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Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong Fei Luan Juanjuan yang feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

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Meta-analysis of the Occurrence Characteristics and Influencing Factors of Microplastics in Agricultural Soil in China

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Huanjing Kexue/Environmental Science 2025年第1期46卷 498-509页

作者： Wu, Ting Jiao, yang-yang Jiao, hai-Hua School of Life Science Shanxi Normal University Taiyuan 030032 China Department of Life Sciences Changzhi University Changzhi 046011 China Henan Institute of Advanced Technology Zhengzhou University Zhengzhou 450003 China

The potential threat of soil microplastics（MPs，particle sizes smaller than 5 mm）to the agricultural environment and food security production has become a hot issue，but there are few systematic studies on the characteristics and influencing factors of MP pollution in agricultural soil in China. Based on the data of soil MPs and related environmental factors（temperature，precipitation，soil pH，and organic carbon）and social and economic factors（permanent population，gross regional product per capita，gross industrial product per capita，and cultivated land area per capita）extracted from 6 694 samples from 85 published studies from 2020 to 2023，meta-analysis was performed. The characteristics of MPs pollution in agricultural soil and the key factors affecting the accumulation of MPs in soil in six administrative regions of China were analyzed. The results showed that soil MPs had six colors：（semi-）transparent，black，white，yellow，blue，green，and red. There were five kinds of shapes：fragment，fiber，film，particle，and foam. The particle size was between 0.01 and 5.0 mm. There were nine types of MPs：polyethylene（PE），polypropylene（PP），polystyrene（PS），polyester（PES），polyethylene terephthalate（PET），polyvinyl chloride （PVC），rayon（RY），polyacrylonitrile（PAN），and polyamide（PA）. The abundance gradient of soil MPs in different regions was as follows：South-central region > Northwest region > Southwest region > East China region > North China region > Northeast region. The（semi-）transparent（27.6%），fragmented（32.2%），0.01~0.5 mm（66.3%），and PE （37%）types of MPs had the highest detection rates. The characteristics of soil MPs are the result of natural environmental factors（temperature，precipitation，soil pH，organic carbon）and social factors（permanent population，gross regional product per capita，gross industrial product per capita，cultivated land area per capita）. © 2025 Science Press. All rights reserved.

关键词： Polyvinyl chlorides

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固体火箭发动机无损检测图像质量研究

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推进技术 2001年第4期22卷 345-348页

作者：刘海峰杨兴根海军航空工程学院机械工程系山东烟台264001

详细介绍了在利用工业CT进行固体火箭发动机无损检测中 ,提高图像质量方面的几点尝试———光轴对准、提高系统的信噪比、提高探测器效率、采用合适的硬滤手段和选用适当的图像滤波函数。给出了测试数据和处理前后的图像比较。上述几点... 详细信息

详细介绍了在利用工业CT进行固体火箭发动机无损检测中 ,提高图像质量方面的几点尝试———光轴对准、提高系统的信噪比、提高探测器效率、采用合适的硬滤手段和选用适当的图像滤波函数。给出了测试数据和处理前后的图像比较。上述几点尝试收到了较好的处理效果。

关键词：固体推进剂火箭发动机 X射线检验无损检测工业CT 图像质量光轴对准信噪比探测器硬滤手段图像滤波函数 ICT设备

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坚强内固定在颧骨骨折治疗中的应用

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上海口腔医学 2003年第1期12卷 69-70页

作者：孟海峰杨刚岭山东省滨州市人民医院口腔颌面外科山东滨州256610

目的采用坚强内固定技术治疗颧骨骨折,使颧骨骨折病人有效恢复面部外形及功能。方法本组16例颧骨及复合骨折的病人,对开放性的颧骨骨折采用软组织开放创口手术进路,闭合性骨折采用口内前庭沟黏膜切口、眉弓外三分之一切口联合睑缘下切口... 详细信息

目的采用坚强内固定技术治疗颧骨骨折,使颧骨骨折病人有效恢复面部外形及功能。方法本组16例颧骨及复合骨折的病人,对开放性的颧骨骨折采用软组织开放创口手术进路,闭合性骨折采用口内前庭沟黏膜切口、眉弓外三分之一切口联合睑缘下切口,充分暴露骨折线,使颧骨各断端达到解剖复位。选用适合的微型钛板在颧牙槽嵴、颧额缝及眶下缘处行坚强内固定。结果本组16例病人15例一期愈合,经3～6个月复查,外形及功能恢复良好。1例开放骨折的病人,术后伤口感染,经治疗伤口二期愈合;另1例并发颧弓骨折的病人,术后轻度张口受限。结论采用坚强内固定技术治疗颧骨骨折,可以有效地恢复病人的外形及口腔功能。

关键词：坚强内固定颧骨骨折治疗开放性闭合性微型钛板

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-feng Wang Wen-Jie Shi Yu-Xin yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

