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CCS Chemistry 2024年第4期6卷 1060-1070页

作者： Sifan Li hai-Wu du Paul W.Davies Wei Shu Department of Chemistry Shenzhen Grubbs InstituteSouthern University of Science and TechnologyShenzhen 518055Guangdong School of Chemistry University of BirminghamEdgbastonBirmingham B152TT

Sterically congestedα-tertiary primary amines are ubiquitous substructures in pharmaceutical and agrochemical agents yet are challenging to ***,straightforward photoredox-catalyzed access to structurally diverseα,α,α-trisubstituted primary amines from denitrogenative alkylarylation or dialkylation of vinyl azides with N-hydroxyphthalimide(NHPI)esters and cyanoarenes or aryl aldehydes has been *** use of vinyl azide as a precursor to a primary aminewas enabled by the dual role of the Hantzsch ester to form an electron donor-acceptor complex and serve as a sacrificial *** strategy provides a modular synthesis ofα-tertiary primary amines,including unprotected 1,2-amino alcohols,from simple materials with excellent functional group *** synthetic applicability of this method was demonstrated by streamlined access to 2,2-disubstituted *** investigations support two parallel reductive photocatalytic cycles allowing for the denitrogenative alkylarylation or dialkylation of vinyl azides via decarboxylative radical addition followed by heteroradical cross-coupling betweenα-amino radicals and aryl anion radicals or ketyl anion radicals.

关键词： photocatalysis α-tertiary primary amines 1 2-amino alcohols vinyl azide electron donor-acceptor complex

Di-and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair

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Science China(Life Sciences) 2024年第6期67卷 1089-1105页

作者： Runfa Chen Meng-Jie Zhao Yu-Min Li Ao-Hui Liu Ru-Xin Wang Yu-Chao Mei Xuefeng Chen hai-Ning du Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismHubei Clinical Research Center of Emergency and ResuscitationEmergency Center of Zhongnan HospitalWuhan UniversityWuhan 430072China Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismWuhan UniversityWuhan 430072China

Histone H3 Lys36(H3K36)methylation and its associated modifiers are crucial for DNA double-strand break(DSB)repair,but the mechanism governing whether and how different H3K36 methylation forms impact repair pathways is ***,we unveil the distinct roles of H3K36 dimethylation(H3K36me2)and H3K36 trimethylation(H3K36me3)in DSB repair via non-homologous end joining(NHEJ)or homologous recombination(HR).Yeast cells lacking H3K36me2 or H3K36me3 exhibit reduced NHEJ or HR efficiency.y Ku70 and Rfa1 bind H3K36me2-or H3K36me3-modified peptides and chromatin,*** these interactions impairs y Ku70 and Rfa1 recruitment to damaged H3K36me2-or H3K36me3-rich loci,increasing DNA damage sensitivity and decreasing repair ***,H3K36me2-enriched intergenic regions and H3K36me3-enriched gene bodies independently recruit y Ku70 or Rfa1 under DSB ***,human KU70 and RPA1,the homologs of y Ku70 and Rfa1,exclusively associate with H3K36me2 and H3K36me3 in a conserved *** findings provide valuable insights into how H3K36me2 and H3K36me3 regulate distinct DSB repair pathways,highlighting H3K36 methylation as a critical element in the choice of DSB repair pathway.

关键词： histone H3K36 methylation Ku70 RPA non-homologous end joining homologous recombination

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Sorbitol-Electrolyte-Additive Based Reversible Zinc Electrochemistry

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电化学（中英文） 2024年第7期30卷 28-37页

作者： Qiong Sun hai-Hui du Tian-Jjiang Sun Dian-Tao Li Min Cheng Jing Liang hai-Xia Li Zhan-Liang Tao Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Renewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin300071China Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China School of Chemistry and Life SciencesSuzhou University of Science and TechnologySuzhou 215009JiangsuChina

The unstable zinc(Zn)/electrolyte interfaces formed by undesired dendrites and parasitic side reactions greatly hinder the development of aqueous zinc ion ***,the hydroxy-rich sorbitol was used as an additive to reshape the solvation structure and modulate the interface *** strong interactions among sorbitol and both water molecules and Zn electrode can reduce the free water activity,optimize the solvation shell of water and Zn^(2+)ions,and regulate the formation of local water(H_(2)O)-poor environment on the surface of Zn electrode,which effectively inhibit the decomposition of water molecules,and thus,achieve the thermodynamically stable and highly reversible Zn *** a result,the assembled Zn/Zn symmetric cells with the sorbitol additive realized an excellent cycling life of 2000 h at 1 mA·cm^(-2)and 1 mAh·cm^(-2),and over 250 h at 5 ***^(-2)and 5 ***^(-2).Moreover,the Zn/Cu asymmetric cells with the sorbitol additive achieved a high Coulombic efficiency of 99.6%,obtaining a better performance than that with a pure 2 mol-L^(-1)ZnSO_(4)*** the constructed Zn/poly1,5-naphthalenediamine(PNDA)batteries could be stably discharged for 2300 cycles at 1 A g^(-1)with an excellent capacity retention *** result indicates that the addition of 1 mol-L^(-1)non-toxic sorbitol into a conventional ZnSO_(4)electrolyte can successfully protect the Zn anode interface by improving the electrochemical properties of Zn reversible deposition/decomposition,which greatly promotes its cycle performance,providing a new approach in future development of high performance aqueous Zn ion batteries.

