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中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： Yang Cheng Feng Lu Bo Wang Jian Li Jin-Hee Han Daisuke Ito Deok-Hoon Kong Lubin Jiang Jian Wu Kwon-Soo Ha Eizo Takashima Jetsumon Sattabongkot Won Sun park Seok-Ho Hong Sanjay A.Desai Louis H.Miller Takafumi Tsuboi Eun-Taek Han Department of Medical Environmental Biology and Tropical Medicine School of MedicineKangwon National University Department of Parasitology Wuxi Medical School Jiangnan University Laboratory of Malaria and Vector Research (LMVR) National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH) Division of Malaria Research Proteo-Science Center Ehime University Department of Molecular and Cellular Biochemistry School of Medicine Kangwon National University Key Laboratory of Molecular Virology & Immunology Unit of Human Parasite Molecular and Cell Biology Institut Pasteur of Shanghai Mahidol Vivax Research Unit Faculty of Tropical Medicine Mahidol University Department of Physiology School of Medicine Kangwon National University Department of Internal Medicine School of Medicine Kangwon National University

Plasmodium vivax, a major agent of malaria in both temperate and tropical climates, has a limited capacity for infecting humans lacking the Duffy(Fy) blood group antigen as this receptor is critical for erythrocyte invasion. Recent surveys in various endemic regions, however, have reported P. vivax infections in Duffy-negative individuals, suggesting that the parasite may utilize alternative receptor-ligand pairs to complete erythrocyte invasion. Here, we identified and characterized a novel parasite ligand, GPI-anchored micronemal antigen(Pv GAMA), that can bind human erythrocytes regardless of Duffy antigen status. Specific antibodies raised against PvG AMA localize the protein to the parasite microneme, consistent with a role in invasion. These antibodies also inhibited Pv GAMA binding to erythrocytes in a dose-dependent manner. Pv GAMA appears to play a role in a sialic acid-independent, chymotrypsin-sensitive invasion pathway. Thus, Pv GAMA may be an adhesion molecule for invasion of Duffy positive and negative human erythrocytes and is an important P. vivax vaccine candidate.

关键词： Plasmodium vivax GAMA erythrocyte binding Duffy negative sialic acid-independent vaccine candidate

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预测新辅助放化疗后宫颈癌进展:治疗后DWI的价值

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国际医学放射学杂志 2016年第6期 706-706页

作者： J.J.park C.K.Kim B.K.park 徐贝 Department of Radiology and Center for Imaging Science Samsung Medical CenterSungkyunkwan University School of Medicine

摘要目的探究治疗后扩散加权成像(DWI)对宫颈癌新辅助放化疗(CCRT)进展的预测价值。方法该回顾性分析包括连续100例局部进展宫颈癌在完成CCRT后1个月进

关键词： DWI 新辅助放化疗治疗后宫颈癌

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阴道管状绒毛状腺瘤

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世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 54-54页

作者： Lee S.E. park N.H. park I.A. 王伟华 Dept. of Obstetrics and Gynecology College of Medicine Seoul National University 28 Yun Gun- dong Chong No- Gu Seoul South Korea

Tubulo- villous adenomas are common in the colon and rectum, but extremely rare in the vagina. As far as we know, only two cases of tubulo- villous adenoma have ever been reported. We report the third case of enteric- type tubulo- villous adenoma of the vagina. A 61- year- old woman presented a symptom of intermittent vaginal spotting and a tumor located outside the vaginal introitus near the urethra. The tumor was excised and pathologically confirmed as a tubulo- villous adenoma. Because some tubulo- villous adenomas in the colon and rectum can progress to the cancer, this case requires long- term followup to detect recurrence and malignant transformation.

关键词：管状绒毛状腺瘤病理检查道中

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全球地震台网记录苏门答腊-安达曼特大地震

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世界地震译丛 2005年第1期36卷 1-5页

作者： J.park K.Anderson R.Aster R.Butler T.Lay D.Simpson 邹本良孙旭丽吕春来杨智娴不详吉林省地震局

2004年12月26日，苏门答腊岛北端附近的印度尼西亚消减带于格林尼治时午夜过后的零时58分47秒开始破裂。破裂沿巽他海沟向西北方向扩展了约1200km，到达安达曼群岛，持续了约7分钟。海底发生的断层位移产生了巨大的海啸，海啸席卷苏门... 详细信息

2004年12月26日，苏门答腊岛北端附近的印度尼西亚消减带于格林尼治时午夜过后的零时58分47秒开始破裂。破裂沿巽他海沟向西北方向扩展了约1200km，到达安达曼群岛，持续了约7分钟。海底发生的断层位移产生了巨大的海啸，海啸席卷苏门答腊岛北部沿岸高度达10m，

关键词：苏门答腊岛地震安达曼群岛海啸振幅信号方向性

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血氧水平依赖性MR成像预测宫颈癌同步放化疗治疗反应的初步经验

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国际医学放射学杂志 2014年第5期 492-492页

作者： C.K.Kim S.Y.park B.K.park W.park S.J.Huh 黄育斌 Department of Radiology and Center for Imaging Science Samsung Medical CenterSungkyunkwan University School of Medicine50 Ilwon-dongGangnam-guSeoulRepublic of Korea

摘要目的探究血氧水平依赖性(BOLD)MRI预测宫颈癌病人同步放化疗(CCRT)治疗反应的价值。方法 30例经活检确诊为宫颈癌的病人在进行CCRT前后分别接受BOLD

关键词：治疗反应病人宫颈癌 MR 血氧

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142651例静脉对比增强CT扫描中对比剂外渗的发生率、后果及危险因素

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国际医学放射学杂志 2019年第1期 128-128页

作者： E.J.Hwang C.I.Shin Y.H.Choi C.M.park 马娟微 Department of Radiology Seoul National University College of Medicine

摘要目的评估大规模人群中进行增强CT扫描时,静脉注射对比剂(CM)外渗发生、后果及危险因素。方法本研究经伦理委员会批准。收集2015年1月—2017年4月期间

关键词：危险因素对比剂发生率 CT

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Design,Synthesis and Biological Evaluation of Novel Inhibitors Targeting EGFRT790M Mutant for Overcoming Clinical Resistance

Design,Synthesis and Biological Evaluation of Novel Inhibito...

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中国化学会第十届全国有机合成化学学术研讨会

作者： Shaohua Chang,Shilin Xu,Tianfeng Xu,Lianwen Zhang,Jinfeng Luo,Xiaoyun Lu, Zhang Zhang,Zhengchao Tu,Xiaomei Ren,and Ke DingKey Laboratory of Regenerative Biology and Institute of Chemical Biology,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,#190 Kaiyuan Avenue,Guangzhou Science park, Guangzhou 510530,China.

The EGFR mutant contributes approximately 50%for clinically acquired resistance against gefitinib or ***,almost all the single agent clinical trials of the 2nd generation irreversible EGFR inhibitors seem disappointing to overcome the EGFR related *** have designed and synthesized 5,8-dioxo-pyrimido[4,5-e][1,4]diazepin,2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives and tetra-heterocycli compounds as novel EGFR *** most potent compounds 2q and 2s inhibited the enzymatic activities of wild-type and mutated EGFRs with IC values in subnanomolar ranges,including the T790M *** kinase inhibitory efficiencies of the compounds

关键词： EGFR T790M mutation clinically acquired resistance irreversible inhibitor

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Quasioptical System of Trao Telescope

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天文研究与技术 1999年第S1期 86-89页

作者： Jong Ae park 1,2 , Seog Tae Han 1, Tai Seong Kim 1, Kwang Dong Kim 1, Hyo Ryoung Kim 1, Hyun Soo Chung 1, Chang Hoon Lee 1, Se Hyung Cho 1, Jongmann Yang 2 1. (Taeduk Radio Astronomy Observatory (TRAO), Hwaam dong, Yusung gu Taejon

The quasioptical system of the dual channel receiver is designed and developed for the simultaneous observation with two bands. The frequency independent matching of Gaussian beam is applied to design the quasioptical system with two focusing elements for each band, respectively. The emphasis is on the design to be satisfied with two bands simultaneously. The beam measurement system is also developed to measure the quasioptical system and their components as well as to align the quasioptical elements. We have measured the intensity distributions of the Gaussian beam in the transverse plane and the variations of the beam widths along the propagation axis near the Cassegrain focus. The measured results are also compared the theory.

关键词： Quasioptical System of Trao Telescope

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Comparative genomic hybridization (CGH) microarray reveals genetic diversity among the main epidemic leptospira interrogans in China

Comparative genomic hybridization (CGH) microarray reveals g...

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首届全国微生物基因组学学术研讨会

作者： Ping He, Yue-Ying Sheng, Yao-Zhou Shi, Xiu-Gao Jiang, Jin-Hong Qin, Zhi-Ming Zhang, Guo-Ping Zhao, Xiao-Kui Guo Department of microbiology and parasitology. Shanghai Jiaotong university, Shanghai 20025, China National engineering center for biochip at Shanghai, Zhangjiang High Tech park, 201203, China.

Leptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in accidental hosts, including humans. Comparative genomic hybridization (CGH) microarray analysis was used to compare the gene content of L. interrogans serovar Lai strain Lai with the gene contents of other L. interrogans strains. Missing genes in a tested strain were detected on a microarray slide spotted with 3,528 open reading frames (ORFs) of L. interrogans serovar Lai strain Lai. For 11 strains subjected to the CGH microarray analyses 280 ORFs were found to be absent in at least one strain. The common backbone of the L. interrogans genome was estimated to contain about 2,948 ORFs. The strain-specific genes include genes encoding cell surface structures, metabolism genes and Cellular processes. Genes involved in O-antigen synthesis were highly divergent in strains belonging to the different serogroups, which revealed that antigenic differences between the serogroups are due to genes in the rfb locus. Examination of the genomic context of the strain-specific genes suggests that many are horizontally acquired. The data demonstrated that the CGH microarray technique is useful for genomic comparisons.

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非小细胞肺癌的临床T分期:CT影像上一维和二维测量结果判断肿瘤预后的表现

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国际医学放射学杂志 2019年第3期 359-359页

作者：法良国 H.Kim J.M.Goo Y.T.Kim C.M.park Department of Radiology Seoul National University College of Medicine

摘要目的对于接受过外科手术切除的非小细胞肺癌(NSCLC)病人,根据其CT影像上肿瘤的长径和平均直径而进行的临床T分期的预后表现进行对比研究。材料与方法

关键词：小细胞肺癌肿瘤预后 NSCLC CT

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