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Intranasal administration nanosystems for brain-targeted drug delivery

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Nano Research 2023年第12期16卷 13077-13099页

作者： Yue Jiang Xueting Pan Tao Yu hai wang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute of Functional Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

The existence of the blood-brain barrier(BBB)restricts the entry of drugs from the circulation into the central nervous system(CNS),which severely affects the treatment of neurological diseases,including glioblastoma,Parkinson’s disease(PD),and Alzheimer’s disease(AD).With the advantage of bypassing the BBB and avoiding systemic distribution,intranasal administration has emerged as an alternative method of delivering drugs to the *** delivery directly to the brain using intranasal nanosystems represents a new paradigm for neurological disease treatment because of its advantages in improving drug solubility and stability in vivo,enabling targeted drug delivery and controlled release,and reducing non-specific *** it has shown efficacy in animal models and clinical ***,this review describes the mechanisms of intranasal delivery of brain-targeted drugs,the properties of nanosystems for intranasal administration(e.g.,liposomes,nanoemulsions,and micelles),and strategies for intranasal drug delivery to enhance brain-targeted drug *** applications of nanosystems in intranasal drug delivery and disease treatment have been comprehensively *** encouraging results have been reported,significant challenges still need to be overcome to translate these nanosystems into ***,the future prospects of intranasal drug delivery nanosystems are discussed in depth,expecting to provide useful insights and guidance for effective neurological disease treatment.

关键词： intranasal administration nanosystems brain-targeted delivery neurological diseases drug delivery

Phase Selection and Microstructure Evolution Dependance on Composition for Zr-Fe Eutectic Alloys

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Acta Metallurgica Sinica(English Letters) 2024年第10期37卷 1689-1702页

作者： Dong-Dong Zuo Jian Chang hai-Peng wang School of Physical Science and Technology Northwestern Polytechnical UniversityXi’an710072China

The knowledge of the phase selection and microstructure evolution of Zr-Fe eutectic alloys is still poorly *** presumed eutectic alloy with a nominal composition of Zr76.0Fe24.0 was discovered to contain a significant proportion ofα-Zr ***,phase selection and microstructure evolution dependance on composition for Zr-Fe eutectic alloys was experimentally determined by using differential scanning calorimetry(DSC)and meticulous electron *** alloys,spanning the composition range of 73.5-74.7%Zr,were examined to investigate microstructure evolution and non-isothermal crystallization *** indicate that in alloys ranging from Zr_(73.5)Fe_(26.5) to Zr_(73.9)Fe_(26.1),the primary FeZr_(2) phase demonstrates preferential growth,followed by eutectic microstructure formation during liquid alloy *** volume fraction of FeZr_(2) dendrites decreases as the Zr content ***,in alloys ranging from Zr_(74.0)Fe_(26.0) to Zr_(74.7)Fe_(25.3),primaryβ-Zr dendrites preferentially grow,followed by a eutectic reaction in the remaining liquid *** content ofα-Zr dendrites reduces with decreasing Zr *** mentioned above,a critical composition range for phase selection is defined as Zr_(x)Fe100.0−x(73.9

关键词： Phase selection Thermal analysis Microstructure evolution Crystallization kinetic

Preparation, Electrochemical Property and Application in Bulk-modified Electrode of Dawson-type Phospho-molybdate-doped Polypyrrole Composite Nanoparticles

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Chemical Research in Chinese Universities 2006年第5期22卷 556-559页

作者： wang Xiu-li ZHAO hai-yan wang Yi-fei Faculty of Chemistry and Chemical Engineering Bohai University Jinzhou 121000 P. R. China

A kind of inorganic-organic hybrid semiconductor composite nanoparticles： Dawson-type phosphomolybdate- doped polypyrrole （P2Mo18-PPy） was designed and prepared using microemulsion oxidation-polymerization at room temperature and characterized by TEM and IR. The P2Mo18-PPy was used as a bulk-modifier to fabricate a chemically modified carbon paste electrode（CPE） by direct mixing, which represents the example of polyoxometalates（ POMs）- doped semiconductor polymer nanoparticles modified electrode. Both the advantage of POMs-doped polymer and the surface-renewal property of the CPE were fully utilized. The electrochemical behavior of the P2Mo18-PPY bulk-modified CPE（P2Mo18-PPy-CPE） was investigated with cyclic voltammetry. Three couples of reversible redox peaks were observed in the range from ＋ 800 to 0 mV, which corresponded to the reduction and oxidation through two-, four- and six-electron processes, respectively. The P2 Mo18-PPY-CPE showed a high electrocatalytic activity for the reduction of nitrite, which expanded the application of POMs-doped semiconductor polymer nanoparticles.

