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Ataxia Telangiectasia Syndrome Revealed by Severe Pneumonia

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Case Reports in Clinical Medicine 2015年第5期4卷 184-188页

作者： Hind Serhane Nisserine Louhab hafsa sajiai Selma Aitbatahar Lamyae Amro Department of Respiratory Medicine Laboratory PCIM Faculty of Medicine and Pharmacy Cadi Ayyad University Marrakesh Morocco Department of Neurological Medicine Faculty of Medicine and Pharmacy Cadi Ayyad University Marrakesh Morocco

Ataxia Telangiectasia (AT) is a rare autosomal recessive multisystem disease. The diagnosis is often made on a clinical triad that combines neurological signs dominated by a progressive cerebellar ataxia, oculocutaneous signs (telangiectasia, coffee stain milk), immunodeficiency (humoral and cellular) with sinopulmonary infections and elevated alphaphetoprotein. The diagnosis of AT is usually early, however, some forms may be revealed late. We reported a case of a 19-year-old patient, admitted for severe pneumonia with Klebsiella Pneumonia. In its history, it was found a notion of recurrent respiratory infections and bronchiectasis. In its clinical examination, it had been discovered cerebellar ataxia and occulocutaneous telangiectasia. The determination of plasmatic alphafoetoprotein was elevated, and the search of immunodeficiency showed a mixed deficit (humoral and cellular) suggesting the diagnosis of AT.

关键词： Ataxia Telangiectasia Cerebellar Ataxia Occulocutaneous Telangiectasia Alphaphotoprotein Immunodeficiency Autosomal Recessive Disease

<i>Pneumocystis jiroveci</i>Pneumonia in an Immunocompetent Female Patient

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Case Reports in Clinical Medicine 2014年第7期3卷 420-423页

作者： Lamyae Amro Ghizlane Hamzaoui hafsa sajiai Hind Serhane Abdelhaq Alaoui Yazidi Department of Respiratory Medicine Laboratory PCIM Faculty of Medicine and Pharmacy Cadi Ayyad University Marrakesh Morocco

Introduction: The pneumocystosis is an infection caused by a saprophytic germ Pneumocystis jiroveci. It is exceptional in immunocompetent patients. Case report: This is a 30-year-old patient, admitted to the service for an acute respiratory failure. She was treated for pulmonary tuberculosis 6 months ago. The review has objectified clinique cyanosis of the lips and extremities with a blood pressure 120/70 mmHg, a heart rate of 70 bats/min, a temperature of 38°C and SaO2 to 82% in the open air. The chest radiograph objectified reticulonodular opacities on the right. The patient was put under bi-broad-spectrum antibiotics. Due to the non improvement of the patient’s state, the search for Pneumocystis jiroveci in induced sputum was made and it was positive. The search for a field of immunosuppression was negative.

关键词： Pneumocystosis Pneumocystis jiroveci Immunocompetent

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Lung Cancer in Women

Journal of Health Science 2016年第2期4卷 68-73页

作者： Anas Arrad hafsa sajiai Meryem Rachidi Hind Serhane Salma Ait Batahar Lamyae Amro Pneumology Department of University Hospital Center Mohammed VI Marrakesh 40000 Morocco

At the same smoking level, women have a higher risk of lung cancer. The aim of the study was to evaluate epidemiological, clinical and histological profile of women＇s lung cancer. A retrospective study including women patients with a confirmed lung cancer followed at the Pneumology Department of University Hospital Center Mohammed VI of Marrakesh in Morocco between January 2010 and December 2014. 14 cases were included in the study. The average age of patients was 54.2 years. Active smoking was noted in 2 patients （14.4%）. The chest X-ray showed an atelectasis in 6 cases （42.8%）, hilar opacity in 6 cases （42.8%） and alveolar opacity in 2 cases （14.4%）, pleural effusion was present in 3 cases （21.4%）. Histological confirmation was obtained in 10 cases （71.4%） by bronchial biopsy, 2 cases with pleural biopsy （14.4%）, one case （7.1%） by lymph node biopsy and one case trans-parietal biopsy （7.1%）. An adenocarcinoma was found in 9 cases （64.3%）, squamous cell carcinoma in 4 cases （28.6%） and small cell carcinoma in one case （7.14%）. The study shows that the lung cancer in women in our context occurs more often in non-smoker patients and it＇s usually an adenocarcinoma type.

关键词： Lung cancer women adenocarcinoma non smoker

Purulent Hydroaeric Pleural Effusion Due to Infection with <i>Gemella morbillorum</i>: A Case Report

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Case Reports in Clinical Medicine 2014年第11期3卷 583-586页

作者： Hind Serhane hafsa sajiai Anas Arrad Selma Ait Batahar Lamyae Amro Abdelhaq Alaoui-Yazidi Department of Respiratory Medicine Laboratory PCIM Faculty of Medicine and Pharmacy Cadi Ayyad University Marrakesh Morocco

Gemella morbillorum (G. morbillorum) is an opportunistic bacterium, which can sometimes cause severe infections especially in immunocompromised subjects. Respiratory infections due to this germ are rare, but are described. We reported a new observation of 34-year-old female patient, admitted for unusual location and clinical presentation of respiratory infection with G. morbillorum;she was presented a left pleuritic pain, a productive cough associated with purulent and foul sputum and dyspnea with onset one month earlier. The clinical examination was objectified a polypnea at 32 cycles/minutes, intercostal indrawing and mixed pleural effusion syndrome. She had also many dental caries and bad oral health status. Chest radiography showed an air-fluid image in the left chest and the thoracocentesis had revealed purulent fluid. The culture of this fluid had isolated a G. morbillorum. The diagnosis of mixed pleural effusion due to G. morbillorum in an immunosuppressed diabetic patient was made. The patient was put on antibiotics, thoracic drainage and Chest physiotherapy with good improvement.

关键词： Gemella morbillorum Gemella Species Respiratory Infection Hydroaeric Pleural Effusion

Incense smoke(IS)inhalation exposure system:Physicochemical characterization,IS particle deposition and clearance in human airway using MPPD model

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Particuology 2024年第4期87卷 271-285页

作者： Vyas Kumar hafsa Hashmi Anshita Nasreen Ghazi Ansari Jyotsna Singh Inhalation Toxicology Facility Regulatory Toxicology GroupCSR-Indian Institute of Toxicology ResearchLucknow22001UPIndi Academy of Scientific and Innovative Research(AcsSIR) Ghaziabad201002UPIndia Analytical Chemistry Regulatory Toxicology GroupCSIR-Indian Institute of Toxicology ResearchLucknow226001UPIndia

Incense smoke(IS)is source of indoor air pollution and key risk for diverse human *** in-formation is available regarding controlled IS rodent inhalation exposure system and IS particulate matter(PM)deposition in human *** aimed to demonstrate stable ISPM physicochemical parameters of 10 incense products inside the customized whole body inhalation exposure chamber(without animal)connected to smoke generation unit via aerosol mixing *** analyzed for size segregated PM emission,ISPM in vitro aerodynamics(MMAD and GSD determination),fine and ultrafine particle's SEM,SEM-EDX and PAH *** real life exposure scenario by utilizing MMAD,GSD and PM concentration after Tier 1 exposure assessment as key input parameters,ISPM dosimetry in infant(3 months)and adult(21 years male and female)human airways was calculated using multiple-path particle dosimetry(MPPD 3.04)*** median aerodynamic diameter(MMAD)and geo-metric standard deviation(GSD)ranged between 0.55 and 2.10μm and 1.22 to 1.77(polydisperse)***1.0 and PM0.1 showed multiple morphology and presence of heavy and trace *** like acenaphthylene,anthracene,fluorene,naphthalene and phenanthrene were detected(0.84-143.17μg/g).MPPD results showed higher ISPM deposition in pulmonary region and lowest in trachea bronchial *** deposition in tissue was higher in lower,peripheral lung as compared to upper and central lung *** body inhalation exposure system showed stable IS atmosphere(physi-cochemical parameters)indicating the device suitability in future inhalation *** ISPM deposition fraction and clearance data showed deep lung penetrating and retention behavior with higher risk in infant followed by female and then *** modeled particle deposition and clearance data may be useful in risk assessment analysis of IS.

关键词： Inhalation Incense smoke Multiple-path particle dosimetry(MPPD) Particle deposition Particulate matter(PM) Mass median aerodynamic diameter (MMAD) Human airway

Tetrachloroethane(TeCA)removal through sequential graphite-mixed metal oxide electrodes in a bioelectrochemical reactor

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Environmental Science and Ecotechnology 2024年第1期17卷 59-67页

作者： Marco Zeppilli hafsa Yaqoubi Edoardo Dell’Armi Agnese Lai Mustapha Belfaquir Laura Lorini Marco Petrangeli Papini Department of Chemistry University of Rome SapienzaPiazzale Aldo Moro 5Rome00185Italy Department of Chemistry Ibn Tofail UniversityLaboratory of Advanced Material and Process EngineeringCampus UniversitaireBP.242KenitraMorocco

Electro-bioremediation offers a promising approach for eliminating persistent pollutants from groundwater since allows the stimulation of biological dechlorinating activity,utilizing renewable electricity for process operation and avoiding the injection of chemicals into *** this study,a two-chamber microbial electrolysis cell has been utilized to achieve both reductive and oxidative degradation of tetrachloroethane(TeCA).By polarizing the graphite granules cathodic chamber at650 mV vs the standard hydrogen electrode and employing a mixed metal oxide(MMO)counter electrode for oxygen production,the reductive and oxidative environment necessary for TeCA removal has been *** experiments were conducted using two feeding solutions:an optimized mineral medium for dechlorinating microorganisms,and synthetic groundwater containing sulphate and nitrate anions to investigate potential side *** bioelectrochemical process efficiently reduced TeCA to a mixture of trans-dichloroethylene,vinyl chloride,and ethylene,which were subsequently oxidized in the anodic chamber with removal efficiencies of 37±2%,100±4%,and 100±5%,*** introduction of synthetic groundwater with nitrate and sulphate stimulated reductions in these ions in the cathodic chamber,leading to a 17%decrease in the reductive dechlorination rate and the appearance of other chlorinated by-products,including cis-dichloroethylene and 1,2-dichloroethane(1,2-DCA),in the cathode ***,despite the lower reductive dechlorination rate during synthetic groundwater operation,aerobic dechlorinating microorganisms within the anodic chamber completely removed VC and 1,*** study represents the first demonstration of a sequential reductive and oxidative bioelectrochemical process for TeCA mineralization in a synthetic solution simulating contaminated groundwater.

关键词： Chlorinated aliphatic hydrocarbons Microbial electrolysis cells Oxidative dechlorination Reductive dechlorination Sulphate reduction Nitrate reduction

Predictors of prognosis in Alzheimer’s disease: The role of cognitive dysfunction, immune abnormalities, and advanced neuroimaging

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World Journal of Clinical Cases 2024年第27期12卷 6004-6006页

作者： hafsa Arshad Raja Abdulqadir J Nashwan Rawalpindi Medical University Rawalpindi 46000Pakistan Department of Nursing Hamad Medical CorporationDoha 3050Qatar

Alzheimer’s disease(AD)is a grave illness that results in cognitive and social issues.A recent study examined the association between neuroimaging results,cognitive dysfunction,atypical cellular immune function,and poor prognostic factors in AD patients who demonstrated poor *** prognosis was associated with abnormal cellular immune function,extrapyramidal symptoms,altered consciousness,abnormal electroencephalogram,modified Rankin scale,increased neutrophil lymphocyte ratio,and severe *** impaired cellular immune function characterized by a reduction in the blood T lym-phocytes’proportion predicted poor prognosis as an independent risk factor in *** initiation and maintenance of AD medications is associated with better outcomes.

