellness 2024年第2期13卷 869-878页

作者： yangfan Leng Liubin yang Siyi Pan Leilei Zhan fang Yuan College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Fruit&Vegetable Processing&Quality Control Huazhong Agricultural UniversityWuhan 430070China Wuhan GeneCreate Biological Engineering Co. Ltd.Wuhan 430070China

Edible plant derived exosome-like nanoparticles(ELNs)have been shown to have multiple nutraceutical ***,the diversity of plant materials makes the plant derived ELN study *** efforts are still needed to explore the feasible isolation methods of edible plant derived ELNs and the possible roles of food-derived ELNs in improving human *** this study,a size exclusion chromatography based method was compared with the traditional ultracentrifugation method to isolate blueberry derived ELNs(B-ELNs),and the miRNA profile of B-ELNs was analyzed by high-throughput sequencing.A total of 36 miRNAs were found to be enriched in B-ELNs compared with berry tissue,and their potential cross-kingdom human gene targets were further *** showed that size exclusion chromatography was effective for B-ELN *** most abundant miRNAs in B-ELNs mainly belonged to the miR166 family and miR396 *** gene prediction indicated that B-ELNs could potentially regulate pathways related to the human digestive system,immune system and infectious diseases.

关键词： Edible plant derived exosomes-like nanoparticles Size exclusion chromatography miRNA Target gene prediction Blueberry

Atomically dispersed Ni electrocatalyst for superior urea-assisted water splitting

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Journal of Energy Chemistry 2024年第3期90卷 1-6,I0002页

作者： fang Luo Shuyuan Pan Yuhua Xie Chen Li Yingjie Yu Zehui yang College of Materials Science and Engineering State Key Laboratory of New Textile Materials&Advanced Processing TechnologyWuhan Textile UniversityWuhan 430200China Hubei Hydrogen Energy Technology Innovation Center Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074HubeiChina

Urea oxidation reaction(UOR) has been selected as substitution for oxygen evolution reaction ascribing to its low thermodynamic voltage as well as utilization of nickel as ***,we report the formation of nickel single atoms(Ni-SAs) as exceptional bifunctional electrocatalyst toward UOR and hydrogen evolution reaction(HER) in urea-assisted water *** UOR catalysis,Ni-SAs perform a superior catalytic performance than Ni-NP/NC and Pt/C ascribing to the formation of HOO-Ni-N_(4) structure evidenced by in-situ Raman spectroscopy,corresponding to a boosted mass activity by 175-fold at 1.4 V *** than Ni-NP/***,Ni-SAs requires only 450 mV overpotential to obtain HER current density of 500 mA cm^(-2).136 mA cm^(-2) is achieved in urea-assisted water splitting at1.7 V for Ni-SAs,boosted by 5.7 times than Pt/C-IrO_(2) driven water splitting.

关键词： Urea oxidation reaction Hydrogen evolution reaction Nickel single atoms Water splitting

Optoelectronic Synapses Based on MXene/Violet Phosphorus van der Waals Heterojunctions for Visual‑Olfactory Crossmodal Perception

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Nano-Micro Letters 2024年第6期16卷 38-52页

作者： hailong Ma Huajing fang Xinxing Xie Yanming Liu He Tian yang Chai Center for Advancing Materials Performance From the Nanoscale(CAMP‑Nano) State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Institute of Microelectronics and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100084People’s Republic of China Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongPeople’s Republic of China

The crossmodal interaction of different senses,which is an important basis for learning and memory in the human brain,is highly desired to be mimicked at the device level for developing neuromorphic crossmodal perception,but related researches are ***,we demonstrate an optoelectronic synapse for vision-olfactory crossmodal perception based on MXene/violet phosphorus(VP)van der Waals *** from the efficient separation and transport of photogenerated carriers facilitated by conductive MXene,the photoelectric responsivity of VP is dramatically enhanced by 7 orders of magnitude,reaching up to 7.7 A W^(−1).Excited by ultraviolet light,multiple synaptic functions,including excitatory postsynaptic currents,pairedpulse facilitation,short/long-term plasticity and“learning-experience”behavior,were demonstrated with a low power ***,the proposed optoelectronic synapse exhibits distinct synaptic behaviors in different gas environments,enabling it to simulate the interaction of visual and olfactory information for crossmodal *** work demonstrates the great potential of VP in optoelectronics and provides a promising platform for applications such as virtual reality and neurorobotics.