关键词： Dawson-type phosphomolybdate Polypyrrole Composite nanoparticles Bulk-modified Carbon paste electrode Electrocatalysis

Grid trust based on pre-measure and two-level reputation

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The Journal of China Universities of Posts and Telecommunications 2007年第4期14卷 70-76页

作者： ZHANG Lin wang Ru-chuan wang hai-yan School of Computer Nanjing Univesity of Posts and TelecommunicationsNanjing 210003 China

Security has been the focus of grid systems recently. As a kind of tool, grid security infrastructure （GSI） provides the authentication and authorization services and so on. These mechanisms mostly belong to the objective factors, which have not met the needs of security. As the subjective factor, trust model plays an important role in security field. A new two-level reputation trust architecture for grid is given to reduce the costs of system management largely, in which trust relationships amongst virtual organizations （VOs） are built on domain trust managers （DTMs） rather than resource nodes （RNs）. Taking inter-domain trust propagation for example, trust model is improved by integrating global reputation and the subjective trust concept of each recommender into synthesizing final trust value. Moreover, before the grid starts to interact with the trustworthy entities, the pre-measure scheme is presented to filter distrustful entities further, which is based on accuracy and honesty. Experimental results indicate that the model can prevent from the malicious attacks better.

关键词： grid computing trust model reputation pre-measure

A Method of Determining Selectivity Coefficients Based on the Practical Slope of Ion Selective Electrodes

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Chinese Chemical Letters 2002年第4期13卷 355-358页

作者： hai Xia wang Min PU School of Science Xi’an Jiaotong UniversityXi’an 710049

It is a problem to be solved that the experimental selectivity coefficients of ion selective electrodes (ISEs) depend on the activity. This paper studied the new method of determining selectivity coefficients. A mixed ion response equation, which was similar to Nicolsky-Eisenman (N-E) equation recommended by IUPAC, was proposed. The equation includes the practical response slope of ISEs to the primary ion and the interfering ion. The selectivity coefficient was defined by the equation instead of the N-E equation. The experimental part of the method is similar to that based on the N-E equation. The values of selectivity coefficients obtained with this method do not depend on the activity whether the electrodes exhibit the Nernst response or non-Nernst response. The feasibility of the new method is illustrated experimentally.

关键词： Ion selective electrodes potentiometric selectivity coefficients Nicolsky-Eisenman equation.

Research on tasks schedule and data transmission of video sensor networks based on intelligent agents and intelligent algorithms

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The Journal of China Universities of Posts and Telecommunications 2009年第6期16卷 84-91,112页

作者： HUANG hai-ping wang Ru-chuan SUN Li-juan wang hai-yuan XIAO Fu College of Computer Nanjing University of Posts and Telecommunications Nanjing 210003 China State Key Laboratory for Novel Software Technology Nanjing University Nanjing 210093 China

As a novel application technology,wireless video sensor networks become the current research focus,especially on target tracking and surveillance *** on multiple agents＇ technique,this article introduces a series of intelligent algorithms such as simulated annealing algorithm（SA）,genetic algorithm（GA）,and ant colony optimization algorithm（ACO） or their mixed algorithms,to resolve the optimization of tasks schedule and data *** article analyzes the performance of abovementioned algorithms and verifies their feasibility associated with *** simulations demonstrates that the mixed algorithms based on SA and GA obtain the optimal solution to tasks schedule,and those combined with SA-ACO show advantages on multimedia sensor networks routing optimization.

