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Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity:a review

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journal of Integrative Medicine 2018年第4期16卷 211-222页

作者： Bruno jose Martins Da Silva Amanda Anastacia Pinto hage Edilene Oliveira Silva Ana Paula Drummond Rodrigues Laboratory of Parasitology and Laboratory of Structural Biology Institute of Biological SdencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Structural Biology and Bioimaging Rio de JaneiroRio de Janeiro 21941-901Brazil Laboratory of Electron Microscopy Department of Health SurveillanceMinistry of HealthEvandro Chagas InstituteBelemPard 66087-082Brazil

Leishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosine and liposomal amphotericin B is currently the only effective treatment. However, adverse effects, long-term treatment and the emergence of parasite resistance have led to the search for alternative treatments. Natural products used in traditional medicine provide an unlimited source of molecules for the identification of new drugs, and the Amazon region has abundant biodiversity that includes several species of plants and animals, providing a rich source of new products and com- pounds. Although the literature describes numerous promising compounds and extracts for combating Leishmania protozoans, the results of such research have not been embraced by the pharmaceutical industry for the development of new drugs. Therefore, this review focused on the antileishmanial activity of extracts, isolated compounds and essential oils commonly used by the local population in the Brazilian Amazonian region to treat several illnesses and described in the literature as promising compounds for combating leishmaniasis.

关键词： Amazonian plants Leishmaniasis treatment Plant compounds Plant extracts Plant oils

Stability of highly supersaturated vanadium electrolyte solution and characterization of precipitated phases for vanadium redox flow battery

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journal of Energy Chemistry 2021年第10期30卷 436-445,I0012页

作者： Waldemir M.Carvalho jr Laurent Cassayre Delphine Quaranta Fabien Chauvet Ranine El-hage Theodore Tzedakis Béatrice Biscans Laboratoire de Génie Chimique Universitéde ToulouseCNRSINPUPSToulouseFrance

The vanadium redox flow battery(VRFB)has been receiving great attention in recent years as one of the most viable energy storage technologies for large-scale ***,higher concentrations of vanadium species are required in the H_(2)O-H_(2)SO_(4) electrolyte in order to improve the VRFB energy *** might lead to unwanted precipitation of vanadium compounds,whose nature has not been accurately characterized *** this purpose,this study reports the preparation ofⅤ^((Ⅱ)),ⅤV^((Ⅲ)),Ⅴ^((Ⅳ))andⅤ^((Ⅴ))supersaturated solutions in a 5 M H_(2)SO_(4)-H_(2)O electrolyte by an electrolytic method,from the only vanadium sulfate compound commercially available(VOSO_(4)).The precipitates obtained by ageing of the stirred solutions are representative of the solids that may form in a VRFB operated with such supersaturated *** solid phases are identified using thermogravimetric analysis,X-ray diffraction and *** report that dissolvedⅤ^((Ⅱ)),Ⅴ^((Ⅲ))andⅤ^((Ⅳ))species precipitate as crystals of VSO_(4),V_(2)(SO_(4))3 and VOSO_(4) hydrates and not in their anhydrous form;conversely V^((Ⅴ))precipitates as an amorphous V_(2) O_(5) oxide partially *** measured hydration degrees(respectively 1.5,9,3 and 0.26 mol of H_(2)O per mol of compound)might significantly affect the overall engineering of VRFB operating with high vanadium concentrations.

关键词： Vanadium Redox Flow Batteries Supersaturated electrolyte Precipitation Vanadium sulfate Vanadium hydrates

Endoscopic ultrasound-through-the-needle biopsy in pancreatic cystic lesions: A large single center experience

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World journal of Gastrointestinal Endoscopy 2019年第11期11卷 531-540页

作者： Rintaro Hashimoto john G Lee Kenneth j Chang Nabil El hage Chehade jason B Samarasena H.H.Chao Comprehensive Digestive Disease Center Division of Gastroenterology and Hepatology Department of Medicine University of CaliforniaIrvine

BACKGROUND Establishing a diagnosis of pancreatic cystic lesions(PCLs)preoperatively still remains ***,endoscopic ultrasound(EUS)-through-the-needle biopsy(EUS-TTNB)using microforceps in PCLs has been made *** To assess the efficacy and safety of EUS-TTNB in the diagnosis of *** We retrospectively collected data of patients with PCLs who underwent both EUS-fine-needle aspiration(FNA)for cytology and EUS-TTNB at our institution since ***-FNA for cytology was followed by EUS-TTNB in the same *** of the cyst location,primary diagnosis,adverse events,and comparison between the cytologic fluid analyses and histopathology was *** success of EUS-TTNB was defined as visible tissue present after *** success was defined as the presence of a specimen adequate to make a histologic or cytologic *** A total of 56 patients(mean age 66.9±11.7,53.6%females)with PCLs were enrolled over the study *** mean cyst size was 28.8 mm(12-85 mm).The EUS-TTNB procedure was technically successful in all patients(100%).The clinical success rate using EUS-TTNB was much higher than standard EUS-FNA,respectively 80.4%(45/56)vs 25%(14/56).Adverse events occurred in 2 patients(3.6%)who developed mild pancreatitis that resolved with medical *** TTNB specimens,23 of 32 cases(71.9%)with intraductal papillary mucinous neoplasm were further differentiated into gastric type(19 patients)and pancreaticobiliary type(4 patients)based on immunochemical *** EUS-TTNB for PCLs was technically feasible and had a favorable safety ***,the diagnostic yield for PCLs was much higher with EUS-TTNB than standard EUS-FNA cytology and fluid carcinoembryonic *** should be considered as an adjunct to EUS-FNA and cytologic analysis in the diagnosis and management of PCLs.

关键词： Pancreatic cyst lesion Endoscopic ultrasound Endoscopic ultrasound-guided fine needle aspiration Cyst fluid Biopsy

未完成与反奢华英国ROUGH LUXE酒店

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室内设计与装修 2009年第7期 66-71页

作者： Rabin hage Samuele Martelli 夏天

距离伦敦国王十字车站不远的一处街角藏匿着一间令人啧啧称奇的设计酒店，这就是由著名设计师Rabihhage亲自操刀设计的ROUGHLUXE。Rabih毕业于巴黎圣艾蒂安高等美术学院，是一位建筑师、画家，并拥有自己的画廊和设计工作室，这位设计... 详细信息

距离伦敦国王十字车站不远的一处街角藏匿着一间令人啧啧称奇的设计酒店，这就是由著名设计师Rabihhage亲自操刀设计的ROUGHLUXE。Rabih毕业于巴黎圣艾蒂安高等美术学院，是一位建筑师、画家，并拥有自己的画廊和设计工作室，这位设计师才华横溢并极具创造力，是先锋派的一员。

关键词：酒店英国设计工作室设计师美术学院建筑师创造力先锋派

北京城区居民体质指数与慢性病危险因素关系分析

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卫生研究 2003年第4期32卷 363-366页

作者：付萍薛安娜姜垣金水高王淑琴杨正雄 Bridget Hus-hage Mark Wahlqvist 中国疾病预防控制中心营养与食品安全所北京100050 Monash University Melbourne

对 1 995～ 1 998年营养与食品安全所老年与临床营养室在北京地区慢性病社区防治研究中积累的1 2 4 6例 2 5～ 74岁居民的部分体检资料进行分析 ,观察不同人群体质指数 (BMI)、腰围 (WC)水平与慢性疾病相关因素血清总胆固醇 (TC)、高... 详细信息

对 1 995～ 1 998年营养与食品安全所老年与临床营养室在北京地区慢性病社区防治研究中积累的1 2 4 6例 2 5～ 74岁居民的部分体检资料进行分析 ,观察不同人群体质指数 (BMI)、腰围 (WC)水平与慢性疾病相关因素血清总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL C)、甘油三酯 (TG)、收缩压 (SBP)、舒张压 (DBP)、血糖 (FBG)及与高血压、高脂血症、糖尿病的检出率的关系。结果 :该人群超重及肥胖率男性为 41 7%及1 4 6 % ,女性为 32 0 %及 2 0 4%。超重及肥胖组高血压、高脂血症、糖尿病的检出率明显高于BMI正常组。相关分析结果表明BMI、WC与TC、TG、SBP、DBP呈显著正相关 ;与HDL C、HDL C TC呈显著负相关 ,WC与FBG呈显著正相关。提示为早期预防慢性病 ,应对BMI>2

