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HPLC法测定六味木香胶囊中木香烃内酯和去氢木香内酯

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中草药 2014年第16期45卷 2349-2351页

作者：王海宁贵州省食品药品检验所贵州贵阳550004

目的建立以HPLC法测定六味木香胶囊中木香烃内酯和去氢木香内酯的方法。方法色谱柱为VP-ODS柱（250mm×4.6 mm,5μm）,流动相为甲醇-水（72∶28）,检测波长为225 nm,柱温为25℃,体积流量为1.0 mL/min。结果木香烃内酯、去氢木香内酯进... 详细信息

目的建立以HPLC法测定六味木香胶囊中木香烃内酯和去氢木香内酯的方法。方法色谱柱为VP-ODS柱（250mm×4.6 mm,5μm）,流动相为甲醇-水（72∶28）,检测波长为225 nm,柱温为25℃,体积流量为1.0 mL/min。结果木香烃内酯、去氢木香内酯进样量分别在203.12～2 031.20、207.84～2 078.40 ng与峰面积积分值呈良好的线性关系（r=0.999 9）;平均回收率分别为101.1%、101.2%,RSD分别为0.48%、0.73%（n=6）。结论建立的方法简便、准确、重复性好、专属性强,可用于该制剂的质量控制和评价。

关键词：六味木香胶囊 HPLC 木香烃内酯去氢木香内酯质量标准

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哈罗德·拉斯基的马克思主义思想及当代反思

安徽师范大学学报（社会科学版） 2020年第3期48卷 55-61页

作者：魏宁海南京医科大学马克思主义学院南京211166

哈罗德·拉斯基作为英国现当代对自由主义危机和发展弊端进行反思与评判最为激进的代表人物之一,以独特的视域研读、审视和阐释马克思主义,很大程度上纠正了传统马克思主义研究的范式,为实现马克思主义的英国化,将马克思理论与英国的传... 详细信息

哈罗德·拉斯基作为英国现当代对自由主义危机和发展弊端进行反思与评判最为激进的代表人物之一,以独特的视域研读、审视和阐释马克思主义,很大程度上纠正了传统马克思主义研究的范式,为实现马克思主义的英国化,将马克思理论与英国的传统哲学方式进行融合做出了重要的试探,为之后英国马克思主义的体系建构创造了重要的发展条件,体现了独特的时代价值和理论价值。

关键词：拉斯基马克思主义资本主义政治学自由主义

Anatomical hepatectomy for achieving textbook outcome for perihilar cholangiocarcinoma treated with curative-intent resection: A multicenter study

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iLIVER 2022年第4期1卷 245-251页

作者： Cheng Chen Zhi-Peng Liu Wei-Yue Chen Xiang Wang Yun-Hua Liu Yue Wang Xing-Chao Liu hai-ning Fan Jie Bai Yan Jiang Yan-Qi Zhang hai-Su Dai Zhi-Yu Chen Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Clinical Research Center of Oncology Lishui Hospital of Zhejiang UniversityZhejiangChina Department of Hepatobiliary Surgery Sichuan Provincial People's HospitalChengduChina Department of Hepatobiliary Surgery Affiliated Hospital of Qinghai UniversityXiningChina Department of Health Statistics College of Military Preventive MedicineThird Military Medical University(Army Medical University)ChongqingChina

Background and aim:The textbook outcome(TO)is a comprehensive measure that is superior to individual measures for analysis of surgical quality of *** hepatectomy(AH)is beneficial in terms of short-term outcomes in patients undergoing *** study was performed to investigate the association between AH and achieving the TO for patients with perihilar cholangiocarcinoma(pCCA)treated with curative-intent ***:This study involved patients who underwent curative-intent resection for newly diagnosed pCCA from January 2013 to January 2018 at three hospitals in *** patients were divided into two groups according to the type of hepatectomy:the AH group and non-AH *** incidence and distribution of achieving the TO were compared between the two *** and multivariable logistic regression analyses were used to identify independently predictive factors associated with achieving the TO in patients with ***:In total,333 patients were enrolled[AH group,225(67.6%);non-AH group,108(32.4%)].The incidence of achieving the TO in all patients was 24.3%,and the incidence was significantly higher in the AH than non-AH group(30.7%vs.11.1%,respectively).Multivariable analysis revealed that AH,total bilirubin concentration of<34μmol/L,maximum tumor size of<3 cm,no macrovascular invasion,and no lymph node metastasis were independently associated with a higher incidence of achieving the ***:The TO was achieved in approximately one-fourth of patients with pCCA who underwent curative-intent *** use of AH was more conducive to achieving the TO in patients with pCCA.

