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TWO new rotenoids from the root of Derris elliptica

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Chinese Chemical Letters 2008年第10期19卷 1218-1220页

作者： hai ying lu Jing Yu Liang Ping Yu Wei Qu Ling Zhao Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 PR China

Two new rotenoids 4＇,5＇-dihydroxy-6a,12a-dehydrodeguelin （1）,11.4t,5＇-tdhydroxy-6a,12a-dehydrodeguelin （2）, along with two known rotenoids rotenone and deguelin were isolated from the root of Derris elliptica c... 详细信息

关键词： Derris elliptica Rotenoid

De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients

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World Journal of Gastroenterology 2011年第43期17卷 4804-4809页

作者： Xiao-Hong Fan Jian-Zhang Geng Li-Fen Wang ying-ying Zheng hai-ying lu Jing Li Xiao-Yuan Xu Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

AIM:To investigate the appropriate time for combination therapy in HBeAg positive chronic hepatitis B(CHB) patients with decompensated ***:Thirty HBeAg positive CHB patients with decompensated cirrhosis were enrolled in the *** of the patients were given 48 wk combination therapy with lamivudine(LAM) and adefovir dipivoxil(ADV) .Briefly,10 patients were given the de novo combination therapy with LAM and ADV,whereas the other 20 patients received ADV in addition to LAM after hepatitis B virus(HBV) genetic ***:Serum alanine aminotransferase and total bilirubin were both improved in the two groups at 4,12,24 and 48 wk after *** albumin was also improved at 24 and 48 wk after combination therapy in both *** serum HBV DNA level wasstill detectable in every patient in the two groups at 4 and 12 wk after combination ***,in the de novo combination group,serum HBV DNA levels in 4(40%) and 9(90%) patients was decreased to below 1×10 3 copies/mL at 24 and 48 wk after the combination treatment,*** parallel,serum HBV DNA levels in 2(20%) and 8(40%) patients in the add-on combination group became undetectable at 24 and 48 wk after combination treatment,***,6(60%) patients in the de novo combination group achieved HBeAg seroconversion after 48 wk treatment,whereas only 4(20%) patients in the add-on combination group achieved ***-Pugh score of patients in the de novo combination group was better than that of patients in the add-on combination group after 48 wk ***,patients in the de novo combination group had a significantly decreased serum creatinine level and elevated red blood cell ***:De novo combination therapy with LAM and ADV was better than add-on combination therapy in terms of Child-Pugh score,virus inhibition and renal function.

关键词： Hepatitis B Chronic Cirrhosis Decompensated De novo combination Lamivudine Adefovir dipivoxil

Early renal injury indicators can help evaluate renal injury in patients with chronic hepatitis B with long-term nucleos(t)ide therapy

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World Journal of Clinical Cases 2020年第24期8卷 6306-6314页

作者： Tong-Tong Ji Ning Tan hai-ying lu Xiao-Yuan Xu Yan-Yan Yu Department of Infectious Diseases Peking University First HospitalBeijing 100034China

BACKGROUND Patients with chronic hepatitis B(CHB)with long-term nucleos(t)ide therapy may experience renal *** renal function indicators,such as urine protein,serum urea nitrogen(BUN),and serum creatinine,are normal when early mild lesions ***,more sensitive renal function indicators are *** To investigate the significance of early renal injury indicators in evaluating renal injury in patients with CHB with long-term nucleos(t)ide *** We collected the clinical data of 69 outpatients with CHB at Peking University First Hospital from March 2018 to January 2020 who had been treated with longterm nucleos(t)ide therapy and analyzed the results of early renal injury *** normal distribution data were analyzed by the t-test to determine the difference between two *** non-normally distributed data were analyzed by the Mann-Whitney U-test between two *** Kruskal-Wallis H test was used to determine the differences among multiple *** data were analyzed by the chi-square *** related factors of early renal injury indicators were analyzed by logistic regression *** The average treatment duration with nucleos(t)ide analogs of the 69 patients with CHB was 99.7±28.7 *** cases of patients with elevated BUN and hypophosphatemia were 6(8.7%)and 13(18.8%),respectively;31(44.9%)patients had abnormal early renal injury indicators,including 9 patients with abnormal urine microalbumin,7 patients with abnormal urine immunoglobulin,6 patients with abnormal urine transferrin,and 19 patients with abnormalα1 *** were no significant differences in the mean values of age,sex,BUN,estimated glomerular filtration rate(eGFR),serum uric acid,serum calcium,or serum phosphorus between the two groups of patients with and without early renal injury ***,the mean levels of serum creatinine and urine creatinine,N-acetyl-β-D-glucosidase enzyme,α1 microglo