关键词： Violet phosphorus MXene Van der Waals heterojunctions Optoelectronic synapses Crossmodal perception

Intrinsic charge transport behaviors in graphene-black phosphorus van der Waals heterojunction devices

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Chinese Physics B 2018年第7期27卷 480-485页

作者： Guo-Cai Wang Liang-Mei Wu Jia-Hao Yan Zhang Zhou Rui-Song Ma hai-fang yang Jun-Jie Li Chang-Zhi Gu Li-Hong Bao Shi-Xuan Du Hong-Jun Gao Institute of Physics Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100190 China

Heterostructures from mechanically-assembled stacks of two-dimensional materials allow for versatile electronic device applications. Here, we demonstrate the intrinsic charge transport behaviors in graphene-black phosphorus heterojunction devices under different charge carrier densities and temperature regimes. At high carder densities or in the ON state, tunneling through the Schottky barrier at the interface between graphene and black phosphorus dominates at low temperatures. With temperature increasing, the Schottky barrier at the interface is vanishing, and the channel current starts to decrease with increasing temperature, behaving like a metal. While at low carder densities or in the OFF state, thermal emission over the Schottky barrier at the interface dominates the carriers transport process. A barrier height of ～ 67.3 meV can be extracted from the thermal emission-diffusion theory.

关键词： black phosphorus heterojunction contact barrier height

Combining prognostic value of serum carbohydrate antigen 19-9 and tumor size reduction ratio in pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 798-809页

作者： Dong-Qin Xia Yong Zhou Shuang yang fang-Fei Li Li-Ya Tian Yan-Hua Li hai-Yan Xu Cai-Zhi Xiao Wei Wang Oncology Treatment Center of Traditional Chinese Medicine Chongqing University Cancer HospitalChongqing 400030China Department of Oncology Chongqing Weisiteng Biotech Translational Research InstituteChongqing 430039China Chongqing Key Laboratory on Big Data for Bio Intelligence Chongqing University of Posts and TelecommunicationsChongqing 430065China

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a common cancer with increasing morbidity and mortality due to changes of social *** To evaluate the significance of serum carbohydrate antigen 19-9(CA19-9)and tumor size changes pre-and post-neoadjuvant therapy(NAT).METHODS This retrospective study was conducted at the Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing University Cancer *** study specifically assessed CA19-9 levels and tumor size before and after *** A total of 156 patients who completed NAT and subsequently underwent tumor resection were included in this *** average age was 65.4±10.6 years and 72(46.2%)patients were *** survival analysis,we defined the post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level as the CA19-9 ratio(CR).The patients were divided into three groups:CR0.5 and*** regard to tumor size measured by both computed tomography and magnetic resonance imaging,we defined the post-NAT tumor size/pre-NAT tumor size as the tumor size ratio(TR).The patients were then divided into three groups:TR0.5 and*** on these groups divided according to CR and TR,we performed both overall survival(OS)and disease-free survival(DFS)***-rank tests showed that both OS and DFS were significantly different among the groups according to CR and TR(P<0.05).CR and TR after NAT were associated with increased odds of achieving a complete or near-complete pathologic ***,CR(hazard ratio:1.721,95%CI:1.373-3.762;P=0.006),and TR(hazard ratio:1.435,95%CI:1.275-4.363;P=0.014)were identified as independent factors associated with *** This study demonstrated that post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level and post-NAT tumor size/pre-NAT tumor size were independent factors associated with OS in patients with PDAC who received NAT and subsequent surgical resection.

关键词： Pancreatic ductal adenocarcinoma Carbohydrate antigen 19-9 Tumor size Pathologic response Biomarkers

MUS Model:A Deep Learning-Based Architecture for IoT Intrusion Detection

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Computers, Materials & Continua 2024年第7期80卷 875-896页

作者： Yu Yan Yu yang Shen fang Minna Gao Yiding Chen College of Information Engineering University of Engineering of the Chinese People’s Armed Police Force(PAP)Xi’an710000China College of Missile Engineering Rocket Force Engineering UniversityXi’an710000China

In the face of the effective popularity of the Internet of Things(IoT),but the frequent occurrence of cybersecurity incidents,various cybersecurity protection means have been proposed and *** them,Intrusion Detection System(IDS)has been proven to be stable and ***,traditional intrusion detection methods have shortcomings such as lowdetection accuracy and inability to effectively identifymalicious *** address the above problems,this paper fully considers the superiority of deep learning models in processing highdimensional data,and reasonable data type conversion methods can extract deep features and detect classification using advanced computer vision techniques to improve classification *** TransformField(MTF)method is used to convert 1Dnetwork traffic data into 2D images,and then the converted 2D images are filtered by UnsharpMasking to enhance the image details by sharpening;to further improve the accuracy of data classification and detection,unlike using the existing high-performance baseline image classification models,a soft-voting integrated model,which integrates three deep learning models,MobileNet,VGGNet and ResNet,to finally obtain an effective IoT intrusion detection architecture:the MUS *** types of experiments are conducted on the publicly available intrusion detection dataset CICIDS2018 and the IoT network traffic dataset N_BaIoT,and the results demonstrate that the accuracy of attack traffic detection is greatly improved,which is not only applicable to the IoT intrusion detection environment,but also to different types of attacks and different network environments,which confirms the effectiveness of the work done.

