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Assessment of Comparative Genomic Hybridization Experiment by an in situ Synthesized CombiMatrix Microarray with Yersinia pestis Vaccine Strain EV76 DNA

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Biomedical and Environmental Sciences 2010年第5期23卷 384-390页

作者： YUAN-hai YOU PENG wang YAN-HUA wang hai-BIN wang DONG-ZHENG YU RONG hai JIAN-ZHONG ZHANG National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective The quality of microarray data influences the accuracy of comparative genomic analyses to a large *** ensure that the results obtained by using an in situ synthesized microarray are accurate,data quality is to be assessed by evaluating the melting temperature (Tm) of probes,probability of false synthesis rates,and fragmentation of labeled *** DNA from the Yersinia pestis vaccine strain EV76 was used for microarray *** results were confirmed by *** and bioinformatics methods were employed to perform microarray data analyses and *** Correlation coefficients of the three datasets were above 0.95 after two-time stripping and hybridization with a labeled DNA with the size of fragmentation being 200 bp-2 kb,which showed that the hybridization results were highly *** coefficients were lower with the values ranging from 0.87 to 0.92 between the datasets generated from hybridization with different sizes of the labeled DNA *** the relationship between Tm and signal intensity,there was a different distribution of Tm in the lowest 300 or 3 000 probes with a range of 70 ℃-72 ℃ and the highest 300 or 3 000 probes with a range of 72 ℃-74 ℃.Conclusion The results of this study suggest that the initial microarray design may affect the accuracy of final analyses and that the probe Tm and the size of the labeled fragment may be the two factors of the greatest importance.

关键词： Array CGH Data quality Assessment

Formation and impact-induced separation of tandem EFPs

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Defence Technology（防务技术） 2020年第3期16卷 668-677页

作者： Hong-bing Ma Yuan-feng Zheng hai-fu wang Chao Ge Cheng-hai Su State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

The formation and separation behaviors of tandem EFPs are studied by the combination of experiments and *** results show that different formation and separation processes can be obtained by adjusting the double-layer liners,and simulations agree with experiments ***,the interaction process between the two liners is discussed in details,and the formation and separation mechanism are *** can be found that there are four phases in the formation and separation processes,including impact phase,propulsion phase,slide phase and free flight *** the impact phase,the velocities of two liners rise in turns with kinetic energy *** the propulsion phase,the axial impact becomes insignificant,but the radial interaction between two liners influences the appearance of tandem ***,it should be mentioned that the inner surface of foregoing EFP remains to be in contact with the outer surface of following EFP in the propulsion phase,and the following one would continue to push the foregoing one for about 10μ to 20 μs,causing the velocities of following and foregoing EFPs gradually decreasing and increasing *** the slide phase,an obvious relative movement occurs between the two EFPs,and there would be barely kinetic energy ***,the two EFPs separate gradually and get into the phase of free ***,if the outer and inner liners have the same thickness,the outer copper-inner copper liners form two long EFPs,the outer copper-inner steel liners become a foregoing short steel EFP and a following long copper EFP,and the outer steel-inner copper liners produce a foregoing long copper EFP and a following conical steel *** addition,thickness match also has an important impact on formation appearance and separation process for both outer copperinner copper liners and outer steel-inner copper *** the thickness ratio of outer liner to inner liner decreasing,the length and length-diameter ratio of both foreg

关键词： Shaped charge Liner Tandem EFPs Formation Separation

Combined and interactive effects of interference fit and preloads on composite joints

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Chinese Journal of Aeronautics 2014年第3期27卷 716-729页

作者： Liu Longquan Zhang Junqi Chen Kunkun wang hai School of Aeronautics and Astronautics Shanghai Jiao Tong University

