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An excimer ‘ON–OFF’ switch based on telomeric G-quadruplex and rGO for trace thrombin detection

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Chinese Chemical Letters 2022年第9期33卷 4243-4247页

作者： Long Zhao Farid Ahmed hai xiong Institute for Advanced Study Shenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China

In the recent decade,GO has emerged as an amazing 2D nanomaterial for developing DNA-based biosensors due to its fluorescence quenching properties,whereas similar research based on rGO was reported ***,a novel multi-pyrene functionalized G-rich DNA probe based on the screened rGO showed much higher fluorescence quenching efficiency and excimer emission than that of universal *** from the universal thrombin detection of the G4-forming aptamer-TBA(GGTTGGTGTGGTTGG),the original telomeric sequence is used in this *** excimer emission“ON-OFF”switch amplified the response of thrombin detection is as low as 50 ***,for four pyrene moieties that are sited in a crowded steric circumstance,the melting temperature(T_(m))values and molecular dynamics simulations showed a positive effect on duplex G-quadruplex or _(G)DNA·_(c)DNA stability,without disturbing its helix structure.

关键词： G-quadruplexr GOMulti-pyrene excimer Biosensor Thrombin detection

Biocompatible and non cytotoxic nucleoside-based AIEgens sensor for lighting-up nucleic acids

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Chinese Chemical Letters 2021年第5期32卷 1687-1690页

作者： Qiuyun Xiao Xuan Zhao hai xiong Institute for Advanced Study Shenzhen UniversityShenzhen 518060China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

Aggregation-induced emission luminogens(AIEgens) have been used in biomacromolecules ***,TPE-dC and TPE-dU acted as the nucleoside-based AIEgens sensors in the first case,which can be used to detect ctDNA and rRNA in vitro and light up the nucleus in vivo depending on the intermolecular binding *** AIE process enables the quantitative analysis or visualization of nucleic acids in solution or gels state,***,confocal laser scanning microscopy(CLSM) images of L929 cells stained with TPE-dC or TPE-dU clearly shows that nucleoside-based AIEgens bio-probes can pass the cell membranes to reach the cell nucleus,without cytotoxicity at the imaging condition(incubation time> 12 h,and 10 μmol/L of concentration).Since the nucleus is rich in DNA/RNA,fluorescence turn-on mode has a great potential in nucleus imaging and clinical diagnosis.

关键词： AIEgens Nucleoside Biosensor Nucleus localization Cell imaging

Emerging trends and future challenges of advanced 2D nanomaterials for combating bacterial resistance

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Bioactive Materials 2024年第8期38卷 225-257页

作者： Saima Hameed Sumaira Sharif Muhammad Ovais hai xiong Institute for Advanced Study Shenzhen UniversityShenzhen518060PR China School of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen518060PR China Institute of Molecular Biology and Biotechnology The University of LahoreLahorePakistan BGI Genomics BGI ShenzhenShenzhen518083GuangdongPR China

The number of multi-drug-resistant bacteria has increased over the last few decades,which has caused a detrimental impact on public health *** resolving antibiotic resistance development among different bacterial communities,new antimicrobial agents and nanoparticle-based strategies need to be designed foreseeing the slow discovery of new functioning *** research studies have revealed the significant disinfection potential of two-dimensional nanomaterials(2D NMs)to be severed as effective antibacterial agents due to their unique physicochemical *** review covers the current research progress of 2D NMs-based antibacterial strategies based on an inclusive explanation of 2D NMs’impact as antibacterial agents,including a detailed introduction to each possible well-known antibacterial *** impact of the physicochemical properties of 2D NMs on their antibacterial activities has been deliberated while explaining the toxic effects of 2D NMs and discussing their biomedical significance,dysbiosis,and cellular *** to the challenges,we also discussed the major issues regarding the current quality and availability of nanotoxicity ***,smart advancements are required to fabricate biocompatible 2D antibacterial NMs and exploit their potential to combat bacterial resistance clinically.

关键词： 2D nanomaterials Physicochemical properties Antibacterial mechanism Multi-drug-resistance Cellular nanotoxicity Nanotoxicity data availability

Intermolecular hydrogen-bond interaction to promote thermoreversible 2'-deoxyuridine-based AIE-organogels

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Chinese Chemical Letters 2021年第4期32卷 1363-1366页

作者： Xuan Zhao Long Zhao Qiuyun Xiao hai xiong Institute for Advanced Study Shenzhen University.Shenzhen 518060China

Fluorescent supramolecular nucleoside-based organogels or hydrogels have attracted increasing attention owing to their tunable stability,drug delivery,tissue engineering,and inherent biocompatibility for applications in designing *** the temperature of a constant TPE-Octa-dU gelato r at MGC as low as 0.2 wt%was increased with gel to sol transition,a progressive decrease in the fluorescence intensity was observed.~1 H NMR study in ethanol-d_(6)/H_(2)O revealed the existence of intermolecular hydrogen-bond interaction between uridine nucleobase and triazole *** on these experiments,thus organogels induced by hydrogen bonding can promote an aggregation-induced emission(AIE)of TPE *** gelation properties have been investigated systematically,including AIE-shapemorphing architecture owing to their unique solid-liquid interface and easy *** the same line,the related TPE-EdU derivative which was synthesized from 5-ethynyl-2'-deoxyuridine does not delive r organogels or hydrogels,a nd under similar circumstances TPE moiety of TPE-EdU does not efficiently exhibit AIE phenomenon either.