关键词：肥胖体质指数慢性病危险因素北京

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生殖系统的免疫调节

国外兽医学（畜禽疾病） 1993年第3期4卷 27-30页

作者： hage-Van Noort M 韩韦章

生殖系统的免疫调节,是一种可以提高或降低繁殖率的新方法。在兽医临床上,这种方法可用作为不切除生殖腺的“阉割”,也可用于治疗内分泌失调引起的疾病,内源性激素常被着作是动物的“自身物质”,但可将内源性激素和某种异体蛋白偶联而... 详细信息

生殖系统的免疫调节,是一种可以提高或降低繁殖率的新方法。在兽医临床上,这种方法可用作为不切除生殖腺的“阉割”,也可用于治疗内分泌失调引起的疾病,内源性激素常被着作是动物的“自身物质”,但可将内源性激素和某种异体蛋白偶联而使其获得免疫原性。内源性激素的免疫中和,需要体内出现高效价的特异抗体。在过去十年里,已经证明:采用类固醇激素(如雄烯二酮)、蛋白质激素(如抑制素)和肽类激素(如促黄体素释放激素,LHRH)等进行主动或被动免疫,可以影响内分泌系统的平衡。一个新的很有发展前途的新技术是选择特殊的多肽作为抗原对动物进行主动免疫以产生抑制素和人绒毛膜促性腺素抗体,从而达到提高动物繁殖率的目的。

关键词：生殖系统免疫调节兽医学

一项关于社会经济地位较差的学龄前儿童血管功能评估的初步研究

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中华高血压杂志 2017年第3期25卷 283-284页

作者： Ghazi L Dudenbostel T Xing D Ejem D Turner-Henson A joiner CI Affuso O Azuero A Oparil S Calhoun DA Rice M hage FG 曲浥晨机构不详

Ghazi L, Dudenbostel T, Xing D, Ejem D, Turner-Henson A, joiner CI, Affuso O, Azuero A, Oparil S, Calhoun DA, Rice M, hage FG. Assessment of vascular function in low socioeconomic status preschool children： a pilot study. j Am Soc Hypertens ,2016 ： 1-9. 全球高血压患者〉10亿例，每年造成710万人死亡。在美国，〉8000万例成人及200万～300万例儿童患高血压。按当前趋势预计到2030年，美国高血压成年患者将增加2700万。越来越多的证据表明，包括高血压在内的心血管病危险因素在童年时期即出现并持续至成人后。因此，对日后可能出现心血管病高危因素的儿童，在早期予以干预十分重要。

关键词：学龄前儿童血管功能评估社会经济地位心血管病危险因素高血压患者成年患者高危因素 low

Application of Hartree-Fock Method for Modeling of Bioactive Molecules Using SAR and QSPR

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Computational Molecular Bioscience 2014年第1期4卷 1-24页

作者： Cleydson B. R. Santos Cleison C. Lobato Francinaldo S. Braga Sílvia S. S. Morais Cesar F. Santos Caio P. Fernandes Davi S. B. Brasil Lorane I. S. hage-Melim Williams j. C. Macêdo josé C. T. Carvalho Laboratory of Modeling and Computational Chemistry Federal University of Amap&#225 Macap&#225 Brazil Laboratory of Modeling and Computational Chemistry Federal University of Amap&#225 Macap&#225 Brazil Laboratory of Drug Research School of Pharmaceutical Sciences Federal University of Amap&#225 Macap&#225 Brazil Laboratory of Modeling and Computational Chemistry Federal University of Amap&#225 Macap&#225 Brazil Institute of Technology Federal University of Par&#225 Bel&#233m Brazil Laboratory of Modeling and Computational Chemistry Federal University of Amap&#225 Macap&#225 Brazil Postgraduate Program in Biotechnology and Biodiversity-Network BIONORTE Campus Universit&#225rio Marco Zero Macap&#225 Brazil Laboratory of Modeling and Computational Chemistry Federal University of Amap&#225 Macap&#225 Brazil Postgraduate Program in Biotechnology and Biodiversity-Network BIONORTE Campus Universit&#225rio Marco Zero Macap&#225 Brazil Laboratory of Drug Research School of Pharmaceutical Sciences Federal University of Amap&#225 Macap&#225 Brazil Laboratory of Modeling and Computational Chemistry Federal University of Amap&#225 Macap&#225 Brazil Postgraduate Program in Biotechnology and Biodiversity-Network BIONORTE Campus Universit&#225rio Marco Zero Macap&#225 Brazil Laboratory of Drug Research School of Pharmaceutical Sciences Federal University of Amap&#225 Macap&#225 Brazil Laboratory of Statistical and Computational Modeling University of the State of Amap&#225 Macap&#225 Brazil

The central importance of quantum chemistry is to obtain solutions of the Schr?dinger equation for the accurate determination of the properties of atomic and molecular systems that occurred from the calculation of wave functions accurate for many diatomic and polyatomic molecules, using Self Consistent Field method (SCF). The application of quantum chemical methods in the study and planning of bioactive compounds has become a common practice nowadays. From the point of view of planning it is important to note, when it comes to the use of molecular modeling, a collective term that refers to methods and theoretical modeling and computational techniques to mimic the behavior of molecules, not intend to reach a bioactive molecule simply through the use of computer programs. The choice of method for energy minimization depends on factors related to the size of the molecule, parameters of availability, stored data and computational resources. Molecular models generated by the computer are the result of mathematical equations that estimate the positions and properties of the electrons and nuclei, the calculations exploit experimentally, the characteristics of a structure, providing a new perspective on the molecule. In this work we show that studies of Highest Occupied Molecular Orbital Energy (HOMO), Low Unoccupied Molecular Orbital Energy (LUMO) and Map of molecular electrostatic potential (MEP) using Hatree-Fock method with different basis sets (HF/3-21G*, HF/3-21G**, HF/6-31G, HF/6-31G*, HF/6-31G** and HF/6-311G), that are of great importance in modern chemistry, biochemistry, molecular biology, and other fields of knowledge of health sciences. In order to obtain a significant correlation, it is essential that the descriptors are used appropriately. Thus, the quantum chemical calculations are an attractive source of new molecular descriptors that can, in principle, express all the geometrical and electronic properties of molecules and their interactions with biological

关键词： Molecular Modeling Meps Maps Orbital Frontier Quantum Chemical Methods

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妊娠糖尿病筛查与筛查阳性的危险因素分析

中国全科医学 2004年第2期7卷 86-88页

作者：张红杨西林张翠萍邵平 Bridget H-H Hsu-hage 天津市妇女保健所 300204 香港中文大学医学院流行病和生物统计中心澳大利亚墨尔本大学乡村卫生系

目的　在天津市区开展系统的妊娠糖尿病筛查、诊断和治疗 ,调查筛查阳性率和危险因素。方法　于 1999年在天津市内六区进行了妊娠糖尿病筛查。筛查孕周为 2 6～ 30周 ,使用 1小时 5 0g葡萄糖筛查试验 (GCT) ,血糖值≥7 8mmol/L的孕妇再... 详细信息

目的　在天津市区开展系统的妊娠糖尿病筛查、诊断和治疗 ,调查筛查阳性率和危险因素。方法　于 1999年在天津市内六区进行了妊娠糖尿病筛查。筛查孕周为 2 6～ 30周 ,使用 1小时 5 0g葡萄糖筛查试验 (GCT) ,血糖值≥7 8mmol/L的孕妇再进一步做口服葡萄糖耐量试验 (OGTT)。结果　筛查 94 71名孕妇 ,其中 9 38%的孕妇筛查阳性。 70 1名接受OGTT ,174名诊断为妊娠糖尿病。筛查阳性的危险因素有 :年龄 (OR :1 0 5 2 ,95 %CI:1 0 30～ 1 0 73) ,孕前体重 (OR :1 0 37,95 %CI:1 0 2 7～ 1 0 4 6 ) ,孕期增重 (OR :1 0 2 6 ,95 %CI:1 0 0 9～ 1 0 4 4 ) ,身高 (OR :0 94 3,95 %CI:0 92 7～ 0 95 9) ,糖尿病家族史 ,吸烟 (OR :3 2 84 ,95 %CI:1 0 5 2～ 10 2 5 3) ,妊高征 (OR :1 5 90 ,95 %CI:1 2 2 7～ 2 0 6 0 )。结论　天津市区妊娠糖尿病的筛选阳性率为 9 38%。高龄 ,身材矮 ,孕前体重高 ,孕期过多增重 ,糖尿病家族史。

关键词：妊娠并发症糖尿病筛查阳性危险因素诊断治疗