关键词： Perihilar cholangiocarcinoma Textbook outcome Anatomical hepatectomy Short-term outcome Resection

Effects of astaxanthin on oxidative stress induced by Cu^(2+) in prostate cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第2期18卷 161-171页

作者： Hong-zhou MENG Xiao-feng NI hai-ning YU Shan-shan WANG Sheng-rong SHEN Department of Urology the First Affiliated Hospital School of Medicine Zhejiang University Department of Food Science and Nutrition Zhejiang University College of Pharmaceutical Sciences Zhejiang University of Technology

Astaxanthin（AST）, a carotenoid molecule extensively found in marine organisms and increasingly used as a dietary supplement, has been reported to have beneficial effects against oxidative stress. In the current paper, the effects of AST on viability of prostate cells were investigated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide（MTT） assay; cell apoptosis and intracellular reactive oxygen species（ROS） levels were determined by flow cytometry; the mitochondrial membrane potential（MMP） was measured by fluorospectrophotometer; and activities of malondialdehyde（MDA）, superoxide dismutase（SOD）, catalase（CAT）, and glutathione peroxidase（GSH-Px） were evaluated by a detection kit. The results show that copper ion（Cu^2＋） induced apoptosis, along with the accumulation of intracellular ROS and MDA, in both prostate cell lines（RWPE-1 and PC-3）. AST treatments could decrease the MDA levels, increase MMP, and keep ROS stable in RWPE-1 cell line. An addition of AST decreased the SOD, GSH-Px, and CAT activities in PC-3 cell line treated with Cu^2＋, but had a contrary reaction in RWPE-1 cell lines. In conclusion, AST could contribute to protecting RWPE-1 cells against Cu^2＋-induced injuries but could cause damage to the antioxidant enzyme system in PC-3 cells.

关键词： Oxidative stress PC-3 RWPE-1 Astaxanthin Copper ion

Reliability Analysis of Clock Source of Railway Time Synchronization Network Based on SPN

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Reliability Analysis of Clock Source of Railway Time Synchro...

Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant

作者： hai ning Zhang Cai-zhen Yu Yang Tang Yan LanZhou JiaoTong University

Railway time synchronization network is an important part of railway communication *** provides unified and standard time information for railway *** the timing reference signal source of railway time synchronization network,the reliability of clock source is the basis to ensure the accuracy and precision of the time information of railway time synchronization *** it is of great significance to do the study about the reliability of clock source to the realization of railway time *** accordance with failover principle,in this thesis,three levels master clock failover models were established by using Stochastic Petri Nets（SPN） first,and then the TimeNET software was used to check structure and analyze steady state of *** analysis results showed that master clocks of all levels with high reliability can meet the requirements of clock source of railway time synchronization netw ork.

关键词： Railway Time Synchronization Network Clock Source SPN Reliability Analysis

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1237-1250页

作者： Jingwen Jiang hai-ning Chen Ping Jin Li Zhou Liyuan Peng Zhao Huang Siyuan Qin Bowen Li Hui Ming Maochao Luo Na Xie Wei Gao Edouard C.Nice Qiang Yu Canhua Huang State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041P.R.China West China School of Basic Medical Sciences&Forensic Medicine Sichuan UniversityChengdu 610041P.R.China Colorectal Cancer Center Department of General SurgeryState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041P.R.China Department of Biochemistry and Molecular Biology Monash UniversityClaytonVICAustralia Cancer Precision Medicine Genome Institute of SingaporeAgency for ScienceTechnologyand ResearchBiopolisSingapore 138672Singapore

The single-nucleotide polymorphism(SNP)of p53,in particular the codon 72 variants,has recently been implicated as a critical regulator in tumor ***,the underlying mechanism remains *** we found that cancer cells carrying codon 72-Pro variant of p53 showed impaired metastatic potential upon serine ***-wide mapping of p53-interacting proteins uncovered a specific interaction of the codon 72 proline variant(but not p5372R)with phosphoserine aminotransferase 1(PSAT1).Interestingly,p53^(72P)-PSAT1 interaction resulted in dissociation of peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α)that otherwise bound to p53^(72P),leading to subsequent nuclear translocation of PGC-1αand activation of oxidative phosphorylation(OXPHOS)and tricarboxylic acid(TCA)*** of PSAT1 restored p53^(72P)-PGC-1αinteraction and impeded the OXPHOS and TCA function,resulting in mitochondrial dysfunction and metastasis ***,pharmacological targeting the PSAT1-p53^(72P)interaction by aminooxyacetic acid(AOA)crippled the growth of liver cancer cells carrying the p53^(72P)variant in both in vitro and patient-derived xenograft ***,AOA plus regorafenib,an FDA-proved drug for hepatocellular carcinoma and colorectal cancer,achieved a better anti-tumor effect on tumors carrying the p53^(72P)***,our findings identified a gain of function of the p53^(72P)variant on mitochondrial function and provided a promising precision strategy to treat tumors vulnerable to p53^(72P)-PSAT1 perturbation.