关键词： Early renal injury Chronic hepatitis B Nucleos(t)ide analog N-acetyl-β-Dglucosidase enzyme α1 microglobulin Urine immunoglobulin

Solvent-free Reactions of Formylferrocene with Active Methylene Containing Compounds

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有机化学 2003年第Z1期23卷 286-287页

作者： BAI Yin-Juan GAN hai-ying lu Jun SHI Zhen Department of Chemistry Northwest University Xi''an 710069 Department of Chemistry Northwest University Xi''an 710069 Department of Chemistry Northwest University Xi''an 710069 Department of Chemistry Northwest University Xi''an 710069

　　Since ferrocene was synthesized, derivatives of ferrocene have attracted the attention of chemists, and recently solvent-free organic reaction has been an important new dimension in preparative organic chemistry. [1] Solventless synthesis without the use of supporting reagents which can avoid the risk of high pressure development and volatile toxic solvent employment is very amaizing and eco-friendly.……

关键词： organic chemistry organic reaction high pressure

Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs

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World Journal of Gastroenterology 2006年第26期12卷 4219-4223页

作者： hai-ying lu Zheng Zeng Xiao-Yuan Xu Nai-Lin Zhang Min Yu Wei-Bo Gong Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

AIM： To investigate the clinical significance and presence of mutations in the surface （S） and overlapping polymerase gene of hepatitis B patients with coexisting HBsAg and anti-HBs. METHODS： Twenty-three patients with chronic hepatitis B were studied. Of the 23 patients, i i were both positive for hepatitis B virus （HBV） surface antigen （HBsAg） and antibody to HBV surface antigen （anti-HBs）, 12 were negative for anti-HBs while positive for HBsAg. DNA was extracted from 200 μL serum of the patients. Nucleotide of the surface and overlapping polymerase gene from HBV-infected patients was amplified by PCR, and the PCR products were sequenced. RESULTS： Forty-one mutations were found within the surface gene protein of HBV in 15 patients （10 with coexisting HBsAg and anti-HBs）. Six （14.6%） out of 41 mutations were located at ＂α＂ determinant region in 5 patients （4 positive for HBsAg and anti-HBs）. Eleven mutations （26.8%） occurred in the downstream or upstream of ＂α＂ determinant region. Lamivudine （LMV）- selected mutations were found in three patients who developed anti-HBs, which occurred in amino acid positions （196, 198, 199） of the surface protein and in YMDD motif （M204I/V） of the polymerase protein simultaneously. Presence of these mutations did not relate to changes in ALT and HBV DNA ***： Besides mutations in the ＂α＂ determinant region, mutations at downstream or upstream of the ＂α＂ determinant region may contribute to the development of anti-HBs. These mutations do not block the replicating competency of HBV in the presence of high titer of anti-HBs.

关键词： Hepatitis B virus surface antigen Antibody to hepatitis B virus surface Mutation

Comprehensive study on the spatial distribution of heavy metals and their environmental risks in high-sulfur coal gangue dumps in China

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Journal of Environmental Sciences 2024年第2期136卷 486-497页

作者： yingbo Dong Huan lu hai Lin School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants Beijing 100083China

