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Scolopendra subspinipes mutilans protected the ceruleininduced acute pancreatitis by inhibiting high-mobility group box protein-1

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World Journal of Gastroenterology 2013年第10期19卷 1551-1562页

作者： Il-Joo Jo Gi-Sang Bae Kyoung-Chel Park sun Bok Choi Won-Seok jung Su-Young jung jung-Hee Cho Mee-Ok Choi Ho-Joon Song sung-Joo Park Department of Herbology School of Oriental MedicineWonkwang UniversityIksanJeonbuk 540-749South Korea Department of Beauty Science Kwangju women's UniversityKwangju 506-713South Korea Hanbang Body-fluid Research Center Wonkwang UniversityIksanJeonbuk 540-749South Korea Jeollanamdo Development Institute for Korean Traditional Medicine JangheungJeollanamdo 529-851South Korea

AIM:To evaluate the inhibitory effects of Scolopendra subspinipes mutilans(SSM) on cerulein-induced acute pancreatitis(AP) in a mouse ***:SSM water extract(0.1,0.5,or 1 g/kg) was administrated intraperitoneally 1 h prior to the first injection of *** AP developed,the stable cholecystokinin analogue,cerulein was injected hourly,over a 6 h *** samples were taken 6 h later to determine serum amylase,lipase,and cytokine *** pancreas and lungs were rapidly removed for morphological examination,myeloperoxidase assay,and real-time reverse transcription polymerase chain *** specify the role of SSM in pancreatitis,the pancreatic acinar cells were isolated using collagenase *** the cells were pre-treated with SSM,then stimulated with *** cell viability,cytokine productions and high-mobility group box protein-1(HMGB-1) were ***,the regulating mechanisms of SSM action were ***:The administration of SSM significantly attenuated the severity of pancreatitis and pancreatitis associated lung injury,as was shown by the reduction in pancreatic edema,neutrophil infiltration,vacuolization and *** treatment also reduced pancreatic weight/body weight ratio,serum amylase,lipase and cytokine levels,and mRNA expression of multiple inflammatory mediators such as tumor necrosis factor-α and interleukin-1β.In addition,treatment with SSM inhibited HMGB-1 expression in the pancreas during *** accordance with in vivo data,SSM inhibited the cerulein-induced acinar cell death,cytokine,and HMGB-1 *** also inhibited the activation of c-Jun NH2-terminal kinase,p38 and nuclear factor(NF)-κ***:These results suggest that SSM plays a protective role during the development of AP and pancreatitis associated lung injury via deactivating c-Jun NH2-terminal kinase,p38 and NF-κB.

关键词： Scolopendra subspinipes mutilans Cytokines Acute pancreatitis High-mobility group box protein-1

Direct modification of spermatogonial stem cells using lentivirus vectors in vivo leads to efficient generation of transgenic rats

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Asian Journal of Andrology 2019年第2期21卷 190-195页

作者： Bang-Jin Kim Yong-Hee Kim Myeong-Geun Oh Ki-jung Kim Sang-Eun jung Ju-Hee Jin sun-Uk Kim Kwan-Sik Min Buom-Yong Ryu Department of Animal Scienee and Technology College of Biotechnology and Natural ResourcesChung-Ang UniversityAnseongGyeonggi-do 17546Korea National Primate Research Center Korea Research Institute of Bioscienee and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Animal Biotechnology Graduate School of Future Con verge nee Tech no logyDepartment of Animal Life ScienceInstitute of Genetic Engi neeringHankyong National UniversityAnseongGyeon ggi-do 17579Korea Department of Cancer Biology University of PennsylvaniaPhiladelphiaPA 19104USA.

Spermatogonial stem cells(SSCs)transmit genetic information to the next progeny in ***,SSCs are a potential target for germ I i ne modifications to gen erate tran sgenic an *** this study,we report a technique for the gen erati on of tran sgenic rats by in vivo manipulation of SSCs with a high success *** in juvenile rats were transduced in vivo with high titers of lentivirus harbori ng enhan ced green fluoresce nt protei n and mated with wild-type females to create foun der *** founder rats expressed the transgene and passed on the transgene with an overall success rate of 50.0%.Subsequent generations of progeny from the founder rats both expressed and passed on the ***,direct modification of SSCs in juvenile rats is an effective means of generating transgenic rats through the male *** technology could be adapted to larger animals,in which existing methods for gene modificatio n are in adequate or in applicable,resulti ng in the gen eration of tran sge nic an imals in a variety of species.

