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Prevalence of Helicobacter pylori infection among patients with esophageal carcinoma

World Journal of gastroenterology 2024年第29期30卷 3479-3487页

作者： Miriam López-gómez Maria Morales Rebeca Fuerte Marta Muñoz Pedro-David Delgado-López Jorge Francisco gómez-Cerezo Enrique Casado Department of Medical Oncology Precision Oncology LaboratoryInfanta Sofía University HospitalSan Sebastián de los Reyes 28231MadridSpain Department of Medical Oncology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain Department of Internal Medicine Infanta Sofía University HospitalSan Sebastián de los Reyes 28703MadridSpain Department of Pathology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain Department of Neurosurgery Burgos University HospitalBurgos 09006Spain Department of Internal Medicine Infanta Sofía University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain Department of Medical Oncology Infanta Sofia University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain

BACKgROUND Helicobacter pylori(***)is a widespread microorganism related to gastric adenocarcinoma(AC).In contrast,it has been reported that an inverse association exists between *** infection and esophageal *** mechanisms underlying this supposedly protective effect remain *** To determine the prevalence of *** infection in esophageal carcinoma patients,we performed a retrospective observational study of esophageal tumors diagnosed in our *** We retrospectively reviewed the prevalence of *** infection in a cohort of patients diagnosed with esophageal *** or previous proton pump inhibitor(PPI)usage was also *** A total of 89 patients with esophageal carcinoma(69 males,77.5%),with a mean age of 66 years(range,26-93 years)were *** was the most frequent pathological variant(n=47,52.8%),followed by squamous cell carcinoma(n=37,41.6%).Fourteen ACs(29.8%)originated in the gastroesophageal junction and 33(70.2%)in the esophageal ***,54 patients(60.7%)presented at stages III and *** *** infection occurred only in 4 patients(4.5%),3 with AC(6.3%of all ACs)and 1 with squamous cell carcinoma(2.7%of all squamous cell tumors).All patients with previous *** infection had stage *** one patient had received prior *** eradication therapy,whereas 86(96.6%)had received previous or concomitant PPI *** In our cohort of patients,and after histologic evaluation of paraffin-embedded primary tumors,we found a very low prevalence of previous *** *** also reviewed the medical history of the patients,concluding that the majority had received or were on PPI *** minimal prevalence of *** infection found in this cohort of patients with esophageal carcinoma suggests a protective role.

关键词： Helicobacter pylori Eradication Esophageal tumor Dysbiosis Proton pump inhibitors Carcinogenesis Microbiota Incidence

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Studies of polyol production by the yeast Yarrowia lipolytica growing on crude glycerol under stressful conditions

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Carbon Resources Conversion 2024年第3期7卷 17-31,F0004页

作者： Eleni-Stavroula Vastaroucha Nikolaos g.Stoforos george Aggelis Seraphim Papanikolaou Department of Food Science and Human Nutrition Agricultural University of Athens75 Iera Odos11855AthensGreece Unit of Microbiology Department of BiologyUniversity of Patras26504 Rio PatrasGreece

Crude glycerol,the principal by-product of biodiesel production process,was employed as substrate by three wild-type Yarrowia lipolytica strains(ACA-YC 5030,LMBF 20 and NRRL Y-323).Stressful conditions(low pH value=2.0±0.3,low incubation temperature T=20±1℃,non-aseptic conditions)were ***-esting production of yeast biomass and polyols(***,mannitol and arabitol)was noted at pH=2.0±0.3 and T=20±1℃.Strains failed to produce significant quantities of cellular lipid,while variable quantities of intra-cellular polysaccharides were *** under previously pasteurized media supported significant biomass and polyols production for most of the tested strains,while only one strain(NRRL Y-323),managed to produce polyols at media that were not previously thermally treated at *** production of mannitol was favored at low initial glycerol(glol0)concentrations,whereas higher glol0 quantities favored the biosynthesis of *** the strain NRRL Y-323,highly aerated/agitated bioreactor trials showed different physiological profiles as compared to the respective flask ***,in flask experiments with the strain NRRL Y-323 at high glol0 amounts(≈140 g/L)at low medium pH(=2.0±0.3),a significant production of polyols(=84.2 g/L)with the corresponding remarkable conversion yield on glycerol consumed=62%w/w was *** application:Renewable and biodegradable fuels,such as biodiesel,are safer and environmentally friendlier than the conventional petroleum *** is a cost-effective substrate obtained as the main side-product from biodiesel production process and is currently being employed in the realm of Industrial Microbi-ology and Biotechnology to produce metabolic products with added *** research focuses on using glycerol as a starting substrate for biotechnological conversions aiming at producing,amongst other compounds,polyols,microbial biomass,citric acid,*** selected strains of the generall

