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Asymmetric Oscillation and Acoustic Response from an Encapsulated Microbubble Bound within a Small Vessel

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Chinese Physics Letters 2010年第6期27卷 114-117页

作者： HUANG Bei zheng hai-Rong ZHANG Dong Institute of Acoustics Key Laboratory of Modern Acoustics (Ministry of Education) Nanjing University Nanjing 210093 Paul C. Lauterbur Research Center for Biomedical imaging IBHE Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055

Understanding the dynamics of ultrasonic excited microbubbles bound within microvessels is of significance for novel ultrasonic imaging, drug delivery and therapeutic biomedicad applications. A finite element model （FEM） considering acoustic nonlinearity is developed to describe the asymmetric oscillation and acoustic response from mn encapsulated microbubble bound within a small vessel. Numerical simulation is performed for a 2 μm encapsulated microbubble bound within 8-20μm vessels using 2 MHz ultrasound excitation. The oscillation of the bound microbubble becomes more asymmetric under larger ultrasound pressure or within the smaller vessel. The normalized difference between the major and minor axes of epllipse is estimated to be 2.16%for the 8 μm vessel at an acoustic pressure of 0.5 MPa. In addition, the fundamental component of the acoustic scattering from the bound microbubble is enhanced by 6 dB while the second harmonic component is decreased by approximately 29 dB compared with the free microbubble.

关键词： Ultrasonics Encapsulation Pressure

不同手术对高龄股骨粗隆间骨折患者髋关节功能及术后恢复的影响

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川北医学院学报 2024年第4期39卷 461-464页

作者：李祎李奎蒙郑海张家口市第一医院骨外科河北张家口075000

目的:探讨不同手术治疗高龄股骨粗隆间骨折对患者髋关节功能及术后恢复的影响。方法:根据手术方式的不同将86例高龄股骨粗隆间骨折患者分为采用内固定(股骨近端防旋髓内钉)治疗的A组和采用人工股骨头置换术治疗的B组,每组各43例。比较... 详细信息

目的:探讨不同手术治疗高龄股骨粗隆间骨折对患者髋关节功能及术后恢复的影响。方法:根据手术方式的不同将86例高龄股骨粗隆间骨折患者分为采用内固定(股骨近端防旋髓内钉)治疗的A组和采用人工股骨头置换术治疗的B组,每组各43例。比较两组住院时间、切口长度、手术时间、卧床时间、术中出血、骨折愈合时间、并发症发生情况、炎症反应、骨代谢指标、疼痛、髋关节功能及生活能力。结果:B组切口长度、手术时间及术中出血量均高于A组,但住院时间、卧床时间及骨折愈合时间均短于A组(P0.05)。结论:人工股骨头置换术治疗高龄股骨粗隆间骨折,患者术后恢复更快,炎症、骨代谢及术后疼痛情况更好,有利于髋关节、生活能力恢复。

关键词：股骨粗隆间骨折高龄置换髓内钉内固定髋关节功能

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计算机建模在口服缓控释片体外释放曲线预测中的应用

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药学学报 2024年第6期59卷 1593-1600页

作者：陈潇郑海花潘新彤向柏潘振华党云洁河北医科大学药学院河北石家庄050017 河北医科大学第二医院河北石家庄050000

缓控释制剂是能降低药物毒副作用、提高患者依从性和增强疗效的理想制剂,其中口服缓控释片的应用最为广泛。制剂体外释放与药物的体内吸收密切相关,然而目前的体外释放实验均为劳动密集型和破坏性的,大数据的缺乏也导致难以建立良好的... 详细信息

缓控释制剂是能降低药物毒副作用、提高患者依从性和增强疗效的理想制剂,其中口服缓控释片的应用最为广泛。制剂体外释放与药物的体内吸收密切相关,然而目前的体外释放实验均为劳动密集型和破坏性的,大数据的缺乏也导致难以建立良好的体内外相关性。计算机建模作为一种可将客观原理转化为数学模型的技术手段,在数据预测方面有很大的前景。本综述探讨了可用于口服缓控释片体外释放曲线预测的计算机建模手段,并进一步讨论了可提高模型准确度的辅助技术,为药物的开发提供了新的思路。

