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Ouabain-Induced Auditory Nerve Degeneration in Congenic ly5.1 Mice

Journal of Otology 2011年第2期6卷 19-28页

作者： Lauren A.Kilpatrick Devadoss J Samuvel ZHU Ju-hong Nancy Smythe LANG hai-nan Department of Pathology and Laboratory Medicine Medical University of South Carolina Charleston SC 29425 United States Department of Otolaryngology - Heary & Neck Surgery Medical University of South Carolina Charleston SC 29425 United States

The ly5.1 mouse,also termed ***-Ptprca Pepcb/BoyJ,is a congenic strain widely used as a recipient in animal studies of bone marrow *** previous study documented that a majority of type I spiral ganglion neurons (SGNs) in the apical turns of ly5.1 mice are unmyelinated and aggregate into neuronal clusters,similar to the spiral ganglion in the human ***,a well known Na-K ATPase inhibitor,has been shown to induce neuronal degeneration in a variety of neural tissues including the adult gerbil and CBA/CaJ mouse spiral ***,functional and pathological changes of the auditory nerves in young-adult ly5.1 mice were examined at 3,7 and 14 days after ouabain *** to observations in CBA/CaJ mice,ouabain application selectively removed type I SGNs,resulting in an immense decline of the auditory nerve *** of glial cells was seen in the injured auditory nerves at 7 days after ouabain *** data indicate that the 'human-like' features of unmyelinated type I SGNs have no protective impact on the fate of SGNs after ouabain *** incorporating bromodeoxyuridine (BrdU) and expressing Sox2 were also counted in the auditory nerves of control and ouabain-treated *** number of Sox2+ glial cells significantly increased at 3 and 7 days ***,the highest density of BrdU+ cells appeared in the apical turn of the injured auditory nerve shortly after ouabain exposure,suggesting that the pattern of SGN loss at the apical turn in ly5.1 mouse may have some impact on the reaction of non-neuronal cells in response to acute ototoxic drug exposure in the auditory nerve.

关键词： primary auditory nerve ly5.1 mouse ouabain neural degeneration Sox2 BrdU glial cells

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Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

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World Journal of Gastroenterology 2016年第46期22卷 10180-10188页

作者： Wei Jiang Mei-Hua Guo Xin hai Pharmacy Department First Affiliated Hospital of Harbin Medical University

AIM To evaluate the hepatoprotective effect of lycopene(ly) on non-alcoholic fatty liver disease(NAFLD) in rat. METHODS A rat model of NAFLD was first established by feeding a high-fat diet for 14 wk. Sixty-five rats were randomly divided into normal group, model group and ly treatment groups. Alanine aminotransferase(ALT), aspartate aminotransferase(AST), triglycerides(TG), total cholesterol(TC) in serum and low density lipoproteincholesterol(LDL-C), high density lipoprotein-cholesterol(HDL-C), free fatty acid(FFA), malondialdehyde(MDA), superoxide dismutase(SOD), glutathione(GSH) in liver tissue were evaluated, respectively. While the hepatoprotective effect was also confirmed by histopathological analysis, the expression levels of TNF-α and cytochrome P450(CYP) 2E1 in rat liver were determined by immunohistochemistry *** A significant decrease was observed in the levels of serum AST(2.07-fold), ALT(2.95-fold), and the blood lipid TG(2.34-fold) and TC(1.66-fold) in the dose of 20 mg/kg ly-treated rats(P ly significantly raised the levels of antioxidant enzyme SOD in a dose-dependent manner,to 90.95 ± 9.56, 109.52 ± 11.34 and 121.25 ± 10.68(P ly, the levels of GSH were significantly increased(P ly treatment. Meanwhile, pretreatment with 5, 10 and 20 mg/kg of ly significantly reduced MDA amount by 30.87, 45.51 and 54.49% in the liver homogenates, respectively(P ly treatment group showed significantly decreased levels of lipid products LDL-C(P ly decreased content of FFA, compared to the model group(P ly-treated group also exhibited a down-regulated TNF-α and CYP2E1 expression, decreased infiltration of liver fats and reversed histopathological changes, all in a dosedependent manner(P < 0.

