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产程中子宫收缩的监测

中国实用妇科与产科杂志 2024年第2期40卷 147-150页

作者：张盼盼周玮重庆医科大学附属妇女儿童医院/重庆市妇幼保健院重庆401147

产程中子宫收缩的监测对分娩进展及母儿安全至关重要。子宫收缩的启动和产程中持续规律的宫缩由激素、机械和电活动等综合作用形成,其机制复杂,影响因素较多,尚未完全阐明。目前,临床上常用的子宫收缩监测方法还存在很多不足和争议,产... 详细信息

产程中子宫收缩的监测对分娩进展及母儿安全至关重要。子宫收缩的启动和产程中持续规律的宫缩由激素、机械和电活动等综合作用形成,其机制复杂,影响因素较多,尚未完全阐明。目前,临床上常用的子宫收缩监测方法还存在很多不足和争议,产科医务人员和孕产妇需要无创、简便、准确的子宫收缩监测手段。文章就该领域近年来的研究成果做一阐述,从临床角度和生理角度探讨子宫收缩的监测及未来的研究方向,并指导临床实践。

关键词：子宫收缩宫缩压力监测宫内压力导管子宫肌电图

One-year status of hepatic venous pressure gradient measurement from 85 hospitals in China

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Portal Hypertension & Cirrhosis 2024年第2期3卷 116-123页

作者： Jitao Wang Ting Cui Linpeng zhang Zhiping Yan Lei Li Jinjun Chen Junhui Sun Hua Xiang He Zhu Hao Wu Jiancuo Gengzang Feng zhang wei Wu Guohong Cao Wuhua Guo haibin Shi Hui Xue Guangjun Huang Qiang Yu Meng Niu Huiling Xiang Derun Kong wei Gou Xuefeng Luo Fuliang He Min Yuan wei Liu Yong Wang Hongjie Hu Xiaoli Zhu Tao Yu Qinxue Sun wei Qu Ting Lu Deqiang Ma Li zhang Jun Ma Jun Yang Ketao Mu Xiaoliang Zhu Kai Xiong Huiguo Ding Shengjuan Yao Mingsheng Huang Fang Wang Zexin Wang Yong Huang Jianan Li Hongfeng Yi Birun Huang Zhongwei Zhao Duiping Feng Yanming Lei Changlong Hou Wenbo Guo Shirong Liu Gaojun Teng Kangshun Zhu Fan Wu Xiaogang Hu Wenfeng zhang Shaoqi Yang Zhouchao Hu Pengfei Pang Shaowu Zhuang weidong Wang Qingliang Zhu Kunpeng zhang Chengyu Liu Dongliang Li Chao Ma Hong Jiang Xingong Zhao weixin Ren Zhiwei Wang Lei Yu Fuhuang Lin Chaoguang Yan Feng Wang Lei Yu Hui Huan Wenyong Shen Shaofei He Chengda zhang Jinlun Bao Jiangtao Liu Jun Wu Jianbo Zhao Jian zhang Xiaolong Qi Hebei Provincial Key Laboratory of Cirrhosis&Portal Hypertension Xingtai People's HospitalXingtaiHebeiChina Center of Portal Hypertension Department of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuChina Department of Interventional Therapy Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijingChina Department of Intervention Taiyuan Third People's HospitalTaiyuanShanxiChina Department of Intervention Zhongshan Hospital Affiliated to Fudan UniversityShanghaiChina Department of Interventional Medicine The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Infectious Diseases Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdongChina Hepatobiliary and Pancreatic Intervention Center The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangChina Interventional Vascular Surgery Hunan Provincial People's HospitalChangshaHunanChina Department of Intervention Sixth People's Hospital of ShenyangShenyangLiaoningChina Department of Gastroenterology West China Hospital of Sichuan UniversityChengduSichuanChina Department of Intervention The Fourth People's Hospital of Qinghai ProvinceXiningQinghaiChina Department of Gastroenterology Nanjing Drum Tower HospitalNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Radiology Shulan(Hangzhou)HospitalHangzhouZhejiangChina Department of Intervention Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouFujianChina Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Department of Interventional Radiology Fifth Medical Center

Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in *** article aimed to investigate the status of hepatic venous pressure gradient measurement in China in ***:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online *** counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in ***:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured *** average cost of HVPG measurement was 5646.8±2327.9 *** the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy ***:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this *** is still necessary to continue promoting and popularizing this technology in the future.