关键词： Supramolecular Organogel Aggregation-induced emission Nucleoside Click chemistry

A new nine-membdered lactone from a marine fungus Cladosporium sp.F14

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Chinese Chemical Letters 2010年第11期21卷 1355-1357页

作者： Cheng hai Gao Xu Hua Nong Shu Hua Qi xiong Ming Luo Si Zhang hai Rong xiong Key Laboratory of Marine Bio-resources Sustainable Utilization/Research Center for Marine Microbes/ Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology The Chinese Academy of Sciences Guangzhou 510301 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China Life Science College South-Central University for Nationalities Wuhan 430074 China

A new nine-membered lactone,cladospolide E（1）,was isolated from a culture broth of a marine fungus Cladosporium sp.F14. The structure of compound 1 was determined on the basis of extensive spectroscopic analysis,inc... 详细信息

关键词： Cladosporium sp Marine fungus Nine-membered lactone Cladospolide E

Influence of nitrogen implantation into HSS substrate on internal stress and adhesion strength of c-BN films

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 286-290页

作者： ZHANG Ping CAI Zhi-hai TAN Jun xiong Wan-quan National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China

Cubic boron nitride(c-BN) films were deposited on HSS substrate implanted with nitrogen ion by RF-magnetron sputtering. The films were analyzed by bending beam method, scratch test, XRD and AFM. The results show that the implantation of N ion can reduce the internal stress and improve the adhesion strength of the *** critical load comes to 16.92N, compared to 1.75N of c-BN film on the unimplanted HSS. AFM shows that the surface of the c-BN film on the implanted HSS is low in roughness and small in grain size. The phase structure of the nitrogen implanted layer was analyzed by XRD. The influence of nitrogen implanted layer on the internal stress and adhesion strength of c-BN films were also investigated.

关键词： cubic boron nitride film HSS ion implantation internal stress adhesion

Percutaneous transhepatic access for catheter ablation of a patient with heterotaxy syndrome complicated with atrial fibrillation:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7006-7012页

作者： hai-xiong Wang Na Li Jian An Xue-Bin Han Department of Cardiology Shanxi Cardiovascular HospitalTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Atrial fibrillation(AF)is one of the most common arrhythmias,and radiofrequency catheter ablation is the most effective treatment *** inferior vena cava(IVC)is a common approach for radiofrequency ablation of ***,this approach may not be applied to some cases such as chronic venous occlusions,surgical ligation of the IVC,and heterotaxy syndrome(HS).CASE SUMMARY A 68-year-old man with HS suffered from severely symptomatic persistent AF for 9 years,and we successfully ablated by percutaneous transhepatic *** In patients without femoral vein access,the use of the hepatic vein for pulmonary vein isolation is a viable alternative for invasive electrophysiology procedures.

Synthesis, Crystal Structure and Characterization of a New Hydrogen-bonded Organic Framework

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Chinese Journal of Structural Chemistry 2021年第8期40卷 1082-1087,971页

作者： SUN Jing LIU hai-xiong LIU Tian-Fu Jinshan College Fujian Agriculture and Forestry UniversityFuzhou 350002China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

The hydrogen-bonded organic framework(PFC-32),constructed by tetrahydroxyquinone(THQN)and diethylamine(DEA),was readily prepared via hydrothermal synthesis in DEF(N,N-diethylformamide).PFC-32 was characterized by PXRD,IR,UV-Vis,TGA and photoluminescence(PL).Single crystal analysis reveals that PFC-32 shows a three-dimensional(3 D)framework,where the THQN anions are coplanar and separated by DEA ***-32 displays intrinsic photoluminescence property owing to the alleviation of the aggregation-caused quenching(ACQ)effect caused byπ-πstacking.

关键词： tetrahydroyquinone diethylamine hydrogen-bonded organic framework

Learning Robotic Hand-eye Coordination Through a Developmental Constraint Driven Approach

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International Journal of Automation and computing 2013年第5期10卷 414-424页

作者： Fei Chao Xin Zhang hai-xiong Lin Chang-Le Zhou Min Jiang Cognitive Science Department Fujian Provincial Key Laboratory of Brain-like Intelligent Systems Xiamen University

The skill of robotic hand-eye coordination not only helps robots to deal with real time environment,but also afects the fundamental framework of robotic cognition.A number of approaches have been developed in the literature for construction of the robotic hand-eye ***,several important features within infant developmental procedure have not been introduced into such *** paper proposes a new method for robotic hand-eye coordination by imitating the developmental progress of human *** work employs a brain-like neural network system inspired by infant brain structure to learn hand-eye coordination,and adopts a developmental mechanism from psychology to drive the *** entire learning procedure is driven by developmental constraint： The robot starts to act under fully constrained conditions,when the robot learning system becomes stable,a new constraint is assigned to the *** that,the robot needs to act with this new condition *** all the contained conditions have been overcome,the robot is able to obtain hand-eye coordination *** work is supported by experimental evaluation,which shows that the new approach is able to drive the robot to learn autonomously,and make the robot also exhibit developmental progress similar to human infants.

关键词： Robotics developmental robotics developmental learning robotic hand-eye coordination robotic reaching