关键词： lycopene Antioxidant Hepatoprotective Non-alcoholic fatty liver Cytochrome P450 2E1

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Self-assembly of tau fragments as a key pathologic event in tauopathies

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Neural Regeneration Research 2024年第12期19卷 2565-2566页

作者： ly Thi Huong Luu Le Jung Hoon Lee Min Jae Lee Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea

Tau protein is encoded by the microtubuleassociated protein tau(MAPT)gene and stabilizes microtubules in the *** has unique biophysical properties that make it both highly water-soluble and positively *** tau is an intrinsically disordered protein lacking defined secondary structures,it can acquire highly organized-sheet structures and stack into a filamentous inclusion such as a paired helical filament(PHF).

关键词： tau pathologic assembly

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CONVERGENCE RESULTS FOR NON-OVERLAP SCHWARZ WAVEFORM RELAXATION ALGORITHM WITH CHANGING TRANSMISSION CONDITIONS

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Acta Mathematica Scientia 2022年第1期42卷 105-126页

作者： Minh-Phuong TRAN Thanh-Nhan NGUYEN Phuoc-Toan HUYNH Nhu-Binh ly Minh-Dang NGUYEN Quoc-Anh HO Applied Analysis Research Group Faculty of Mathematics and StatisticsTon Duc Thang UniversityHo Chi Minh cityVietnam Department of Mathematics Ho Chi Minh City University of EducationHo Chi Minh cityVietnam Faculty of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh cityVietnam

In this paper,we establish a new algorithm to the non-overlapping Schwarz domain decomposition methods with changing transmission conditions for solving one dimensional advection reaction diffusion *** precisely,we first describe the new algorithm and prove the convergence results under several natural assumptions on the sequences of parameters which determine the transmission *** we give a simple method to estimate the new value of parameters in each *** interesting advantage of our method is that one may update the better parameters in each iteration to save the computational cost for optimizing the parameters after many *** some numerical experiments are performed to show the behavior of the convergence rate for the new method.

关键词： domain decomposition method Schwarz waveform relaxation algorithm advection reaction diffusion changing transmission conditions

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Influence of induced ciprofloxacin resistance on efflux pump activity of Klebsiella pneumoniae

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第9期14卷 837-843页

作者： hai-qin ZHONG Shun ZHANG Hong PAN Ting CAI Department of Internal Medicine School of MedicineNingbo University Stem Cell Laboratory Ningbo No.2 Hospital Clinical Laboratory Ningbo No.2 Hospital Emergency Department Ningbo No.2 Hospital

Objective:The efflux pump(EP) is one of the major mechanisms of antibiotic resistance in Klebsiella ***,there are few reports on the effect of the abuse of antibiotic use on the activity of *** determine whether the use of low efficacy antibiotics has any effect on the activity of EPs and induces drug resistance in ***,we investigated the effect of ciprofloxacin on the activity of EPs in *** ***:Sixteen susceptible *** strains were isolated from patients and their minimum inhibitory concentrations(MICs) of ciprofloxacin were measured in the absence and presence of the pump inhibitor carbonyl cyanide m-chlorophenyl hydrazone(CCCP).The strains were then induced with a gradient of ciprofloxacin until the MICs of the strains showed no further increase,to obtain induced resistant *** EP activities of the strains before and after induction were compared using EP inhibition and ethidium bromide(EtBr) accumulation ***:The MIC values of the strains were 16 256 times higher after induction than before *** the presence of CCCP,the MIC values of 50% of the induced strains were 2 4-fold lower than that in the absence of this *** EtBr accumulation assay showed that the fluorescence of EtBr in the induced cells was lower than that in the cells before ***:EPs are widespread in susceptible and drug-resistant *** *** with ciprofloxacin may increase the activity of EPs in *** EtBr accumulation assay is more sensitive than the EP inhibition assay in evaluating the activity of EPs in ***.

