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Ethyl acetate fraction of cynanchum peniculatum and bee venom therapy in experimental canine stifle osteoarthritis

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畜牧与兽医 2012年第S2期44卷 40-40页

作者： hae beom lee Min Su Kim Ki Chang lee Md. Rafiqul Alam Nam Soo Kim Department of Surgery College of Veterinary Medicin and Bio-Safety Research InstituteChonbuk National University Department of Surgery and Obstetrics Faculty of Veterinary ScienceBangladesh Agricultural University

This study evaluated the therapeutic effects of the phytomedicine,ethyl acetate fraction of the Cynanchum peniculatum (EACP) and bee venom (BV) of the honey bee (Apis mellifera) for the treatment of experimental stifle osteoarthritis (OA) in 24 skeletally mature mixed small breed dogs (age 2 to 6 years,weight 2. 8 to 9 kg). One year after induction of OA,the animals were randomly allocated in 2 groups; the EACP-group received 10% solution of EACP 0. 5mL plus 0. 2 mL lidocaine; and the BV-group received 10% solution of BV 0. 5 mL plus 0. 2 mL lidocaine intraarticularly twice in a week in the OA-induced stifles for one month. The joint tissue specimens,synovial fluid (SF) and blood samples were collected prior to and 12 months after induction of OA,and one month posttreatment. TRAP levels in SF and serum were measured using a spectrophotometer,and TRAP-positive cells in joint tissues were identified by enzyme histochemistry. TIMP-2 in SF and serum was detected by ELISA. Histochemistry revealed an increased number of TRAP positive cells in tissues from OA-affected joints which was decreased after one month treatment with BV and EACP. After one-month administration of EACP and BV,the levels of TRAP in SF of the index stifles as well as that in the serum were significantly decreased (P<0. 05),whereas,the levels of TIMP-2 in SF of the index stifles as well as that in the serum were increased indicating the therapeutic effects of the EACP and BV on improvement of the conditions of *** intraarticular administration of EACP and BV were found effective for the treatment of OA in the dog.

关键词： osteoarthritis Cynanchum peniculatum Bee venom TRAP TIMP-2 gog

Macrophage activation syndrome in children with Kawasaki disease: diagnostic and therapeutic approaches

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World Journal of Pediatrics 2020年第6期16卷 566-574页

作者： Seung beom Han Soo-Young lee Department of Pediatrics Daejeon St.Mary's Hospital.College of MedicineThe Catholic University of Korea64 Daeheung-ro.Jung-guDaejeon 34943Republic of Korea Department of Pediatrics.Bucheon St.Mary's Hospital College of MedicineThe Catholic University of Korea327 Sosa-roWonmi-gu.Bucheon 14647Republic of Korea

Background Macrophage activation syndrome(MAS)is a rare,life-threatening complication of Kawasaki disease(KD).Early recognition and treatment of MAS are very important,but sometimes it is difficult to distinguish MAS from a severe form of *** sources A PubMed search was performed in Clinical Queries using the key terms“macrophage activation syndrome or secondary hemophagocytic lymphohistiocytosis(HLH)”and“Kawasaki disease”.Results KD patients with MAS show high intravenous immunoglobulin(IVIG)resistance and coronary *** is also as high as MAS in other *** fever greater than 10 days is highly associated with development of MAS in *** is observed in more than two-thirds of KD patients with *** is often the earliest laboratory finding of *** is highly specific and sensitive for detecting MAS in KD;so,ferritin levels should be checked if there are unexplained clinical exacerbations in KD *** the under-recognition of MAS in KD,it is prudent to consider resistant KD as occult/subclinical *** KD patients with MAS have good outcomes on immune ***,if KD patients fulfill the HLH-2004 diagnostic criteria,they may undergo longer and more intensive treatment than *** The possible existence of MAS should be taken into account when a KD patient shows persistent fever,splenomegaly,thrombocytopenia,hyperferritinemia,or IVIG *** under-diagnosis of MAS in patients with KD is an important issue to be ***,however,there is a possibility of over-treatment of MAS in patients with KD.

关键词： Macrophage activation syndrome Kawasaki disease Children

Dynamic observation of dendrite growth on lithium metal anode during battery charging/discharging cycles

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npj Computational Materials 2022年第1期8卷 960-972页

作者： hae Gon lee Se Young Kim Joon Sang lee Next Generation Battery Research Center Korea Electrotechnology Research Institute(KERI)12Jeongiui-gilSeongsan-guChangwon-siGyeongsangnam-do51543Republic of Korea Department of Mechanical Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul03722Republic of Korea

Lithium metal is considered one of the most promising anode materials for application in next-generation ***,despite decades of research,practical application of lithium metal batteries has not yet been achieved because the fundamental interfacial mechanism of lithium dendrite growth is not yet fully *** this study,a series of reactive molecular dynamics (MD) simulations was performed to investigate the electrochemical dynamic reactions at the electrode/electrolyte *** allows quantitative characterization of morphological phenomena and real-time interfacial visualization of the dynamic growth of dead lithium and dendrites during repeated *** computational protocol was utilized to investigate the dendrite mitigation mechanism when an electrolyte additive (hydrogen fluoride) is dissolved in an organic ethylene carbonate (EC) electrolyte *** was confirmed that beneficial decomposition reactions between electrolyte components form a protective film on the anode surface,suppressing large interphase volume changes and unnecessary degradation reactions.

