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Lightweight,Strong and High Heat-Resistant Poly(lactide acid)Foams via Microcellular Injection Molding with Self-Assembly Nucleating Agent

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Chinese Journal of Polymer Science 2024年第6期42卷 739-750页

作者： Xiao-Hu bing Wen-Yu Ma Ming-Hui Wu Peng Gao Xiao Zhou hai-bin luo Long Wang Wen-Ge Zheng School of materials Science and Engineering Shanghai UniversityShanghai200444China Ningbo Key Lab of Polymer Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(lactide acid)(PLA)foams have shown considerable promise as eco-friendly alternatives to nondegradable plastic foams,such as polystyrene(PS)***,PLA foam typically suffers from low heat-resistance and poor cellular structure stemming from its inherent slow crystallization rate and low melt *** this study,a high-performance PLA foam with well-defined cell morphology,exceptional strength and enhanced heat-resistance was successfully fabricated via a core-back microcellular injection molding(MIM)*** scanning calorimetry(DSC)results revealed that the added hydrazine-based nucleating agent(HNA)significantly increased the crystallization temperature and accelerated the crystallization process of ***,the addition of a 1.5 wt%of HNA led to a significant reduction in PLA’s cell size,from 43.5µm to 2.87µm,and a remarkable increase in cell density,from 1.08×10^(7)cells/cm^(3)to 2.15×10^(10)cells/cm^(3).This enhancement resulted in a final crystallinity of approximately 55.7%for the PLA blend foam,a marked improvement compared to the pure PLA ***,at 1.5 wt%HNA concentration,the tensile strength and tensile toughness of PLA blend foams demonstrated remarkable improvements of 136%and 463%,***,the Vicat softening temperature of PLA blend foam increased significantly to 134.8°C,whereas the pure PLA foam exhibited only about 59.7℃.These findings underscore the potential for the preparation of lightweight injection-molded PLA foam with enhanced toughness and heat-resistance,which offers a viable approach for the production of high-performance PLA foams suitable for large-scale applications.

关键词： Poly(lactide acid) Nucleating agent Microcellular injection molding Heat-resistance Toughness

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Curved carbon photo-oxygenation catalysts for the suppression and nanoscopic imaging ofβ-amyloid peptides fibrillation

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Nano Research 2022年第4期15卷 3387-3397页

作者： Yuanyuan Ma Zhongju Ye Chen Zhang Yanjun Zhao hai-bin luo Lehui Xiao College of Chemistry Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular RecognitionCollege of ChemistryNankai UniversityTianjin 300071China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China School of Pharmaceutical Science&Technology Tianjin UniversityTianjin 300072China

The progression of Alzheimer’s disease(AD)is characterized with the deposition and aggregation ofβ-amyloid(Aβ).Visualizing Aβaggregates at high spatial resolution is beneficial for AD diagnosis and ***,we designed a new molecule by conjugating corannulene(Cor)with rhodamine B isothiocyanate(Rhb),namely Cor-Rhb,for the nanoscopic imaging and modulating Aβpeptide *** low duty cycle,high photon output and sufficient switching cycles enable Cor-Rhb suitable for localization-based nanoscopic fluorescence *** find that Cor-Rhb can inhibit Aβpeptides fibrillization and interact directly with mature fibrils,triggering their disaggregation under light *** reduced Aβ-mediated cytotoxicity after the addition of Cor-Rhb is also *** explorations suggest that Cor-Rhb displays great potential as a multifunctional therapeutic agent against amyloid-related diseases,and may largely facilitate a variety of super-resolution based biological applications.

关键词： nanoscopic imaging β-amyloid reactive oxygen species fluorescence imaging fibrillation

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Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3103-3112页

作者： Xu-Nian Wu Qian Zhou Ya-Dan Huang Xi Xie Zhe Li Yinuo Wu hai-bin luo School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510006China Key Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute School of Pharmaceutical SciencesHainan UniversityHaikou 570228China

Our previous study demonstrated that phosphodiesterase 8(PDE8)could work as a potential target for vascular dementia(Va D)using a chemical probe ***,compound 3a is a chiral compound which was obtained by chiral resolution on HPLC,restricting its usage in ***,a series of non-chiral 9-benzyl-2-chloro-adenine derivatives were discovered as novel PDE8 *** 15 exhibited potent inhibitory activity against PDE8A(IC_(50)=11 nmol/L),high selectivity over other PDEs,and remarkable drug-like properties(worthy to mention is that its bioavailability was up to 100%).Oral administration of 15 significantly improved the c AMP level of the right brain and exhibited dosedependent effects on cognitive improvement in a Va D mouse ***,the X-ray crystal structure of the PDE8A—15 complex showed that the potent affinity and high selectivity of 15 might come from the distinctive interactions with H-pocket including T-shapedπ—πinteractions with Phe785 as well as a unique H-bond network,which have never been observed in other PDE-inhibitor complex before,providing new strategies for the further rational design of novel selective inhibitors against PDE8.