关键词： Klebsiella pneumoniae Efflux pump Ciprofloxacin Antibiotic resistance

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KIFC1 overexpression promotes prostate cancer cell survival and proliferation in vitro by clustering of amplified centrosomes via interaction with Centrin 2

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BIOCELL 2021年第5期45卷 1369-1391页

作者： ANZANA PARVIN bang-HONG WEI SHUANG-LI HAO WAN-XI YANG FU-QING TAN The Sperm Laboratory College of Life SciencesZhejiang UniversityHangzhou310058China The First Affiliated Hospital College of MedicineZhejiang UniversityHangzhou310003China Department of Biotechnology and Genetic Engineering Faculty of Biological SciencesIslamic UniversityKushtia7003Bangladesh

Mitotic kinesin KIFC1 plays critical roles in mitosis by regulating the spindle length,pole formation,and known for clustering extra centrosomes in cancer *** clustering is associated with the survival of cancer cells,but this phenomenon remains obscure in prostate cancer(PCa).The present study demonstrated that PCa cells showed centrosome amplification and clustering during interphase and mitosis,***1 is highly expressed in PCa cells and tumor tissues of prostatic adenocarcinoma(PAC)***-regulation of KIFC1 facilitated the PCa cell survival in vitro by ensuring bipolar mitosis through clustering the multiple centrosomes,suggesting centrosome clustering could be a leading cause of prostate ***,the silencing of KIFC1 resulted in normal centrosome number or multipolar mitosis by inhibiting the clustering of amplified centrosomes in PCa ***,knockdown of KIFC1 by RNAi in PCa cells reduced cancer cell survival,and ***1 interacted with centrosome structural protein Centrin 2 in clustering of amplified centrosomes in PCa cells to ensure the bipolar mitotic spindle *** of Centrin 2 in PCa cells inhibited the centrosome amplification and ***,up-regulated KIFC1 promotes PCa cell proliferation via progression of cell cycle possibly through aberrant activation of cyclin dependent kinase 1(Cdk1).Therefore,KIFC1 can be a prognostic marker and therapeutic target of PCa for inhibiting the cancer cell proliferation.

关键词： KIFC1 Centrosome clustering Centrosome amplification Prostate cancer

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Enhancing light yield of Tb^(3+)-doped fluoride nanoscintillator with restricted positive hysteresis for low-dose high-resolution X-ray imaging

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Nano Research 2023年第2期16卷 3339-3347页

作者： Yi Cheng Lei Lei Wenjuan Zhu Yubin Wang hai Guo Shiqing Xu Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province Institute of Optoelectronic Materials and DevicesChina Jiliang UniversityHangzhou 310018China College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Physics Zhejiang Normal UniversityJinhua 321004China

Developing scintillators with high light yield(ly),superior irradiation stability,and weak afterglow is of significance for the realization of low-dose high-resolution X-ray excited optical luminescence(XEOL)*** doped fluoride nanoparticles possess low toxicity,superior environmental stability,facial fabrication process,and tunable emissions,which are appropriate candidates for the next generation nanoscintillators(NSs).However,the low ly and strong positive hysteresis greatly restrict their practical ***,we propose an effective strategy that engineers energy gap to significantly enhance the *** results verify that the tetragonal LiLuF4 host benefits the crystal level splitting of Tb^(3+)ions,which greatly promotes the electrons population on the Tb^(3+):5D4 level followed by the enhanced *** ly of LiLuF4:Tb@LiLuF4 NSs is calculated to be~31,169 photons/MeV,which is much higher than the lead halide perovskite colloidal CsPbBr3(~21,000 photons/MeV)and LuAG:Ce(~22,000 photons/MeV)***,the positive hysteresis is remarkably restricted after coating a thin *** X-ray detection limit and spatial resolution are measured to be~21.27 nGy/s and~7.2 lp/mm,*** further verify that this core/shell NS can be employed as scintillating screen to realize XEOL imaging under the low dose rate of 13.86μGy/*** results provide an effective route to develop high performance NSs,which will promote great opportunities for the development of low-dose high-resolution XEOL imaging devices.