关键词： battery lithium electrolyte

Direct optical-structure correlation in atomically thin dichalcogenides and heterostructures

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Nano Research 2020年第5期13卷 1363-1368页

作者： Akshay Singh hae Yeon lee Silvija Gradcak Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AveCambridgeMA 02141USA

Atomically thin transition metal dichalcogenides(TMDs)have distinct opto-electronic properties including enhanced luminescence and high on-off current ratios,which can be further modulated by making more complex TMD ***,resolution limits of conventional optical methods do not allow for direct nanoscale optical-structural correlation measurements in these materials,particularly of buried interfaces in TMD *** we use,for the first time,electron beam induced cathodoluminescence in a scanning transmission electron microscope(CL-STEM)to measure optical properties of monolayer TMDs(WS2,MoS2 and WSSe alloy)encapsulated between layers of *** observe dark areas resulting from localized(~100 nm)imperfect interfaces and monolayer folding,which shows that the intimate contact between layers in this application-relevant heterostructure is required for proper inter layer *** also realize a suitable imaging method that minimizes electron-beam induced changes and provides measurement of intrinsic *** overcome the limitation of small electron interaction volume in TMD monolayer(and hence low photon yield),we find that encapsulation of TMD monolayers with hBN and subsequent annealing is ***-STEM offers to be a powerful method to directly measure structure-optical correspondence in lateral or vertical heterostructures and alloys.

关键词： cathodoluminescence two-dimensional(2D)materials transition metal dichalcogenides interfaces heterostructures

Development of Non-Dissipative Direct Time Integration Method for Structural Dynamics Application

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Computer Modeling in Engineering & Sciences 2019年第1期118卷 41-89页

作者： Sun-beom Kwon Jae-Myung lee Department of Naval Architecture and Ocean Engineering Pusan National UniversityJangjeon-DongGeumjeong-GuBusan 609-735Korea.

A direct time integration scheme based on Gauss-Legendre quadrature is proposed to solve problems in linear structural *** proposed method is a oneparameter non-dissipative *** stability,accuracy,and dispersion characteristics are achieved using appropriate values of the *** proposed scheme has second-order accuracy with and without physical ***,its stability,accuracy,and dispersion are *** addition,its performance is demonstrated by the two-dimensional scalar wave problem,the single-degree-of-freedom problem,two degrees-of-freedom spring system,and beam with boundary *** wave propagation problem is solved in the high frequency wave regime to demonstrate the advantage of the proposed *** the proposed scheme is applied to solve the wave problem,more accurate solutions than those of other methods are obtained by using the appropriate value of the *** the single-degree-offreedom system,two degrees-of-freedom system,and the time responses of beam,the proposed scheme can be used effectively owing to its high accuracy and lower computational cost.

关键词： Structural dynamics finite elements direct time integration Gauss-Legendre quadrature non-dissipative scheme.

Synthesis of Fe_3O_4-coated silica aerogel nanocomposites

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中国有色金属学会会刊：英文版 2012年第S3期22卷 702-706页

作者： Jun Sung lee Eun Jung lee hae Jin HWANG Devision of Materials Science and Engineering Inha University

Fe3O4:SiO2 nanocomposite powders were synthesized by a two-step process,which included the precipitation of FeCl2 and FeCl3 and the gelation of silicic acid solution derived from water *** first,Fe3O4 nanoparticles having a crystallite size of 20 nm were obtained by controlling the ratio of Fe(II) and Fe(III) *** the second step,Fe3O4 particles were embedded in SiO2 matrix by the hydrolysis and subsequent condensation of the silicic acid solution containing Fe3O4 *** was found that the Fe3O4 nanoparticles homogenously disperse in the SiO2 *** Fe3O4:SiO2 nanocomposite exhibited an enhanced thermal stability against oxidation compared with pure ***-IR analysis indicates the presence of the Si-O-Fe bond in the Fe3O4:SiO2 (1:10,mole fraction) nanocomposite.

关键词： nanocomposite Fe3O4 SiO2 sol gel synthesis

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Velocity Profiles between Two Baffles in a Shell and Tube Heat Exchanger

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Journal of Thermal Science 2015年第4期24卷 356-363页

作者： Tae-Hyun Chang Chang-Hoan lee hae-Soo lee Kwon-Soo lee Senior Research Fellow of RESEAT Korea Institute of Science and Technology Information Korea Institute of Science and Technology Information Postdoctoral Research Fellow School of Mechanical Engineering of Kyungnam University International University of Korea

Heat exchangers are extensively utilized for waste heat recovery,oil refining,chemical processing,and steam *** this study,velocity profiles are measured using a 3D particle image velocimetry(PIV)system between two baffles in a shell and tube heat exchanger for parallel and counter *** PIV and computational fluid dynamics results show the occurrence of some strong vectors near the *** vectors are assumed due to the clearance between the inner tubes and the front ***,the major parts of the vectors are moved out through the bottom opening of the rear baffle,and other vectors produce a large circle between the two *** simulations are conducted to investigate the effects of the baffle on the heat exchanger using the Fluent *** k-εturbulence model is employed to calculate the flows along the heat exchanger.

关键词： Baffle P1V Shell and tube heat exchanger Cut off ratio CFD