关键词： metastasis impaired tumors

Value of the pudendal nerves terminal motor latency measurements in the diagnosis of occult stress urinary incontinence

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Chinese Medical Journal 2011年第23期124卷 4046-4049页

作者： ZHU Lan hai ning LANG Jing-he YU Shi-yun LI Bin WONG Felix Department of Obsterics and Gynecology Peking Union Medical College Hospital Peking Union Medical College Beijing 100730 China

Background Occult stress urinary incontinence may lead to de novo stress urinary incontinence after pelvic floor repair surgery. A measurement of pudendal nerve terminal motor latency can reflect the integrity of the nerves. We aimed to explore the value of pudendal nerve terminal motor latency in the diagnosis of occult stress urinary incontinence in pelvic organ prolapse patients. Methods Ten patients with stress urinary incontinence （SUI group）, 10 with SUI and uterine or vaginal prolapse （POP＋SUI group） and 10 with uncomplicated uterine or vaginal prolapse （POP group） were evaluated for their pudendal nerve terminal motor latency using a keypoint electromyogram. Results The amplitude of positive waves was between 0.1 and 0.2 mV. The nerve terminal motor latency was between 1.44 and 2.38 ms. There was no significant difference in the wave amplitudes of pudendal nerve evoked action potential among the three different groups （P 〉0.05）. The pudendal nerve latency of the SUI group, POP＋SUI group and POP group were （2.9_＋0.7） seconds, （2.8_＋0.7） seconds and （1.9_＋0.5） seconds respectively. The difference between the SUI group and POP＋SUI group was not statistically significant （P 〉0.05）, whereas the difference between the SUI and POP groups and between the POP＋SUI and POP groups were statistically significant （P 〈0.05）. There was a positive correlation between pudendal nerve latency and the severity of SUI; the correlation coefficient was 0.720 （P 〈0.01）. Conclusions Patients with SUI may have some nerve demyelination injuries in the pudendal nerve but the damage might not involve the nerve axons. The measurement of pudendal nerve latency may be useful for the diagnosis of SUI in POP patients.

关键词： pelvic organ prolapse stress urinary incontinence occult pudendal nerves terminal motor latency

Effects of lower body positive pressure treadmill on functional improvement in knee osteoarthritis:A randomized clinical trial study

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World Journal of Clinical Cases 2021年第34期9卷 10604-10615页

作者： Hong-Xin Chen Yao-Xuan Zhan hai-ning Ou Yao-Yao You Wan-Ying Li Shan-Shan Jiang Mei-Feng Zheng Lin-Zi Zhang Ke Chen Qiu-Xia Chen Department of Rehabilitation Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700Guangdong ProvinceChina Department of General Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700Guangdong ProvinceChina Guangzhou Key Laboratory of Enhanced Recovery After Abdominal Surgery The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700Guangdong ProvinceChina Department of Rehabilitation Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Rehabilitation Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006Guangdong ProvinceChina Department of Osteology The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700Guangdong ProvinceChina

BACKGROUND Knee joint pain and stiffness are the two main symptoms of knee osteoarthritis(OA)and thus restrict a patient’s activities,such as walking and walking up and *** lower body positive pressure(LBPP)treadmill as one of the emerging body weight support system devices brings new hope for exerciserelated rehabilitation for knee OA *** To investigate the biomechanical effects and the subjective clinical assessment of LBPP treadmill walking exercise when compared with conventional therapy in mild to moderate knee OA *** Eighteen patients with mild-to-moderate knee OA were recruited in this randomized controlled trial(RCT)*** eligible knee OA patients were randomly assigned to two groups:LBPP and control *** patients in the LBPP group performed an LBPP walking training program for 30 min/session per day,6 d per week for 2 wk whereas the patients in the control group performed walking on the ground for the same *** patients underwent clinical assessments and three-dimensional gait analysis at pre-and 2-wk *** The Western Ontario and McMaster Universities Arthritis Index and visual analog scale scores in both the LBPP group and control group were found to decrease significantly at the post-treatment point than the pre-treatment point(LBPP:70.25±13.93 vs 40.50±11.86;3.88±0.99 vs 1.63±0.52;control:69.20±8.88 vs 48.10±8.67;3.80±0.79 vs 2.60±0.70,Pning might be an effective approach for alleviating pai

关键词： Lower body positive pressure Three-dimensional gait analysis Walking training Rehabilitation Knee osteoarthritis

大型浮托安装驳船在极浅水中的运动特性和触底条件分析

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船舶力学 2018年第7期22卷 827-837页

作者：杨光吕海宁熊凌志杨宁海洋石油工程股份有限公司天津300451 上海交通大学海洋工程国家重点实验室上海200240

结合我国渤海锦州9-3油田新建导管架平台的实际工程背景,针对大型浮托安装驳船在极浅水条件下运动性能和触底现象开展数值计算和物理实验研究。通过两者之间的相互对比,验证了计算结果的正确性。实验中观察到驳船的浅水效应现象,并对该... 详细信息

结合我国渤海锦州9-3油田新建导管架平台的实际工程背景,针对大型浮托安装驳船在极浅水条件下运动性能和触底现象开展数值计算和物理实验研究。通过两者之间的相互对比,验证了计算结果的正确性。实验中观察到驳船的浅水效应现象,并对该现象的产生原因进行了分析。结合实际海域的海洋环境条件,开展敏感性分析,得到驳船在不同海况下的运动特性,并对驳船是否会发生触底进行了评估。研究结果为保障极浅水条件下,导管架组块浮托安装实际工程的安全应用提供了有力支撑。

关键词：浅水效应触底分析系泊驳船浮托安装