关键词： germline modification lentivirus spermatogonial stem cell testis transgenic animal

Optimally arranged TiO_(2)@MoS_(2) heterostructures with effectively induced built-in electric field for high-performance lithium-sulfur batteries

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Journal of Energy Chemistry 2023年第8期83卷 496-508,I0012页

作者： Jeongyoub Lee Changhoon Choi jung Been Park Seungho Yu Jinho Ha Hyungsoo Lee Gyumin Jang Young sun Park Juwon Yun Hayoung Im Subin Moon Soobin Lee jung-Il Choi Dong-Wan Kim Jooho Moon Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea Energy Storage Research Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Mathematics and Computing(Computational Science and Engineering) Yonsei UniversitySeoul 03722Republic of Korea

To overcome the serious technological issues affecting lithium-sulfur(Li-S) batteries,such as sluggish sulfur redox kinetics and the detrimental shuttle effect,heterostructure engineering has been investigated as a strategy to effectively capture soluble lithium polysulfide intermediates and promote their conversion reaction by integrating highly polar metal oxides with catalytically active metals ***,to fully exploit the outstanding properties of heterostructure-based composites,their detailed structure and interfacial contacts should be designed ***,optimally arranged TiO_(2)and MoS_(2)-based heterostructures(TiO_(2)@MoS_(2)) are fabricated on carbon cloth as a multifunctional interlayer to efficiently trap polysulfide intermediates and accelerate their redox *** to the synergistic effects between TiO_(2)and MoS_(2)and the uniform heterointerface distribution that induces the ideally oriented built-in electric field,Li-S batteries with TiO_(2)@MoS_(2)interlayers exhibit high rate capability(601 mA h g^(-1)at 5 C),good cycling stability(capacity-fade rate of 0.067% per cycle over 500 cycles at2 C),and satisfactory areal capacity(5.2 mA h cm^(-2)) under an increased sulfur loading of 5.2 mg cm^(-2).Moreover,by comparing with a MoS_(2)@TiO_(2)interlayer composed of reversely arranged heterostructures,the effect of the built-in electric field’s direction on the electrocatalytic reactions of polysulfide intermediates is thoroughly investigated for the first *** superior electrocatalytic activities of the rationally arranged TiO_(2)@MoS_(2)interlayer demonstrate the importance of optimizing the built-in electric field of heterostructures for producing high-performance Li-S batteries.

关键词： Lithium-sulfur batteries Shuttle effect TiO_(2)-MoS_(2)heterostructure engineering Built-in electric field Multifunctional interlayers

Study on durability of Pt supported on graphitized carbon under simulated start-up/shut-down conditions for polymer electrolyte membrane fuel cells

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Journal of Energy Chemistry 2018年第1期27卷 326-334页

作者： Won Suk jung Department of Chemical Engineering University of South CarolinaColumbiaSC 29208USA

The primary issue for the commercialization of proton exchange membrane fuel cell（PEMFC） is the carbon corrosion of support under start-up/shut-down conditions. In this study, we employ the nanostructured graphitized carbon induced by heat-treatment. The degree of graphitization starts to increase between 900 and 1300 ℃ as evidenced by the change of specific surface area, interlayer spacing, and ID/IG value. Pt nanoparticles are deposited on fresh carbon black（Pt/CB） and carbon heat-treated at 1700 ℃（Pt/HCB17） with similar particle size and distribution. Electrochemical characterization demonstrates that the Pt/HCB17 shows higher activity than the Pt/CB due to the inefficient microporous structure of amorphous carbon for the oxygen reduction reaction. An accelerating potential cycle between 1.0 and 1.5 V for the carbon corrosion is applied to examine durability at a single cell under the practical start-up/shutdown conditions. The Pt/HCB17 catalyst shows remarkable durability after 3000 potential cycles. The Pt/HCB17 catalyst exhibits a peak power density gain of 3%, while the Pt/CB catalyst shows 65% loss of the initial peak power density. As well, electrochemical surface area and mass activity of Pt/HCB17 catalyst are even more stable than those of the Pt/CB catalyst. Consequently, the high degree of graphitization is essential for the durability of fuel cells in practical start-up/shut-down conditions due to enhancing the strong interaction of Pt and π-bonds in graphitized carbon.