关键词： Phosphodiesterase 8(PDE8) Vascular dementia Structure-based drug design MM-GB/SA Free energy prediction Structure—activity relationship binding potencies

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Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia:Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1180-1191页

作者： Qian Zhou Meiling Le Yiyi Yang Wenjuan Wang Yuqi Huang Quan Wang Yijing Tian Meiyan Jiang Yong Rao hai-bin luo Yinuo Wu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Key Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute School of Pharmaceutical SciencesHainan UniversityHaikou 570228China Song Li’Academician Workstation of hainan University(School of Pharmaceutical Sciences) Sanya 572000China

Vascular dementia(VaD)is the second commonest type of dementia which lacks of efficient treatments *** as a prominent pathological feature of VaD,is highly involved in the development of *** order to verify the therapeutic potential of PDE1 inhibitors against VaD,the anti-neuroinflammation,memory and cognitive improvement were evaluated in vitro and in vivo by a potent and selective PDE1 inhibitor ***,the mechanism of 4a in ameliorating neuroinflammation and VaD was systematically ***,to optimize the drug-like properties of 4a,especially for metabolic stability,15 derivatives were designed and *** a result,candidate 5f,with a potent IC50 value of 4.5 nmol/L against PDE1C,high selectivity over PDEs,and remarkable metabolic stability,efficiently ameliorated neuron degeneration,cognition and memory impairment in VaD mice model by suppressing NF-κB transcription regulation and activating cAMP/CREB *** results further identified PDE1 inhibition could serve as a new therapeutic strategy for treatment of VaD.

关键词： Vascular dementia Phosphodiesterase 1(PDE1) Neuroinflammation Structural-based drug design cAMP/CREB axis

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Switching Behavior of Cascode GaN Under Influence of Gate Driver

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1816-1833页

作者： bin luo Guangzhao luo Sihai Li School of Automation Northwestern Polytechnical UniversityXi’an 710072China

With high-frequency,low power dissipation and high-efficiency characteristics,Gallium nitride(GaN)power devices are of significant benefit in designing high-speed motor drives,as they improve performance and reduce ***,due to the cascode structure,coupling with the parasitics in gate driver and power circuits,power converters based on cascode GaN are prone to overshoot and oscillate on switching waveforms,which may lead to serious EMC problems,or even device *** complicated structure of cascode GaN device makes the gate driver design comparatively *** analytical model of the switching process considering gate driver parameters is proposed in this *** influence of gate driver parameters on switching behavior is investigated from the perspective of switching speed,waveform overshoot,and power ***-offs among overshoot,switching speed,and power loss are discussed;guidelines to design gate driver parameters are given.

关键词： Gallium nitride(GaN) gate driver oscillation and overshoot switching characteristics

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A novel inhibitor of N^(6)-methyladenosine demethylase FTO induces m RNA methylation and shows anti-cancer activities

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Acta Pharmaceutica Sinica B 2022年第2期12卷 853-866页

作者： Guoyou Xie Xu-Nian Wu Yuyi Ling Yalan Rui Deyan Wu Jiawang Zhou Jiexin Li Shuibin Lin Qin Peng Zigang Li Hongsheng Wang hai-bin luo School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Key Laboratory of Tropical Biological Resources of Ministry of Education School of Life and Pharmaceutical SciencesHainan UniversityHaikou 570228China Center for Translational Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen 518067China

N^(6)-methyladenosine(m^(6)A)modification is critical for m RNA splicing,nuclear export,stability and *** mass and obesity-associated protein(FTO),the first identified m^(6)A demethylase,is critical for cancer ***,we developed small-molecule inhibitors of FTO by virtual screening,structural optimization,and *** a result,two FTO inhibitors namely 18077 and 18097 were identified,which can selectively inhibit demethylase activity of ***,18097 bound to the active site of FTO and then inhibited cell cycle process and migration of cancer *** addition,18097 reprogrammed the epi-transcriptome of breast cancer cells,particularly for genes related to P53 pathway.18097 increased the abundance of m^(6)A modification of suppressor of cytokine signaling1(SOCS1)m RNA,which recruited IGF2 BP1 to increase m RNA stability of SOCS1 and subsequently activated the P53 signaling ***,18097 suppressed cellular lipogenesis via downregulation of peroxisome proliferator-activated receptor gamma(PPARγ),CCAAT/enhancer-binding protein alpha(C/EBPa),and C/EBPβ.Animal studies confirmed that 18097 can significantly suppress in vivo growth and lung colonization of breast cancer ***,we identified that FTO can work as a potential drug target and the small-molecule inhibitor 18097 can serve as a potential agent against breast cancer.

