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Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis

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World Journal of Gastroenterology 2023年第14期29卷 2153-2171页

作者： Cai-Song Chen Yao-Gang Zhang hai-Jiu Wang hai-ning fan Research Center for High Altitude Medicine of Qinghai University Affiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina Qinghai Province Research Key Laboratory for Echinococcosis Affiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Qinghai Province Research Key Laboratory for EchinococcosisAffiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina

BACKGROUND The NOD-like receptor family pyrin domain-containing 3(NLRP3)inflammasome is a significant component of the innate immune system that plays a vital role in the development of various parasitic ***,its role in hepatic alveolar echinococcosis(HAE)remains *** To investigate the NLRP3 inflammasome and its mechanism of activation in *** We assessed the expression of NLRP3,caspase-1,interleukin(IL)-1β,and IL-18 in the marginal zone and corresponding normal liver of 60 patients with HAE.A rat model of HAE was employed to investigate the role of the NLRP3 inflammasome in the marginal zone of *** experiments were conducted to investigate the effect of Echinococcus multilocularis(***)in stimulating Kupffer cells and ***,immunohistochemistry,Western blotting,and enzyme-linked immunosorbent assay were used to evaluate NLRP3,caspase-1,IL-1β,and IL-18 expression;flow cytometry was used to detect apoptosis and reactive oxygen species(ROS).RESULTS NLRP3 inflammasome activation was significantly associated with *** of ROS production decreased NLRP3-caspase-1-IL-1βpathway activation and mitigated hepatocyte damage and *** *** induces hepatocyte damage and inflammation by activating the ROS-mediated NLRP3-caspase-1-IL-1βpathway in Kupffer cells,indicating that ROS may serve as a potential target for the treatment of HAE.

关键词： Hepatic alveolar echinococcosis Inflammasome Inflammation Kupffer cell NLR family pyrin domain-containing 3 protein Reactive oxygen species

Current status of drug therapy for alveolar echinococcosis

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World Journal of Hepatology 2024年第11期16卷 1243-1254页

作者： Qin-Dong Jing Ji-De A Lin-Xun Liu hai-ning fan Department of General Surgery Qinghai Provincial People’s HospitalXining 810000Qinghai ProvinceChina School of Clinical Medicine Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Hepatic Hydatidosis Qinghai Provincial People’s HospitalXining 810007Qinghai ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Qinghai Province Research Key Laboratory for EchinococcosisAffiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina

Alveolar echinococcosis(AE)is a chronic zoonotic parasitic disease caused by infection with Echinococcus *** is associated with a high mortality rate and poses a significant threat to human *** primary treatment for AE is surgical resection of the lesions;however,owing to its long incubation period and insidious disease progression,many patients are diagnosed only after the onset of complications such as liver cirrhosis,jaundice,and portal hypertension,which preclude curative surgical *** patients who are unwilling or unable to undergo surgery,lifelong administration of anti-AE medications is *** compounds,such as albendazole and mebendazole,are the current mainstays of treatment,offering good ***,these medications primarily inhibit parasite proliferation rather than eradicate the infection,and their long-term use can lead to significant drug-related toxic ***,there is an urgent need to develop new therapeutic strategies that convey better efficacy and reduce the adverse effects associated with current *** advancements in AE therapy include novel synthetic compounds such as antiviral agents,antibiotics,antineoplastic agents,immunosuppressants,and antiangiogenic agents,as well as natural compounds derived from traditional Chinese and Tibetan *** new drugs show promising clinical potential because they interfere with parasitic metabolic pathways and cellular *** review aims to discuss recent research on AE drug therapy,including mechanisms of action,dosing regimens,signalling pathways,and therapeutic outcomes,with a goal of providing new insights and directions for the development of anti-AE drugs and summarizing current advancements in AE pharmacotherapy.