关键词： Polymer electrolyte membrane fuel ceils Membrane electrolyte assembly Carbon corrosion Start-up/shut-down Durability

Tolerating Permanent State Transition Faults in Asynchronous Sequential Machines

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Journal of Computer Science & Technology 2016年第5期31卷 1028-1037页

作者： jung-Min Yang School of Electronics Engineering Kyungpook National University Daegu 41566 Korea

Corrective control theory lays a novel foundation for the fault-tolerant control of asynchronous sequential machines. In this paper, we present a corrective control scheme for tolerating permanent state transition faults in the dynamics of asynchronous sequential machines. By a fault occurrence, the asynchronous machine may be stuck at a faulty state, not responding to the external input. We analyze the detectability of the considered faults and present the necessary and sufficient condition for the existence of a controller that overcomes any permanent transition faults. Fault tolerance is realized by using potential reachability and asynchronous mechanisms in the machine. A case study on an asynchronous counter is provided to illustrate the proposed fault detection and tolerance scheme.

关键词： asynchronous sequential machine corrective control permanent fault fault tolerance

Implementation of spatial touch system using time-of-flight camera

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重庆邮电大学学报（自然科学版） 2009年第2期21卷 222-227页

作者： AHN Yang-Keun PARK Young-Choong CHOI Kwang-Soon PARK Woo-Chool SEO hae-Moon jung Kwang-Mo Intelligent Home Platform Research Center Korea Electronics Technology Institute Seoul Korea

Recently developed time-of-flight principle based depth-sensing video camera technologies provide precise per-pixel range data in addition to color video. Such cameras will find application in robotics and vision-based human computer interaction scenarios such as games and gesture input systems. Time-of-flight principle range cameras are becoming more and more available. They promise to make the 3D reconstruction of scenes easier, avoiding the practical issues resulting from 3D imaging techniques based on triangulation or disparity estimation. A spatial touch system was presented which uses a depth-sensing camera to touch spatial objects and details on its implementation, and how this technology will enable new spatial interactions was speculated.

关键词：飞行时间输入系统空间对象照相机三维成像技术空间相互作用彩色图像人机交互

Double hits with bioactive nanozyme based on cobalt-doped nanoglass for acute and diabetic wound therapies through anti-inflammatory and pro-angiogenic functions

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Bioactive Materials 2024年第1期31卷 298-311页

作者： Nandin Mandakhbayar YunSeong Ji Ahmed El-Fiqi Kapil DPatel Dong Suk Yoon Khandmaa Dashnyam Oyunchimeg Bayaraa Gangshi Jin Khaliunsarnai Tsogtbaatar Tae-Hyun Kim jung-Hwan Lee hae-Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Glass Research Department National Research CentreCairo12622Egypt School of Cellular and Molecular Medicine(CMM) University of BristolBristolBS81TD United Kingdom Department of Biomedical Science Hwasung Medi-Science UniversityHwaseong-Si 18274Gyeonggi-DoRepublic of Korea Drug Research Institute Mongolian University of Pharmaceutical SciencesUlaanbaatar 14250Mongolia R&D Center TE BiosOsongRepublic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan31116Republic of Korea UCL Eastman-Korea Dental Medicine Innovation Centre Dankook UniversityCheonan31116Republic of Korea Cell&Matter Institute Dankook UniversityCheonan 31116Republic of Korea