关键词： m6A FTO inhibitors Cancer cell Lipogenesis SOCS1

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Free energy perturbation(FEP)-guided scaffold hopping

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1351-1362页

作者： Deyan Wu Xuehua Zheng Runduo Liu Zhe Li Zan Jiang Qian Zhou Yue Huang Xu-Nian Wu Chen Zhang Yi-You Huang hai-bin luo School of Pharmaceutical Sciences Hainan UniversityHaikou 570228China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China School of Pharmaceutical Sciences Guangzhou Medical UniversityGuangzhou 511436China

Scaffold hopping refers to computer-aided screening for active compounds with different structures against the same receptor to enrich privileged scaffolds,which is a topic of high interest in organic and medicinal ***,most approaches cannot efficiently predict the potency level of candidates after scaffold ***,we identified potent PDE5 inhibitors with a novel scaffold via a free energy perturbation(FEP)-guided scaffold-hopping strategy,and FEP shows great advantages to precisely predict the theoretical binding potenciesΔGFEPbetween ligands and their target,which were more consistent with the experimental binding potenciesΔGEXP(the mean absolute deviations|ΔGFEP-ΔGEXP|binding pattern in its crystal structure with PDE5 from the famous starting drug *** work provides the first report via the FEPguided scaffold hopping strategy for potent inhibitor discovery with a novel scaffold,implying that it will have a variety of future applications in rational molecular design and drug discovery.

关键词： Free energy perturbation Scaffold hopping Privileged scaffolds Drug discovery binding potencies Molecular design PDE5 inhibitors Pulmonary arterial hypertension

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Editorial of Special Column “Research on Emerging COVID-19(Target, Mechanism, and Therapeutics)”

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1146-1148页

作者： hai-bin luo Shilin Chen Peiqing Liu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Laboratory of Pharmacology&Toxicology and New Drug R&D Center School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou 510006China

Coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has become a global crisis1,*** from SARS-Co V-2 can result in severe lymphopenia,prolonged coagulation profiles,lethal acute respiratory distress syndrome(ARDS),watery diarrhea,cardiac disease,multiorgan dysfunction,and sudden death3,4.

关键词： acute respiratory distress

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Perspective of drug design with high-performance computing

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National Science Review 2021年第12期8卷 11-12页

作者： Zhe Li Hui Li Kunqian Yu hai-bin luo Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical Sciences Sun Yat-Sen University State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology Shanghai Tech University Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical Sciences Hainan University

In recent decades, the development of high-performance computing(HPC)continues to follow Moore’s law, with many computational methods in drug design experiencing a *** prediction, virtual screening,molecular dynamics simulations and protein folding are crucial applications of computational drug design to accelerate drug discovery(Fig. 1). Reliable prediction of the receptor/ligand binding affinities that determine the pharmacological effects of drugs is the most important application of HPC in drug discovery, and is the main focus of this Perspective.

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Detecting APT-Exploited Processes through Semantic Fusion and Interaction Prediction

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Computers, Materials & Continua 2024年第2期78卷 1731-1754页

作者： bin luo Liangguo Chen Shuhua Ruan Yonggang luo School of Cyber Science and Engineering Sichuan UniversityChengdu610065China Key Laboratory of Data Protection and Intelligent Management(Sichuan University) Ministry of EducationChengdu610065China Cyber Science Research Institute Sichuan UniversityChengdu610065China

Considering the stealthiness and persistence of Advanced Persistent Threats(APTs),system audit logs are leveraged in recent studies to construct system entity interaction provenance graphs to unveil threats in a ***-based provenance graph APT detection approaches require elaborate rules and cannot detect unknown attacks,and existing learning-based approaches are limited by the lack of available APT attack samples or generally only perform graph-level anomaly detection,which requires lots of manual efforts to locate attack *** paper proposes an APT-exploited process detection approach called ThreatSniffer,which constructs the benign provenance graph from attack-free audit logs,fits normal system entity interactions and then detects APT-exploited processes by predicting the rationality of entity ***,ThreatSniffer understands system entities in terms of their file paths,interaction sequences,and the number distribution of interaction types and uses the multi-head self-attention mechanism to fuse these ***,based on the insight that APT-exploited processes interact with system entities they should not invoke,ThreatSniffer performs negative sampling on the benign provenance graph to generate non-existent edges,thus characterizing irrational entity interactions without requiring APT attack *** last,it employs a heterogeneous graph neural network as the interaction prediction model to aggregate the contextual information of entity interactions,and locate processes exploited by attackers,thereby achieving fine-grained APT *** results demonstrate that anomaly-based detection enables ThreatSniffer to identify all attack *** to the node-level APT detection method APT-KGL,ThreatSniffer achieves a 6.1%precision improvement because of its comprehensive understanding of entity semantics.

关键词： Advanced persistent threat provenance graph multi-head self-attention graph neural network

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