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稀有金属材料与工程 2006年第A3期35卷 240-241页

作者： Jui-Fu Cheng jung-Chuan Chou Tai-Ping sun Shen-Kan Hsiung Institute of Electronic Engineering Chung Yuan Christian University Chung-Li Taiwan 320 China Graduate School of Electronic Engineering National Yunlin University of Science and Technology Douliou Taiwan 640 China Institute of Electrical Engineering National Chi Nan University Nantou Taiwan 545 China

This paper presents the studying results of the sodium ion sensor device based on the SnO_2/ITO glass structure in the detection of rinsing solution for contact *** selective membrane contains poly (vinyl chloride) (PVC),bis (2-ethylhexyl) sebacate (DOS),(12-crown-4) methylmalonate (B12C4),and sodium tetrakis (4-fluoropbenyl) borate dehydrate (NaTFBD). The final weight ratios are PVC:DOS:B12C4:NaTFBD=33:66:2:*** this condition,the sensor has performances with linear sensitivity,short response time,good repeatability and *** sensor was used to measure the rinsing solution for the contact *** the experimental results show close to the accurate value for four commercial products,this sensor can preliminary be used in detecting the rinsing solution for the contact *** this structure and sodium-sensing membrane to construct the sodium sensor is proven successfully in this application.

关键词： sodium ion sensor solution for contact lenses tin oxide electrode B12C4

Study on the Drift Calibration Method and Device for the Tin Oxide pH Electrode

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稀有金属材料与工程 2006年第A3期35卷 210-212页

作者： Chu-Neng Tsai jung-Chuan Chou Tai-Ping sun Shen-Kan Hsiung Institute of Electronic Engineering Chung Yuan Christian University Chung-Li Taiwan 320 China Graduate School of Electronic Engineering National Yunlin University of Science and Technology Douliou Taiwan 640 China Department of Electrical Engineering National Chi Nan University Nantou Taiwan 545 China

Drift phenomenon has been known as the drawback of sensors and causes inaccuracy on the long-term measurement. In general,there are two methods to reduce the drift *** is to tune the parameters of the fabrication process to improve the properties of the front-ended *** is to compensate the drift phenomenon by adding extra drift compensation circuit or software in the back-ended readout *** this study,a drift calibration method for the potentiometric sensor was presented and the drift calibration method was performed by using the *** to experimental results,the drift phenomenon of the SnO_2 pH electrode was reduced by the drift calibration device.

关键词： drift phenomenon long-term measurement drift calibration method drift calibration device SnO2 pH electrode

Potentiometric Urea Biosensor Based on Ion-Selective Electrode by Different Immobilization Procedures

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稀有金属材料与工程 2006年第A3期35卷 309-312页

作者： Nien-Hsuan Chou jung-Chuan Chou Tai-Ping sun Shen-Kan Hsiung Institute of Electronic Engineering Chung Yuan Christian University Chung-Li Taiwan 320 China Graduate School of Electronic Engineering National Yunlin University of Science and Technology Douliou Taiwan 640 China Department of Electrical Engineering National Chi Nan University Nantou Taiwan 545 China

Enzyme was immobilized on an ammonium ion-selective electrode by different *** ion-selective electrode is not completely ion-specific,and interfering ions react with the ion-selective electrode membrane,altering the measured ***,the characteristics of the effect of other ions on ammonium ion-selective electrode-based urea biosensors are *** on the experimental results,the urea biosensor based on entrapment had a high response voltage of around 189 mV and fast response time of around 16 ***,selectivity of the urea biosensor in different interfering ions was considered to elucidate the characteristics of ammonium ion-selective electrode-based biosensors.

关键词： enzyme immobilization ammonium ion-selective electrode interfering ions urea biosensors selectivity

Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage Ⅲ and Ⅳcolorectal cancer

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World Journal of Gastroenterology 2017年第3期23卷 505-515页

作者： Jae Hyun Kim Jun Yeop Lee hae Koo Kim Jin Wook Lee sung Gyu jung Kyoungwon jung sung Eun Kim Won Moon Moo In Park Seun Ja Park Division of Gastroenterology Department of Internal MedicineKosin University College of MedicineBusan 602-702South Korea

AIM To evaluate the prognostic value of the neutrophil-tolymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in patients with colorectal cancer(CRC).METHODS Between April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression *** The median follow-up duration was 46 mo(interquartile range, 22-73). The estimation of NLR and PLR was based on the time of diagnosis. In multivariate Cox regression analysis, high NLR (≥ 3.0) and high PLR(≥ 160) were independent risk factors predicting poor long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. However, high NLR and high PLR were not prognostic factors in patients with stage Ⅰ and Ⅱ *** In this study, we identified that high NLR (≥ 3.0) and high PLR (≥ 160) are useful prognostic factors to predict long-term outcomes in patients with stage Ⅲ and Ⅳ CRC.