Regeneration of pathological wounds,such as diabetic ulcers,poses a significant challenge in clinical settings,despite the widespread use of *** overcome clinical side effects and complications,drug-free therapeutics need to be developed to promote angiogenesis while overcoming inflammation to restore regenerative *** study presents a novel bioactive nanozyme based on cobalt-doped nanoglass(namely,CoNZ),which exhibits high enzymatic/catalytic activity while releasing therapeutic *** oxide“Co3O4”tiny crystallites produced in situ through a chemical reaction with H2O2 within CoNZ nanoparticles play a crucial role in scavenging *** showed that CoNZ-treatment to full-thickness skin wounds in mice significantly accelerated the healing process,promoting neovascularization,matrix deposition,and epithelial lining while reducing pro-inflammatory ***,CoNZ was highly effective in treating pathological wounds(streptozotocin-induced diabetic wounds).Rapid scavenging of ROS by CoNZ and down-regulation of pro-inflammatory markers while up-regulating tissue healing signs with proliferative cells and activated angiogenic factors contributed to the observed healing *** vitro experiments involving CoNZ-cultures with macrophages and endothelial cells exposed to high glucose and ROS-generating conditions further confirmed the effectiveness of ***-promoted angiogenesis was attributed to the release of cobalt ions,as evidenced by the comparable effects of CoNZ-extracted ionic medium in enhancing endothelial migration and tubule formation via activated HIF-1α.Finally,we compared the in vivo efficacy of CoNZ with the clinically-available drug *** demonstrated that CoNZ was as effective as the drug in closing the diabetic wound,indicating the potential of CoNZ as a novel drug-free therapeutic approach.

关键词： Diabetic wound Nanozyme Anti-inflammation Angiogenesis Therapeutic materials

Next High Performance and Low Power Flash Memory Package Structure

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Journal of Computer Science & Technology 2007年第4期22卷 515-520页

作者： jung-Hoon Lee ERI Control Instrumentation EngineeringGyeongSang National UniversityJinju660-701Korea

In general, NAND flash memory has advantages in low power consumption, storage capacity, and fast erase/write performance in contrast to NOR flash. But, main drawback of the NAND flash memory is the slow access time for random read operations. Therefore, we proposed the new NAND flash memory package for overcoming this major drawback. We present a high performance and low power NAND flash memory system with a dual cache memory. The proposed NAND flash package consists of two parts, i.e., an NAND flash memory module, and a dual cache module. The new NAND flash memory system can achieve dramatically higher performance and lower power consumption compared with any conventionM NAND-type flash memory module. Our results show that the proposed system can reduce about 78% of write operations into the flash memory cell and about 70% of read operations from the flash memory cell by using only additional 3KB cache space. This value represents high potential to achieve low power consumption and high performance gain.

关键词： flash memory NAND-type NOR-type memory localities buffer or cache memory

Novel predictors for lymph node metastasis in submucosal invasive colorectal carcinoma

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World Journal of Gastroenterology 2017年第32期23卷 5936-5944页

作者： Kwangil Yim Daeyoun David Won In Kyu Lee Seong-Taek Oh Eun sun jung sung Hak Lee Department of Hospital Pathology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Department of Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Department of Surgery Uijeongbu St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

AIM To evaluate a novel grading system to predict lymph node metastasis(LNM) in patients with submucosal invasive colorectal carcinoma(SICRC).METHODS We analyzed the associations between LNM and various clinicopathological features in 252 patients with SICRC who had undergone radical surgery at the Seoul Saint Mary's hospital between 2000 and *** LNM was observed in 31 patients(12.3%). The depth and width of the submucosal invasion, lymphatic invasion, tumor budding, and the presence of poorly differentiated clusters(PDCs) were significantly associated with the incidence of LNM. Using multivariate analysis, the receiver operating characteristic curvewas calculated and the area under curve(AUC) was used to compare the ability of the different parameters to identify the risk of LNM. The most powerful clinicopathological parameter for predicting LNM was lymphatic invasion(difference AUC = 0.204), followed by the presence or absence of tumor budding(difference AUC = 0.190), presence of PDCs(difference AUC = 0.172) and tumor budding graded by the Ueno method(difference AUC = 0.128). CONCLUSION Our results indicate that the tumor budding and the depth multiplied by the width measurements of submucosal invasion can provide important information for patients with SICRC.

关键词： Colorectal cancer Neoplasm invasion Lymph node Metastasis