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Research progress on pharmacological effect and mechanism of baicalein in Parkinson diseases

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中国药理学与毒理学杂志 2018年第4期32卷 341-342页

作者： Xiao-yue ZHAO hai-gang wang Qi-meng ZHOU Ping HE Guan-hua DU Beijing Key Laboratory of Drug Targets Identification and Drug Screening Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

Parkinson disease(PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and deposition of cytosolic inclusions in surviving neurons(Lewy bodies),resulting in motor deficits and non-motor *** Levodopa remains the gold standard treatment for PD,side effects like dyskinesia followed by long-term use could notbe ***,there is a need for *** new *** is a flavonoid isolated from traditional Chinese herb,Scutellaria baicalensis *** laboratory discovered that baicalein could effectively attenuate neurotoxicity of 6-hydroxydopamine(6-OHDA) and promote the differentiation of PC12 cells through high throughput drug *** at the *** vivo studies have shown that baicalein exerts significant therapeutic effect,particularly in the attenuation of muscle tremor in 6-OHDA-lesioned *** on the result from the so far acquired knowledge and previous findings from our laboratory,we could consider *** mechanism of baicalein focus on the activities ofanti-oxidation and *** could prevent oxidative stress and apoptosis through maintaining the mitochondrial function,inhibition of collapse of mitochondrial membrane potential,increase the activity of antioxidant enzymes and restraint of lipid peroxidation via several pathways such as Keap1/Nrf2/***-inflammatory activity of baicalein exert by attenuating activation of astrocyte and microglia,as well as the production of cathepsin B and ***,promoting the degradation of α-synuclein contributes to the neuroprotective effect of baicalein against Lewy bodies ***,baicalein also modulates the metabolic balance between glutamate(GLu) and gamma-aminobutyric acid(GABA).Overall,*** could protect nervous systemby inhibiting oxidative damage and neuroinflammation caused by environmental and genetic *** article reviewed the developments of studies on pharmaco

关键词：帕金森病治疗方法黄芩素临床分析

Landslide susceptibility assessment in Western Henan Province based on a comparison of conventional and ensemble machine learning

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China Geology 2023年第3期6卷 409-419页

作者： Wen-geng Cao Yu Fu Qiu-yao Dong hai-gang wang Yu Ren Ze-yan Li Yue-ying Du The Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological ScienceChina Geological SurveyMinistry of Natural ResourcesShijiazhuang 050061China Key Laboratory of Groundwater Sciences and Engineering Ministry of Natural ResourcesShijiazhuang050061P.R.China North China University of Water Resources and Electric Power Zhengzhou 450011China China Institute of Geo-Environment Monitoring Beijing 100081China

Landslide is a serious natural disaster next only to earthquake and flood,which will cause a great threat to people’s lives and property *** traditional research of landslide disaster based on experience-driven or statistical model and its assessment results are subjective,difficult to quantify,and no *** a new research method for landslide susceptibility assessment,machine learning can greatly improve the landslide susceptibility model’s accuracy by constructing statistical *** Western Henan for example,the study selected 16 landslide influencing factors such as topography,geological environment,hydrological conditions,and human activities,and 11 landslide factors with the most significant influence on the landslide were selected by the recursive feature elimination(RFE)*** machine learning methods[Support Vector Machines(SVM),Logistic Regression(LR),Random Forest(RF),Extreme Gradient Boosting(XGBoost),and Linear Discriminant Analysis(LDA)]were used to construct the spatial distribution model of landslide *** models were evaluated by the receiver operating characteristic curve and statistical *** analysis and comparison,the XGBoost model(AUC 0.8759)performed the best and was suitable for dealing with regression *** model had a high adaptability to landslide *** to the landslide susceptibility map of the five models,the overall distribution can be *** extremely high and high susceptibility areas are distributed in the Funiu Mountain range in the southwest,the Xiaoshan Mountain range in the west,and the Yellow River Basin in the *** areas have large terrain fluctuations,complicated geological structural environments and frequent human engineering *** extremely high and highly prone areas were 12043.3 km^(2)and 3087.45 km^(2),accounting for 47.61%and 12.20%of the total area of the study area,*** study reflects the distribution of landslide susceptibil

关键词： Landslide susceptibility model Risk assessment Machine learning Support vector machines Logistic regression Random forest Extreme gradient boosting Linear discriminant analysis Ensemble modeling Factor analysis Geological disaster survey engineering Middle mountain area Yellow River Basin

SSR Analysis on Diversity of AA Genome Oryza Species in the Southeast and South Asia

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Rice science 2008年第4期15卷 289-294页

作者： Jian-zhen LU[a] Xiao-li ZHANG[b] hai-gang wang[b] Xiao-ping YUAN[a] Qun XU[a] Yi-ping wang[a] Han-yong YU[a] Sheng-xiang TANG[a] Xing-hua WEI[a] [a] State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China [b] Shanxi Agricultural University Taigu 030801 China