关键词： Colorectal cancer Neutrophil Lymphocyte Platelet Prognosis

Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4

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World Journal of Gastroenterology 2005年第30期11卷 4674-4678页

作者： Youn-jung Kim hae-Jeong Park Seo-Hyun Yoon Mi-Ja Kim Kang-Hyun Leem Joo-Ho Chung Hye-Kyung Kim Department of Dental Hygiene Department of Pharmacology Department of Obesity Management College of Oriental Medicine Department of Food and Biotechnology

AIM: Oligomeric proanthocyanidins (OPC), natural polyphenolic compounds found in plants, are known to have antioxidant and anti-cancer effects. We investigated whether the anti-cancer effects of the OPC are induced by apoptosis on human colorectal cancer cell line, ***: Colorectal cancer cell line, SNU-C4 was cultured in RPMI 1640 medium supplemented with 10% fetal bovine serum. The cytotoxic effect of OPC was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenylt-etrazolium bromide (MTT) assay. To find out the apoptotic cell death, 4, 6-diamidino-2-phenylindole (DAPI) staining,terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcriptionpolymerase chain reaction (RT-PCR), and caspase-3 enzyme assay were ***: In this study, cytotoxic effect of OPC on SNUC4 cells appeared in a dose-dependent manner. OPC treatment (100 μg/mL) revealed typical morphological apoptotic features. Additionally OPC treatment (100 μg/mL)increased level of BAX and CASPASE-3, and decreased level of BCL-2 mRNA expression. Caspase-3 enzyme activity was also significantly increased by treatment of OPC (100 μg/mL) compared with ***: These data indicate that OPC caused cell death by apoptosis through caspase pathways on human colorectal cancer cell line, SNU-C4.

关键词： Oligomeric pranthocyanidins Apoptosis Anticancer effects Colorectal cancer

Curative resection of leiomyosarcoma of the descending colon with metachronous liver metastasis: A case report

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 992-999页

作者： Soo-Hyeon Lee Sang-Ho Bae Sang-Cheol Lee Tae-sung Ahn Zisun Kim hae-Il jung Department of Surgery Soonchunhyang University Cheonan HospitalCheonan 31151ChungnamSouth Korea Department of Internal Medicine Soonchunhyang University Cheonan HospitalCheonan 31151ChungnamSouth Korea Department of Surgery Soonchunhyang University Bucheon HospitalBucheon 14584GyeonggiSouth Korea

BACKGROUND Leiomyosarcoma(LMS)has a poor prognosis and rarely originates from the *** resection is possible,surgery is the first treatment most commonly ***,no standard treatment exists for hepatic metastasis of LMS;although,several treatments,such as chemotherapy,radiotherapy,and surgery,have been ***,the management of liver metastases remains *** SUMMARY We present a rare case of metachronous liver metastasis in a patient with LMS originating from the descending colon.A 38-year-old man initially reported abdominal pain and diarrhea over the previous two *** revealed a 4-cm diameter mass in the descending colon,40 cm from the anal *** tomography revealed intussusception of the descending colon due to the 4-cm *** patient underwent a left *** analysis of the tumor revealed that it was positive for smooth muscle actin and desmin,and negative for cluster of differentiation 34(CD34),CD117,and discovered on gastrointestinal stromal tumor(GIST)-1,which are characteristic of gastrointestinal LMS.A single liver metastasis developed 11 mo postoperatively;the patient subsequently underwent curative resection *** patient remained disease-free after six cycles of adjuvant chemotherapy(doxorubicin and ifosfamide),and 40 and 52 mo after liver resection and primary surgery,*** cases were obtained from a search of Embase,PubMed,MEDLINE,and Google *** Early diagnosis and surgical resection may be the only potential curative options for liver metastasis of gastrointestinal LMS.

关键词： Leiomyosarcoma Colon Liver metastasis Surgical resection Treatment Case report

Tonsil-derived stem cells as a new source of adult stem cells

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World Journal of Stem Cells 2019年第8期11卷 506-518页

作者： Kyung-Ah Cho Hyun jung Lee Hansaem Jeong Miri Kim Soo Yeon jung hae Sang Park Kyung-Ha Ryu Seung Jin Lee Byeongmoon Jeong Hyukjin Lee Han Su Kim Department of Microbiology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Chemistry and Nano Science Ewha Womans University Seoul 03760 South Korea College of Pharmacy Graduate School of Pharmaceutical Sciences Ewha Womans University Seoul 03760 South Korea Department of Otorhinolaryngology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Otorhinolaryngology College of Medicine Hallym University Chuncheon 24252 South Korea Department of Pediatrics College of Medicine Ewha Womans University Seoul 07985 South Korea

Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors (i.e., under 10 years old). As such, TSCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal (e.g., hepatocytes and parathyroid-like cells), and even ectodermal cells (e.g., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.

