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An Affirmative Result of the Open Question on Determining Function Jumps by Spline Wavelets

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Acta Mathematica Sinica,English Series 2018年第5期34卷 921-932页

作者： hai ying zhang Xian Liang SHI Jian Zhong WANG Science of College Hangzhou Dianzi University Hangzhou 310018 P. R. China College of Mathematics and Computer Science Hu'nan Normal University Changsha 410081 P. R. China Department of Mathematics and Statistics Sam Houston State University Huntsville TX 77341 USA

We study the open question on determination of jumps for functions raised by Shi and Hu in 2009. An affirmative answer is given for the case that spline-wavelet series are used to approximate the functions.

关键词： Jump B-spline wavelets

Influence of initial check, information exchange, final accuracy check, reaction information nursing on the psychology of elderly with lung cancer

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World Journal of Clinical Cases 2024年第4期12卷 737-745页

作者： Cui Jiang Jing Ma Wen He hai-ying zhang The Second Ward of Thoracic Radiotherapy Hubei Cancer Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079Hubei ProvinceChina Nursing School Henan University of Science and TechnologyLuoyang 471000Henan ProvinceChina Department of Intensive Care Unit Wuhan First HospitalWuhan 430033Hubei ProvinceChina Department of Nursing Huangpi District People′s Hospital of WuhanWuhan 430300Hubei ProvinceChina

BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and *** patients usually have poor self-care and are more likely to show a series of psychological *** To investigate the effectiveness of the initial check,information exchange,final accuracy check,reaction(IIFAR)information care model on the mental health status of elderly patients with lung *** This study is a single-centre *** randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January *** elderly patients with lung cancer were randomly divided into two groups,with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care *** differences in psychological distress,anxiety and depression,life quality,fatigue,and the locus of control in psychology were compared between these two groups,and the causes of psychological distress were *** After the intervention,Distress Thermometer,Hospital Anxiety and Depression Scale(HADS)for anxiety and the HADS for depression,Revised Piper’s Fatigue Scale,and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group(P<0.05).After the intervention,Quality of Life Questionnaire Core 30(QLQ-C30),Internal Health Locus of Control,and Powerful Others Health Locus of Control scores were significantly higher in the observation and the control groups compared to the pre-intervention period in their same group,and QLQ-C30 scores were significantly higher in the observation group compared to those of the control group(P<0.05).CONCLUSION The IIFAR information care model can help elderly patients with lung cancer by reducing their anxiety and depression,

关键词： Initial check,information exchange,final accuracy check,reaction information care model Lung cancer Mental health

Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson’s disease

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Neural Regeneration Research 2022年第6期17卷 1357-1363页

作者： Jia-Nan Yan hai-ying zhang Jun-Rui Li ying Chen Yong-Cheng Jiang Jia-Bing Shen Kai-Fu Ke Xiao-Su Gu Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Clinical Medicine The First Clinical Medical College of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology and Suzhou Clinical Research Center of Neurological Disease The Second Afflicted Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

Autophagy has been shown to play an important role in Parkinson’s *** hypothesized that skin-derived precursor cells exhibit neuroprotective effects in Parkinson’s disease through affecting *** this study,6-hydroxydopamine-damaged SH-SY5Y cells were pretreated with a culture medium containing skin-derived precursors differentiated into Schwann cells(SKP-SCs).The results showed that the SKP-SC culture medium remarkably enhanced the activity of SH-SY5Y cells damaged by 6-hydroxydopamine,reduced excessive autophagy,increased tyrosine hydroxylase expression,reducedα-synuclein expression,reduced the autophagosome number,and activated the PI3K/AKT/mTOR *** activator rapamycin inhibited the effects of SKP-SCs,and autophagy inhibitor 3-methyladenine had the opposite *** findings confirm that SKP-SCs modulate the PI3K/AKT/mTOR pathway to inhibit autophagy,thereby exhibiting a neuroprotective effect in a cellular model of Parkinson’s *** study was approved by the Animal Ethics Committee of Laboratory Animal Center of Nantong University(approval No.S20181009-205)on October 9,2018.