The combined and interactive effects of the bolt-hole fit conditions and the preloads of the fasteners on the load carrying capacity of single-lap composite-to-titanium bolted joints have been investigated both experimentally and numerically. Quasi-static tests of the hybrid joints with different fit conditions are implemented, and a three dimensional finite element progressive failure analysis model is proposed to predict the influences of the bolt-hole fit conditions and fastener＇s pre- loads on the mechanical behaviors of the joints. Based on the experimental validated simulation method, a multi-factor, mixed levels orthogonal design table and the analysis of variance method are used to arrange the simulation conditions and to further study the interactive effects of preloads and fit conditions. Through the analysis of the results, for the researched double bolt, single-lap composite-titanium joints, it is found that： the effects of both the interference fit and the preloads change from positive into negative mode with the increase of the interference fit values or preload values; appropriate bolt-hole fit conditions and preloads can improve the bolt-hole contact conditions of the loaded joints, and then retard the fiber failures around the fastener holes, and increase the load carrying capacity of the joints eventually; the interactive effect of the bolt-hole interference fit conditions and preloads cannot be ignored and the parameters need to be considered together and synthetically as the joints are being optimized.

关键词： Bolted joints Composite Interactive effect Interference fit Preloads

Robust model selection for positive and unlabeled learning with constraints

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Science China(Information Sciences) 2022年第11期65卷 94-106页

作者： Tong WEI hai wang Weiwei TU Yufeng LI Department of Computer Science and Technology Nanjing University 4Paradigm Inc.

Positive and unlabeled(PU) learning is the problem in which training data contains only PU samples. Although PU learning is widely used in real-world applications, its model selection remains challenging. Specifically, traditional model selection methods are often highly sensitive to the class prior as well as the data size, resulting in human overhead in hyperparameter optimization. In this paper, we present a method called ODE(robust model selection) for robust model selection in PU learning. Two novel model evaluators based on the integral probability metric and area under the curve, which are free of the class prior, are introduced, and a variance reduction method is further employed to improve the quality of model selection. In addition, we perform model selection under user-defined constraints and propose a fast halvingstyle searching algorithm to efficiently identify the most promising model configuration. Extensive empirical studies demonstrate that our proposed method performs more robustly and is more computationally efficient than many state-of-the-art methods.

关键词： positive and unlabeled learning model selection automated machine learning

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Role of the duodenum in regulation of plasma ghrelin levels and body mass index after subtotal gastrectomy

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World Journal of Gastroenterology 2008年第15期14卷 2425-2429页

作者： hai-Tao wang Qi-Cheng Lu Qing wang Rong-Chao wang Yun Zhang hai-Long Chen Hong Zhao hai-Xin Qian Department of Gastroenterology 3rd Affiliated Hospital Suzhou University Changzhou 213003 Jiangsu Province China Department of Nuclear Medicine 3rd Affiliated Hospital Suzhou University Changzhou 213003 Jiangsu Province China Department of Gastroenterology First Affiliated Hospital Suzhou University. Suzhou 215006 Jiangsu Province. China

AIM: To investigate the role of the duodenum in the regulation of plasma ghrelin levels and body mass index (BMI), and the correlation between them after subtotal gastrectomy. METHODS: Forty-two patients with T0-1N0-1M0 gastric cancer were divided into two groups after gastrectomy according to digestive reconstruction pattern, Billroth Ⅰ group (n = 23) and Billroth Ⅱ group (n = 19). Ghrelin levels were determined with radioimmunoassay (RIA) before and on d 1, 7, 30 and 360 after gastrectomy, and BMI was also measured. RESULTS: The two groups had identical postoperative trends in ghrelin alterations during the early stage, both decreasing sharply to a nadir on d 1 (36.7% vs 35.7%), then markedly increasing on d 7 (51.0% vs 51.1%). On d 30, ghrelin levels in the Billroth Ⅰ group were slightly higher than those in the Billroth Ⅱ group. However, those of the Billroth Ⅰ group recovered to 93.6% on d 360, which approached, although lower than, the preoperative levels, and no statistically significant difference was observed. Those of the Billroth Ⅱ group recovered to only 81.6% and manifested significant discrepancy with preoperative levels (P = 0.033). Compared with preoperative levels, ghrelin levels of the two groups decreased by 6.9% and 18.4% and BMI fellby 3.3% and 6.4%, respectively. The linear regression correlations were revealed in both groups between decrease of ghrelin level and BMI (R12 = 0.297, P = 0.007; R22 = 0.559, P < 0.001).CONCLUSION: Anatomically and physiologically, the duodenum compensatively promotes ghrelin recovery and accordingly enhances BMI after gastrectomy. Regarding patients with insufficient ghrelin secretion, ghrelin is positively associated with BMI.

