检索结果-南通市图书馆

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

在线全文

学校读者我要写书评

暂无评论

深大基坑开挖对邻近地铁车站影响研究

华东交通大学学报 2009年第1期26卷 7-11页

作者：海明雷孙玉永王炳龙同济大学道路与交通工程教育部重点实验室上海201804

在运营地铁车站周边进行基坑开挖,无疑会对车站结构的变形产生影响.为确保邻近地铁车站的正常运营,运用PLAXIS软件建立平面数值分析模型模拟实际基坑开挖过程,研究了世博轴深大基坑工程开挖对邻近耀华路地铁车站水平、竖直及总变形的影... 详细信息

在运营地铁车站周边进行基坑开挖,无疑会对车站结构的变形产生影响.为确保邻近地铁车站的正常运营,运用PLAXIS软件建立平面数值分析模型模拟实际基坑开挖过程,研究了世博轴深大基坑工程开挖对邻近耀华路地铁车站水平、竖直及总变形的影响,并分析了不同基坑连续墙位移下运营车站的变形情况.计算结果表明,在基坑开挖过程中,运营车站竖向隆起量先增加后减少,而水平变形不断增加.运营车站竖向、水平变形的最大值均与基坑连续墙侧向变形最大值呈线性关系.

关键词：基坑开挖地铁车站数值模拟 PLAXIS

The Anion Binding Affinity Determines the Strength of Anion Specificities of Thermosensitive Polymers

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2021年第11期39卷 1351-1356页

作者： lei-lei Lian Si-Yuan Xu hai-Yang Yuan Guang-ming Liu Hefei National Laboratory for Physical Sciences at the Microscale Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesDepartment of Chemical PhysicsUniversity of Science and Technology of ChinaHefei 230026China

In this work,we demonstrate that the strength of anion specificities of thermosensitive polymers is determined by the affinity of direct anion binding to the *** have prepared a series of thermosensitive statistical copolymers with distinct thermoresponsive *** anions can specifically interact with the different types of thermosensitive polymers in very different strengths.A similar strength of specific anion effects on thermoresponsive behaviors can be observed at very different salt concentrations for the different types of thermosensitive polymers.A stronger anion binding to the thermosensitive polymers gives rise to a more obvious anion specificity and vice *** work presented here opens up opportunities for the application of ion binding affinity to modulate the strength of ion specificities of thermosensitive polymers.

关键词： Specific ion effect Polyzwitterion Ion-polymer interaction Thermosensitivity Ion-pairing

Preparation and Spectroscopic Study of Different Stoichiometric Solid Supramolecular Inclusion Complexes of β-Cyclodextrin with Short Chain Aliphatic Amines

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2008年第2期21卷 174-180页

作者： Le-xin Song Chuan-feng Teng hai-ming Wang lei Bai Department of Chemistry University of Science and Technology of China Hefei 230026 China

The solid Supramolecular complexes of β-cyclodextrin （β-CD） with ethylenediamine 1, diethylenetriamine 2 and triethylamine 3 were obtained and characterized using elemental analysis, powder X-ray diffraction, infrared spectroscopy, thermogravimetric analysis, and ^1H nuclear magnetic resonance spectroscopy. Based on the results of elemental analysis and ^1H NMR, the guest-host stoichiometries of the three solid complexes were determined to be 5：2 for 1-β-CD, hl for 2-β-CD, and 1：3 for 3-β-CD. The yields were relative to the molar volume ratio of guest to β-CD cavity, and increased in the order： 1-β-CD〈2-3-CD〈3-β-CD. X-ray diffraction patterns of the inclusion complexes gave very good exhibitions not only in location of diffraction peaks but also in shape and diffraction intensity of the peaks due to the intermolecular complexations between β-CD and the guests. The formation of host-guest inclusion complexes exhibited obviously enhanced phase change temperatures of the complexed guests such as 1 and 3. The H-5 protons located at the narrower rim inside the CD cavity experienced a higher shift upon inclusion while all other protons experienced lower shifts.