关键词： Biomass glycerol Polyols Yarrowia lipolytica

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Context-Aware Augmented Reality Using Human-Computer Interaction Models

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Journal of Control and Decision 2024年第1期11卷 1-14页

作者： Ying Sun Qiongqiong guo Shumei Zhao Karthik Chandran g.Fathima Henan intelligent education and intelligent technology application engineering technology research center Zhengzhou Railway Vocational and technical collegeZhengzhouHenanPeople’s Republic of China Henan Provincial Research Center of Wisdom Education and Intelligent Technology Application Engineering Technology Zhengzhou Railway Vocational and technical collegeZhengzhouHenanPeople’s Republic of China Department of Mechatronics Engineering Jyothi Engineering CollegeKeralaIndia CSE Adhiyamaan College of Engineering HosurTamilnaduIndia

Augmented Reality is a technique that allows users to overlap digital information with their physical *** Augmented Reality(AR)displays have an exceptional characteristic from the Human–Computer Interaction(HCI)*** to its increasing popularity and application in diverse domains,increasing user-friendliness and AR usage are ***-aware is one approach since an AR application can adapt to the user,environment,needs and enhance ergonomic principles and *** paper proposes the Intelligent Contextaware Augmented Reality Model(ICAARM)for Human–Computer Interaction *** study explores and reduces interaction uncertainty by semantically modeling user-specific interaction with context,allowing personalised *** information is captured from an AR device to understand user interactions and *** depictions carry semantics to Augmented Reality applications about the user’s intention to interact with a specific device ***,this study describes personalised gesture interaction in VR/AR applications for immersive/intelligent environments.

关键词： Augmented Reality Context-aware Human–Computer Interaction

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3D laparoscopy and fluorescence imaging can improve surgical precision for hepatectomy

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 544-547页

作者： Joshua Sheng Hao Lim Vishal g.Shelat Department of general Surgery Tan Tock Seng HospitalSingaporeSingapore

Laparoscopic hepatectomy for the treatment of hepatocellular carcinoma(HCC)has been shown to have superior short-term and comparable long-term outcomes compared with open hepatectomy in experienced centres(1).Short-term advantages include small incisions,reduced post-operative pain,faster recovery,reduced blood loss and lower risk of complications(2).However,the loss of tactile sensation makes it challenging to accurately locate lesions and define tumour margins.

关键词： 3D laparoscopy hepatocellular carcinoma(HCC) indocyanine green dye(ICg dye) liver resection

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Skeletal microstructures of cheilostome bryozoans(phylum Bryozoa,class gymnolaemata):crystallography and secretion patterns

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Marine Life Science & Technology 2024年第3期6卷 405-424页

作者： Christian grenier Erika griesshaber Wolfgang Schmahl Björn Berning Antonio g.Checa Departamento de Estratigrafía y Paleontología Universidad de Granada18071 GranadaSpain Instituto Andaluz de Ciencias de La Tierra CSIC-Universidad de Granada18100 ArmillaSpain Department of Earth and Environmental Sciences Ludwig-Maximilians Universität80333 MunichGermany Institute for geology University of Hamburg20146 HamburgGermany

gymnolaemata bryozoans produce CaCO3 skeletons of either calcite,aragonite,or *** extensive research,their crystallography and biomineralization patterns remain *** present a detailed study of the microstructures,min-eralogy,and crystallography of eight extant cheilostome species using scanning electron microscopy,electron backscatter diffraction,atomic force microscopy,and micro-computed *** distinguished five basic microstructures,three calcitic(tabular,irregularly platy,and granular),and two aragonitic(granular-platy and fibrous).The calcitic microstruc-tures consist of crystal aggregates that transition from tabular or irregularly platy to granular *** aragonite consists of fibers arranged into *** all cases,the crystallographic textures are axial,and stronger in aragonite than in calcite,with the c-axis as the fiber *** reconstruct the biomineralization sequence in the different species by considering the distribution and morphology of the growth fronts of crystals and the location of the secretory *** bimineralic species,calcite formation always predates aragonite *** interior compound walls,growth proceeds from the cuticle toward the zooecium *** conclude that,with the exception of tabular calcite,biomineralization is remote and occurs within a relatively wide extrapallial space,which is consistent with the inorganic-like appearance of the *** biomineralization mode is rare among invertebrates.

