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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 17-18页

作者： hagemans m.l.c. Winkel l.P.F. Van Doorn P.A. A.T. Van Der Ploeg 郭俊 Erasmus mc-Sophia Dr Molewaterplein 60 3015 GJ Rotterdam Netherlands Dr.

late-onset Pompe’s disease (acid maltase deficiency, glycogen storage diseas e type II) is a slowly progressive myopathy caused by deficiency of acid α-glu cosidase. current developments in enzyme replacement therapy require detailed kn owledge of the kind and severity of symptoms and the natural course of the disea se in the patient population.A detailed questionnaire covering the patients’med ical history and current situation was developed and information was gathered fr om 54 Dutch patients. The mean age of the participants was 48.6 ±15.6 *** first complaints started at a mean age of 28.1±14.3 years and were mostly rela ted to mobility problems and limb-girdle weakness. Fifty-eight percent of the adult patients indicated the presence of mild muscular symptoms during childhood . Twenty-eight percent of the patients waited > 5 years for the final diagnosis after the first visit to a physician for disease related complaints. At the tim e of questionnaire completion,48%of the study population used a wheelchair and 37%used artificial *** such as rising from an armchair,taking stairs or getting upright after bending over were difficult or impossible for m ore than two-thirds of the *** age at onset, the rate of disease pr ogression and the sequence of respiratory and skeletal muscle involvement varied substantially between patients. Seventy-six percent of the participants indica ted being troubled by fatigue and 46%by pain. This survey has mapped the age at onset, presenting symptoms, heterogeneity in progression and range of disease s everity in a large group of Dutch patients. We conclude that early manifestation s in childhood require proper attention to prevent unnecessary delay of the diag nosis. The follow-up of patients with late-onset Pompe’s disease should focus on respiratory and limb-girdle muscle function, the capacity to perform daily activities, and the presentation of fatigue and pain.

关键词： Pompe 酸性麦芽糖酶糖原贮积病问卷反馈 α-葡萄糖苷酶发病年龄肌病首次就诊缺乏症疼痛情况

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庞贝病成年和儿童患者的病情与年龄和病程相关

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 57-57页

作者： hagemans m.l.c. Winkel l.P.F. Hop W.c.J. A.T. Van Der Ploeg 张琪 Erasmus mc-Sophia Dr. Molewaterplein 60 3015 GJ Rotterdam Netherlands Dr.

Information about 255 children and adults with Pompe disease was gathered thr ough a questionnaire. Disease severity was associated with disease duration and not with age; an early manifestation of the disease implied earlier wheelchair o r ventilator dependency. The patient group under age 15 included a subgroup with a more severe and rapid course of the disease. They require more intensive foll ow- up and early intervention, before irreversible damage has occurred.

关键词：庞贝亚组呼吸机依赖问卷调查

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Spent coffee grounds as a renewable source of energy: An analysis of bulk powder flowability

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Particuology 2019年第2期17卷 92-100页

作者： l. massaro Sousa m.c. Ferreira Drying center for Pastes Suspensions and Seeds. Chemical Engineering Department Federal University of Sao Carlos. P.O. Box 676 13565-905 Sao Carlos Brazil

The main use for spent coffee grounds (ScG) produced in the soluble coffee industry is thermal energy generation in the industry itself. The ScG are processed using operations that are strongly dependent on powder flow behavior. In this study, we evaluated two classical flowability in dices of non-consolidated ScG powders: the angle of repose (AoR), and the Hausner ratio (HR). The influences of the mean particle diameter, particle size distribution (PSD), and water content on the AoR and HR values of ScG were analyzed for powders with a mean particle size range of 225-550 μm. For powders with a mean particle size close to 350 μm and for mixtures containing more than 40% fine particles, the HR (>1.35) and AoR (>45 °) values were characteristic of poor flowability. The AoR was sensitive to the powder PSD, and powders with similar mean particle sizes had higher AoR values when the PSD was larger. For powders w让h water contents up to 50%, the flowability indices were not greatly affected by the water content. A modified linear-mixture packing model was used to predict the packed bed void fractions for binary and ternary mixtures of the three base powders. The model was used to construct a ternary diagram to estimate the HR values of the mixtures. An equation was fitted to correlate HR and AoR. The proposed diagram and the equation provide insight into flow behavior and could be used for process design of industrial plants that handle ScG.