The accumulation of coal gangue(CG)from coal mining is an important source of heavy metals(HMs)in *** spatial distribution and environment risk assessment are extremely important for the management and remediation of *** soil samples were collected from the high-sulfur CG site in northern China and analyzed for six *** results showed that the soil was heavily contaminated by Mn,Cr and Ni based on the Nemerow index,and posed seriously ecological risk depended on the geo-accumulation index,potential ecological risk index and risk assessment *** semi-variogram model and ordinary kriging interpolation accurately portrayed the spatial distribution of ***,Mn,and Cr were distributed by band diffusion,Ni was distributed by core,the distribution of Cu had obvious patchiness and Zn was more *** spatial autocorrelation indicated that all HMs had strong spatial *** BCR sequential extraction was employed to qualify the geochemical fractions of *** data indicated that Fe and Cr were dominated by residual fraction;Cu,Ni and Zn were dominated by reducible and oxidizable fractions;Mn was dominated by reducible and acid-extractable(25.38%-44.67%)*** correlation analysis showed that pH was the main control factor affecting the non-residue fractions of ***,acid production from high sulfur CG reduced soil pH by 2-3,which indirectly promoted the activity of ***,the conceptual model of HMs contamination at the CG site was proposed,which can be useful for the development of ecological remediation strategies.

关键词： High-sulfur coal gangue Soil contamination Heavy metals Spatial distribution Geochemical fractions Risk assessment

Nuclei-rich galvanizing strategy for suppressing zinc dendrite growth

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Rare Metals 2024年第8期43卷 4016-4018页

作者： hai-Xia Wu Kai-lu Guo College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyang 471934China

The uncontrolled growth of zinc dendrites on zinc anode hinders the application of zinc ion *** solve this problem,lu's group proposed a nuclei-rich galvanizing strategy for suppressing the zinc dendrite *** allows the nuclei-rich zinc electrode to cycle steadily for1200 h and have a high Coulombic efficiency of 99.7%at15 mA·cm^(-2)with a deposited amount of 10 mAh·cm^(-2).Moreover,the Zn-MnO_(2) battery with a low N/P ratio of 1.9exhibited sustained cycling life.

关键词： cycling sustained battery

Zeolite polymer membrane as protective interface for Mg battery

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Rare Metals 2024年第9期43卷 4636-4638页

作者： hai-Xia Wu Kai-lu Guo College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyang 471934China

Excessive electrolyte decomposition seriously determines the performance of high-voltage Mg batteries. In Nazar's work, the strategy using a zeolite polymer membrane as a protective interface was proposed to restrain the electrolyte decomposition. This strategy could boost Mg plating/stripping performance up to 6000 h in zeolite/Mg|zeolite/Mg symmetric cells and 91%capacity retention in zeolite/Mg||Mo_(3)S_(4)battery after 200 *** storage devices have been intensively explored because of their important roles in our daily lives [1D3].

关键词： zeolite interface electrolyte

The Contribution of United States Aircraft Reconnaissance Data to the China Meteorological Administration Tropical Cyclone Intensity Data:An Evaluation of Homogeneity

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Advances in Atmospheric Sciences 2024年第4期41卷 639-654页

作者： Ming ying Xiaoqin lu Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China

This paper investigates the homogeneity of United States aircraft reconnaissance data and the impact of these data on the homogeneity of the tropical cyclone(TC)best track data for the seasons 1949-1987 generated by the China Meteorological Administration(CMA).The evaluation of the reconnaissance data shows that the minimum central sea level pressure(MCP)data are relatively homogeneous,whereas the maximum sustained wind(MSW)data show both overestimations and spurious abrupt *** comparisons suggest that both the reconnaissance MCP and MSW were well incorporated into the CMA TC best track *** no spurious abrupt changes were evident in the reconnaissance-related best track MCP data,two spurious changepoints were identified in the remainder of the best-track MCP ***,the influence of the reconnaissance MSWs seems to extend to the best track MSWs unrelated to reconnaissance,which might reflect the optimistic confidence in making higher estimates due to the overestimated extreme wind“observations”.In addition,the overestimation of either the reconnaissance MSWs or the best track MSWs was greater during the early decades compared to later decades,which reflects the important influence of reconnaissance data on the CMA TC best track *** wind-pressure relationship(WPR)used in the CMA TC best track dataset is also evaluated and is found to overestimate the MSW,which may lead to inhomogeneity within the dataset between the aircraft reconnaissance era and the satellite era.

关键词： tropical cyclone intensity homogeneity best track aircraft reconnaissance