关键词： Alveolar echinococcosis Drug therapy Albendazole Synthetic compounds Natural compounds

Vascular reconstruction provides short-term and long-term survival benefits for patients with hilar cholangiocarcinoma:A retrospective,multicenter study

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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 595-603页

作者： Yi-Xian Huang Chao Xu Cheng-Cheng Zhang Guang-Yi Liu Xing-Chao Liu hai-ning fan Bi Pan Yuan-Cheng Li Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Hepatobiliary Surgery Liaocheng People’s HospitalLiaocheng 252000China Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital Chengdu 610000China Qinghai University Affiliated Hospital Xining 810016China

Background:In patients with hilar cholangiocarcinoma(HCCA),radical resection can be achieved by resection and reconstruction of the ***,whether vascular reconstruction(VR)improves long-term and short-term prognosis has not been demonstrated ***:This was a retrospective multicenter study of patients who received surgery for HCCA with or without *** associated with overall survival(OS)and recurrence-free survival(RFS)were identified based on Cox ***-Meier curves were used to explore the impact of *** mean survival time(RMST)was used for comparisons of short-term survival between the ***’intraoperative and postoperative characteristics were ***:Totally 447 patients were *** divided these patients into 3 groups:VR with radical resections(n=84);non-VR radical resections(n=309)and non-radical resection(we pooled VRnonradical and non-VR nonradical together,n=54).Cox regression revealed that carbohydrate antigen 242(CA242),vascular invasion,lymph node metastasis and poor differentiation were independent risk factors for OS and *** was no significant difference of RMST between the VR and non-VR radical groups within 12 months after surgery(10.18 vs.10.76 mon,P=0.179),although the 5-year OS(Pning short-term survival compared with resection wit

关键词： Hilar cholangiocarcinoma Hepatectomy Vascular reconstruction Prognosis

Anatomical hepatectomy for achieving textbook outcome for perihilar cholangiocarcinoma treated with curative-intent resection: A multicenter study

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iLIVER 2022年第4期1卷 245-251页

作者： Cheng Chen Zhi-Peng Liu Wei-Yue Chen Xiang Wang Yun-Hua Liu Yue Wang Xing-Chao Liu hai-ning fan Jie Bai Yan Jiang Yan-Qi Zhang hai-Su Dai Zhi-Yu Chen Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Clinical Research Center of Oncology Lishui Hospital of Zhejiang UniversityZhejiangChina Department of Hepatobiliary Surgery Sichuan Provincial People's HospitalChengduChina Department of Hepatobiliary Surgery Affiliated Hospital of Qinghai UniversityXiningChina Department of Health Statistics College of Military Preventive MedicineThird Military Medical University(Army Medical University)ChongqingChina

Background and aim:The textbook outcome(TO)is a comprehensive measure that is superior to individual measures for analysis of surgical quality of *** hepatectomy(AH)is beneficial in terms of short-term outcomes in patients undergoing *** study was performed to investigate the association between AH and achieving the TO for patients with perihilar cholangiocarcinoma(pCCA)treated with curative-intent ***:This study involved patients who underwent curative-intent resection for newly diagnosed pCCA from January 2013 to January 2018 at three hospitals in *** patients were divided into two groups according to the type of hepatectomy:the AH group and non-AH *** incidence and distribution of achieving the TO were compared between the two *** and multivariable logistic regression analyses were used to identify independently predictive factors associated with achieving the TO in patients with ***:In total,333 patients were enrolled[AH group,225(67.6%);non-AH group,108(32.4%)].The incidence of achieving the TO in all patients was 24.3%,and the incidence was significantly higher in the AH than non-AH group(30.7%vs.11.1%,respectively).Multivariable analysis revealed that AH,total bilirubin concentration of<34μmol/L,maximum tumor size of<3 cm,no macrovascular invasion,and no lymph node metastasis were independently associated with a higher incidence of achieving the ***:The TO was achieved in approximately one-fourth of patients with pCCA who underwent curative-intent *** use of AH was more conducive to achieving the TO in patients with pCCA.