关键词： alpha-synuclein autophagosomes autophagy neural regeneration neuroprotection Parkinson’s disease PI3K/AKT/mTOR pathway skin-derived precursor Schwann cells

srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1

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Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 630-638页

作者： Quan-Peng zhang hai-ying zhang Xian-Fang zhang Jiu-Hong Zhao Zhi-Jian Ma Dan Zhao Xi-Nan Yi Department of Anatomy Hainan Medical College Neuroscience Research Institute Hainan Medical College

Objective:To explore effect of srGAP3 promotes neurite outgrowth of dorsal root ganglion ***:In this study,expression of Slit1 was observed predominantly in the *** expression of Robo2 and srCAP3 was detected in sensory neurons of postnatal rat cultured dorsal root ganglion(DRG).Furthermore,upregulation of srGAP3 following sciatic nerve transection was detected by immunohistochemistry and Western ***:It was observed that inhibition of nenrite outgrowth in cultured adult DRG neurons following treatment with anti-srGAP3 or anti-Robo2 was more effectively(1.5-fold higher) than that following treatment with an anti-BDNF positive control *** demonstrated that srGAP3 interacted with Robo2 and Slit1 protein to decrease Rac1-CTP activity in cultured adult rat DRG neurons and the opposite effect on Rac1-GTP activity was detected by co-immunoprecipitation and immunoblotting analyses following treatment with anti-Robo2 or *** data demonstrated a role for srGAP3 in nenrite outgrowth ol DRG sensory ***:Our observations suggest that srGAP3 promotes neurile outgrowth and filopodial growth cones by interacting with Robo2 to inactivate Rac1 in mammalian DRG neurons.

关键词： Rats Dorsal root ganglion Slit-Robo GTPase activating protein 3

Tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia

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Asian Pacific Journal of Tropical Medicine 2018年第4期11卷 309-312页

作者： Lin Huang Dan-Xin Wang Li-Min Zhou Tao Wang hai-ying zhang Yun-Xia zhang Yin-Dong zhang Institute of Tropical Agriculture and Forestry Hainan University Department of Nursery The Affiliated Hospital of Hainan Medical College Public Research Laboratory of hainan Medical University

Objective: To investigate the relationship between polymorphisms of rs1532624 and rs289741 loci in cholesteryl ester transfer protein(CETP) genes and atherosclerotic cerebral infarction(ACI). Methods: The CETP gene rs1532624 and rs289741 in 95 patients with ACI and 177 healthy subjects were genotyped by Mass ARRAY mass spectrometry. Each locus genotype and allele frequency distributions were compared. Results: The difference of allele frequency distribution between the rs1532624(χ~2=1.723, P=0.189) and rs289741(χ~2=2.466, P=0.116) were not statistically significant. The frequency distribution of rs1532624 genotype between the cerebral infarction group and healthy control group was statistically significant(χ~2=7.096, P=0.029), while rs289741 genotype frequency distribution between the two groups was not statistically significant(χ~2=2.906, P=0.234). Conclusion: ACI have a positive correlation with rs1532624 polymorphism, and AA genotype may be susceptible factors of ACI.

关键词： Cholesteryl ester transfer protein gene Atherosclerotic cerebral infarction Gene polymorphism

Surviving winter on the Qinghai-Xizang Plateau:Extensive reversible protein phosphorylation plays a dominant role in regulating hypometabolism in hibernating Nanorana parkeri

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Zoological Research 2024年第1期45卷 1-12页

作者： Yong-Gang Niu Deng-Bang Wei Xue-Jing zhang Ti-Sen Xu Xiang-Yong Li hai-ying zhang Zhi-Fang An Kenneth B.Storey Qiang Chen Department of Life Sciences Dezhou UniversityDezhouShandong 253023China State Key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXiningQinghai 810016China School of Life Sciences Lanzhou UniversityLanzhouGansu 730000China Department of Biology Carleton UniversityOttawaON K1S 5B6Canada