关键词： Spent coffee ground Biomass Flowability Hausner ratio Angle of repose

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Artificial Intelligence Based Smart Routing in Software Defined Networks

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computer Systems Science & Engineering 2023年第2期44卷 1279-1293页

作者： c.Aswini m.l.Valarmathi Department of Information Technology Government College of TechnologyCoimbatore641013India Department of computer Science and Engineering Dr.Mahalingam College of Engineering and TechnologyPollachi642003India

In a non-static information exchange network,routing is an overly com-plex task to perform,which has to satisfy all the needs of the *** Deﬁned Network(SDN)is the latest and widely used technology in the future communication networks,which would provide smart routing that is visible *** various features of routing are supported by the information centric network,which minimizes the congestion in the dataﬂow in a network and pro-vides the content awareness through its mined *** to the advantages of the information centric network,the concepts of the information-centric net-work has been used in the paper to enable an optimal routing in the software-deﬁned *** there are many advantages in the information-centric network,there are some disadvantages due to the non-static communication prop-erties,which affects the routing in *** this regard,artiﬁcial intelligence meth-odology has been used in the proposed approach to solve these difﬁculties.A detailed analysis has been conducted to map the content awareness with deep learning and deep reinforcement learning with *** novel aligned internet investigation technique has been proposed to process the deep reinforcement *** performance evaluation of the proposed systems has been con-ducted among various existing approaches and results in optimal load balancing,usage of the bandwidth,and maximization in the throughput of the network.

关键词： content aware routing software deﬁned networks deep learning load balancing

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Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： c.Y.morassuti A.P.l Silva l.A.O.Nunes S.m.lima l.H.c.Andrade Optical and Photothermal Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of São carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical thermometry Judd-Ofelt Rare earths

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THE EFFEcT OF BORON AND cARBON ADDITION ON WElDABIlITY OF DS TmS-75 SUPERAllOY

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Acta metallurgica Sinica(English letters) 2005年第1期18卷 24-32页

作者： m.c. chaturvedi N.l. Richards Department of mechanical and Industrial Engineering University of manitoba Winnipeg Manitoba R3T 5V6 CanadaDepartment of Mechanical and Industrial Engineering University of Manitoba Winnipeg Manitoba R3T 5V6 Canada

Four alloys TmS-75 (Base), Base+B, Base+c and TmD-103 (Base+B+c) with varying levels of B, c were directionally solidified (DS), and their weldability was investigated by bead-on-plate electron beam welding. It was found that cracking occurred in the weld-metal, as well as in the heat affected zone (HAZ). Both γ/γ' and/or γ/carbide eutectic contributed to the weld-metal cracking, and the γ/γ' eutectic was found to be mainly responsible for cracking in HAZ. However, constitutional liquation of carbides seems to have made some contribution also. The B addition had a detrimental effect on HAZ cracking susceptibility, while c addition improved it appreciably even in the presence of B. In addition, no obvious differences were observed in cracking susceptibility of weld-metal in the four alloys. The cracking modes and mechanisms underlying the effect of B and c addition on weldability could be explained on the basis of microstructures of the four alloys.

关键词： Ni-based superalloy low melting point constituents liquation cracking

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How can the neutrino interact with the electromagnetic field？

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chinese Physics c 2018年第1期42卷 23-31页

作者： m.Novello c.E.l.Ducap centro Brasileiro de Pesquisas Fisicas (cEAc/cBPF) Rua Dr. Xavier Sigaud 150 CEP 22290-180 Rio de Janeiro Brazil

maxwell electrodynamics in the fixed minkowski space-time background can be described in an equivalent way in a curved Riemannian geometry that depends on the electromagnetic field and that we call the electromagnetic metric（e-metric for short）. After showing such geometric equivalence we investigate the possibility that new processes dependent on the e-metric are allowed. In particular, for very high values of the field, a direct coupling of uncharged particles to the electromagnetic field may appear.