关键词：口服缓控释片计算机建模体外释放曲线数学建模机器学习

维普期刊数据库

Norms of Dual Complex Vectors and Dual Complex Matrices

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Communications on Applied Mathematics and Computation 2023年第4期5卷 1484-1508页

作者： Xin-He Miao zheng-hai Huang School of Mathematics Tianjin UniversityTianjin300354China

In this paper,we investigate some properties of dual complex numbers,dual complex vectors,and dual complex ***,based on the magnitude of the dual complex number,we study the Young inequality,the Hölder inequality,and the Minkowski inequality in the setting of dual complex ***,we define the p-norm of a dual complex vector,which is a nonnegative dual number,and show some related ***,we study the properties of eigenvalues of unitary matrices and unitary triangulation of arbitrary dual complex *** particular,we introduce the operator norm of dual complex matrices induced by the p-norm of dual complex vectors,and give expressions of three important operator norms of dual complex matrices.

关键词： Dual complex number Dual complex vector Dual complex matrix p-norm Operator norm

Bi-block positive semidefiniteness of bi-block symmetric tensors

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Frontiers of Mathematics in China 2021年第1期16卷 141-169页

作者： zheng-hai H UANG Xia LI Yong WANG School of Mathematics Tianjin UniversityTianjin 300354China

The positive definiteness of elasticity tensors plays an important role in the elasticity *** this paper,we consider the bi-block symmetric tensors,which contain elasticity tensors as a ***,we define the bi-block M-eigenvalue of a bi-block symmetric tensor,and show that a bi-block symmetric tensor is bi-block positive(semi)definite if and only if its smallest bi-block M-eigenvalue is(nonnegative)***,we discuss the distribution of bi-block M-eigenvalues,by which we get a sufficient condition for judging bi-block positive(semi)definiteness of the bi-block symmetric tensor ***,we show that several classes of bi-block symmetric tensors are bi-block positive definite or bi-block positive semidefinite,including bi-block(strictly)diagonally dominant symmetric tensors and bi-block symmetric(B)*** give easily checkable sufficient conditions for judging bi-block positive(semi)definiteness of a bi-block symmetric *** a byproduct,we also obtain two easily checkable sufficient conditions for the strong ellipticity of elasticity tensors.

关键词： Bi-block symmetric tensor bi-block symmetric Z-tensor bi-block symmetric B 0-tensor diagonally dominant bi-block symmetric tensor bi-block M-eigenvalue

Estimations on upper and lower bounds of solutions to a class of tensor complementarity problems

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Frontiers of Mathematics in China 2019年第3期14卷 661-671页

作者： Yang XU Weizhe GU zheng-hai HUANG School of Mathematics Tianjin University Tianjin 300350 China

We introduce a class of structured tensors, called generalized row strictly diagonally dominant tensors, and discuss some relationships between it and several classes of structured tensors, including nonnegative tensors, Btensors, and strictly copositive tensors. In particular, we give estimations on upper and lower bounds of solutions to the tensor complementarity problem (TCP) when the involved tensor is a generalized row strictly diagonally dominant tensor with all positive diagonal entries. The main advantage of the results obtained in this paper is that both bounds we obtained depend only on the tensor and constant vector involved in the TCP;and hence, they are very easy to calculate.

关键词： Tensor complementarity problem (TCP) generalized row strictly diagonally dominant tensor upper and lower bounds of solutions

面向精准预测的交通大数据处理方法与技术探究——以惠州市为例

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智能城市 2024年第7期10卷 18-20页

作者：罗海正郭亚东惠州学院广东惠州516007

交通大数据的质量对于精准交通流量预测和智能交通系统的效能提升至关重要。以惠州市为例,利用Python语言对1个月的运营车辆数据进行处理,采用基于位置和速度阈值的方法过滤错误值,利用均值修复法修复异常值,基于时间间隔分割轨迹,并采... 详细信息

交通大数据的质量对于精准交通流量预测和智能交通系统的效能提升至关重要。以惠州市为例,利用Python语言对1个月的运营车辆数据进行处理,采用基于位置和速度阈值的方法过滤错误值,利用均值修复法修复异常值,基于时间间隔分割轨迹,并采用隐马尔可夫模型进行路网匹配,以获取用于预测的数据成果并进行可视化分析,选定特定路段和时间段进行测试。结果显示,交通大数据处理方法在实际应用中展现精准预测的潜力和较高的实用性。