Changes in protein abundance and reversible protein phosphorylation(RPP)play important roles in regulating hypometabolism but have never been documented in overwintering frogs at high *** test the hypothesis that protein abundance and phosphorylation change in response to winter hibernation,we conducted a comprehensive and quantitative proteomic and phosphoproteomic analysis of the liver of the Xizang plateau frog,Nanorana parkeri,living on the Qinghai-Xizang *** total,5170 proteins and 5695 phosphorylation sites in 1938 proteins were *** on proteomic analysis,674 differentially expressed proteins(438 up-regulated,236 down-regulated)were screened in hibernating *** versus summer *** enrichment analysis revealed that higher expressed proteins in winter were significantly enriched in immune-related signaling pathways,whereas lower expressed proteins were mainly involved in metabolic processes.A total of 4251 modified sites(4147 up-regulated,104 down-regulated)belonging to 1638 phosphoproteins(1555 up-regulated,83 down-regulated)were significantly changed in the *** hibernation,RPP regulated a diverse array of proteins involved in multiple functions,including metabolic enzymatic activity,ion transport,protein turnover,signal transduction,and alternative *** changes contribute to enhancing protection,suppressing energy-consuming processes,and inducing metabolic ***,the activities of phosphofructokinase,glutamate dehydrogenase,and ATPase were all significantly lower in winter compared to *** conclusion,our results support the hypothesis and demonstrate the importance of RPP as a regulatory mechanism when animals transition into a hypometabolic state.

关键词： Nanorana parkeri Proteomic Phosphoproteomic Hibernation Reversible protein phosphorylation Metabolism

SYNTHESIS OF NOVEL THIOPHENEDIMETHYLENE BRIDGED HOMOBINUCLEAR METALLOCENES AND THEIR CATALYTIC PROPERTIES FOR ETHYLENE POLYMERIZATION

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Chinese Journal of Polymer Science 2006年第1期24卷 21-27页

作者： Xi-jie Liu Jun-quan Sun hai-ying zhang Xiao-hui Xiao and Feng Lin Department of Chemical Engineering,College of Material and Chemical Engineering,Zhejiang University,Hangzhou 310027,China Zhejiang Univ Coll Mat & Chem Engn Dept Chem Engn Hangzhou 310027 Peoples R China

By treating disodium（thiophenedimethylene）dicyclopentadienide C4H2S（CH2C5H4Na）2 with two equivalent of CpTiCl3 or CpZrC13 DME at 0℃ in THF, two new thiophenedimethylene bridged binuclear metallocenes [Cl2MC5H5][C5H4CH2C4H2SCH2C5H4][C5H5MCl2] （M = Ti 3, M = Zr 4） were synthesized in high yield and their structures were characterized by ^1H-NMR. These complexes were used as catalysts for ethylene polymerization in the presence of methylaluminoxane （MAO）. The effects of polymerization temperature, time, concentration of catalyst, molar ratio of MAO/Cat on polymerization were studied in detail. The catalytic activities of thiophenedimethylene bridged binuclear metallocene catalysts （3, 4） reached 2.44 × 10^5 g PE mol^-1 cat^-1· h^-1, 9.61 × 10^5 g PE mol^-1 · cat^-1· h^-1 respectively, which are higher than that of pheneyldimethylene bridged binuclear metallocene catalysts and much higher than that of corresponding mononuclear metallocenes （Cp2TiCl2 and Cp2ZrCl2）. The molecular weight distribution curves of polyethylenes produced by binuclear metallocene catalysts （3, 4） and by mononuclear metallocene catalyst have only single peak, but the former （MWD = 3.5-4.7） is obviously broader than the latter （MWD = 2.0-2.2）.

关键词： Binuclear metallocene Thiophenedimethylene bridged Ethylene polymerization.

Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson’s disease

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Neural Regeneration Research 2023年第5期18卷 1099-1106页

作者： hai-ying zhang Yong-Cheng Jiang Jun-Rui Li Jia-Nan Yan Xin-Jue Wang Jia-Bing Shen Kai-Fu Ke Xiao-Su Gu Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Clinical Medicine The First Clinical Medical College of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina

Skin-derived precursor Schwann cells have been reported to play a protective role in the central nervous system. The neuroprotective effects of skin-derived precursor Schwann cells may be attributable to the release of growth factors that nourish host cells. In this study, we first established a cellular model of Parkinson’s disease using 6-hydroxydopamine. When SH-SY5 Y cells were pretreated with conditioned medium from skin-derived precursor Schwann cells, their activity was greatly increased. The addition of insulin-like growth factor-2 neutralizing antibody markedly attenuated the neuroprotective effects of skin-derived precursor Schwann cells. We also found that insulin-like growth factor-2 levels in the peripheral blood were greatly increased in patients with Parkinson’s disease and in a mouse model of Parkinson’s disease. Next, we pretreated cell models of Parkinson’s disease with insulin-like growth factor-2 and administered insulin-like growth factor-2 intranasally to a mouse model of Parkinson’s disease induced by 6-hydroxydopamine and found that the level of tyrosine hydroxylase, a marker of dopamine neurons, was markedly restored, α-synuclein aggregation decreased, and insulin-like growth factor-2 receptor downregulation was alleviated. Finally, in vitro experiments showed that insulin-like growth factor-2 activated the phosphatidylinositol 3 kinase(PI3 K)/AKT pathway. These findings suggest that the neuroprotective effects of skin-derived precursor Schwann cells on the central nervous system were achieved through insulinlike growth factor-2, and that insulin-like growth factor-2 may play a neuroprotective role through the insulin-like growth factor-2 receptor/PI3 K/AKT pathway. Therefore, insulin-like growth factor-2 may be an useful target for Parkinson’s disease treatment.

关键词： 6-hydroxydopamine alpha-synuclein insulin-like growth factor-2 receptor insulin-like growth factor-2 neurodegeneration neuroprotection Parkinson’s disease skin-derived precursor Schwann cells

The protective effect and underlying mechanism of hainan papaya water extract against neuronal apoptosis induced by A β 40

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 653-658页

作者： Jiu-Hong Zhao hai-ying zhang Xian-Fang zhang Xu Dong Qi-Bing Liu Yue-Li Liu Yi-Di Huang Quan-Peng zhang Gang Luo Zhi-Jian Ma Xi-Nan Yi Department of Anatomy Hainan Medical College Neuroscience Research Institute Hainan Medical College School of Pharmacy Hainan Medical College

Objective:To investigate whether hainan papayas has protective effects in an Aimary neuron injury model and elucidate the underlying molecular mecha β 40-induced ***:Cultured primary neurons from the dorsal root ganglia(DRG) of Sprague-Dawley(SD) rats were treated with 20 μM A culture medium β 40 peptide,100 μg/L hainan papaya water extract,peptide plus extract,or for 24 *** viability was measured by MTT assay,and neuronal apoptosis was evaluated by DAPI *** signaling pathway-associated molecule activation and changes in Bax expression were analyzed by Western blotting and ***:A cell viability rate of(44.11±6.59)% in the Ading different concentrations of the extract β 40 group was rescued to(79.13±6.64)% by *** showed pyknotic nuclei in 39.5% of A β 40-treated cells;the fraction dropped to 17.4% in the 100 μg/L extract *** phosphorylation was observed in the Aent with 100 μg/L *** papaya water ex β 40 group but was ameliorated by pretreatmtract also prevented Ation of MEK,RSK1 and CREB associated with ERK signaling and d β 40-induced phosphorylaownregulated Bax expression in the ***:The resultss suggest that hainan papaya water extract has protective effects on neurons;the mechanism may be related to suppression of ERK signaling activation.

关键词： A β peptide Neuron protection ERK signaling pathway