关键词： neutrino electromagnetic field effective metric

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ImPROVING THE mEcHANIcAl PROPERTIES OF cOPPER AllOYS BY THERmO-mEcHANIcAl PROcESSING

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Acta metallurgica Sinica(English letters) 2004年第2期17卷 111-117页

作者： m.c.Somani l.P.Karjalainen Department of mechanical Engineering University of Oulu90014 OuluFinlandDepartment of Mechanical EngineeringUniversity of Oulu90014 OuluFinland

Systematic physical simulation of thermo-mechanical processing routes has been ap-plied on a Gleeble 1500 simulator to four copper alloys (mass %) cu-0.57co-0.32Si,cu-0.55cr-0.065P, cu-0.22Zr-0.035Si and cu-1.01Ni-0.43Si aimed at clarifying theinfluences of processing conditions on their final properties, strength and electricalconductivity. Flow curves were determined over wide temperature and strain rateranges. Hardness was used as a measure of the strength level achieved. High hard-ness was obtained as using equal amounts (strains 0.5) of cold deformation beforeand after the precipitation annealing stage. The maximum values achieved for thecu-co-Si, cu-cr-P, cu-Zr-Si and cu-Ni-Si alloys were 190, 165, 178 and 193 HV5,respectively. A thermo-mechanical schedule involving the hot deformation-ageing-colddeformation stages showed even better results for the cu-Zr-Si alloy. consequently,the processing routes were designed based on simulation test results and wires of 5 and2mm in diameters have been successfully processed in the industrial scale.

关键词： copper allys thermo-mechanical processing ageing strength flow stress hardness

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Analysis and design of axially loaded piles in rock

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Journal of Rock mechanics and Geotechnical Engineering 2019年第3期11卷 535-548页

作者： c.m.Haberfield A.l.E.lochaden Golder Associates Pty.ltd. MelbourneAustralia

Despite significant advancements in in situ test techniques,construction practices,understanding of rock joint and rock mass behaviours,and numerical analysis methods,the design of bored concrete cast-insitu piles in rock is still largely based on the assessment of bearing ***,for many of the rock conditions encountered,the bearing capacity of piles is a nebulous concept and a figment of the designer’s *** if it can be reasonably quantified,it has little,if any,significance to the performance of a pile in *** load carrying capacity of even low strength rock(in most situations)is far in excess of the strength of the structure(for example,a building column)transmitting the *** performance of a pile in rock is usually a displacement issue and is a function of rock mass stiffness rather than rock mass *** addition,poor pile performance is much more likely to result from poor construction practices than excessive displacement of the rock *** occur for footings that are undermined,or where unfavourable structure in the rock allows movement towards a free surface to ***,codes of practices,reference books and other sources of design information should focus foundation design in rock on displacement rather than strength *** investigations should measure rock mass stiffness and defect properties,as well as intact rock *** paper summarises the fundamental concepts relating to performance of piles in rock and provides a basis for displacement focused design of piles in *** also presents comments relating to how piles are modelled in widely used commercial finite element software for soil-structure interaction analysis,within the context of the back-analysis of a pile load test,and proposes recommendations for pile analysis and design.

关键词： Pile design Pile analysis Pile load test Finite element analysis

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Effect of TiN Particles and Grain Size on the charpy Impact Transition Temperature in Steels

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Journal of materials Science & Technology 2012年第10期28卷 878-888页

作者： J.Du m.Strangwood c.l.Davis School of metallurgy and materials University of Birmingham

The toughness of ferritic steels is influenced by the grain size distribution, second phase, precipitates and coarse inclusions. In this work an examination of the effect of coarse TiN particles （〉0.5 μm） and ferrite grain size on the charpy impact transition temperature in high strength low alloyed steels has been carried out. Steels with high Ti content （up to 0.045 wt%）, have been heat-treated and furnace cooled to obtain a ferrite-pearlite microstructure with different ferrite grain sizes. coarse TiN particle size and ferrite grain size distributions have been measured and charpy impact testing has been carried out. Scanning electron microscopy （SEm） analysis has been used to measure the grain boundary carbide thickness and to determine if the coarse TiN particles are acting as cleavage initiation sites by fractographic analysis. The charpy ductile-brittle transition temperatures （DBTT） have been predicted using standard literature equations, and compared to the measured values. The relationship between the ferrite grain size and coarse TiN particle size and number density in terms of whether the coarse TiN particles act as effective cleavage initiation sites is discussed in this paper.

关键词： TiN particles Grain size charpy impact test Ductile-brittle transitiontemperatures (DBTT) Steels

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