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Discovering peptides and computational investigations of a multiepitope vaccine target Mycobacterium tuberculosis

Synthetic and Systems Biotechnology 2024年第3期9卷 391-405页

作者： Truc ly Nguyen Heebal Kim Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences Seoul National UniversitySeoul08826Republic of Korea Interdisciplinary Program in Bioinformatics Seoul National UniversitySeoul08826Republic of Korea eGnome Inc.Seoul05836Republic of Korea

Mycobacterium tuberculosis(MTB)is the causative agent of tuberculosis(TB),a prevalent airborne infectious *** the availability of the Bacille Calmette-Guerin vaccine,its global efficacy remains modest,and tuberculosis persists as a significant global public health *** this challenge and advancing towards the End MTB Strategy,we developed a multiepitope vaccine(MEV)based on immunoinformatics and compu-tational *** screening of MBT protein identified immune-dominant epitopes based on Major Histocompatibility Complex(MHC)allele binding,immunogenicity,antigenicity,allergenicity,toxicity,and cytokine *** epitopes were integrated into an MEV construct with adjuvant and linkers,forming a fully immunogenic vaccine *** analyses encompassed the evaluation of immunological and physicochemical properties,determination of tertiary structure,molecular docking with Toll-Like Receptors(TLR),molecular dynamics(MD)simulations for all atoms,and immune *** MEV comprises 534 amino acids,featuring 6 cytotoxic T lymphocyte,8 helper T lymphocyte,and 7 linear B lymphocyte epitopes,demonstrating high antigenicity and ***,molecular docking studies and triplicate MD simulations revealed enhanced interactions and stability of MEV with the TLR4 complex compared to *** addition,the immune simulation indicated the capacity to effectively induce elevated levels of an-tibodies and cytokines,emphasizing the vaccine’s robust immunogenic *** study presents a promising MEV against TB,exhibiting favorable immunological and physicochemical *** findings provide theoretical support for TB vaccine *** study aligns with the global initiative of the End MTB Strategy,emphasizing its potential impact on addressing persistent challenges in TB control.

关键词： Mycobacterium tuberculosis Tuberculosis Multiepitope vaccine Docking molecular Molecular dynamics simulation Immune simulation

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ROLLING DEFORMATION LAW OF ALUMINIUM ALLOY CLAD SHEET

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中国有色金属学会会刊：英文版 1999年第2期9卷 77-81页

作者： Zhou, HZ Wang, ly Huang, GJ SW Aluminium Fabricat Plant Chongqing 401326 Peoples R China Chongqing Univ Dept Met & Mat Engn Chongqing 400044 Peoples R China

１ＩＮＴＲＯＤＵＣＴＩＯＮＡｌＳｉ／ＡｌＭｎｔｒｉｌａｙｅｒｂｒａｚｅｄｃｌａｄａｌｕｍｉｎｉｕｍｓｈｅｅｔｉｓｔｈｅｍａｉｎｍａｔｅｒｉａｌｆｏｒｍａｋｉｎｇｅｖａｐｏｒａｔｏｒａｎｄｃｏｏｌｅｒｉｎｔｈ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＡｌＳｉ／ＡｌＭｎｔｒｉｌａｙｅｒｂｒａｚｅｄｃｌａｄａｌｕｍｉｎｉｕｍｓｈｅｅｔｉｓｔｈｅｍａｉｎｍａｔｅｒｉａｌｆｏｒｍａｋｉｎｇｅｖａｐｏｒａｔｏｒａｎｄｃｏｏｌｅｒｉｎｔｈｅａｉｒｃｏｎｄｉｔｉｏｎｅｒｏｆ...

关键词： aluminium alloyclad sheetrolling deformationdeformation lawcan be divided into 3 stages: free (slip or nonrestraining) deformation stage partial restraining (partial clad) deformation stage full restraining (full clad) deformation stage.

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SEPARATION　CHARACTERISTICS　OF　THE　HYDROCYCLONE　WITH　A　CENTRAL　CONE　AND　ANNULAR　TEETH

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中国有色金属学会会刊：英文版 1996年第4期6卷 11-15页

作者： Chu, ly Chen, WM Luo, Q NORTHEASTERN UNIV DEPT MINERAL ENGN SHENYANG 110006 PEOPLES R CHINA SICHUAN UNION UNIV DEPT CHEM PROC MACHINERY CHENGDU 610065 PEOPLES R CHINA

ＳＥＰＡＲＡＴＩＯＮＣＨＡＲＡＣＴＥＲＩＳＴＩＣＳＯＦＴＨＥＨＹＤＲＯＣＹＣＬＯＮＥＷＩＴＨＡＣＥＮＴＲＡＬＣＯＮＥＡＮＤＡＮＮＵＬＡＲＴＥＥＴＨ￥ＣｈｕＬｉａｎｇｙｉｎ；ＣｈｅｎＷｅｎｍｅｉ（Ｄｅｐａｒｔｍｅｎｔｏ... 详细信息