关键词：惠州市交通大数据均值修复法数据质量精准预测

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薄壳山核桃CiSPL2基因克隆、亚细胞定位及表达分析

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南方农业学报 2024年第1期55卷 47-56页

作者：王敏席东莫正海张仕杰朱灿灿江苏省中国科学院植物研究所江苏南京210095 上海市农业科学院园艺研究所上海201403 上海市青浦区农业技术推广服务中心上海201700

【目的】克隆薄壳山核桃SQUAMOSA启动子结合蛋白(SPL)转录因子基因CiSPL2,并对其进行亚细胞定位及表达分析,为探究该基因在薄壳山核桃雌花发育过程的分子机制提供理论依据。【方法】根据薄壳山核桃基因组数据,采用RT-PCR方法克隆CiSPL2... 详细信息

【目的】克隆薄壳山核桃SQUAMOSA启动子结合蛋白(SPL)转录因子基因CiSPL2,并对其进行亚细胞定位及表达分析,为探究该基因在薄壳山核桃雌花发育过程的分子机制提供理论依据。【方法】根据薄壳山核桃基因组数据,采用RT-PCR方法克隆CiSPL2基因编码区(CDS)序列,利用生物信息学软件分析其序列特征和蛋白理化性质,构建pCAMBIA1300-CiSPL2-GFP融合表达载体,瞬时转化烟草后观察荧光信号确定亚细胞定位情况。基于转录组数据和实时荧光定量PCR检测CiSPL2基因在不同组织及不同雌花芽分化时期的表达模式。【结果】薄壳山核桃CiSPL2基因CDS长度为1398 bp,共编码465个氨基酸残基,相对分子量为51.78 kD,理论等电点(p I)为8.28,不稳定系数为49.89,脂肪酸氨基酸指数为64.62,平均亲水性平均值(GRAVY)为-0.617,为不稳定的亲水性蛋白,含有SBP结构域(位于第183~257位氨基酸),亚细胞定位于细胞核。CiSPL2蛋白的二级结构主要由α-螺旋(17.42%)、延伸链(13.55%)、β-转角(1.72%)和无规则卷曲(67.31%)组成。薄壳山核桃CiSPL2蛋白与核桃JrSPL2蛋白氨基酸序列的相似性最高,为95.05%,其次是光皮桦BlSPL2蛋白,相似性为70.83%。CiSPL2蛋白与核桃JrSPL2蛋白亲缘关系最近。CiSPL2基因启动子中含有植物激素响应、干旱胁迫响应和分生组织表达元件。CiSPL2基因在雌花和果实中的表达水平显著高于其他组织(P<0.05),在雌花芽分化各阶段均有表达,在雌花序形成期表达水平最高。【结论】CiSPL2基因含有SPL转录因子家族典型的SBP保守结构域,推测其参与调控薄壳山核桃雌花芽分化和发育过程。

关键词：薄壳山核桃 CiSPL2基因系统发育分析亚细胞定位基因表达

Loss of heterozygosity analyzed by single nucleotide polymorphism array in cancer

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World Journal of Gastroenterology 2005年第43期11卷 6740-6744页

作者： hai-Tao zheng Zhi-hai Peng Sheng Li Lin He Department of General Surgery Shanghai First People's Hospital Shanghai Jiaotong University Shanghai 200080 China Shanghai Institutes for Nutrition Science Chinese Academy of Sciences Shanghai 200031 China

Neoplastic progression is generally characterized by the accumulation of multiple genetic alterations including loss of tumor suppression gene function. Loss of heterozygosity （LOH） has been used to identify genomic regions that harbor tumor suppressor genes and to characterize different tumor types, pathological stages and progression. LOH pattern has been detected by allelotyping using restriction fragment length polymorphism, and later by simple sequence length polymorphisms （SSLPs or microsatellite） for 10 years. This paper reviews the detection of LOH by recently developed single nucleotide polymorphism （SNP） arrays （all analyzed by Affymetrix array）; furthermore, its advantage and disadvantage were analyzed in several kinds of cancer.

关键词： Loss of heterozygosity Single nucleotidepolymorphism Array Cancer