关键词： Cyberspace security intrusion detection deep learning Markov Transition Fields(MTF) soft voting integration

Phase structure evolution and its effect on magnetic and mechanical properties of B-doped Sm_(2)Co_(17)-type magnets with high Fe content

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Chinese Physics B 2024年第9期33卷 582-588页

作者： Yao-Wen Li Zhuang Liu hai-Chen Wu fang Wang Chao-Qun Zhu Dong-Liang Tan Yu Liu yang yang Ming-Xiao Zhang Ren-Jie Chen A-Ru Yan Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry ofEducation&School of Chemistry and Materials Science Shanxi Normal UniversityTaiyuan 030032China CISRI&NIMTE Joint Innovation Center for Rare Earth Permanent Magnets Ningbo Institute ofMaterial Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China

The unique cellular microstructure of Fe-rich Sm_(2)Co_(17)-type permanent magnets is closely associated with the structure of the solid solution *** investigate the phase structure,magnetic properties,and mechanical behavior of B-doped Sm_(2)Co_(17)-type magnets with high Fe *** doped B atoms can diffuse into the interstitial vacancy,resulting in lattice expansion and promote the homogenization of the phase organizational structure during the solid solution treatment in ***,the resulting second phase plays a dominant role to result in more microtwin structures and highly ordered 2:17R phases in the solid solution stage,which inhibits the ordering transformation of 1:7H phase during aging and affects the generation of the cellular structure,and to result in a decrease in magnetic properties,yet the interface formed between it and the matrix phase hinders the movement of dislocations and enhances the mechanical ***,the precipitation of high flexural strain grain boundary phase induced by B element doping is also a new and effective way to improve the flexural strain of Sm_(2)Co_(17)-type *** study provides a new understanding of the phase structure evolution and its effect on the magnetic and mechanical properties of Sm_(2)Co_(17)-type magnets with high Fe content.

关键词： Sm_(2)Co_(17)-type magnets magnetic and mechanical properties

Repressing iron overload ameliorates central poststroke pain via the Hdac2-Kv1.2 axis in a rat model of hemorrhagic stroke

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Neural Regeneration Research 2024年第12期19卷 2708-2722页

作者： He fang Mengjie Li Jingchen yang Shunping Ma Li Zhang Hongqi yang Qiongyan Tang Jing Cao Weimin yang Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Nutrition The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurology Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Human Anatomy School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Neuroscience Research Institute Zhengzhou University Academy of Medical SciencesZhengzhouHenan ProvinceChina

Thalamic hemorrhage can lead to the development of central post-stroke *** in histone acetylation levels,which are regulated by histone deacetylases,affect the excitability of neurons surrounding the hemorrhagic ***,the regulato ry mechanism of histone deacetylases in central post-stroke pain remains unclea ***,we show that iron overload leads to an increase in histone deacetylase 2expression in damaged ventral posterolateral nucleus *** this increase restored histone H3 acetylation in the Kcna2 promoter region of the voltage-dependent potassium(Kv)channel subunit gene in a rat model of central post-stroke pain,thereby increasing Kcna2expression and relieving central ***,in the absence of nerve injury,increasing histone deacetylase 2 expression decreased Kcna2expression,decreased Kv current,increased the excitability of neurons in the ventral posterolateral nucleus area,and led to neuropathic pain ***,treatment with the iron chelator deferiprone effectively reduced iron overload in the ventral posterolateral nucleus after intracerebral hemorrhage,reversed histone deacetylase 2 upregulation and Kv1.2 downregulation,and alleviated mechanical hypersensitivity in central post-stroke pain *** results suggest that histone deacetylase 2 upregulation and Kv1.2 downregulation,mediated by iron overload,are important factors in central post-stroke pain pathogenesis and co uld se rve as new to rgets for central poststroke pain treatment.

关键词： central post-stroke pain hemorrhagic stroke histone deacetylase iron overload voltage-gated potassium ion channel 1.2