关键词： Biomineralization Bryozoan Skeleton Calcite Aragonite Electron backscatter diffraction

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Enhancing fault-clearing algorithm for renewable-energy-based distribution systems using artificial neural networks

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Clean Energy 2024年第5期8卷 97-116页

作者： Rania g.Mohamed M.A.Ebrahim Shady H.E.Abdel Aleem Electrical Engineering Department Institute of Aviation Engineering and TechnologyGiza12658Egypt Electrical Engineering Department Faculty of Engineering at ShoubraBenha UniversityCairo11629Egypt

Integrating small and large-scale photovoltaic(PV)solar systems into electrical distribution systems has become mandatory due to increased electricity bills and the concern for limiting greenhouse ***,the reliable and efficient operation of PV-based distribution systems can be confronted by the intermittence and high variability of solar sources and their consequential *** this regard,this article suggests a moderated fault-clearing strategy based on the incremental conductance–maximum power point tracking(IC–MPPT)technique and artificial neural networks(ANNs)to enhance fault detection,localization,and restoration pro-cesses in PV-based distribution *** proposed strategy leverages IC–MPPT to ensure optimal power generation from the PV solar system,even in the presence of *** tracking the maximum power point,the algorithm maintains the performance of the system and mitigates against the impact of faults on the output ***,an ANN is employed to improve fault detec-tion and localization *** developed ANN-based moderated fault-clearing strategy is trained using historical data and fault scenarios,enabling it to recognize fault patterns and make informed decisions through extensive simulations and comparisons with traditional fault-clearing *** accomplish this study,benchmarks in PV-based distribution systems are constructed and em-ployed using the MATLAB®/Simulink®software ***,to validate the efficacy of the developed ANN-based moderated fault-clearing strategy,a real case study of a 1-MW PV-based distribution system in an industrial field located in giza governorate,Egypt,is tested and *** obtained results demonstrate the effectiveness of the IC–MPPT and ANN-based moderated fault-clearing strategy in achieving faster fault detection,precise fault localization,and efficient restoration in PV solar-based dis-tribution systems while preserving maximum power extraction under small and larg

关键词： photovoltaic solar systems fault-clearing algorithm incremental conductance renewable energy artificial neural network maximum power point tracking

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Existing and emerging biomarkers in hepatocellular carcinoma:relevance in staging,determination of minimal residual disease,and monitoring treatment response:a narrative review

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 39-55页

作者： Dana A.Dominguez Paul Wong Laleh g.Melstrom Department of Surgical Oncology City of Hope National Medical CenterDuarteCAUSA University of California San FranciscoSan FranciscoCAUSA

Background and Objective:With the development of novel active systemic therapies,the landscape of hepatocellular carcinoma(HCC)management is rapidly ***,HCC lacks sensitive and specific biomarkers to predict prognosis,monitor for minimal residual disease after locoregional therapy,and predict treatment *** this review,we aim to summarize the best supporting evidence for refining existing,and development of novel biomarkers for staging,prognosis,determination of minimal residual disease and monitoring treatment response in HCC,focusing on those with evidence in clinical ***:PubMed and Embase databases were searched using the keywords;hepatocellular carcinoma,biomarker,minimal residual disease,surveillance,prognosis,staging,alpha-fetoprotein(AFP),liquid biopsy,treatment response,adjuvant,*** clinical studies were *** Content and Findings:AFP remains the major workhorse as the most widely used biomarker in HCC,however,its lack of wide applicability due to the high proportion of patients with HCC who are AFP negative,limits its value throughout all stages of HCC *** work has been done to combine AFP with other clinical and serologic factors to increase its accuracy and utility as a ***,it is likely that other more novel biomarkers such as those obtained through liquid biopsy will provide the prognostic power necessary for applications such as detecting recurrence and predicting treatment *** biopsy provides not only a wealth of potential biomarkers including circulating tumor cells and cell-free RNA/DNA,but also the ability to examine the mutational characteristics of the tumor with next generation *** early evidence supports the potential impact of many new biomarkers,validation in large clinical trials is ***:This review highlights the paucity of sensitive and specific,widely applicable biomarkers,throughout all phases of management of

关键词： Hepatocellular carcinoma(HCC) biomarker liquid biopsy alpha-fetoprotein(AFP)

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Lattice dynamics and thermoelectric properties of diamondoid materials

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Interdisciplinary Materials 2024年第1期3卷 5-28页