ＳＥＰＡＲＡＴＩＯＮＣＨＡＲＡＣＴＥＲＩＳＴＩＣＳＯＦＴＨＥＨＹＤＲＯＣＹＣＬＯＮＥＷＩＴＨＡＣＥＮＴＲＡＬＣＯＮＥＡＮＤＡＮＮＵＬＡＲＴＥＥＴＨ￥ＣｈｕＬｉａｎｇｙｉｎ；ＣｈｅｎＷｅｎｍｅｉ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｃａｌＰｒｏｃｅｓｓｉ...

关键词： ydrocyclone central cone annular teeth separation sharpness classification efficiency separation characteristics

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Prognostic factors of trans-ethmosphenoid optic canal decompression for indirect traumatic optic neuropathy

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1222-1226页

作者： Ying-Jie Ma Bo Yu Yun-hai Tu bang-Xun Mao Xin-Yi Yu Wen-Can Wu Eye Hospital of Wenzhou Medical University Wenzhou 325000 Zhejiang Province China Department of Orbital and Oculoplastic Surgery Eye Hospital of Wenzhou Medical University Wenzhou 325000 Zhejiang Province China

AIM： To investigate a possible correlation between visual acuity（VA） prognosis and the presence at baseline of various orbital and ocular signs in patients affected by indirect traumatic optic neuropathy（ITON）. METHODS： From July 1 st, 2012 to July 1 st, 2015, 224 adults diagnosed with ITON who underwent endoscopic transethmosphenoid optic canal decompression（ETOCD） were reviewed. Visual outcome before and after treatment were taken into comparison. RESULTS： Accompanied older in age, longer time to medical treatment and existence of optic canal fracture（OCF） were the independent predictors for poor postoperative VA and lower improvement degree of visual acuity（IDVA）, while worse preoperative VA was predictive factor for poor postoperative VA only. Mean value of IDVA in patients with OCF was 0.19±0.30. Mean value of IDVA in patients without OCF was 0.29±0.35. IDVA in cases without OCF was significant higher than those with OCF（t=2.272, P〈0.05）. CONCLUSION： Patients suffered from ITON without OCF before ETOCD have better surgical outcome than those with OCF. Older in age, longer time to medical treatment and existence of OCF are independent factors for poor VA prognosis and lower IDVA. Preoperative VA is independent factor for VA prognosis only.

关键词： trans-ethmosphenoid optic canal decompression indirect traumatic optic neuropathy adults visual acuity improvement degree of visual acuity

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Genetic Algorithms of Structural Fuzzy Reliability Index

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China Ocean Engineering 1998年第1期13卷 33-42页

作者： Hu, YC Li, XJ Zhang, ly Tianjin Univ Dept Ocean Engn & Naval Architecture Tianjin 300072 Peoples R China

In this paper the simple generation algorithms are improved. According to the geometric meaning of the structural reliability index, a method is proposed to deal with the variables in the standard normal space. With consideration of variable distribution, the correlation coefficient of the variables and its fuzzy reliability index, the feasibility and the reliability of the algorithms are proved with an example of structural reliability analysis and optimization.

关键词： structural fuzzy reliability index generation algorithm reliability analysis and optimization correlation coefficient normal space

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CONTROLLING　OVERGRINDING　OF　VALUABLE　MATERIALS　USING　MODIFIED　AIRSPARGED　HYDROCYCLONE

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中国有色金属学会会刊：英文版 1996年第3期6卷 16-21页

作者： Chu, ly Luo, Q Yu, RH SICHUAN UNION UNIV DEPT CHEM PROC MACHINERYCHENGDU 610065PEOPLES R CHINA NORTHEASTERN UNIV DEPT MINERAL ENGNSHENYANG 110006PEOPLES R CHINA

ＣＯＮＴＲＯＬＬＩＮＧＯＶＥＲＧＲＩＮＤＩＮＧＯＦＶＡＬＵＡＢＬＥＭＡＴＥＲＩＡＬＳＵＳＩＮＧＭＯＤＩＦＩＥＤＡＩＲＳＰＡＲＧＥＤＨＹＤＲＯＣＹＣＬＯＮＥ￥ＣｈｕＬｉａｎｇｙｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｃ... 详细信息

ＣＯＮＴＲＯＬＬＩＮＧＯＶＥＲＧＲＩＮＤＩＮＧＯＦＶＡＬＵＡＢＬＥＭＡＴＥＲＩＡＬＳＵＳＩＮＧＭＯＤＩＦＩＥＤＡＩＲＳＰＡＲＧＥＤＨＹＤＲＯＣＹＣＬＯＮＥ￥ＣｈｕＬｉａｎｇｙｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｃａｌＰｒｏｃｅｓｓｉｎｇＭａｃｈｉ...

