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Fungal corneal endotheliitis： a series of case reports

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 1061-1065页

作者： Shuang-Yong Wang hai-feng zhu Yan Cheng Jie Wu Ying Tian The Third Affiliated Hospital Guangzhou Medical University Guangzhou 510150 Guangdong Province China The First Hospital of Xi'an Xi'an 710002 Shaanxi Province China Shaanxi Provincial Institute of Ophthalmology Shaanxi Provincial Key Laboratory of Ophthalmology Clinical Research Center for Ophthalmologic Diseases of Shaanxi Xi'an 710002 Shaanxi Province China

Dear Editor,The cornea is the ocular structure most commonly affected by fungi. In general, fungal organisms infiltrate into cornea following ocular injuries, such as the vegetative trauma, leading to infectious fungal keratitis, which is characterized by epithelial defects, comeal edema and ulceration, satellite lesions in the surrounding cornea, and white fluffy hypopyon. Secondary attenuation of cell defense mechanisms ailer prolonged use of topical or systemic corticosteroid or immunosuppressive agents may also result in endogenous fungal infection.

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A Generative Model Approach for Geo-Social Group Recommendation

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Journal of Computer Science & Technology 2018年第4期33卷 727-738页

作者： Peng-Peng Zhao hai-feng zhu Yanchi Liu Zi-Ting Zhou Zhi-Xu Li Jia-Jie Xu Lei Zhao Victor S. Sheng School of Computer Science and Technology Soochow University Suzhou 215006 China Department of Management Science and Information Systems Rutgers University Piscataway NJ 08854 U.S.A. Department of Computer Science University of Central Arkansas Conway 72035 U.S.A.

With the development and prevalence of online social networks, there is an obvious tendency that people are willing to attend and share group activities with friends or acquaintances. This motivates the study on group recommendation, which aims to meet the needs of a group of users, instead of only individual users. However, how to aggregate different preferences of different group members is still a challenging problem： 1） the choice of a member in a group is influenced by various factors, e.g., personal preference, group topic, and social relationship; 2） users have different influences when in diffe- rent groups. In this paper, we propose a generative geo-social group recommendation model （GSGR） to recommend points of interest （POIs） for groups. Specifically, GSGR well models the personal preference impacted by geographical information, group topics, and social influence for recommendation. Moreover, when making recommendations, GSGR aggregates the preferences of group members with different weights to estimate the preference score of a group to a POI. Experimental results on two datasets show that GSGR is effective in group recommendation and outperforms the state-of-the-art methods.

关键词： group recommendation topic model social network

Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression

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Cell Research 2003年第5期13卷 385-391页

作者： JIAN WEN DONG, hai feng zhu, WEI ZHONG zhu, hai LEI DING, TIE MIN MA, ZHAO NIAN ZHOU 1 Laboratory of Hypoxic Cardiovascular Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.2 Department of Physiology and Pathophysiology, Health Science Center Peking University, Beijing 100083 China Laboratory of Hypoxic Cardiovascular Physiology Shanghai Institutes for Biological SciencesChinese Academy of Sciences Shanghai China Department of Physiology and Pathophysiology Health Science Center Peking University Beijing China

Intermittent hypoxia has been shown to provide myocardial protection against ishemia/reperfusion-induced injury. Cardiac myocyte loss through apoptosis has been reported in ischemia/reperfusion injury. Our aim was to investigate whether intermittent hypoxia could attenuate ischemia/reperfusion-induced apoptosis in cardiac myocytes and its potential mechanisms. Adult male Sprague-Dawley rats were exposed to hypoxia simulated 5000 m in a hypobaric chamber for 6 h/day, lasting 42 days. Normoxia group rats were kept under normoxic conditions. Isolated perfused hearts from both groups were subjected to 30 min of global ischemia followed by 60 min reperfusion. Incidence of apoptosis in cardiac myocytes was determined by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling （TUNEL） and DNA agarose gel electrophoresis. Expressions of apoptosis related proteins, Bax and Bcl-2, in cytosolic and membrane fraction were detected by Western Blotting. After ischemia/reperfusion, enhanced recovery of ca

关键词： intermittent hypoxia apoptosis cardiac myocytes Bax Bcl-2.