关键词： Perihilar cholangiocarcinoma Textbook outcome Anatomical hepatectomy Short-term outcome Resection

Development of a model based on the age-adjusted Charlson comorbidity index to predict survival for resected perihilar cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2023年第6期15卷 1036-1050页

作者： Yu Pan Zhi-Peng Liu hai-Su Dai Wei-Yue Chen Ying Luo Yu-Zhu Wang Shu-Yang Gao Zi-Ran Wang Jin-Ling Dong Yun-Hua Liu Xian-Yu Yin Xing-Chao Liu hai-ning fan Jie Bai Yan Jiang Jun-Jie Cheng Yan-Qi Zhang Zhi-Yu Chen Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Clinical Research Center of Oncology Lishui Hospital of Zhejiang UniversityLishui 323000Zhejiang ProvinceChina Faculty of Education Southwest UniversityChongqing 400715China Department of General Surgery 903rd Hospital of People’s Liberation ArmyHangzhou 310000Zhejiang ProvinceChina Department of Clinical Pharmacy The General Hospital of Western Theater CommandChengdu 610000Sichuan ProvinceChina Department of Hepatobiliary Surgery Sichuan Provincial People's HospitalChengdu 610000Sichuan ProvinceChina Department of Hepatobiliary Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Health Statistics College of Military Preventive MedicineThird Military Medical University(Army Medical University)Chongqing 400038China

BACKGROUND Perihilar cholangiocarcinoma(pCCA)has a poor prognosis and urgently needs a better predictive *** predictive value of the age-adjusted Charlson comorbidity index(ACCI)for the long-term prognosis of patients with multiple malignancies was recently ***,pCCA is one of the most surgically difficult gastrointestinal tumors with the poorest prognosis,and the value of the ACCI for the prognosis of pCCA patients after curative resection is *** To evaluate the prognostic value of the ACCI and to design an online clinical model for pCCA *** Consecutive pCCA patients after curative resection between 2010 and 2019 were enrolled from a multicenter *** patients were randomly assigned 3:1 to training and validation *** the training and validation cohorts,all patients were divided into low-,moderate-,and high-ACCI ***-Meier curves were used to determine the impact of the ACCI on overall survival(OS)for pCCA patients,and multivariate Cox regression analysis was used to determine the independent risk factors affecting *** online clinical model based on the ACCI was developed and *** concordance index(C-index),calibration curve,and receiver operating characteristic(ROC)curve were used to evaluate the predictive performance and fit of this *** A total of 325 patients were *** were 244 patients in the training cohort and 81 patients in the validation *** the training cohort,116,91 and 37 patients were classified into the low-,moderate-and high-ACCI *** Kaplan-Meier curves showed that patients in the moderate-and high-ACCI groups had worse survival rates than those in the low-ACCI *** analysis revealed that moderate and high ACCI scores were independently associated with OS in pCCA patients after curative *** addition,an online clinical model was developed that had ideal C-indexes of 0.725 and 0.675 for predicting OS in the training and vali

关键词： Perihilar cholangiocarcinoma Age-adjusted Charlson comorbidity index Resection Survival Model Prognosis

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考虑同伴群动态交流分组的行人仿真模型研究

交通运输系统工程与信息 2017年第2期17卷 136-141页

作者：何民韩智泉于海宁樊冬昆明理工大学交通工程学院昆明650500 昆明轨道交通集团有限公司昆明650011 洛阳市规划建筑设计研究院有限公司河南洛阳471000

朋友、家人等社会群体结伴出行的同伴群在行人流中常占有较高比例.由于交流需求,同伴群趋于肩并肩行走以横向成排或接近浅V型的形态前进.在现有研究中,基于社会力的同伴群行人微观仿真模型对这一现象的描述最符合实际.本文观测发现,随... 详细信息