关键词： Aqueous zinc ion batteries Dendrite Sorbitol additive Solvation regulation Interface modulation

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北朝粟特和氏家族考辨

西域研究 2024年第1期 8-14,186页

作者：杜海兰州大学敦煌学研究所新疆吐鲁番学研究院

北朝时期“和跋—和士开”应为粟特胡人后裔,其家族源自“金山”,后迁徙至“豺山”,并于道武帝拓跋珪时期归魏。通过对比“和跋—和士开”家族史料与素和氏家族史料,可知和跋家族并非源于鲜卑素和氏。正史、墓志未明确记载和跋、和安等... 详细信息

北朝时期“和跋—和士开”应为粟特胡人后裔,其家族源自“金山”,后迁徙至“豺山”,并于道武帝拓跋珪时期归魏。通过对比“和跋—和士开”家族史料与素和氏家族史料,可知和跋家族并非源于鲜卑素和氏。正史、墓志未明确记载和跋、和安等人的族属,与魏收刻意逢迎权臣和士开有关。和士开逝后,文献中不再避讳其在文化、相貌、地域上的粟特胡人特征。

关键词：和跋和士开素和氏北朝粟特

基于符号回归方法探索磁性斯格明子结构近似解析式

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物理学报 2024年第1期73卷 43-50页

作者：史猛王伟伟杜海峰中国科学院合肥物质科学研究院强磁场科学中心合肥 230031 中国科学技术大学合肥 230026 安徽大学物质科学与信息技术研究院合肥 230601 中国科学院合肥物质科学研究院强磁场科学中心合肥 230031

磁性斯格明子是一种非平庸的拓扑磁结构,它能够在具有Dzyaloshinskii-Moriya(DM)相互作用的手性磁体中稳定存在,其静态以及动态特性与其结构特征息息相关.然而,一般情况下斯格明子结构解析式并不存在.因此,许多研究者给出了近似解析式.... 详细信息

磁性斯格明子是一种非平庸的拓扑磁结构,它能够在具有Dzyaloshinskii-Moriya(DM)相互作用的手性磁体中稳定存在,其静态以及动态特性与其结构特征息息相关.然而,一般情况下斯格明子结构解析式并不存在.因此,许多研究者给出了近似解析式.本文介绍了使用符号回归算法探索磁性斯格明子结构解析式的新方法,在考虑DM相互作用和外部磁场对磁性斯格明子结构的影响下,使用符号回归算法得到了两个较为合适的近似解析式,其适用范围与占主导地位的相互作用有关.研究结果验证了符号回归算法在探索磁性斯格明子结构解析式的强大能力,为磁结构的解析式探索提供了新思路.

关键词：磁性斯格明子符号回归磁性斯格明子结构 Dzyaloshinskii-Moriya相互作用

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分子对接在中药开发的应用现状与挑战

中国中药杂志 2024年第3期49卷 671-680页

作者：杜海涛王琳丁洁杜亚轩王平山东省中医药研究院山东济南250014 山东中医药大学药学院山东济南250355 沈阳药科大学中药学院辽宁沈阳110016

中医药学是中国古代科学的瑰宝,也是打开中华文明宝库的钥匙。为将其“说清楚,讲明白”,相关药效物质基础及调控靶点的研究一直备受关注。分子对接技术是一种计算机辅助的药物设计方法,能够直观展示成分与靶点蛋白之间的相互作用关系。... 详细信息

中医药学是中国古代科学的瑰宝,也是打开中华文明宝库的钥匙。为将其“说清楚,讲明白”,相关药效物质基础及调控靶点的研究一直备受关注。分子对接技术是一种计算机辅助的药物设计方法,能够直观展示成分与靶点蛋白之间的相互作用关系。随着中药现代化的需求以及算法算力的更新,分子对接作为先导研究是中药新药研发的必然需求。该文总结近年来分子对接技术在中医药开发的研究进展,对于进一步推动中药活性成分的分子对接筛选研究提供一定的参考价值,为提高中药新药的研发提供思路与方法。

关键词：分子对接活性成分中药新药靶点筛选

Integrated analysis of plasma rotation effect on HL-3 hybrid scenario

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Chinese Physics B 2024年第8期33卷 329-336页

作者：薛淼郑国尧薛雷李佳鲜王硕杜海龙朱毅仁周月 Southwestern Institute of Physics Chengdu 610000China

The hybrid scenario,which has good confinement and moderate MHD instabilities,is a proposed operation scenario for international thermonuclear experimental reactor(ITER).In this work,the effect of plasma rotation on the HL-3 hybrid scenario is analyzed with the integrated modeling framework *** results show that toroidal rotation has no obvious effect on confinement with a high line averaged density of n_(bar)~(7)×10^(19)m^(-3).In this case,the ion temperature only changes from 4.7 keV to 4.4 keV with the rotation decreasing from 10^(5) rad/s to 10^(3) rad/s,which means that the turbulent heat transport is not *** in the scenarios characterized by lower densities,such as n_(bar)~4×10^(19)m^(-3),turbulent transport becomes dominant in determining heat *** ion temperature rises from 3.8 keV to 6.1 keV in the core as the rotation velocity increases from 10^(3) rad/s to 10^(5) rad/*** the ion temperature rising,the rotation velocity does not obviously affect electron temperature or ***,it is noteworthy that the variation in rotation velocity does not significantly affect the global confinement of plasma in scenarios with low density or with high density.

关键词： HL-3 hybrid scenario toroidal rotation integrated modeling

DoS攻击下的幂次趋近律滑模控制系统稳定性分析

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控制与决策 2024年第6期39卷 1986-1994页

作者：都海波李申申陈维乐朱文武合肥工业大学电气与自动化工程学院合肥230009 东南大学自动化学院南京210018

研究拒绝服务(denial-of-service,DoS)攻击下的n阶受扰系统基于幂次趋近律的滑模控制.首先,通过构造状态预测器重建攻击活跃期间丢失的系统状态,基于预测器状态和非光滑函数,设计能量受限型DoS攻击情况下的幂次趋近律滑模控制器,进一步... 详细信息

研究拒绝服务(denial-of-service,DoS)攻击下的n阶受扰系统基于幂次趋近律的滑模控制.首先,通过构造状态预测器重建攻击活跃期间丢失的系统状态,基于预测器状态和非光滑函数,设计能量受限型DoS攻击情况下的幂次趋近律滑模控制器,进一步分析保持系统稳定性的充分条件;其次,当系统存在外部干扰情况下,证明幂次趋近律滑模控制方法仍能保持非光滑控制器的强抗干扰能力;最后,通过数值仿真对所提出的理论证明结果进行验证.

关键词：拒绝服务攻击滑模控制状态预测器幂次趋近律

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无规共聚型聚小分子受体聚合物的发展和应用

广州化工 2024年第5期52卷 25-28,63页

作者：杜海川汪倩兰州交通大学材料科学与工程学院甘肃兰州730000

有机太阳能电池(OSCs)对实现低碳经济的发展具有重要意义。因其具有质轻、制备柔性、便携式设备等独特优势,具有巨大的商业开发价值。全聚合物太阳能电池(All-PSCs)凭借良好的光热稳定性及机械性能,被认为更有潜力应用于未来的柔性、可... 详细信息

有机太阳能电池(OSCs)对实现低碳经济的发展具有重要意义。因其具有质轻、制备柔性、便携式设备等独特优势,具有巨大的商业开发价值。全聚合物太阳能电池(All-PSCs)凭借良好的光热稳定性及机械性能,被认为更有潜力应用于未来的柔性、可穿戴设备中。然而,目前的能量转换效率(PCE)相比基于小分子受体材料的光伏器件还相对较低,其中一个最重要的原因是缺乏高效的聚合物受体。本文首先将对发展节点以及目前应用高效率All-PSCs中的受体聚合物的研究进展进行简要介绍,随后将重点对其中通过无规共聚策略合成的聚小分子受体聚合物的优势与发展进行综述并对未来聚小分子受体聚合物的发展进行展望。

关键词：有机太阳能电池全聚合物太阳能电池受体聚合物无规共聚光电转换效率

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不同粉碎机对粮食水分测定结果的影响

粮油科学与工程 2024年第5期38卷 35-36,40页

作者：陈婷杜海方正杰徐州市检验检测中心江苏徐州221000

使用3种实验室粉碎机处理小麦和粳稻样品,按GB5009.3—2016《食品安全国家标准食品中水分的测定》中的直接干燥法测定样品水分含量,研究不同粉碎机对水分含量检测结果的影响。结果表明:粉碎机的粉碎程度对同一样品水分检测结果差异明显... 详细信息

使用3种实验室粉碎机处理小麦和粳稻样品,按GB5009.3—2016《食品安全国家标准食品中水分的测定》中的直接干燥法测定样品水分含量,研究不同粉碎机对水分含量检测结果的影响。结果表明:粉碎机的粉碎程度对同一样品水分检测结果差异明显,样品细度越小,水分检测值越低;样品水分含量越高,测试结果差异越大。建议粮食水分检测粉碎机优先选用水分测试粉碎磨,尽量不用锤式旋风磨。

关键词：粮食水分水分测试粉碎磨锤式旋风磨

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