关键词： nanoscintillators X-ray excited optical luminescence(XEOL)imaging crystal level splitting low-dose high-resolution

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Nonregular Boundary Value Problem for the Cauchy-Riemann Operator

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Advances in Pure Mathematics 2020年第11期10卷 623-630页

作者： Ibrahim ly Sadou Tao Département de Mathématiques Université Joseph KI-ZERBO Ouagadougou Burkina Faso

The purpose of the research is to assign a formally exact elliptic complex of length two to the Cauchy-Riemann Operator. The Neumann problem for this complex in a bounded domain with smooth boundary in R2 will be stud... 详细信息

关键词： Cauchy-Riemann Operator Boundary Value Problem Normal Solvability

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Multi-exponential model to describe pressure-dependent P-and S-wave velocities and its use to estimate the crack aspect ratio

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 385-395页

作者： Mihály Dobróka Norbert Péter Szabó Tünde Edit Dobróka Mátyás Krisztián Baracza Department of Geophysics University of MiskolcMiskolc-Egyetemváros3515Hungary MTA-ME Geoengineering Research Group University of MiskolcMiskolc-Egyetemváros3515Hungary Research Institute of Applied Earth Sciences University of MiskolcMiskolc-Egyetemváros3515Hungary

We present new quantitative model describing the pressure dependence of acoustic P-and S-wave *** that a variety of individual mechanisms or defects(such as cracks,pore collapse and grain crushing)can contribute to the pressure-dependent change of the wave velocity,we order a characteristic pressure to all of them and allow a series of exponential terms in the description of the(Pand S-waves)velocity-pressure *** estimate the parameters of the multi-exponential rock physical model in inversion procedures using laboratory measured P-and S-wave velocity *** is known,the conventional damped least squares method gives acceptable results only when one or two individual mechanisms are *** the number of exponential terms leads to highly nonlinear ill-posed inverse *** to this reason,we develop the spectral inversion method(SIM)in which the velocity amplitudes(the spectral lines in the characteristic pressure spectrum)are only considered as *** characteristic pressures(belonging to the velocity amplitudes)are excluded from the set of inversion unknowns,instead,they are defined in a set of fixed positions equidistantly distributed in the actual interval of the independent variable(pressure).Through this novel linear inversion method,we estimate the parameters of the multi-exponential rock physical model using laboratory measured P-and S-wave velocity *** characteristic pressures are related to the closing pressures of cracks which are described by well-known rock mechanical relationships depending on the aspect ratio of elliptical *** gives the possibility to estimate the aspect ratios in terms of the characteristic pressures.

关键词： Multi-exponential rock physical model Spectral inversion method(SIM) Crack aspect ratio Characteristic pressures

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Effect of special Hungarian probiotic kefir on faecal microflora

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World Journal of Gastroenterology 2006年第7期12卷 1129-1132页

作者： MáriaFigler GyulaMózsik BélaSchaffer BeátaGasztonyi Pongrác cs BélaSzili Regina Rab SándorSzakály Department First Hungarian Faculty

AIM： To investigate the effect of a four-week consumption of a special Hungarian probiotic agent （Biofir） on the faecal microflora in human healthy subjects.METHODS： The effect of Biofir with 10^6/cm^3 initial germs on the faecal microflora was studied in 120 healthy volunteers （71 females, 49 males）. The traditional Russian type kefir was used as control. The various germ groups and pH values were determined in wk 2, 4 and 6.RESULTS： The number of all microbes increased during the 4-week probiotic treatment. The number of microbes increased 4,3-fold in the control group and 6.8-fold in Biofir-treated group. The probiotic kefir caused multiplication of the probiotic flora, meanwhile the undesired bacteria multiplied in the control group. No significant change of pH values of the faeces was found in both groups.CONCLUSION： The Hungarian probiotic keflr （Biofir） is capable of promoting multiplication of probiotic bacterial flora in the large bowel.

关键词： Hungarian probiotic agent (Biofir) Faecal microflora Large bowel

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