作者： Hongyao Xie Li‐Dong Zhao Mercouri g.Kanatzidis School ofMaterialsScienceand Engineering BeihangUniversityBeijingChina Department ofChemistry Northwestern UniversityEvanstonIllinoisUSA

The diamondoid compounds are a large family of important semiconductors,which possess various unique transport properties and had been widely investigated in the fields of photoelectricity and nonlinear *** a significantly long period of time,diamondoid materials were not given much attention in the field of ***,this changed when a series of diamondoid compounds showed a thermoelectric figure of merit(ZT)greater than *** discovery sparked considerable interest in further exploring the thermoelectric properties of diamondoid *** review aims to provide a comprehensive view of our current understanding of thermal and electronic transport in diamondoid materials and stimulate their development in thermoelectric *** present a collection of recent discoveries concerning the lattice dynamics and electronic structure of diamondoid *** review the underlying physics responsible for their unique electrical and phonon transport ***,we provide insights into the advancements made in the field of thermoelectricity for diamondoid materials and the corresponding strategies employed to optimize their ***,we emphasize the challenges that lie ahead and outline potential avenues for future research in the domain of diamondoid thermoelectric materials.

关键词： diamondoid compounds electronic properties thermal conductivity thermoelectric materials

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Opportunities for large language models and discourse in engineering

Energy and AI

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Energy and AI 2024年第3期17卷 136-142页

作者： Jan göpfert Jann M.Weinand Patrick Kuckertz Detlef Stolten Institute of Energy and Climate Research–Techno-economic Systems Analysis(IEK-3) Forschungszentrum Jülich GmbHJülich52425Germany Chair for Fuel Cells RWTH Aachen UniversityFaculty of Mechanical EngineeringAachen52062Germany

In recent years, large language models have achieved breakthroughs on a wide range of benchmarks in natural language processing and continue to increase in performance. Recently, the advances of large language models have raised interest outside the natural language processing community and could have a large impact on daily life. In this paper, we pose the question: How will large language models and other foundation models shape the future product development process? We provide the reader with an overview of the subject by summarizing both recent advances in natural language processing and the use of information technology in the engineering design process. We argue that discourse should be regarded as the core of engineering design processes, and therefore should be represented in a digital artifact. On this basis, we describe how foundation models such as large language models could contribute to the design discourse by automating parts thereof that involve creativity and reasoning, and were previously reserved for humans. We describe how simulations, experiments, topology optimizations, and other process steps can be integrated into a machine-actionable, discourse-centric design process. As an example, we present a design discourse on the optimization of wind turbine blades. Finally, we outline the future research that will be necessary for the implementation of the conceptualized framework.

关键词： Product development process Conceptual design Design methodology Design generation Natural language processing Foundation models Multi-modal models

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Prediction of the undrained shear strength of remolded soil with non-linear regression,fuzzy logic,and artificial neural network

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Journal of Mountain Science 2024年第9期21卷 3108-3122页

作者： YÜNKÜL Kaan KARAÇOR Fatih gÜRBÜZ Ayhan BUDAK TahsinÖmür Department of Civil Engineering Faculty of Engineering and ArchitectureTokat Gaziosmanpaşa UniversityTokat 60100Türkiye Department of Civil Engineering Faculty of Engineering and ArchitectureKafkas UniversityKars 36000Türkiye Department of Civil Engineering Faculty of EngineeringGazi UniversityAnkara 06570Türkiye Ministry of Youth and Sports Ankara 06090Türkiye

This study aims to predict the undrained shear strength of remolded soil samples using non-linear regression analyses,fuzzy logic,and artificial neural network modeling.A total of 1306 undrained shear strength results from 230 different remolded soil test settings reported in 21 publications were collected,utilizing six different measurement *** water content,plastic limit,and liquid limit were used as input parameters for fuzzy logic and artificial neural network modeling,liquidity index or water content ratio was considered as an input parameter for non-linear regression *** non-linear regression analyses,12 different regression equations were derived for the prediction of undrained shear strength of remolded ***-Forward backpropagation and the TANSIg transfer function were used for artificial neural network modeling,while the Mamdani inference system was preferred with trapezoidal and triangular membership functions for fuzzy logic *** experimental results of 914 tests were used for training of the artificial neural network models,196 for validation and 196 for *** was observed that the accuracy of the artificial neural network and fuzzy logic modeling was higher than that of the non-linear regression ***,a simple and reliable regression equation was proposed for assessments of undrained shear strength values with higher coefficients of determination.

关键词： Undrained shear strength Liquidity index Water content ratio Non-linear regression Artificial neural networks Fuzzy logic

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