关键词： Stem cell Tonsil-derived stem cell Differentiation Endoderm Mesoderm Ectoderm Cell therapy

Combination of Korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm Motility in Male Mice

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Chinese Journal of Integrative Medicine 2020年第5期26卷 361-369页

作者： Ja Yoon Ku Min jung Park Hyun Jun Park Nam Cheol Park Bo sun Joo Department of Urology Pusan National University HospitalPusan National University School of MedicineBusan(49241)Republic of Korea Biomedical Research Institute Pusan National University HospitalBusan(49241)Republic of Korea The Korea Institute for Public Sperm Bank Busan(49241)Republic of Korea

Objective: To investigate the effect of hydrogen-rich Korean Red Ginseng(KRG) water(HRGW) mixture on the spermatogenesis and sperm motility of mice of different ages. Methods: Eighty young(3 month-old) and aged(12 month-old) male mice were randomly assigned to 4 groups(n=10 per group) including control group, hydrogen-rich water(HRW) group(10 m L/kg daily), KRG group(50 mg/kg daily) and HRGW group(10 m L/kg HRW and 50 mg/kg KRG daily) by an oral zoned needle for 4 weeks. Sperm count and motility were measured using sperm suspension released from cauda epididymis. Serum follicle stimulating hormone(FSH), luteinizing hormone(LH), testosterone, and reactive oxygen species(ROS) in serum have also been estimated. Tubular changes were examined through histological hematoxylin and eosin staining. Expression of antioxidation(PPx3, PPx4, GSTm5 and GPx4), spermatogenesis(inhibin-α, neptin-2 and CREM), antiaging(SIRT1 and SIRT2), and angiogenesis [visfatin and vascular endothelial growth factor(VEGF)] related genes were examined through realtime polymerase chain reaction. Results: HRW and KRG treatment stimulated spermatogenesis followed by increasing sperm production and sperm motility(P<0.05). These effects were strengthened synergistically by a HRGW mixture(P<0.05 or P<0.01). HRGW greatly increased the expressions of antioxidation, antiaging, spermatogenesis related genes and VEGF especially in aged mice(P<0.05). Serum testosterone and FSH levels also increased, while serum ROS level decreased(all P<0.05). Conclusion: HRGW increases sperm production and motility by enhancing antioxidation and stimulating spermatogenesis and sex hormone production, particularly in aged mice.

关键词： aging ginseng infertlit mineral waters sperm mtility

Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression

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Neural Regeneration Research 2019年第9期14卷 1530-1535页

作者： hae June Lee Yeonghoon Son Minyoung Lee Changjong Moon sung Ho Kim In Sik Shin Miyoung Yang Sangwoo Bae Joong sun Kim Division of Basic Radiation Bioscience Korea Institute of Radiological&Medical Sciences(KIRMAS)SeoulRepublic of Korea National Primate Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)CheongjuRepublic of Korea College of Pharmacy Kyungpook National UniversityDaeguRepublic of Korea College of Veterinary Medicine Veterinary Medical Research InstituteChonnam National UniversityGwangjuRepublic of Korea School of Medicine Wonkwang UniversityJeonbukRepublic of Korea Research Center Dongnam Institute of Radiological&Medical Sciences(DIRAMS)BusanRepublic of Korea

Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain *** investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial *** impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after *** also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic ***-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor *** butyrate pretreatment reversed these *** findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor *** study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval ***16-0002)on December 30,2016.

关键词： sodium butyrate radioprotector ionizing radiation hippocampal damage cAMP response element binding brain-derived neurotrophic factor histone deacetylase inhibitor neurogenesis

Current Status and Future Directions in Environmental Stability of Sulfide Solid-State Electrolytes for All-Solid-State Batteries

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Energy Material Advances 2023年第1期4卷 130-143页

作者： Jianwen Liang Xiaona Li Changhong Wang jung Tae Kim Rong Yang jiantao Wang Xueliang sun Solid State Batteries Research Center GRINM(Guangdong)Institute for Advanced Materials and TechnologyFoshanGuangdong 528051China Department of Mechanical and Materials Engineering.University of Western Ontario LondonOntario N6A 5B9Canada China Automotive Battery Research Institute Co.Ltd.5th Floor No.43Mining Building North Sanhuan Middle RoadBeijing 100088China

Recently,sulfide-based solid-state electrolytes(SSEs)have attracted much attention owing to their high ionic conductivity and feasible mechanical *** environmental stability of sulfide-based SSEs is one of the critical aspects due to the possible decomposition,and ionic conductivity change will affect the fabrication and electrochemical performance of the ***,important efforts have been made to reveal and improve their environmental stability,and a timely summary of the progress is urgently *** this review,we first clarify the definition of environmental stability and its significance in the context of practical *** indicating the degradation mechanisms of sulfide-based SSEs,we summarize several effective strategies to improve their stability and also highlight the related theoretical *** stability of organic solvents of sulfide SSEs is also summarized and discussed,which may help reliable sulfide SSEs in the battery *** main target of this review is to gain insights and provide useful guidance to further improve the environmental stability of sulfide SSEs,which will finally promote the commercialization of sulfide-based all-solid-state batteries.

关键词： battery Solid sulfide