关键词： β-cyclodextrin Inclusion complex Ethylenediamine Supramolecular

SIMULATION OF OIL-WATER TWO PHASE FLOW AND SEPARATION BEHAVIORS IN COMBINED T JUNCTIONS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2012年第6期24卷 848-857页

作者： CHEN Jian-lei HE Li-min LUO Xiao-ming BAI hai-tao WEI Yan-hai College of Pipeline and Civil Engineering China University of Petroleum(East China)

The combined T junctions used for the oil-water separation have the advantages of compactness in structure, consistency in effects and economy in cost. The mixture k- ε turbulence model and the Eulerian multi-fluid model are used to simulate the flow and phase distribution in the combined T junctions. The effects of structural parameters such as the branched pipe interval and height on the flow distribution and the separation behaviors are studied. The results show that the combined T junctions under fixed inlet and outlet boundary conditions form a single hydraulic equilibrium system in which the fluid energy distributes freely till a balance is achieved. The split-flow promotes the separation of the immiscible oil and the water. The separation efficiency increases with the increase of the branched pipe interval and changes slightly with the increase of the branched pipe height. The structural change of the combined T junctions may change the flow direction in the branched pipes. Simulation results can provide some guidance for the design of the combined T junctions as one kind of oil-water separator.

关键词： T junction oil-water separation CFD phase distribution

Variation of toxic pollutants emission during a feeding cycle from an updraft fixed bed gasifier for disposing rural solid waste

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2018年第3期26卷 608-613页

作者： ming lei Jing hai Jiang Cheng Jiawei Lu Jieru Zhang Tao You School of Chemistry and Chemical Engineering South China University of Technology South China Institute of Environmental Sciences Ministry of Environmental Protection (MEP)

The variation of toxic pollutants emission during a feeding cycle was examined by field monitoring from a batch feeding updraft fixed bed gasifier for disposing rural domestic solid waste. Results showed that the content of oxygen in flue gas gradually increased, while SO_2 and HCl in flue gas decreased with time after feeding in a whole feeding cycle. Although large amount of CO was produced during the gasifying, low CO content in flue gas could be obtained after the heat treatment with an electric heating device. The distribution characteristics of dioxin congeners in flue gas indicted the re-synthesis of dioxins after flue gas heating, and the increase of oxygen promoted the synthesis of dioxins. The emission content of dioxins could meet the standard(0.1 ng I-TEQ·m^(-3),GB18458-2014) of China when the oxygen content was controlled below 8.3%. Hence, for a batch feeding gasifier,low oxygen condition should be offered by reducing air intake at the later stage of feeding cycle in order to decrease the re-synthesis of dioxins after the flue gas heating.

关键词： Updraft fixed bed gasifier Solid waste Pollutants Dioxins Emission Variation

Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

在线全文

学校读者我要写书评

暂无评论

Tungsten 2025年第1期 1-31页

作者： Qiao Xie Ying-Jie Yu hai-Jun Zhang Ya-Ping Deng Wen lei The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词：

Structure, charge transfer, and superconductivity of M-doped phenanthrene(M = Al, Ga, and In): A comparative study of K-doped cases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2019年第5期62卷 107-113页

作者： hai-Yan Lv Guo-Hua Zhong ming Chen Chun-lei Yang Xiao-Jia Chen hai-Qing Lin Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Nano Science and Technology Institute University of Science and Technology of China Beijing Computational Science Research Center Center for High Pressure Science and Technology Advanced Research

Aromatic hydrocarbons doped with K have been shown to be potential high-temperature superconductors. To investigate the doping effects of trivalent metals(Al, Ga, and In) that have a smaller radii than K, we studied the crystal structure, stability,charge transfer, band structure, and superconductivity of trivalent metal-doped phenanthrene via first-principles *** with Al/Ga/In considerably differs from doping with K and cannot be simply regarded as a linear developmental change in the structural and electronic characteristics caused by a change in the valence electron numbers. Al/Ga/In atoms are difficult to dope into the intralayer region, and the charge transfer is close to zero, which is far less than the effect of K doping. We found that the metallization of the Al/Ga/In-doped system originates from the formation of gap states instead of charge transfer. The weak superconductivity obtained in the Al/Ga/In-doped system is also different from the K-doped system. These results are helpful in terms of understanding the structure and superconductivity of metal-doped aromatic superconductors.

关键词： phenanthrene aromatic hydrocarbons trivalent metals charge transfer superconductivity