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Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC

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Chinese Chemical Letters 2025年第1期36卷 392-396页

作者： Wenbin Zhou Yafei Gao Xinyu feng Yanqing Zhang Cong yang Lanxi He fenghe Zhang Xiaoguang Li Qing Li School and Hospital of Stomatology Cheeloo College of MedicineShandong UniversityJi’nan 250012China China&Shandong Key Laboratory of Oral Tissue Regeneration Ji’nan 250012China China&Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Ji’nan 250012China Department of Stomatology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJi’nan 250021China

Immunotherapy offers significant potential but is often hampered by the immunosuppressive environment in oral squamous cell carcinoma(OSCC).To address this,we propose an enhanced immunotherapeutic strategy that revitalizes the tumor immune microenvironment(TIME)in OSCC by integrating upconversion-based photodynamic therapy(PDT)with *** a red blood cell membraneinspired biomimetic nanoplatform,our approach concurrently delivers chlorin e6@upconversion nanoparticles(Ce6@UCNP)and doxorubicin(DOX).By leveraging fluorescence resonance energy transfer(FRET)for 980 nm to 660 nm upconversion excitation,we address challenges such as limited tissue penetration and tissue damage,as well as nanoplatform issues including immunogenicity and targeting inaccuracy Our integrated approach enhances PDT and chemotherapy with the goal of transforming immunologically“cold”tumors into“hot”ones through a cascaded therapy,thereby revitalizing the tumor immune microenvironment in OSCC.

关键词： Biomimetic nanoplatform UCNP-PDT Chemotherapy TIME OSCC

Pentaploidization allows introgression of Aegilops tauschii into tetraploid wheat

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Crop Journal 2025年第1期13卷 227-232页

作者： yang, Fan Liu, Zehou Wan, Hongshen yang, Sujie yang, Ning Ding, Hongxia Jiang, Yun feng, Junyan Zhang, Jie Wang, Ying Fan, Xing Zhou, Yonghong Li, Jun yang, Wuyun Crop Research Institute Sichuan Academy of Agricultural Sciences Sichuan Chengdu 610066 China Biotechnology and Nuclear Technology Research Institute Sichuan Academy of Agricultural Sciences Sichuan Chengdu 610066 China Triticeae Research Institute Sichuan Agricultural University Sichuan Chengdu 611130 China College of Agronomy Sichuan Agricultural University Sichuan Chengdu 611130 China

Pentaploid hybrids produced from crosses between hexaploid and tetraploid wheats combine the genetic variation of both parents. Crossing a synthetic hexaploid wheat LM/AT23 with its AB-genome donor, the durum wheat LM, and selfing the pentaploid hybrids to the F7 generation yielded mostly euploid tetraploids and a few hexaploids. Two special derivatives of tetraploid were isolated, including a 4D(4B) substitution line with large panicles and high resistance to stripe rust and a 2DS.2AL translocation line with non-waxy epidermis. The discovery of small D-genome introgressions in the A and B genomes suggested that pentaploidization can be used to induce homoeologous recombination. The introgression of D genome from Aegilops tauschii to the AB genomes might promote the development of super tetraploid wheat with hexaploid biological characteristics (especially stress resistance) and quality functions and the functional study of the introduced chromosomes or fragments. © 2025 Crop Science Society of China and Institute of Crop Science, CAAS

关键词： Aegilops tauschii Alien introgression Homoeologous recombination Interspecific hybridization Pentaploid hybridization

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基于粗集与聚类投票机制的光谱双星特征分析

光谱学与光谱分析 2025年第2期45卷 463-468页

作者：王琦杨海峰蔡江辉运城学院数学与信息技术学院山西运城044000 太原科技大学计算机科学与技术学院山西太原030024 中北大学计算机科学与技术学院山西太原030051

光谱双星通常是指光谱中呈现双主导成分特征,由于该双成分复杂多样,其成因也多种多样,同时光谱信噪比相对比较低,现有许多分析方法将双成分系统光谱分离成两条光谱进行分析,而分离方法无法保证光谱的准确性,现有聚类方法的单次聚类可靠... 详细信息