Corneal collagen cross-linking and liposomal amphotericin B combination therapy for fungal keratitis in rabbits

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1549-1554页

作者： Zhao-Qin Hao Jin-Xin Song Shi-Yin Pan Lin Zhang Yan Cheng Xian-Ning Liu Jie Wu Xiang-Hua Xiao Wei Gao hai-feng zhu Department of Ophthalmology the First Hospital of Xi'anShaanxi Ophthalmological Institute Department of Ophthalmology the First Affiliated Hospital of Xi'an Jiaotong University

AIM： To observe the therapeutic effect of corneal collagen cross-linking（CXL） in combination with liposomal amphotericin B in fungal corneal ***： New Zealand rabbits were induced fungal corneal ulcers by scratching and randomly divided into 3groups, i.e. control, treated with CXL, and combined therapy of CXL with 0.25% liposomal amphotericin B（n =5 each）. The corneal lesions were documented with slit-lamp and confocal microscopy on 3, 7, 14, 21 and 28 d after treatment. The corneas were examined with transmission electron microscopy（TEM） at ***： A rabbit corneal ulcer model of Fusarium was successfully established. The corneal epithelium defect areas in the two treatment groups were smaller than that in the control group on 3, 7, 14 and 21d（P 〈0.05）. The corneal epithelium defect areas of the combined group was smaller than that of the CXL group（P 〈0.05） on 7 and 14 d, but there were no statistical differences on 3, 21 and 28 d. The corneal epithelium defects of the two treatment groups have been healed by day 21. The corneal epithelium defects of the control group were healed on 28 d. The diameters of the corneal collagen fiber bundles（42.960 ±7.383 nm in the CXL group and 37.040±4.160 nm in the combined group） were thicker than that of the control group（24.900±1.868 nm）,but there was no difference between the two treatment groups. Some corneal collagen fiber bundles were distorted and with irregular arrangement, a large number of fibroblasts could be seen among them but no inflammatory cells in both treatment groups. CONCLUSION： CXL combined with liposomal amphotericin B have beneficial effects on fungal corneal ulcers. The combined therapy could alleviate corneal inflammattions, accelerate corneal repair, and shorten the course of disease.

关键词： corneal collagen cross-linking liposomalamphotericin B fungal keratitis confocal microscope rabbit

An effective method and its modifications for isolation of high-quality total RNA from fruit pulps

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Journal of Agricultural Science and Technology 2008年第1期2卷 58-62页

作者： JIA hai-feng zhu Xiao-qin JIN Xiao-lei SHEN Yuan-yue Department of Plant Science and Technology Beijing University of Agriculture Beijing 102206 China

An effective method for isolation of total RNA from pulps of mainly deciduous fruit trees was discussed in this paper. Here we shown that total RNA was successfully isolated from pulps of apple, peach and strawberry, but not grape berry via the effective CTAB method modified by ZENG, et al. However, total RNA was isolated from grape berry according to ZENG＇s protocols with a modification including 16% of β-Mercatoethanol and 3% of PVP in extraction buffer, 1/3 （V/V） of 5mol/L potassium acetate （KAC PH4.8） in supernatant. The detection of the isolated total RNA above using ultraviolet spectrophoto-metry, electrophoresis, reverse transcription and RT-PCR shown that the CTAB and its modifications is a preferred method for isolation of high-quality total RNA from fruit pulps.

关键词： fruit fruit pulps total RNA CTAB method

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang feng Gao Yu-Gui Peng Peng Wu Zong-Lin Li Xue-feng zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

3g/L玻璃酸钠联合角膜绷带镜在翼状胬肉切除术后早期的应用

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国际眼科杂志 2020年第3期20卷 522-525页

作者：王阜蕾朱海峰中国陕西省杨凌示范区医院眼科 712100 中国陕西省西安市第一医院眼科 710002

目的:评价3g/L玻璃酸钠联合角膜绷带镜在翼状胬肉切除术后早期的应用价值。方法:随机双盲对照研究。收集2017-03/2018-03行手术治疗的单眼原发性鼻侧翼状胬肉患者90例90眼,分为A、B、C三组。A组角膜绷带镜+3g/L玻璃酸钠治疗;B组角膜绷带... 详细信息

目的:评价3g/L玻璃酸钠联合角膜绷带镜在翼状胬肉切除术后早期的应用价值。方法:随机双盲对照研究。收集2017-03/2018-03行手术治疗的单眼原发性鼻侧翼状胬肉患者90例90眼,分为A、B、C三组。A组角膜绷带镜+3g/L玻璃酸钠治疗;B组角膜绷带镜+1g/L玻璃酸钠治疗;C组:3g/L玻璃酸钠+包盖治疗。比较三组治疗后眼表刺激症状评分、角膜上皮愈合时间和结膜植片水肿消退时间。结果:术后A组各观察时间点眼表刺激症状评分均低于C组(P0.05),但A组角膜上皮愈合时间明显缩短(P=0.018)。结论:3g/L玻璃酸钠联合角膜绷带镜在翼状胬肉切除术后早期应用具有协同作用,可以有效缩短角膜上皮愈合时间,缓解刺激症状。

关键词：角膜绷带镜玻璃酸钠翼状胬肉角膜上皮修复

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Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury

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Acta Pharmacologica Sinica 2005年第3期26卷 315-322页

作者： hai-lei DING~2 hai-feng zhu~2 Jian-wen DONG~2 Wei-zhong zhu~2 Wei-wei YANG~3 Huang-tian YANG~3 Zhao-nian ZHOU~(2,4)2 Physiological Laboratory of Hypoxia,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China 3 Laboratory of Molecular Cardiology,Health Science Center,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences and Shanghai Second Medical University,Shanghai 200025,China Physiological Laboratory of Hypoxia Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Laboratory of Molecular Cardiology Health Science Center Shanghai Institutes for Biological Sciences Chinese Academy of Sciences and Shanghai Second Medical University Shanghai China

Aim:To investigate the role of inducible nitric oxide synthase (iNOS)-derivednitric oxide (NO) in the cardioprotection of intermittent hypoxia (IH) against is-chemia/reperfusion (I/R) ***:Langendorff-perfused isolated rathearts were used to measure variables of left ventricular function during baselineperfusion,ischemia,and reperfusion *** plus nitrite (NOx) content inmyocardium was measured using a biochemical method,iNOS mRNA and pro-tein expression in rat left ventricles were detected using reverse transcription poly-merase chain reaction (RT-PCR) and Western blot,***:Myo-cardial function recovered better in IH rat hearts than in normoxic control *** iNOS-selective inhibitor aminoguanidine (AG) (100μmol/L) significantlyinhibited the protective effects of IH,but had no influence on normoxic rat *** baseline content of NOx in IH hearts was higher than that in normoxic *** 30 min ischemia,the NOx level in normoxic hearts increased compared tothe corresponding baseline level,whereas there was no significant change in ***,the NOx level in IH hearts was still higher than that of normoxichearts during ischemia and reperfusion *** 100μmol/L significantly di-minished the NOx content in IH and normoxic hearts during ischemia and *** baseline levels of iNOS mRNA and protein in IH hearts were higherthan those of normoxic *** to the corresponding baseline level,iNOS mRNA and protein levels in normoxic rat hearts increased and those in IH rathearts decreased after *** addition of AG 100μmol/L significantlydecreased iNOS mRNA and protein expression in IH rat hearts after I/***:IH upregulated the baseline level of iNOS mRNA and protein expres-sion leading to an increase in NO production,which may play an important role inthe cardiac protection of IH against I/R injury.

关键词： intermittent hypoxia ischemia/reperfusion inducible nitric oxide synthase aminoguanidine: rats

后弹力层剥除联合角膜内皮移植手术技巧在大泡性角膜病变中的应用

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国际眼科杂志 2020年第8期20卷 1456-1459页

作者：程燕吴洁朱海峰惠玲李波西北大学附属第一医院西安市第一医院陕西省眼科疾病临床医学研究中心中国陕西省西安市710002 中国陕西省勉县医院眼科 724200

目的:观察改良的角膜后弹力层剥除联合自动角膜刀取材内皮移植术(DSAEK)手术技巧在大泡性角膜病变中的应用。方法:回顾性分析2018-12/2019-12在我科住院治疗的大泡性角膜病变患者10例10眼,均行DSAEK术,除常规手术步骤,术中在前房灌注管... 详细信息

目的:观察改良的角膜后弹力层剥除联合自动角膜刀取材内皮移植术(DSAEK)手术技巧在大泡性角膜病变中的应用。方法:回顾性分析2018-12/2019-12在我科住院治疗的大泡性角膜病变患者10例10眼,均行DSAEK术,除常规手术步骤,术中在前房灌注管设置、切口设计及角膜周边穿刺等手术技术上进行改进。术后随访6mo,观察角膜植片恢复情况和植片脱位、前房反应等并发症发生情况,评估最佳矫正视力(BCVA)、角膜中央厚度(CCT)、角膜内皮细胞计数(ECD)情况。结果:所有患者均顺利完成手术,无术中并发症发生,术后未见植片脱位和层间积液发生。术后眼压正常,BCVA较术前均有不同程度改善。角膜畏光、眼磨等刺激症状自术后1d开始逐渐减轻,术后2wk完全缓解。术后1mo角膜基质水肿消退,CCT(596.8±19.11μm)较术前(874.0±58.64μm)明显变薄。随访期间,所有患者病情稳定,角膜植片保持透明,但角膜内皮细胞计数均有不同程度衰减。结论:DSAEK术中手术技巧的改进可以明显减少大泡性角膜病变患者术中和术后并发症,提高手术安全性和有效性。

关键词：角膜移植术后弹力层剥除联合角膜内皮移植术大泡性角膜病变手术技巧

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