关键词： video sensor networks intelligent algorithm tasks schedule optimal routing agent

Ultralight Iontronic Triboelectric Mechanoreceptor with High Specific Outputs for Epidermal Electronics

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Nano-Micro Letters 2022年第6期14卷 1-14页

作者： hai Lu wang Zi Hao Guo Xiong Pu Zhong Lin wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004People’s Republic of China CUSTech Institute of Technology Wenzhou 325024ZhejiangPeople’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

The pursuit to mimic skin exteroceptive ability has motivated the endeavors for epidermal artificial *** mechanoreceptors are required to be highly sensitive to capture imperceptible skin deformations and preferably to be self-powered,breathable,lightweight and deformable to satisfy the prolonged wearing *** is still struggling to achieve these traits in single device,as it remains difficult to minimize device architecture without sacrificing the sensitivity or *** this article,we present an all-fiber iontronic triboelectric mechanoreceptor(ITM)to fully tackle these challenges,enabled by the high-output mechano-to-electrical energy *** proposed ITM is ultralight,breathable and stretchable and is quite stable under various mechanical *** the one hand,the ITM can achieve a superior instantaneous power density;on the other hand,the ITM shows excellent sensitivity serving as epidermal *** health status monitoring is readily implemented by the ITM calibrating by detecting vital signals and physical activities of human *** ITM can also realize acoustic-to-electrical conversion and distinguish voices from different people,and biometric application as a noise dosimeter is *** ITM therefore is believed to open new sights in epidermal electronics and skin prosthesis fields.

关键词： Ultralight Iontronic Triboelectric mechanoreceptor Power density Epidermal electronics

πN Elastic Scattering and Resonances in Quark Potential Model

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Communications in Theoretical Physics 2008年第4期49卷 987-992页

作者： wang hai-Jun SU Jun-Chen Center for Theoretical Physics Jilin University Changchun 130023 China

The quark potential model is used to investigate the low-energy elastic scattering of πN system. The model potential consists of the t-channel and s-channel one-gluon exchange potentials and the harmonic oscillator confining potential. By means of the resonating group method, a nonlocal effective potential for the πN system is derived from the interquark potentials and used to calculate the πN elastic scattering phase shifts. By considering the effect of QCD renormalization, the suppression of the spin-orbital coupling and the contribution of the color octet of the clusters （qq） and （qqq）, the numerical results are in fairly good agreement with the experimental data. The same model and method are employed to investigate the possible πN resonances. For this purpose, the resonating group equation is transformed into a standard Schrodinger equation in which the nonlocal effective πN interaction potential is included. Solving the Schrodinger equation by the variational method, we are able to reproduce the masses of some currently concerned πN resonances.

关键词： quark potential model pion-baryon interactions pion elastic scattering

Conserved Residues in the Subunit Interface of tau Glutathione S-transferase Affect Catalytic and Structural Functions

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Journal of Integrative Plant Biology 2011年第1期53卷 35-43页

作者： Cai-Ling wang hai-Ling Yang College of Life Sciences and Biotechnology Beijing Forestry University Beijing 100083 China

The tau class glutathione S-transferases （GSTs） have important roles in stress tolerance and the detoxification of herbicides in crops and weeds. Structural investigations of a wheat tau GST （TaGSTU4） show two subunit interactions： a hydrogen bond between the Tyr93 and Pro65 from another subunit of the dimer, and two salt bridges between residues Glu78 and side chains of Arg95 and Arg99 in the opposite subunit. By investigating enzyme activities, kinetic parameters and structural characterizations, this study showed the following results：（i） the hydrogen bond interaction between the Tyr93 and Pro65 was not essential for dimerization, but contributed to the enzyme＇s catalytic activity, thermal stability and affinity towards substrates glutathione and 1-chloro-2, 4-dinitrobenzene; and （ii） two salt bridges mainly contributed to the protein structure stability and catalysis. The results of this study form a structural and functional basis for rational design of more selective and environmentally friendly herbicides.

关键词： GLUTATHIONE transferase CROP residues PLANTS -- Herbicide tolerance PLANT enzymes ENZYME activation HYDROGEN bonding HERBICIDES -- Toxicology