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High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-Ming Wu Lin He Lin-Sen Ye Xiao-feng yang Jia-Jia Zhang Hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

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Constructing quasi-2D perovskite to collect hot carriers to reduce open-circuit voltage loss for efficient inverted perovskite solar cells

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Science China Chemistry 2025年

作者： Lei Gu Xing Li Chao Wu yang feng Chunming yang Lin Song Frontiers Science Center for Flexible Electronics Institute of Flexible Electronics Northwestern Polytechnical University Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences

Inverted perovskite solar cells （PSCs） have received great attention owing to the high certificated power conversion efficiency（PCE） reaching 26.7%. However, interfacial charge recombination is far superior to perovskite bulk charge recombination due to the use of fullerenes and their derivatives in inverted perovskite solar cells, which induces devastating open circuit voltage（VOC） losses. For this reason the present work attempts to use 4-chloropiperidine hydrochloride for the upper surface modification of perovskite to construct a quasi-two-dimensional （2D） structure with suitable 2D layer widths （n=2, 3 dominant）,which has a smaller electron carrier transport barrier without sacrificing short-circuit current （JSC） in the device. This strategy effectively passivates the interfacial defect states while promoting energy level alignment to achieve carrier dissociation and equilibrium transport at the interface, which in turn resulted in improved fill factor （FF）. In addition, additional energy levels are provided by 2D perovskites to collect hot carriers, resulting in improved device open circuit voltage （VOC）. As a result, the device PCE increases from 22.37%to 24.11%after the 4CPD treatment. In addition, the 4CPD-treated PSCs maintain 90%of the initial PCE after storage in an N2atmosphere at 50°C for 1,080 h, whereas the control devices show a 15%PCE loss under the same aging conditions. This work provides new opportunities to suppress interfacial charge recombination in inverted devices.

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师范院校合并升格背景下的教师教育者专业困境——以一所地方新建本科院校为例

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教师教育研究 2018年第1期30卷 95-102页

作者：宋萑冯海洋李子建教育部普通高校人文社会科学重点研究基地北京师范大学教师教育研究中心北京100875 北京师范大学承德附属学校河北承德067000 香港教育大学

教师教育者的专业化已成为必然趋势,然而国内外对教师教育者的相关研究却明显不足。因此,本文以生态取向的教师专业发展理论为研究视角,采用质性研究方法,对教师教育者的教学工作状态及其影响因素进行了探究。本文以X学院为个案,运用访... 详细信息

教师教育者的专业化已成为必然趋势,然而国内外对教师教育者的相关研究却明显不足。因此,本文以生态取向的教师专业发展理论为研究视角,采用质性研究方法,对教师教育者的教学工作状态及其影响因素进行了探究。本文以X学院为个案,运用访谈、观察、实物收集等技术方法收集资料,采用扎根理论三级编码的方式进行分析。研究发现:教师教育者处于职业倦怠和情绪劳动的状态中,其原因包括,学生出于市场化的要求而选择不配合;学校对教师教育者缺乏支持;教师文化不良。其背后是:教师教育者的情绪劳动与倦怠中的身份转型困境;中师升格的"量质落差";市场化进程中"变"与"不变"的冲突;高校管理中"收"与"放"的权衡。

关键词：专业困境情绪劳动教师教育者身份建构高校—市场—国家共力

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Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： Hua Gao Yunfeng Zhang Menglei Wang Ruoxuan yang Shuai feng Xuan Cao Yaping Zhang Zhongyuan Lu Yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Redox reactions

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高频超声与核磁共振成像在交叉韧带损伤诊断中的比较

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临床医学研究与实践 2018年第2期3卷 132-133页

作者：冯海洋冯海军延川县人民医院陕西延安717200

目的分析探讨高频超声检查与核磁共振成像(MRI)用于交叉韧带损伤中的诊断价值。方法选择我院2015年12月至2016年12月收治的67例交叉韧带损伤患者为研究对象,所有患者均采用高频超声检查和MRI检查,将两种方法的检测结果与关节镜检测结果... 详细信息

目的分析探讨高频超声检查与核磁共振成像(MRI)用于交叉韧带损伤中的诊断价值。方法选择我院2015年12月至2016年12月收治的67例交叉韧带损伤患者为研究对象,所有患者均采用高频超声检查和MRI检查,将两种方法的检测结果与关节镜检测结果进行比较。结果以关节镜检测结果为标准,高频超声诊断检测准确率为97.01%,MRI检测准确率为100.00%,组间比较,无显著差异(χ~2=2.03,P>0.05)。结论高频超声诊断与MRI用于诊断前后交叉韧带损伤均具有较高的诊断准确率,但是高频超声诊断操作方便,临床实用性更高,可以作为临床常规诊断交叉韧带损伤的首选方法使用。

关键词：高频超声核磁共振成像韧带损伤

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