To investigate genetic diversities among the AA genome Oryza species in the Southeast and South Asia, a total of 428 accessions of the AA genome Oryza species were genotyped using 36 simple sequence repeats (SSR) markers distributed throughout the rice genome. All of the 36 SSR markers generated polymorphic bands, revealing 100% polymorphism. The number of alleles per locus ranged from 3 to 17 with the mean of 8.6. The Nei's genetic diversity index (He) ranged from 0.337 at RM455 to 0.865 at RM169 with an average value of 0.650. The genetic diversity of the AA genome Oryza species in the Southeast Asia was obviously higher than that in the South Asia. Among the detected Oryza species in the South and Southeast Asia, O. rufipogon showed the highest genetic diversity. Meanwhile, a higher genetic differentiation (Fst) was found among the detected Oryza species in the Southeast Asia than in the South Asia. The Fst value between O. nivara and O. sativa was the highest. The results from the number of specific alleles, specific loci, and allele frequency confirmed the greater genetic variation among the detected species. In addition, the specific allele in RM161 displayed higher frequency (0.193), suggesting its important function in identifying Oryza species of AA genome.

关键词： genome Oryza species simple sequence repeat genetic diversity South Asia Southeast Asia

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen hai-Di Fan Wan wang Bin wang Ju-Yun Ma Peng-Peng Li hai-Wei Pu Xin-Yian Guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

The role of pinocembrin in t-PA thrombolysis induced hemorrhagic transformation

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The role of pinocembrin in t-PA thrombolysis induced hemorrh...

Research advances in antiplatelet activation of water soluble compounds in Salvia miltiorrhiza

首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Ling Lei Kong Yan Xia Chen hai gang wang Guan Hua Du Beijing Key Laboratory of Drug Targets Identification and Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College

Hemorrhagic transformation(HT) is a frequent complication of ischemic stroke,especially after thrombolytic therapy,and is associated with increased stroke morbidity and *** plasminogen activator(t-PA),as the only FDA-proved drug,is underutilized in ischemic stroke,because of its limited therapeutic window and hemorrhagic *** are no effective drugs to decrease the incidence of HT in ***(PCB) is a natural flavonoid compound and has shown neuroprotective effects in animal stroke *** this study,we investigated the role of PCB in t-PA induced HT in rat thromboembolic stroke model.t-PA was administrated 6 hours after ischemia and PCB was given 5 mins before *** volume,neurological score and hemoglobin were evaluated at 24 hours after *** blue leakage was used to detect blood-brain barrier(BBB) *** results showed that treatment with t-PA at 6 hours after ischemia aggravated brain injury and increased the risk of *** with PCB decreased the infarct volume and brain water content,improve neurological *** addition,the results of hemoglobin and evans blue leakage showed that PCB could protect the BBB permeability and reduce the occurrence of *** conclusion,these results demonstrate that combination PCB with t-PA protects against cerebral ischemia,reduces the occurrence of HT induced by t-PA ***,PCB may be a potential therapeutic drug for t-PA induced HT.

关键词： hemorrhagic transformation tissue plasminogen activator pinocembrin

来源： cnki会议评论

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中国药理学与毒理学杂志 2018年第4期32卷 302-302页

作者： hai-gang wang Rui wang Xiao-yue ZHAO Liang YU Guan-hua DU Beijing Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia Medica Chinese Academy of Medical Science & Peking Union Medical College Beijing 100050 China Guangdong Pharmaceutical University Guangdong 510006 Chi

Platelets are fragments of cytoplasm that are released from the mature megakaryocyte of the bone *** main function of platelets is coagulation and *** play a central role in formation of pathological *** ischemic diseases are caused by excessive *** of platelets,which can lead to thrombosis and *** miltiorrhiza Bunge,the dry roots and rhizomes of the Salvia miltiorrhiza plants,includes some water-soluble compounds,which play positive effects on diverse diseases such as neurodegenerative diseases,diabetic complications or *** *** this paper,the components of the water-soluble in Salvia miltiorrhiza,as well as the applications in thrombotic diseases are *** results show that water-soluble compounds include salvianolic acid A,salvianolic acid B,protocatechuic aldehyde,Danshensu,*** water-soluble compounds are applied to ischemic stroke,myocardial infarction and other diseases caused by *** also discussed the mechanisms of water-soluble compounds on the platelets based on our research results and the data obtained from *** results indicate that water soluble compounds in Salvia miltiorrhiza play the antiplatelet and antithrombotic effects via different mechanisms,for example,salvianolic acid A inhibits platelet aggregation without promoting bleeding by increasing cAMP,inhibiting phosphoinositide 3-kinase(PI3K) and affecting GPCRs(G protein-coupled receptors) signaling ***;salvianolic acid B inhibit platelets as a P2Y12 antagonist and PDE inhibitor;Danshensu inhibits platelet activity may be related to inhibition of calcium *** conclusion,thrombotic diseases seriously affect human life and *** existing antiplatelet drugs have some *** example,aspirin may cause intracranial hemorrhage,and clopidogrel may play a slower *** miltiorrhiza as a traditional Chinese medicine has positive pharmacological activity and exerts antiplatel

关键词：血小板心血管疾病治疗方法临床分析

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模糊专家系统在故障诊断中的应用研究

计算机工程与应用 2004年第3期40卷 21-22页

作者：张晓丹赵海王刚苏羽东北大学信息科学与工程学院沈阳110004

文章提出了一种新的模糊逻辑与专家系统相结合的融合评估模型。该模型将评估过程视为模糊推理过程,并以此构建融合中心的结构模型。在融合算法的研究中,以模糊专家系统的算法实现融合中心的多传感器评估。在实验中将该模型用于丰满水电... 详细信息

文章提出了一种新的模糊逻辑与专家系统相结合的融合评估模型。该模型将评估过程视为模糊推理过程,并以此构建融合中心的结构模型。在融合算法的研究中,以模糊专家系统的算法实现融合中心的多传感器评估。在实验中将该模型用于丰满水电仿真系统的故障诊断过程。经分析表明,此模型优于传统的专家系统故障诊断模型。

关键词：模糊逻辑信息融合模糊专家系统水电仿真水轮机故障诊断

山西重要黍稷种质资源品质性状的初步鉴定与评价

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植物遗传资源学报 2017年第1期18卷 61-69页

作者：王纶王星玉王海岗陈凌王君杰曹晓宁刘思辰康国帅山西省农业科学院农作物品种资源研究所/农业部黄土高原作物基因资源与种质创制重点实验室/杂粮种质资源发掘与遗传改良山西省重点实验室太原030031

营养品质和口感品质是组成黍稷种质子粒品质的重要组成部分。粗蛋白和粗脂肪含量是组成营养品质的主要成分,赖氨酸和可溶性糖含量是组成口感品质的主要成分。通过对山西省有代表性的90份黍稷种质的粗蛋白、粗脂肪、赖氨酸和可溶性糖的测... 详细信息

营养品质和口感品质是组成黍稷种质子粒品质的重要组成部分。粗蛋白和粗脂肪含量是组成营养品质的主要成分,赖氨酸和可溶性糖含量是组成口感品质的主要成分。通过对山西省有代表性的90份黍稷种质的粗蛋白、粗脂肪、赖氨酸和可溶性糖的测定,评价了参试黍稷种质资源的营养品质和口感品质。结果表明,黍稷种质资源的粗蛋白平均含量为11.88%,粗脂肪平均含量为3.69%,赖氨酸平均含量为0.19%,可溶性糖平均含量为2.04%。鉴定筛选出7份粗蛋白含量13.00%、粗脂肪含量4.00%以上的高营养品质种质;15份赖氨酸含量0.20%以上、可溶性糖含量2.00%以上的口感品质优的种质;3份粗蛋白含量13.00%以上、粗脂肪含量4.00%以上、赖氨酸含量0.20%以上和可溶性糖含量2.00%以上的营养品质和口感品质均优的种质。营养品质和口感品质与不同类型种质的相关性分析表明,稷的营养品质好于黍,黍的口感品质好于稷,红粒种质营养品质和口感品质最好,白、褐、复色的种质居中,黄粒的最差;粒形和营养品质及口感品质相关不显著。研究结果为今后优质种质利用提供了参考依据。

关键词：黍稷种质资源营养品质口感品质

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基于信息融合思想的神经网络模型研究及应用

计算机工程与应用 2003年第32期39卷 4-6页

作者：苏羽赵海王刚魏守智苏威积张晓丹东北大学信息科学与工程学院沈阳110004

文章针对水电仿真系统中水轮发电机机组的非线性动态数学模型建模复杂问题,提出了一种基于信息融合思想的神经网络模型。通过现场设置的多个异质传感器采集数据,作为该神经网络模型的输入训练样本数据,网络训练中动态修改网络权值和阈值... 详细信息

文章针对水电仿真系统中水轮发电机机组的非线性动态数学模型建模复杂问题,提出了一种基于信息融合思想的神经网络模型。通过现场设置的多个异质传感器采集数据,作为该神经网络模型的输入训练样本数据,网络训练中动态修改网络权值和阈值,从而完成复杂的非线性建模功能。同时采用了具有较强全局寻优能力的遗传算法在训练中修改网络结构,从而避免神经网络训练速度慢、容易陷入局部极值的缺点,在现场在线数据预测测试中准确率可达95.8%以上,可以满足仿真模型需要。

关键词：信息融合水电仿真神经网络遗传算法非线性建模