关键词： application status hepatic vein pressure gradient questionnaire survey

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废弃玻璃粉风积沙混凝土柱抗震性能试验研究

世界地震工程 2024年第2期40卷 45-54页

作者：王尧鸿张宇姜丽云李志强董伟张巍内蒙古工业大学土木工程学院内蒙古呼和浩特010051 内蒙古自治区土木工程结构与力学重点试验室内蒙古呼和浩特市010051 石河子大学石河子大学水利建筑工程学院新疆石河子832003 内蒙古科技大学土木工程学院内蒙古包头014010 内蒙古电力(集团)有限责任公司巴彦淖尔供电分公司内蒙古巴彦淖尔015000

为研究玻璃粉等质量取代20%水泥与风积沙等质量取代30%天然砂对混凝土柱抗震性能的影响,本文设计和制作4根混凝土柱试件。第1根是普通混凝土柱,第2根是玻璃粉等质量取代20%水泥的混凝土柱,第3根是风积沙等质量取代30%河砂的混凝土柱,第... 详细信息

为研究玻璃粉等质量取代20%水泥与风积沙等质量取代30%天然砂对混凝土柱抗震性能的影响,本文设计和制作4根混凝土柱试件。第1根是普通混凝土柱,第2根是玻璃粉等质量取代20%水泥的混凝土柱,第3根是风积沙等质量取代30%河砂的混凝土柱,第4根是同时用玻璃粉和风积沙分别等质量取代20%水泥和30%河砂的混凝土柱。通过低周往复荷载试验,对比分析各个试件的破坏形态、承载力、滞回性能、骨架曲线、耗能能力、延性系数、刚度退化规律和变形特点。结果表明:20%取代率的玻璃粉取代水泥和30%取代率的风积沙取代天然河砂均能提高混凝土柱的抗震性能,降低构件破坏程度;基于试验结果、Fajfar和Park-Ang提出的地震损伤模型,对其耗能因子β进行修正,得到了修正后的Park-Ang损伤模型,并与废弃玻璃粉风积沙混凝土柱的试验过程吻合较好。

关键词：玻璃粉风积沙混凝土柱抗震性能损伤模型

Establishment of a Multiplex Detection Method for Common Bacteria in Blood Based on Human Mannan-Binding Lectin Protein-Conjugated Magnetic Bead Enrichment Combined with Recombinase-Aided PCR Technology

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Biomedical and Environmental Sciences 2024年第4期37卷 387-398页

作者： ZHAO Zi Jin CHEN Xiao Ping HUA Shao wei LI Feng Yu ZHAO Meng XING Chen Hao WANG Jie TIAN Feng Yu zhang Rui Qing LYU Xiao Na HAN Zhi Qiang WANG Yu Xin LI Hong Yi SHEN Xin Xin MA Xue Jun TIE Yan Qing Graduate School Hebei North UniversityZhangjiakou 075000HebeiChina Department of Clinical Laboratory Hebei General HospitalShijiazhuang 050051HebeiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases NHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Clinical Laboratory Pathology Diagnostic Center Shiyan General HospitalShiyan 442000HubeiChina Graduate School Hebei Medical University Shijiazhuang 050031HebeiChina

Objective Recombinase-aided polymerase chain reaction(RAP)is a sensitive,single-tube,two-stage nucleic acid amplification *** study aimed to develop an assay that can be used for the early diagnosis of three types of bacteremia caused by Staphylococcus aureus(SA),Pseudomonas aeruginosa(PA),and Acinetobacter baumannii(AB)in the bloodstream based on recombinant human mannanbinding lectin protein(M1 protein)-conjugated magnetic bead(M1 bead)enrichment of pathogens combined with *** Recombinant plasmids were used to evaluate the assay *** blood influenza bacteria were used for the specific *** and clinical plasma samples were enriched with M1 beads and then subjected to multiple recombinase-aided PCR(M-RAP)and quantitative PCR(qPCR)*** analysis was used to evaluate the consistency between the two *** The M-RAP method had sensitivity rates of 1,10,and 1 copies/μL for the detection of SA,PA,and AB plasmids,respectively,without cross-reaction to other bacterial *** M-RAP assay obtained results for<10 CFU/mL pathogens in the blood within 4 h,with higher sensitivity than qPCR.M-RAP and qPCR for SA,PA,and AB yielded Kappa values of 0.839,0.815,and 0.856,respectively(P<0.05).Conclusion An M-RAP assay for SA,PA,and AB in blood samples utilizing M1 bead enrichment has been developed and can be potentially used for the early detection of bacteremia.