光谱双星通常是指光谱中呈现双主导成分特征,由于该双成分复杂多样,其成因也多种多样,同时光谱信噪比相对比较低,现有许多分析方法将双成分系统光谱分离成两条光谱进行分析,而分离方法无法保证光谱的准确性,现有聚类方法的单次聚类可靠性比较低。提出一种基于粗集与聚类投票机制的光谱双星分析与评估方法,采用多次聚类和投票思想,给出每条光谱属于相应类别的梯度可靠性。该方法包含两个部分:(1)采用不同思想的聚类算法,将光谱双星数据集进行重构,将每种聚类算法标签采用匈牙利算法将聚类标签对齐作为光谱属性,从而重构数据集。(2)利用投票机制,得票数反映聚类结果的一致程度,获得每条光谱的类别,定义粗集示踪每类光谱特征,采用上/下近似集给出每条光谱所归类别的可靠性。选择郭守敬望远镜(LAMOST)DR10发布光谱双星集作为分析对象,采用基于划分的K-means、基于模型的GMM(Gaussian mixture model)、谱聚类(spectral clustering)和层次聚类(agglomerative clustering)四种聚类算法重构光谱数据集,选择得票数下界μ为2,通过投票得到1、0.75、0.5为可靠性梯度的聚类结果。其中大约1/3的样本可靠性为1,说明这批样本的四种聚类结果完全一致;对每类光谱和投票数的信噪比进行统计分析,投票数低的样本的信噪比相对较低,是它们被不同的聚类算法划分到不同类别的原因之一;对可靠性为1的6类光谱样本进行了物理成因的分析,其中以双星、河内星云+目标恒星两种为主,聚类标签的差异可能由于两种成分流量差异或拼接、定标等数据处理所导致。也有可能由于光谱质量较低导致pipeline误判的因素,其天区位置分布与低质量数据分布特征的研究基本一致。

关键词：光谱双星光谱分析聚类算法郭守敬望远镜(LAMOST)

Gastric gastrointestinal stromal tumor in a patient with neurofibromatosis type I presenting with anemia:A case report

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 394-401页

作者： Guang-yang Bai Ke-Shu Shan Chen-Sheng Li Xiang-Hua Wang Ming-yang feng Yan Gao Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Gastrointestinal Surgery Yinan County People’s HospitalLinyi 276399Shandong ProvinceChina Department of Pathology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are caused by mutations in the KIT and platelet derived growth factor receptor alpha genes in approximately 90%of cases.A minority of wild-type GISTs are associated with neurofibromatosis type 1(NF1),an autosomal dominant genetic disease resulting from pathogenic mutations in the NF1 gene,which encodes the neurofibromin ***1 patients often exhibit multi-system involvement,with café-au-lait macules and neurofibromas being characteristic *** are a rare complication of NF1,with the tumors most frequently occurring in the small intestine(90%of cases),while occurrences in the stomach are *** SUMMARY A 51-year-old woman presented to the emergency department with complaints of dizziness,fatigue,chest tightness,and dark *** examination revealed a red blood cell count of 1.99×1012/L and a hemoglobin level of 43 g/*** underwent blood transfusions and fluid replacement to stabilize her *** investigations identified typical café-au-lait macules on her trunk,limbs,and face,along with *** showed coffee-colored fluid in the gastric cavity,a large submucosal elevation with an exudative covering,and ulcer formation on the gastric *** laparoscopy confirmed the tumor’s origin in the gastric fundus,and resection of the giant GIST was *** analysis revealed a necrotic GIST measuring 18 cm×14 cm,classified as high-risk,with approximately 5 mitotic figures per 10 high-power fields and no tumor at the *** results were CD117(+),delay of germination 1(+),CD34(+),and succinate dehydrogenase complex iron sulfur subunit B intact *** testing using next-generation sequencing confirmed an NF1 gene *** patient underwent successful tumor resection and was discharged home with postoperative regorafenib therapy.A follow-up at one year showed no *** Given the diversity of clinical sympt

关键词： Neurofibromatosis type 1 Gastrointestinal stromal tumors Regorafenib:Anemia Case report

Methanol steam mediated corrosion engineering towards high-entropy NiFe layered double hydroxide for ultra-stable oxygen evolution

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Chinese Chemical Letters 2025年第1期36卷 338-343页

作者： Jinqiang Gao haifeng Yuan Xinjuan Du feng Dong Yu Zhou Shengnan Na Yanpeng Chen Mingyu Hu Mei Hong Shihe yang Guangdong Provincial Key Laboratory of Nano-Micro Materials Research School of Advanced MaterialsPeking University Shenzhen Graduate School(PKUSZ)Shenzhen 518055China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China Department of Physics Hong Kong Baptist UniversityHong Kong 999077China

Rational design of viable routes to obtain efficient and stable oxygen evolution reaction(OER)electrocatalysts remains challenging,especially under industrial ***,we provide a solvent-steam assisted corrosion engineering strategy to directly fabricate high-entropy NiF e-LDH with spatially resolved structural *** fluoride in methanol steam enables the formation of nanosheets while Fe^(3+)effectively enhances their adhesion to the semi-sacrificial nickel-iron foam(NFF),thereby conjuring up a Ni Fe-LDH@NFF catalyst that exhibits remarkable adaptability to robust electrochemical activation yet with excellent *** measurements reveal the in-situ formation of high-valance metal oxyhydroxide and the enhancement of adsorption-desorption *** the industrial condition(6 mol/L KOH,60℃),the Ni Fe-LDH@NFF exhibits excellent activity of 50 mA/cm^(2) at 1.55 V and high durability of over 120 h at 200 mA/cm^(2).We anticipate that the steam assisted strategy could promote the development of efficient non-precious electrocatalysts for hydrogen energy.