关键词： Duodenum Ghrelin Body mass index Subtotal gastrectomy Digestive reconstruction

Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

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Rare Metals 2024年第1期43卷 410-412页

作者： Chao-Yue Sun Wen Li hai-Qing wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

Effect of milling process on the core-shell structures and dielectric properties of fine-grained BaTiO_3-based X7R ceramic materials

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International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 345-348页

作者： Tian wang Xiao-hui wang hai Wen Long-tu Li State Key Laboratory of New Ceramics and Fine Processing Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

Fine-grained BaTiO3-based X7R ceramic materials were prepared and the effects of milling process on the core-shell structures and dielectric properties were investigated using scanning electron microscope, transmission electron microscope, and energy dispersive spectroscopy （EDS）. As the milling time extends, the dielectric constant of the ceramics increases, whereas the temperature coefficient of capacitance at 125℃ drops quickly. The changes in dielectric properties are considered relevant to the microstructure evolution caused by the milling process. Defects on the surface of BaTiO3 particles increase because of the effects of milling process, which will make it easier for additives to diffuse into the interior grains. As the milling time increases, the shell region gets thicker and the core region gets smaller; however, EDS results show that the chemical inhomogeneity between grain core and grain shell becomes weaker.

关键词： fine-grain barium titanate core-shell structure milling process microstructure capacitor

Electronic transport and magnetic performance of Ni-Nb-Zr metallic glasses

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Rare Metals 2017年第11期36卷 894-898页

作者： hai-Bin wang Qing wang Chong-Lin Chen Chuang Dong School of Materials Science and Engineering Jiangsu University of Science and Technology Zhenjiang 212003 China School of Materials Science and Engineering Dalian University of Technology Dalian 116024 China Department of Physics and Astronomy University of Texas at San Antonio San Antonio TX 78249 USA

The electronic transport and magnetic perfor- mances of Ni-Nb-Zr metallic glasses under low temperature were investigated. X-ray diffraction （XRD） analysis indicates that the Ni-Nb-Zr ribbons prepared by induction melting and melt spinning method have single amorphous phase. The electrical transport property results of these metallic glass alloys indicate that the Ni-Nb-Zr metallic glasses have negative resistivity temperature coefficients （RTC） and low- temperature drift. The negative RTC and corresponding pos- sible values of Fermi energy of Ni-Nb-Zr metallic glasses are interpreted by the extended Ziman-Faber diffraction theory. The magnetic measurements indicate that the magnetic in- tensities of the Ni-Nb-Zr metallic glasses are related to Ni content and atomic sizes while the low temperature has few influences on the magnetic properties.

关键词： Metallic glass Electrical resistance Magneticproperties

The Case of Using Multiple Streams in Streaming

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International Journal of Automation and computing 2013年第6期10卷 587-596页

作者： Muhammad Abid Mughal hai-Xia wang Dong-Sheng wang Tsinghua National Laboratory for Information Science and Technology Department of Computer Science&TechnologyTsinghua University

Off-chip replacement （capacity and conflict） and coherent read misses in a distributed shared memory system cause execution to stall for hundreds of cycles. These off-chip replacement and coherent read misses are recurring and forming sequences of two or more misses called streams. Prior streaming techniques ignored reordering of misses and not-recently-accessed streams while streaming data. In this paper, we present stream prefetcher design that can deal with both problems. Our stream prefetcher design utilizes stream waiting rooms to store not-recently-accessed streams. Stream waiting rooms help remove more off-chip misses. Using trace based simulation% our stream prefetcher design can remove 8% to 66% （on average 40%） and 17% to 63% （on average 39%） replacement and coherent read misses, respectively. Using cycle-accurate full-system simulation, our design gives speedups from 1.00 to 1.17 of princeton application repository for shared-memory computers （PARSEC） workloads running on a distributed shared memory system with the exception of dedup and swaptions workloads.

关键词： Prefetching stream first in first out (FIFO) princeton application repository for shared-memory computers (PARSEC),stream waiting rooms reordering of misses sequitur.