关键词： Staphylococcus aureus Pseudomonas aeruginosa Acinetobacter baumannii Human Mannan-binding lectin protein Bloodstream infection Recombinase-aided PCR assay Multiple detection

Influence of Mass Ratio of Resin and Stabilizer on Mechanical Properties of Mo Fiber-reinforced Granite Polymer Composite

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 912-920页

作者：张超任秀华 BA Dongzhe zhang Jianhua LI Jianyong GUO Mengnan GAO Yinghao WANG Guixin LI Jiayang School of Mechanical and Electronic Engineering Shandong Jianzhu UniversityJinan 250101China Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of Education of ChinaSchool of Mechanical EngineeringShandong UniversityJinan 250061China

Because inferior mechanical strength of granite polymer composite(GPC)has become the main drawback limiting its application and popularization,Mo fibers were added into(GPC)to improve its mechanical *** properties of matrix materials with different mass ratio of resin and stabilizer(MRRS)were investigated *** influences of MRRS on interface bonding strength of Mo fiber-matrix,wettability and mechanical strength of GPC were discussed,respectively,and the theoretical calculation result of MRRS k was obtained,with the optimal value of k=*** k=4,tensile strength,tensile strain and fracture stress of the cured resin achieve the maximum *** for k=7,the corresponding values reach the *** the increase of MRRS k,surface free energy of the cured resin first increases and then decreases,while contact angles between Mo sample and matrix have displayed the opposite *** of resin to Mo fiber is the best at k=*** load of Mo fiber and interface bonding strength appear the maximum at k=4,followed by k=5,k=3 the third,and k=7 the *** k=4,mechanical properties of Mo fiber-reinforced GPC are optimal,which is consistent with the result of theoretical *** study is of great significance to get better component formulas of Mo fiber reinforced GPC and to improve its application in machine tools.

关键词： polymer composite fiber mechanical strength interface bonding

Microphase Separation Behavior on the Surfaces of Poly（dimethylsiloxane）-block-poly（2,2,3,3,4,4,4-heptafl-uorobutyl methacrylate） Diblock Copolymer Coatings

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Microphase Separation Behavior on the Surfaces of Poly（dime...

Evolutionary Diversity of Coxsackievirus A6 Causing Severe Hand,Foot,and Mouth Disease—China,2012-2023

2010年全国高分子材料科学与工程研讨会

作者： Zheng-Hong Luo~*,hai-Jiang Yu,wei zhang (Department of Chemical and Biochemical Engineering,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,P R China

＜正＞Microphase separation behavior on the surfaces of poly（dimethylsiloxane）-block-poly （2,2,3,3,4,4,4-heptafluorobutyl methacrylate）（PDMS-b-PHFBMA） diblock copolymer coatings was *** PDMS-b-PHFBMA diblock copolymers were successfully synthesized via atom transfer radical polymerization（ATRP）.The chemical structure of the copolymers was characterized by nuclear magnetic resonance（NMR） and Fourier transform infrared（FTIR） *** composition was studied by X-ray Photoelectron Spectroscopy（XPS）.Copolymer microstructure was investigated by atomic force microscopy（AFM）.The microstructure observations show that well organized phase-separated surfaces consist of hydrophobic domain from PDMS segments and more hydrophobic domain from PHFBMA segments in the *** increase of the PHFBMA content can strengthen the microphase separation behavior in the PDMS-b-PHFBMA diblock *** the increase of the annealing temperature can also strengthen the microphase separation behavior in the PDMS-b-PHFBMA diblock ***, Flory-Huggins thermodynamic theory was preliminarily used to explain the microphase separation behavior in the PDMS-b-PHFBMA diblock copolymers.

关键词： Microphase separation behavior PDMS-b-PHFBMA Flory-Huggins thermodynamic theory

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China CDC weekly 2024年第20期6卷 442-449页

作者： Huanhuan Lu Jinbo Xiao Wenhui Wang Dongmei Yan Tianjiao Ji Qian Yang haiyan wei Yanhua Du Yunting Zeng Jun Guo Jianhua Chen Hanri Zeng Yingying Liu Shuaifeng Zhou Hong Ji Jianxing Wang Xiaofang Zhou Yong zhang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases World Health Organization Polio Reference Laboratory for the Western Pacific RegionKey Laboratory of Laboratory BiosafetyNational Health and Key Laboratory of Laboratory Biosafety of the National Health CommissionNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Linyi Center for Disease Control and Prevention Linyi CityShandong ProvinceChina Henan Provincial Center for Disease Control and Prevention Zhengzhou CityHenan ProvinceChina Shaanxi Provincial Center for Disease Control and Prevention Xi’an CityShaanxi ProvinceChina hainan Provincial Center for Disease Control and Prevention Haikou CityHainan ProvinceChina Guizhou Provincial Center for Disease Control and Prevention Guiyang CityGuizhou ProvinceChina Gansu Provincial Center for Disease Control and Prevention Lanzhou CityGansu ProvinceChina Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Hunan Provincial Center for Disease Control and Prevention Changsha CityHunan ProvinceChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina Shandong Provincial Center for Disease Control and Prevention Jinan CityShandong ProvinceChina Yunnan Provincial Center for Disease Control and Prevention Kunming CityYunnan ProvinceChina