关键词： High-entropy material Corrosion engineering NiFe-LDH Oxygen evolution reaction Stability

高频超声与核磁共振成像在交叉韧带损伤诊断中的比较

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临床医学研究与实践 2018年第2期3卷 132-133页

作者：冯海洋冯海军延川县人民医院陕西延安717200

目的分析探讨高频超声检查与核磁共振成像(MRI)用于交叉韧带损伤中的诊断价值。方法选择我院2015年12月至2016年12月收治的67例交叉韧带损伤患者为研究对象,所有患者均采用高频超声检查和MRI检查,将两种方法的检测结果与关节镜检测结果... 详细信息

目的分析探讨高频超声检查与核磁共振成像(MRI)用于交叉韧带损伤中的诊断价值。方法选择我院2015年12月至2016年12月收治的67例交叉韧带损伤患者为研究对象,所有患者均采用高频超声检查和MRI检查,将两种方法的检测结果与关节镜检测结果进行比较。结果以关节镜检测结果为标准,高频超声诊断检测准确率为97.01%,MRI检测准确率为100.00%,组间比较,无显著差异(χ~2=2.03,P>0.05)。结论高频超声诊断与MRI用于诊断前后交叉韧带损伤均具有较高的诊断准确率,但是高频超声诊断操作方便,临床实用性更高,可以作为临床常规诊断交叉韧带损伤的首选方法使用。

关键词：高频超声核磁共振成像韧带损伤

替加环素治疗耐碳青霉烯类鲍曼不动杆菌肺炎的疗效观察

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中国医院用药评价与分析 2018年第3期18卷 371-373页

作者：杨涛海峰杨露大连市第三人民医院重症医学科辽宁大连116033

目的:探讨替加环素治疗耐碳青霉烯类鲍曼不动杆菌肺炎的疗效。方法:回顾性选取2013年1月—2016年2月大连市第三人民医院院内感染引起的耐碳青霉烯类鲍曼不动杆菌肺炎患者77例,根据治疗方案分为A组42例和B组35例。A组患者采用替加环素治... 详细信息

目的:探讨替加环素治疗耐碳青霉烯类鲍曼不动杆菌肺炎的疗效。方法:回顾性选取2013年1月—2016年2月大连市第三人民医院院内感染引起的耐碳青霉烯类鲍曼不动杆菌肺炎患者77例,根据治疗方案分为A组42例和B组35例。A组患者采用替加环素治疗,B组患者采用头孢哌酮舒巴坦钠联合米诺环素治疗。观察两组患者的临床疗效和死亡情况。结果:A、B组患者的总有效率分别为78.57%(33/42)、77.14%(27/35),差异无统计学意义(P>0.05);A、B组患者的病死率分别为21.43%(9/42)、22.86%(8/35),差异无统计学意义(P>0.05)。结论:对于耐碳青霉烯类鲍曼不动杆菌肺炎患者,单独采用替加环素与采用头孢哌酮舒巴坦钠联合米诺环素的临床疗效相近。

关键词：替加环素耐碳青霉烯类鲍曼不动杆菌肺炎头孢哌酮舒巴坦钠米诺环素

Self-sustainable Catalytic Nucleic Acid Circuit Powered Hybrid CRISPR-Cas Systems for Point-of-Care Diagnosis of Circadian Clock Gene from Cell Lysates

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Journal of Analysis and Testing 2025年第01期 1-11页

作者： Zhiyuan feng Ran Liu Enming yang Rui Lian Jingjing Zhang State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC)Nanjing University

The CRISPR-Cas13 systems have opened a new avenue for RNA detection due to their exceptional programmable collateral activity against ssRNA. However, most high-performance Cas13-based RNA sensors still suffer from some drawbacks because of the tradeoffs between readout device complexity and analytical sensitivity, which can limit their viability at the point-of-care(POC). To overcome these shortcomings, we herein report a novel target-responsive POC platform for translating RNA detection into a glucose test. Specifically, this platform combines the advantages of three techniques: a hybrid Cas13a/Cas12a system for both RNA recognition with single-base resolution and cascade enzymatic amplification, a self-sustainable catalytic nucleic acid circuit(SCC) with embedded uracil-base and poly-T bulges for Cas13a-and Cas12amediated collateral cleavage, respectively, and a portable glucose meter(PGM) for simple signal readout. The incorporation of an engineered ssDNA–invertase conjugate in SCC led to RNA-to-glucose signal transduction through the hydrolysis of sucrose to glucose. By targeting a 20-nt conserved region of BMAL1 mRNA(mBMAL1), a key circadian clock gene, we demonstrate that SCC can serve as an excellent CRISPR reporter, enabling the direct detection of unamplified mBMAL1 as low as 0.864 fM concurrently with good discrimination ability for single-base mismatch. More importantly, this integrated platform was successfully applied for POC diagnosis of mBMAL1 from different cell lysates, with results that strongly correlate with RT-PCR. Given its wide adaptability, we anticipate that such a CRISPR-SCC system can be easily modified to quantify other RNA biomarkers associated with circadian rhythm.

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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian feng Hua yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics