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Correlation of Programmed Death Ligand-1 (PD-L1) Expression with Clinicopathological Features in Non-Small Cell Lung Carcinoma: Experience from a Tertiary Cancer Care Center in India

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Journal of Cancer Therapy 2020年第3期11卷 172-187页

作者： hafsa Saif K. S. Rajesh Kumar Suhail Sayeed Mufti Ritesh Giri V. Hrishi Vinu Sarathy Veena Ramaswamy Diganta Hazarika Radheshyam Naik Department of Pathology HealthCare Global (HCG) Hospital Bengaluru India Department of Translational Medicine & Therapeutics Health Care Global (HCG) Hospital Bengaluru India Department of Clinical Pharmacy Health Care Global (HCG) Hospital Bengaluru India Department of Medical Oncology Health Care Global (HCG) Hospital Bengaluru India Histopathology Department Health Care Global (HCG) Hospital Bengaluru India Department of Medical Oncology Hematology and BMT Bengaluru India

Background:?According to the GLOBOCAN 2018 report, the estimated incidence of lung cancer in India was 67,795 in both sexes. The treatment of advanced Non-small cell lung cancer (NSCLC) saw a major paradigm shift with recent advances in molecular-targeted therapy. Immune checkpoint blockade therapy is one such novel strategy with promising clinical benefits in advanced NSCLC. Programmed cell death receptor-1/Programmed cell death ligand-1 (PD-1/PD-L1) pathway is one such checkpoint and has thus become the current area of interest in the treatment of lung carcinoma. The PD-1/?PD-L1 pathway is under active investigation as it represents a promising therapeutic target in NSCLC. The expression of PD-L1 in tumor cells has been suggested as a predictive marker of the clinical response to PD-1/?PD-L1-targeted therapy. Methods: This study was carried out at the Department of Pathology, Health Care Global Specialty Hospital, Bangalore from May 2018 to May 2019. In this study, we analyzed pattern of PD-L1 expression by immunohistochemistry testing using our own Laboratory Developed Test (LDT) in NSCLC patients. Results:?Our study group comprised 50 patients of NSCLC. Among our study population, 40% of the patients exhibited PD-L1 immunopositivity (≥1%) with 28% of them having any expression (TPS 1% - 49%) and 12% of them having a high expression (TPS ≥ 50%) of PD-L1. Majority of them exhibited adenocarcinoma type of NSCLC under which the solid subtype showed a direct correlation with PD-L1 positivity (p-value: 0.004) with a poorly differentiated tumor histology being common in our population in relation to PD-L1 positivity (p-value: 0.043). PD-L1 expression did not correlate with age, gender, smoking status or clinical stage in our study. No association was found between tumor histology (SCC or AC) and driver mutation status with expression of PD-L1 in the present study. Conclusions: In our study, PD-L1 immunopositivity was found in 40% of patients and majority of them exhibi

关键词： Lung Cancer PD-L1 IHC Biomarker Immunotherapy

Development of Environment Friendly Paddy Ecosystem for Sustainable Rice Farming through Soil Amendments with Biochar and Alternate Wetting-Drying Irrigations

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American Journal of Climate Change 2021年第4期10卷 581-596页

作者： Muhammad Aslam Ali Md. Rajib Hassan Zubair Al Islam Sanjit Chandra Barman Badiuzzaman Khan Rehana Khatun hafsa Jahan Hiya Md. Touhidul Islam Department of Environmental Science Bangladesh Agricultural University Mymensingh Bangladesh Department of Irrigation and Water Management Bangladesh Agricultural University Mymensingh Bangladesh

Climate change may badly affect the availability of water and soil nutrients to rice plant. Research experiments were conducted at the Environmental Science Departmental field, Bangladesh Agricultural University, Mymensingh during July 2017 to June 2019, to find out the suitable combination of biochar with inorganic fertilizers for minimizing seasonal yield scaled CH4 emissions, reducing global warming potentials (GWPs) and sustainable rice farming under feasible irrigation practices. There were ten experimental treatments with different combinations of inorganic NPKS fertilizers and biochar (15 - 30 t/ha) under conventional flooding (CF) and alternate wetting-drying irrigations (AWDI). This study revealed that NPKS fertilization (50% of the recommended doze) with 15 t/ha biochar amendments under AWD irrigation maximized rice yield 6750 kg/ha and 4380 kg/ha in dry boro and wet aman seasons respectively, while the lowest rice yield 1850 kg/ha and 1550 kg/ha were recorded in continuously irrigated control treatment (T1) during the dry and wet seasons respectively. Seasonal cumulative CH4 emission, yield scaled CH4 emission and GWPs were suppressed significantly with biochar amendments 15 - 30 t/ha under both conventional and AWDI irrigation systems during the wet and dry seasons of rice cultivation. Significant interactions were observed among biochar amendments and irrigation practices during the dry boro rice cultivation. Dry seasonal cumulative CH4 emissions were decreased by 14.7%, 18.9% and 24.8% with biochar amendments at 15 t/ha, 20 t/ha and 30 t/ha respectively under conventional irrigation;while cumulative CH4 emissions were reduced by 10.6%, 26% and 41.6% respectively, under AWDI system. Finally, total global warming potentials (GWPs) were decreased by 6% - 15%, 13% - 30% with biochar amendments under conventional and AWDI irrigations respectively, in wet season;while global warming potentials

关键词： CH4 Flux GWPs AWDI Yield Scaled CH4 Emission Dry Boro Rice Rainfed Aman Rice

Pediatric Nasopharyngeal Rhabdomyosarcoma: About a Case and Review of Literature

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Journal of Cancer Therapy 2021年第1期12卷 10-18页

作者： Dohoué Patricia Eliane Agbanglanon Imane M’barki Oswald Houessou Gaël Kietga Siham Jaba hafsa Elouazzani Séka Evrard Narcisse Hanan Elkacemi Nadia Cherradi Sanaa Elmajjaoui Noureddine Benjaafar Department of Radiotherapy Oncology National Institute of Oncology Rabat Morocco Department of Pathological Anatomy Laboratory Specialties Hospital Rabat Morocco

Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in children, with the head and neck location accounting for up to 40% of cases. The embryonal and alveolar histologic variants are more commonly seen in pediatric patients. The treatment is multimodal and the prognosis of this clinical entity is always gloomy. We report the case of nasopharyngeal rhabdomyosarcoma in a 7-year-old boy child with a good response to early post-therapy. Case Presentation: The patient was diagnosed with nasopharyngeal RMS revealed by a congested nose, ptosis and bilateral blindness, and who received induction chemotherapy followed by concurrent radiotherapy followed by adjuvant chemotherapy. The evolution is marked by a good clinical course but persistence of bilateral blindness

关键词： Rhabdomyosarcoma Nasopharyngeal Pediatric Chemotherapy Radiotherapy

Integrated Rice-Based Shrimp and Crabs Farming: Adaptation to Climate Change and Potential Mitigation of Global Warming in the Coastal Wetlands of Bangladesh

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Journal of Agricultural Chemistry and Environment 2023年第3期12卷 223-237页

作者： Muhammad Aslam Ali Shahroz Mahean Haque Khalid Sohrawardi S. K. Fazlay Rabbi Shuvo Kumar Sarkar hafsa Jahan Hiya Fakir Azmol Huda Sumon Malakar Mahjabeen Rahman Md. Shakir Ahammed Department of Environmental Science Bangladesh Agricultural University Mymensingh Bangladesh Department of Fisheries Management Bangladesh Agricultural University Mymensingh Bangladesh Department of Agricultural Economics Bangladesh Agricultural University Mymensingh Bangladesh Caritas Bangladesh Satkhira Bangladesh Department of Environmental Sciences Rutgers The State University of New Jersey New Brunswick USA

Coastal agriculture is vulnerable to climate change, thereby may affect food production systems and food security in Bangladesh. Methane (CH4) emission from coastal wetlands rice farming is a major environmental concern due to its global warming potential. Therefore, field experiments were conducted at the southern coastal region of Shyamnagar, Satkhira, to investigate the feasibility of Rice-Shrimp and Rice-Crabs mixed farming for adaptation to the changing climate and sustaining food production system. The experimental treatments were designed on rice-based diversified farming systems such as rice sole cropping with no NPKS + no soil amendments (T1), rice sole cropping following farmers’ practice (FP) without soil amendment (T2), rice sole cropping following FP with phosphogypsum (PG) amendment (T3), Rice-Shrimp mixed culture with PG amendment (T4), Rice-Crabs mixed culture with PG amendment (T5), Rice-Shrimp mixed culture + PG amendment with Spirulina (Cyanobacteria) inoculation (T6), and Rice-Crabs mixed culture + PG amendment with Spirulina inoculation (T7). A closed chamber technique was followed to collect gas samples from the rice paddy field and samples were analyzed by Gas Chromatograph. It was found that Rice-Shrimp (T6) and Rice-Crabs mixed farming (T7) practices significantly decreased GWPs compared to the rice sole cropping system. In the dry boro season, the maximum GWPs 4175 kg CO2 eq. ha-1 was recorded from rice sole cropping (T2), which was decreased by 30% and 36.7% under Rice-Shrimp (T6) and Rice-Crabs (T7) mixed farming practices, respectively. Furthermore, in the wet aman season, maximum GWP 4525 kg CO2 eq. ha-1 was recorded from rice sole cropping (T2), which was decreased by 33.0% and 38.8% under Rice-Shrimp and Rice-Crabs mixed farming, respectively. Rice grain yield was low under rice sole cropping (3500 kg/ha), which was increased by 11.0% and 14.7% under Rice-Shrimp mixed farming amended with PG

关键词： Coastal Paddy Shrimp Crabs Spirulina GWPs

Response of Rice Cultivars to Elevated Air Temperature and Soil Amendments: Implications towards Climate Change Adaptations and Mitigating Global Warming Potentials

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American Journal of Climate Change 2024年第3期13卷 406-426页

作者： Muhammad Aslam Ali S. K. Md. Fazlay Rabbi Md. Abdul Baten hafsa Jahan Hiya Shah Tasdika Auyon Md. Shamsur Rahman Deboki Kundu Khairul Amin Sanjit Chandra Barman Tanver Hossain Fariha Binte Nobi Department of Environmental Science Bangladesh Agricultural University Mymensingh Bangladesh Department of Environmental Science and Disaster Management Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Bangladesh Department of Agricultural Extension Mymensingh Region Mymensingh Bangladesh

Global mean surface air temperature is expected to increase 1.1˚C - 6.4˚C by the end of 21st century which may affect rice productivity and methane emissions in the future climate. This experiment was conducted to investigate the response of rice cultivars to elevated air temperature (+1.5˚C higher than ambient) and soil amendments in regards to rice yield, yield scaled methane emissions and global warming potentials. The experimental findings revealed that replacement of inorganic fertilizers (20% - 40% of recommended NPKS) with Vermicompost, Azolla biofertilizer, enriched sugarcane pressmud, rice husk biochar and silicate fertilization increased rice yield 13.0% - 23.0%, and 11.0% - 19.0% during wet aman and dry boro season, respectively. However, seasonal cumulative CH4 fluxes were decreased by 9.0% - 25.0% and 5.0% - 19.0% during rainfed wet aman and irrigated dry boro rice cultivation, respectively with selected soil amendments. The maximum reduction in seasonal cumulative CH4 flux (19.0% - 25.0%) was recorded with silicate fertilization and azolla biofertilizer amendments (9.0% - 13.0%), whereas maximum grain yield increment 10.0 % - 14.0% was found with Vermicompost and Sugarcane pressmud amendments compared to chemical fertilization (100% NPKS) treated soils at ambient air temperature. However, rice grain yield decreased drastically 43.0% - 50.0% at elevated air temperature (3˚C higher than ambient air temperature), eventhough accelerated the total cumulative CH4 flux as well as GWPs in all treatments. Maximum seasonal mean GWPs were calculated at 391.0 kg CO2 eq·ha−1 in rice husk biochar followed by sugarcane pressmud (mean GWP 387.0 kg CO2 eq·ha−1), while least GWPs were calculated at 285 - 305 kg CO2 eq·ha−1 with silicate fertilizer and Azolla biofertilizer amendments. Rice cultivar BRRI dhan 87 revealed comparatively higher seasonal cumulative CH4 fluxes, yield scaled CH4 flux and GWPs than BRRI dhan 71 during wet aman rice growing season;while BRRI dhan

关键词： Rice Paddy Soil Amendments CH4 Flux GWPs Elevated Air Temperature

早期定量CT灌注参数值的变化预测动脉瘤性蛛网膜下腔出血病人延迟性脑缺血

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国际医学放射学杂志 2016年第6期 699-699页

作者： C.Rodriguez-Régent M.hafsa G.Turc W.B.Hassen M.Edjlali A.Sermet 陈振 Department of Neuroradiology Centre Hospitalier Sainte-AnneUniversité Paris Descartes

摘要目的前瞻性比较动脉瘤性蛛网膜下腔出血(a SAH)病人发病当天和第4天CT灌注(CTP)参数值变化对预后的预测价值。方法比较延迟性脑缺血病人组(DCI+组)

关键词：动脉瘤性蛛网膜下腔出血脑缺血脑血管疾病延迟性病人 CT