Introduction:Coxsackievirus A6(CVA6)has emerged as a significant pathogen responsible for severe cases of hand,foot,and mouth disease(HFMD).This study aims to delineate the demographic characteristics and analyze the viral evolution of severe HFMD associated with CVA6,thereby assisting in its surveillance and ***:In this investigation,74 strains of CVA6 were isolated from samples collected from severe HFMD cases between 2012 and *** VP1 gene sequences of CVA6 were amplified and analyzed to assess population historical dynamics and evolutionary characteristics using BEAST,DnaSP6,and ***:A significant portion(94.4%)of severe CVA6-associated HFMD cases(51 out of 54,with 20 lacking age information)were children under 5 years *** the 74 CVA6 strains analyzed,72 belonged to the D3a sub-genotype,while only two strains were D2 *** average genetic distance between VP1 sequences prior to 2015 was 0.027,which increased to 0.051 when compared to sequences *** population dynamics analysis indicated three significant population expansions of severe CVA6-associated HFMD during 2012-2013,2013-2014,and 2019-2020,resulting in the formation of 65 distinct *** with the MCC tree findings,transitioning between regional haplotypes required multiple base substitutions,showcasing an increase in population diversity during the evolutionary process(from 14 haplotypes in 2013 to 55 haplotypes over the subsequent decade).Conclusions:CVA6,associated with severe HFMD,is evolving and presents a risk of outbreak ***,enhanced surveillance of severe HFMD is imperative.

关键词： thereby subsequent finding

基于低碳出行方式的西安市本地居民景点可达性研究

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科技通报 2024年第7期40卷 75-82页

作者：刘娜张海西安交通工程学院交通运输学院西安710300

本文以西安市为研究区,选取了19个4A级及以上旅游景点,基于ArcGIS平台可达性计算的网络分析方法,对比分析了“公交+共享单车+步行”和“地铁+公交+共享单车+步行”2种低碳出行方式下居民到达旅游景点以及从景点到另一景点的平均时间、... 详细信息

本文以西安市为研究区,选取了19个4A级及以上旅游景点,基于ArcGIS平台可达性计算的网络分析方法,对比分析了“公交+共享单车+步行”和“地铁+公交+共享单车+步行”2种低碳出行方式下居民到达旅游景点以及从景点到另一景点的平均时间、最短时间、可达性系数及优化率。研究表明:加入地铁后居民小区到景点的平均时耗由95.7 min降低至80.2 min,其中10个旅游景点可达性较好,5A级旅游景点可达性优化率达12.57%;景点与景点间中转的平均最短时耗为46 min,其中有5个景点的平均可达时间在25 min以内,整体景点在空间上的关联逐渐紧密,景点的综合可达性普遍提升。

关键词：西安轨道交通旅游景点低碳出行交通可达性

Fanlian Huazhuo Formula alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway

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World Journal of Gastroenterology 2024年第30期30卷 3584-3608页

作者： Meng-Yuan Niu Geng-Ting Dong Yi Li Qing Luo Liu Cao Xi-Min Wang Qi-Wen Wang Yi-Ting Wang Zhe zhang Xi-Wen Zhong wei-Bo Dai Le-Yu Li Pharmacology Laboratory Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina Department of Endocrinology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina

BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging *** has been identified to have therapeutic effects on type 2 diabetes mellitus(T2DM)in clinical ***-alcoholic fatty liver disease(NAFLD)is frequently diagnosed in patients with ***,the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further *** To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo and in *** HepG2 cells were treated with free fatty acid for 24 hours to induce lipid accumulation cell ***,experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 24 hours.C57BL/6 mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD,and then treated with the different concentrations of FLHZF for 10 *** FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo and in *** experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress,regulating the AMPKα/SREBP-1C signaling pathway,activating autophagy,and inhibiting hepatocyte *** FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species,autophagy,apoptosis,and lipid synthesis signaling pathways,indicating its potential for clinical application in NAFLD.

关键词： Fanlian Huazhuo Formula Nonalcoholic fatty liver disease Autophagy Apoptosis AMPKα/SREBP-1C signal pathway Oxidative stress