关键词： Amyloid beta peptide Alzheimer's disease Dementia Cellular immunity Prognosis T lymphocytes Magnetic resonance spectroscopy

Semaglutide for the management of diabesity:The real-world experience

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World Journal of Methodology 2024年第3期14卷 68-77页

作者： Mohammed Alkhalifah hafsa Afsar Anindya Shams Dania Blaibel Vishnu Chandrabalan Joseph M Pappachan Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Department of Family Medicine King Faisal Specialist HospitalRiyadh 11211Saudi Arabia Department of Data Science Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom

BACKGROUND Diabesity(diabetes as a consequence of obesity)has emerged as a huge healthcare challenge across the globe due to the obesity *** use of antidiabetic medications including semaglutide is important for optimal management of diabesity as proven by multiple randomized controlled ***,more real-world data is needed to further improve the clinical *** To study the real-world benefits and side effects of using semaglutide to manage patients with *** We evaluated the efficacy and safety of semaglutide use in managing patients with diabesity in a large academic hospital in the United *** parameters were analyzed including demographic information,the data on improvement of glycated hemoglobin(HbA1c),body weight reduction and insulin dose adjustments at 6 and 12 months,as well as at the latest follow up *** data was obtained from the electronic patient records between January 2019 to May *** 106 patients(56 males)with type 2 diabetes mellitus(T2DM),mean age 60.8±11.2 years,mean durations of T2DM 12.4±7.2 years and mean semaglutide treatment for 2.6±1.1 years were *** treatment was associated with significant improvement in diabesity outcomes such as mean weight reductions from baseline 110.4±24.6 kg to 99.9±24.9 kg at 12 months and 96.8±22.9 kg at latest follow up and HbA1c improvement from baseline of 82±21 mmol/mol to 67±20 at 12 months and 71±23 mmol/mol at the latest follow *** insulin dose reduction from mean baseline of 95±74 units to 76.5±56.2 units was also observed at the latest follow *** effects were mild and mainly gastrointestinal like bloating and nausea improving with prolonged use of *** Semaglutide treatment is associated with significant improvement in diabesity outcomes such as reduction in body weight,HbA1c and insulin doses without major adverse *** of largescale real-world data are expected to inform better clinical

关键词： Type 2 diabetes mellitus Diabesity Glucagon-like peptide 1 receptor agonists Semaglutide Insulin dose reduction Weight loss

Surgical Management of a Collision Tumor: The Association of Intracranial Meningioma and Macroadenoma

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Open Journal of Modern Neurosurgery 2024年第1期14卷 48-56页

作者： Salma Abbas Yao Christian Hugues Dokponou Thameen Jaradat Mahjouba Boutarbouch Nadia Cherradi hafsa El Ouazzani Abdessamad El Ouahabi Department of Neurosurgery Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco Department of Pathology Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco

Background: The simultaneous presence of a pituitary adenoma and a meningioma is a rare and underreported condition. The randomly encountered cases need to be reported to further allow our understanding of this collision tumors that are still not understood nor fully described. Patients and Method: We report a case of coexisting nonfunctioning pituitary adenoma and a left temporal lobe meningioma revealed by a 1-year history of progressive vision loss and occasional headaches in a 56-year-old woman. Her clinical condition worsened in the last 5 months with ptosis, cavernous sinus syndrome, and ophthalmoplegia of the right eye without papilledema. There was an improvement in the visual symptoms after subtotal resection of both lesions through a right frontotemporal craniotomy. Histology confirmed a collision tumor. The patient was referred for adjuvant treatment with gamma knife radiosurgery. He was doing well and back to his usual duties 6 months later. Conclusion: A gross total or subtotal resection with adjuvant therapy is the gold standard for the surgical management of collision tumors for a favorable patient outcome.

关键词： Collision Tumors Meningioma Pituitary Adenoma