关键词： modified air-sparged hydrocyclone grinding-classification overgrinding flotation

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Reliability-Based Optimum Design of a Simple Offshore Platform Based on Genetic Algorithms

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China Ocean Engineering 1998年第1期13卷 43-52页

作者： Zhang, ly Hu, YC Li, XJ Tianjin Univ Dept Ocean Engn & Naval Architecture Tianjin 300072 Peoples R China

In this paper, the problem of reliability-based optimal design of simple offshore platform is studied, and a nonlinear fatigue damage model based on damage mechanics and genetic algorithms are used in the fatigue reliability optimum design of the structure under stochastic wave load. The fatigue damage model and the yield failure reliability analyzing model are used in the paper. The reliability of the models and the effectiveness of genetic algorithm are shown by the results of optimum design.

关键词： damage mechanics genetic algorithms reliability-based optimum design fatigue reliability

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A Three-Dimensional Prediction Method for Thermal Diffusion

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China Ocean Engineering 1998年第3期13卷 309-321页

作者： Wang, LX Sun, YL Zheng, ly Ocean Univ Qingdao Inst Environm Oceanog Qingdao 266003 Peoples R China

A three-dimensional, first order turbulence closure, thermal diffusion model is described in this paper. The governing equations consist of an equation of continuity, three components of momentum, conservation equations for salt, temperature and subgridscale energy, and an equation of state. In the model, according to the hypothesis of Kolmogorov and Prandtl, the viscosity coefficient of turbulent flow of homogeneous fluid is related to the local turbulent energy, and the horizontal and vertical exchange coefficients of mass, heat and momentum are computed with the introduction of subgridscale turbulence energy. The governing equations are solved by finite difference techniques. This model is applied to the Jiaozhou bay to predict thermal pollution by the Huangdao power plant. An instantaneous tidal current field is computed, then the distribution of temperature increment is predicted, and finally the effect of wind stress on thermal discharge is discussed.

关键词： three-dimensional turbulence closure thermal diffusion model finite difference techniques subgridscale energy exchange coefficient temperature increment

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Effect of Austenite Ageing on Martensitic Transformation

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Journal of Materials Science & Technology 1997年第6期13卷 508-514页

作者： Chen, QZ Wu, XF Wei, ly Ke, J Univ Sci & Technol Beijing Dept Mat Phys Beijing 100083 Peoples R China

The effect of austenite ageing on martensite transformation in an iron and nickel alloy was studied. Attention was paid to the variation of dislocation configurations in austenite before martensite transformation, The clusters or precipitates produced during austenite ageing and the alteration of dislocation configurations affect together the consequent martensite transformation. Dispersed fine clusters and precipitates cripple nucleus role of special dislocation configurations and drop M-s. Coarse precipitates make M-g rise again. Densely piled up dislocations in nuclei lead to rise of M-s. All the changes in austenite are of benefit to small martensite plates.

关键词： Iron alloys

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Using fluorescence surrogates to track algogenic dissolved organic matter(AOM) during growth and coagulation/flocculation processes of green algae

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Journal of Environmental Sciences 2019年第5期31卷 311-320页

作者： Quang Viet ly Mi-Hee Lee Jin Hur Department of Environment & Energy Sejong University

Tracking the variation of the algogenic organic matter(AOM) released during the proliferation of green algae and subsequent treatment processes is crucial for constructing and optimizing control strategies. In this study, the potential of the spectroscopic tool was fully explored as a surrogate of AOM upon the cultivation of green algae and subsequent coagulation/flocculation(C/F) treatment processes using ZrCl_4 and Al_2(SO_4)_3. Fluorescence excitation emission matrix coupled with parallel factor analysis(EEM-PARAFAC) identified the presence of three independent fluorescent components in AOM, including protein-like(C1), fulvic-like(C2) and humic-like components(C3). Size exclusion chromatography(SEC) revealed that C1 in AOM was composed of large-sized proteins and aromatic amino acids. The individual components exhibited their unique characteristics with respect to the dynamic changes. C1 showed the highest correlation with AOM concentrations(R^2= 0.843) upon the C/F processes. C1 could also be suggested as an optical predictor for the formation of trihalomethanes upon the C/F processes. This study sheds a light for the potential application of the protein-like component(C1) as a practical surrogate to track the evolution of AOM in water treatment or wastewater reclamation systems involving Chlorella vulgaris green algae.

关键词： EEM-PARAFAC Enhanced coagulation Size exclusion chromatography Algal dissolved organic matter Trihalomethanes

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