朋友、家人等社会群体结伴出行的同伴群在行人流中常占有较高比例.由于交流需求,同伴群趋于肩并肩行走以横向成排或接近浅V型的形态前进.在现有研究中,基于社会力的同伴群行人微观仿真模型对这一现象的描述最符合实际.本文观测发现,随着人流密度的增加或同伴群成员数量增多,同伴群通常动态呈现前后分组、横向成排空间形态,这是每个同伴群成员为寻求一个合适的行走位置,对满足交流需求和降低前进阻力权衡决策后呈现的自组织现象.本文提出动态交流分组模型对同伴群成员个体决策机理进行刻画,在此基础上,通过仿真实验分析同伴群对行人流动力学特性产生的影响.仿真研究结果表明,模型较好重现了同伴群随密度和人数增加的动态分组现象;同伴群的存在会降低行人流速度,但其影响强度随人流密度的增加而减弱;同伴群动态交流分组模型的引入会提升仿真行人流的通行效率,使之更加接近真实行人流的运动特性.

关键词：城市交通行人仿真社会力模型同伴群自组织现象

硫化氢对MDA及GSH在大鼠肝星状细胞氧应激中表达的影响

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世界华人消化杂志 2009年第36期17卷 3725-3728页

作者：阳丹才让邓勇任利王聪樊海宁青海大学附属医院肝胆胰外科青海省西宁市810001

目的:探讨硫化氢对MDA与GSH在大鼠肝星状细胞氧应激中表达的影响.方法:将HSC-T6分为8组:空白组(B组,HSC-T6)、对照组(C组,B组+500μmol/LFe-NTA)、 NaHS组(N1:C组+20μmol/L NaHS;N2:C组+100μmol/L NaHS;N3:C组+200μmol/L NaHS)、格列苯脲组(G1:C组+20μmol/LGLBN;G2:C组+200μmol/LGLBN;G3:C组+700μmol/LGLBN).用MDA试剂盒测试血清MDA含量;用GSH试剂盒测定上清中GSH含量.结果:24h后MDA含量对照组和空白组有明显差异(P<0.05),而GSH含量12与24h均有明显差异(均P<0.05).给予 NaHS后,MDA含量24hN2和N3组与对照组均有明显差异(4.48±0.07nmol/mg prot,3.58±0.02nmol/mg prot vs 5.05±0.07nmol/mg prot,均P<0.05),12与24hGSH含量N2和N3组与对照组有明显差异(35.57±2.02mg/g prot,36.92±2.30mg/gprot vs 33.64±2.95mg/g prot;36.49±2.08mg/g prot,37.59±2.03mg/gprot vs 31.06±3.08mg/g prot,均P<0.05).给予GLBN处理后,各项指标结果与给予 NaHS处理后结果相对应,各组与相对应组比较均有明显差异(均P<0.05).结论:氧应激下硫化氢对HSC细胞具有保护作用,可抑制肝纤维化的发生发展.

关键词：肝星状细胞硫化氢硫氢化钠谷胱甘肽

Investigating Conservative Therapy of Cervical Radiculopathy by a Delphi Technique

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Chinese Medical Journal 2015年第21期128卷 2976-2976页

作者： Jian Li Wen-Yi Zhu Lei Zang Yong hai Peng Du ning fan Yu Zhou Li-Kun An Department of Orthopedics Beijing Chao Yang Hospital Capital Medical University Beijing 100020 China

To the Editor： Cervical radiculopathy （CR） is a common problem with an episodic course that affects a large proportion of the population. The review indicated that nonoperative treatment is the main course. However, there is little high-quality evidence on the nonoperative therapy for CR. The purpose of this conservative therapy was built up to serve for the clinical practice. Our research team adopt a Delphi technique, First, we randomly selected an expert panel composed 22 spine surgeons, 3 physiotherapist, and 3 pain management doctors from the medical experts in China. Second, using the Delphi process and iterative rounds, agreement 〉80% was considered consensus. Repeat voting for consensus was performed. Third, we put forward to the following conclusions：（1） Nonoperative treatment is the appropriate initial approach for most patients; （2） a short period （1 week） of immobilization in a cervical collar may relieve radicular pain;

关键词： Investigating Conservative Therapy Cervical Radiculopathy Delphi Technique

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin fan Wen Zhigang Tao hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes