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Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo

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Acta Pharmaceutica Sinica B 2023年第10期13卷 4172-4184页

作者： Xiaosen Ouyang Willayat Y.Wani Gloria A.Benavides Matthew J.Redmann hai vo Thomas van Groen Victor M.Darley-Usmar Jianhua Zhang Department of Pathology University of Alabama at BirminghamBirminghamAL 35294USA Department of Cell Developmental and Integrative BiologyUniversity of Alabama at BirminghamBirminghamAL 35294USA Birmingham VA Medical Center University of Alabama at BirminghamBirminghamAL 35294USA

The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality *** D(CTSD),is one such lysosomal protease,which when deficient in humans lead to neurolipofuscinosis(NCL)and is important in removing toxic protein *** studies demonstrated that CTSD germ-line knockout-CtsdKO(CDKO)resulted in accumulation of protein aggregates,decreased proteasomal activities,and postnatal lethality on Day 26±*** of wildtype CTSD,but not cathepsin B,L or mutant CTSD,decreased a-synuclein toxicity in worms and mammalian *** this study we generated a mouse line expressing human CTSD with a floxed STOP cassette between the ubiquitous CAG promoter and the *** crossing with Nestin-cre,the STOP cassette is deleted in NESTIN+cells to allow CTSD overexpression-CTSDtg(CDtg).The CDtg mice exhibited normal behavior and similar sensitivity to subchronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)induced *** breeding CDtg mice with CDKO mice,we found that over-expression of CTSD extended the lifespan of the CDKO mice,partially rescued proteasomal deficits and the accumulation of Aβ42 in the *** new transgenic mouse provides supports for the key role of CTSD in protecting against proteotoxicity and offers a new model to study the role of CTSD enhancement in vivo.

关键词： Cathepsin D transgenic mouse Mitochondrial bioenergetics Apoptosis Cathepsin D knockout mice Dopamine Autophagy Lysosome Life expectancy Behavior

民宿顾客满意度及其影响因素研究 ——以越南芽庄民宿为例

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民宿顾客满意度及其影响因素研究 ——...

作者：武海英（vo hai ANH）湖北大学

学位级别：硕士

民宿体验是很独特的活动,因为它能够更好地促进房主家庭与游客的紧密关系,以便达到文化传统接触和生意目的。然而,就芽庄市而言,民宿仍然相对新颖,本文以芽庄民宿为对象,研究游客对芽庄民宿的满意度及影响因素,提出提高游客对民宿满意... 详细信息

民宿体验是很独特的活动,因为它能够更好地促进房主家庭与游客的紧密关系,以便达到文化传统接触和生意目的。然而,就芽庄市而言,民宿仍然相对新颖,本文以芽庄民宿为对象,研究游客对芽庄民宿的满意度及影响因素,提出提高游客对民宿满意度的措施。本文对2019年12月参加芽庄民宿旅游的两百名国内与国外游客进行调查。从游客对芽庄民宿旅游满意度的七个影响因素的理论模式出发,通过探索性因子分析方法,本文指出游客对芽庄民宿旅游满意度的八个影响因素,包括文化互动、民宿环境与建筑、服务质量、好客之心、便利、民宿物质基础、安宁、安全。其中,回归分析结果表明,该八个因素都按照影响大到影响小的顺序对游客满意度产生影响,其顺序分别为便利、安全、服务质量、安宁、好客之心、文化互动、物质基础、民宿环境与建筑。本文也指出,对于文化互动、服务质量、便利等因素满意度的评价,不同国籍的游客,具体是国外游客满意度比国内满意度稍微低。从此,在管理芽庄民宿提高游客满意度方面提出一些建议意见,包括确保服务质量、实现游客体验活动的多样化、完善民宿物质基础、改善民宿环境与建筑等措施。

关键词：民宿顾客满意度影响因素芽庄越南

Symbol-Pair Distances of Repeated-Root Negacyclic Codes of Length 2^(s) over Galois Rings

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Algebra Colloquium 2021年第4期28卷 581-600页

作者： hai Q.Dinh Hualu Liu Roengchai Tansuchat Thang M.vo Department of Mathematical Science Kent State UniversityOhioUSA School of Sciencef Hubei University of Technology Wuhan 430068China Centre of Excellence in Econometrics Faculty of Economics Chiang Mai UniversityChiang Mai 52000Thailand Mathematics Department Ohio UniversityOhioUSA Department of General EducationIndustrial University of VinhVinh CityVietnam

Negacyclic codes of length 2^(s) over the Galois ring GR(2a,m)are linearly ordered under set-theoretic inclusion,i.e.,they are the ideals,0≤i≤2^(s)a,of the chain ring GR(2^(a),m)[x]/.This structure is used to obtain the symbol-pair distances of all such negacyclic *** others,for the special case when the alphabet is the finite field F2m(i.e.,a=1),the symbol-pair distance distribution of constacyclic codes over F2m verifies the Singleton bound for such symbol-pair codes,and provides all maximum distance separable symbol-pair constacyclic codes of length 2^(s) over F_(2m).

关键词： negacyclic codes repeated-root codes symbol-pair distance MDS codes

Mean Threshold and ARNN Algorithms for Identification of Eye Commands in an EEG-Controlled Wheelchair

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Engineering（科研） 2013年第10期5卷 284-291页

作者： Nguyen Thanh hai Nguyen Van Trung vo Van Toi Biomedical Engineering Department International University Vietnam National University Ho Chi Minh City Vietnam Faculty of Electrical-Electronics Engineering University of Technical Education Ho Chi Minh City Vietnam

This paper represented Autoregressive Neural Network (ARNN) and meant threshold methods for recognizing eye movements for control of an electrical wheelchair using EEG technology. The eye movements such as eyes open, eyes blinks, glancing left and glancing right related to a few areas of human brain were investigated. A Hamming low pass filter was applied to remove noise and artifacts of the eye signals and to extract the frequency range of the measured signals. An autoregressive model was employed to produce coefficients containing features of the EEG eye signals. The coefficients obtained were inserted the input layer of a neural network model to classify the eye activities. In addition, a mean threshold algorithm was employed for classifying eye movements. Two methods were compared to find the better one for applying in the wheelchair control to follow users to reach the desired direction. Experimental results of controlling the wheelchair in the indoor environment illustrated the effectiveness of the proposed approaches.

关键词： Autoregressive NN Model Threshold algorithm EEG Technology Eye Activity and Electrical Wheelchair

PRRS in Vietnam and Its Diagnosis

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Journal of Life Sciences 2015年第6期9卷 272-276页

作者： Ngoc hai Nguyen Thi Hong Vi Vuong Tan Hung vo Department of Infectious Diseases and Public Health Faculty of Animal Science and Veterinary Medicine Nong Lam UniversityHo Chi Minh city 0084-8 Vietnam HanViet Veterinary Diagnosis Laboratory Nong Lam University Ho Chi Minh city 0084-8 Vietnam

Genotyping 42 serum samples taken from the pigs in the oubreaks from 2009 to 2013 with RT-PCR and nested RT-PCR, showed more than 80% of samples were positive with Chinese PRRSV clade, and the others were European and North American classical PRRSV genotypes. Ten serum samples from unnapprent PRRS herds were examined for antibodies against PRRSV with ELISA and also for PRRSV with RT-PCR. It was clearly that the titer of antibodies against PRRSV by ELISA test could not be used for interpreting PRRSV infection. In despite of PRRS vaccination or non-vaccination, a risk of PRRSV infection and re-infection exist, utilizing RT-PCR in combination with serology will give the producer and veterinarian PRRSV more exact situation in the herds.

关键词： Vietnam PRRS genotype diagnosis ELISA RT-PCR.

Hydrothermal synthesis and characterization of two novel inorganic-organic hybrid materials

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 143-148页

作者： Zeng-he LI hai-dan BAI College of Science Beijing University of Chemical Technology Beijing 100029 China China National Chemical Information Center Beijing 100029 China

By using different organic ligands, two 3D inorganic-organic hybrid compounds Co（C4H4N2）（vo3）2 1 and Co（C12H12N2）（vo3）2 2 were synthesized by hydrothermal reaction and characterized by X-ray crystallography. Crystal data： 1. crystal system orthorhombic, space group Pnna, a=1 0.188（2） A, b=1 1.497（2） A, c=7.3975（15） A, V=866.5（3） A^3, Z=4, Dcalcd= 2.705 g/cm^3; 2. crystal system triclinic, space group P1^- （No. 2）, a=8.3190（17） A, b=8.4764（17） A, c=1 1.183（2） A, a=95.48（3）°, β=92.03（3）°, γ=107.24（3）°,V=748.0（3） A^3, Z=2, Dcalcd= 1.958 g/cm^3. The framework of compound 1 contains both {Co（C4H4N2）} and infinite metavanadate chains. Crystal structure of compound 2 is constructed with inorganic {CoV2O6} layers across-linked by organic 1,2-bis（4-pyridyl） ethane ligands. The two compounds are thermally stable to approximately 410 ℃ and 350 ℃, respectively. Their optical band gaps are determined to be 2.13 eV and 2.12 eV by UV-VIS-NIR diffuse reflectance spectra, which revealed their nature of semiconductor and optical absorption features.

关键词： Inorganic-organic hybrid materials Hydrothermal synthesis Crystal structure Oxovanadium

Responses of Native Tree Species to Soil Water Stress in a Tropical Forest on Limestone,Vietnam

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Open Journal of Forestry 2015年第7期5卷 711-722页

作者： Le Van Binh Nguyen Van Thinh Reinhard Kopp vo Dai hai Ralph Mitlohner Department of Tropical Silviculture and Forest Ecology Georg-August-Universitat GottingenGottingenGermany Vietnamese Academy of Forest Sciences Ha NoiVietnam

Forests over limestone in the tropics have received little attention and limestone forests in Vietnam have been overlooked to an even greater extent in terms of tree physiology. In Ba Be National Park, Vietnam, soil water availability in limestone forests seems to be the most limiting factor in the dry season. Therefore, in order to enhance the preliminary knowledge of choosing native tree species for enrichment planting in the restoration zone, characteristics of the 20 native tree species to soil water stress were investigated in a limestone forest. One-ha plot each consisting of twenty-five 20 m × 20 m plots was established in undisturbed forests. All trees ≥ 10 cm DBH were measured in 20 m × 20 m plots, while twenty-five 5 m × 5 m subplots were established in order to sample the regeneration of tree species with a DBH < 10 cm. The Scholander apparatus and freezing point osmometry were used in order to measure the leaf water potential (Ψw) and leaf osmotic potential (Ψπ) of the 20 native tree species, respectively in this study. 61 species belonging to 34 families of all trees with a DBH ≥ 10 cm were recorded in one ha, while 31 species representing 18 families of trees < 10 cm DBH were identified in 625 m2. The 20 species’ leaf water and osmotic potential values revealed significant differences among species. The maximum leaf water potential was not affected by any anticipated sources of variation, while the minimum water potential, however, showed significant variation to soil water stress. The results in the study area emphasized the importance of water factors in influencing tree species distribution;it could be concluded that native species with wide water potential ranges would be better able to withstand water changes and might be thus good candidates for reforestation (enrichment planting) in limestone areas.

关键词： Tropical Limestone Forests Floristic Composition Native Tree Species Leaf Water Potential Leaf Osmotic Potential

Effects of Foods on Maturity and Spawning Induction Methods on Ovulation of Rice Field Eel Monopterus albus(Zuiew,1793)in Thua Thien Hue Province,Vietnam

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Journal of Agricultural Science and Technology(A) 2017年第B10期7卷 85-92页

作者： Tran Vinh Phuong Nguyen Van Khanh Pham Thi hai Yen vo Dieu Nguyen Van Huy Institute of Biotechnology Hue UniversityPhu ThuongPhu VangThua Thien Hue 530000Vietnam Faculty of Fisheries University of Agriculture and ForestryHue University102 Phung Hung StreetHue 530000Vietnam

Adult rice field eels with 125.52±27.99 g body weight corresponding to 44.79±5.93 cm in length were maturity cultured in a 5 m^2 cement tank without mud for three months with density 30 eels/m^*** broodstocks were fed with three types of food including:sea fish(T1),commercial pellet food(T2)and mixed food—50%sea fish and 50%commercial pellet food(T3).Result showed that the maximum gonadosomatic index(GSI)of female eels fed by sea fish(2.89%±0.67%)was higher than both commercial pellet food(1.62%±0.62%)and mixed food(2.03%±0.82%)(P0.05).Maturity rate of female fed by sea fish(88.91%±9.64%)was higher than commercial pellet food(61.12%±9.64%)(P0.05).*** eels were induced for spawning with two kinds of hormones,including T1:human chorionic ganadotropin(HCG)at 1,500 IU/kg,T2:luteinzing hormone-releasing hormone(LHRH-a)at 150μg/kg and domperidon 10 mg/kg,and T3:control without *** results of spawning induction methods showed that the reproduction rate of female eels induced by LHRH-a and HCG hormones were higher than that by natural reproduction method(P<0.05).Others,the survival rate of fry eels after 5 d using natural reproduction method(92.65%±2.54%)was higher than both using LHRH-a(67.77%±1.91%)and HCG(68.65%±1.23%)hormones(P<0.05).The average diameter of eggs was 3.40-3.41 mm and the length of newly hatched eels was 1.72±0.19 cm.

关键词： Food maturity culture ovulation spawing induction method rice field eel

Fast Second-Order Evaluation for Variable-Order Caputo Fractional Derivative with Applications to Fractional Sub-Diffusion Equations

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Numerical Mathematics(Theory,Methods and Applications) 2022年第1期15卷 200-226页

作者： Jia-Li Zhang Zhi-Wei Fang hai-Wei Sun Department of Mathematics University of MacaoMacaoSARChina

In this paper,we propose a fast second-order approximation to the variable-order(vo)Caputo fractional derivative,which is developed based on L2-1σformula and the exponential-sum-approximation *** fast evaluation method can achieve the second-order accuracy and further reduce the computational cost and the acting memory for the vo Caputo fractional *** fast algorithm is applied to construct a relevant fast temporal second-order and spatial fourth-order scheme(F L2-1σscheme)for the multi-dimensional vo time-fractional sub-diffusion ***,F L2-1σscheme is proved to fulfill the similar properties of the coefficients as those of the well-studied L2-1σ***,F L2-1σscheme is strictly proved to be unconditionally stable and convergent.A sharp decrease in the computational cost and the acting memory is shown in the numerical examples to demonstrate the efficiency of the proposed method.

关键词： Variable-order Caputo fractional derivative exponential-sum-approximation method fast algorithm time-fractional sub-diffusion equation stability and convergence