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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki k.m Bum Jun k.m Seungyon koh Hyo jin Cho Xuelian jin Byung Gon k.m Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Influence of the electrolyte conductivity on the critical current density and the breakdown voltage

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Chinese Journal of Chemical Engineering 2023年第7期59卷 169-175页

作者： hae-kyun Park Dong-Hyuk Park Bum-jin Chung Department of Nuclear Engineering kyung Hee University 1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 17104Korea

The work investigates influence of the electrolyte conductivity on the onset of partial contact glow discharge electrolysis(CGDE)in a water *** current density(CCD)and breakdown voltage were measured together with in situ observation of hydrogen bubble behavior,whose influence has not been focused *** a fixed current during normal electrolysis,hydrogen coalescence adjacent to cathode surface was invigorated at a lower *** analyses elucidated the hydrogen coalescence characteristics by quantifying size and population of detached hydrogen *** CCD increased about 104% within given range of conductivity(11.50-127.48 mS·cm^(-1))due to impaired bubble coalescence,which delays hydrogen film formation on the ***,decreasing trend of breakdown voltage was measured with increased conductivity showing maximum drop of 74%.It is concluded that onset of partial CGDE is directly affected by hydrodynamic bubble behaviors,whereas the electrolyte conductivity affects the bubble formation characteristics adjacent to cathode electrode.

关键词： Water electrolysis Critical current density Breakdown voltage Electrolyte conductivity Hydrogen bubble behavior

Synthesis of Fe_3O_4-coated silica aerogel nanocomposites

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中国有色金属学会会刊：英文版 2012年第S3期22卷 702-706页

作者： Jun Sung LEE Eun Jung LEE hae jin HWANG Devision of materials Science and Engineering Inha University

Fe3O4:SiO2 nanocomposite powders were synthesized by a two-step process,which included the precipitation of FeCl2 and FeCl3 and the gelation of silicic acid solution derived from water *** first,Fe3O4 nanoparticles having a crystallite size of 20 nm were obtained by controlling the ratio of Fe(II) and Fe(III) *** the second step,Fe3O4 particles were embedded in SiO2 matrix by the hydrolysis and subsequent condensation of the silicic acid solution containing Fe3O4 *** was found that the Fe3O4 nanoparticles homogenously disperse in the SiO2 *** Fe3O4:SiO2 nanocomposite exhibited an enhanced thermal stability against oxidation compared with pure ***-IR analysis indicates the presence of the Si-O-Fe bond in the Fe3O4:SiO2 (1:10,mole fraction) nanocomposite.

关键词： nanocomposite Fe3O4 SiO2 sol gel synthesis

Radiation therapy for extrahepatic bile duct cancer: Current evidences and future perspectives

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World Journal of Clinical Cases 2019年第11期7卷 1242-1252页

作者： Taeryool koo hae jin Park kyubo k.m Department of Radiation Oncology Hallym University Sacred Heart Hospital Anyang 14068 South Korea Department of Radiation Oncology Hanyang University College of Medicine Seoul 04763 South Korea Department of Radiation Oncology Ewha Womans University College of Medicine Seoul 07985 South Korea

Extrahepatic bile duct cancer (EBDC) is a rare malignancy that involves neoplastic changes extending from both hepatic ducts to the common bile duct. The treatment of choice is surgical resection, but the predominant pattern of initial treatment failure is locoregional recurrence. Accordingly, adjuvant radiotherapy has been administered after surgical resection based on these rationales. At this time, there is minimal evidence supporting adjuvant radiotherapy, because there have been no phase III trials evaluating its benefit. Relatively small retrospective studies have tried to compare outcomes associated with EBDC treated with or without radiotherapy. We aimed to review studies investigating adjuvant radiotherapy for resected EBDC. Because less than onethird of EBDC cases are amenable to curative resection at diagnosis, other locoregional treatment modalities need to be considered, including radiotherapy. The next aim of this review was to summarize reports of definitive radiotherapy for unresectable EBDC. Patients with advanced EBDC often experience biliary obstruction, which can lead to jaundice and progress to death. Biliary stent insertion is an important palliative procedure, but stents are prone to occlusion after subsequent ingrowth of the EBDC. Radiotherapy can be effective for maintaining the patency of inserted stents. We also reviewed the benefit of palliative radiotherapy combined with the biliary stent insertion. Lastly, we discuss the existing gaps in the evidence supporting radiotherapy in the management of EBDC.

关键词： Extrahepatic bile duct cancer Patterns of failure Adjuvant radiotherapy Definitive radiotherapy Palliative radiotherapy Biliary stent

Polysaccharide from Astragalus membranaceus promotes the activation of human peripheral blood and mouse spleen dendritic cells

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Chinese Journal of Natural medicines 2021年第1期19卷 56-62页

作者： Lim Seong-min Park hae-Bin jin Jun-O Department of medical Biotechnology Yeungnam UniversityGyeongsan 38541South Korea Shanghai Public Health Clinical Center Shanghai Medical CollegeFudan UniversityShanghai201508China

Astragalus membranaceus(***)is a widely used traditional herb in China and *** polysaccharides(AmP),which make up a major part of the root extract,have been shown to modulate immune modulations,especially activation of bone marrow-derived dendritic cells(BmDCs)and T ***,the immune stimulatory effect of AmP in the mouse in vivo and human peripheral blood DCs(PBDCs)has not been well *** this study,we found that intravenous(i.v.)injection of AmP in C57 BL/6 mice induced remarkable elevations in co-stimulatory and mHC class I and II molecule levels in the splenic DCs and its *** stimulatory effect of DCs by AmP was elevated 6 h after treatment,which rapidly decreased 18 h after ***,AmP promoted intracellular production of pro-inflammatory cytokines in spleen DC subsets,which contributed elevation of serum cytokine ***,the AmP promoted PBDC ***,these results demonstrate that AmP can be used as an immune stimulatory molecules in human and mouse.

关键词： Astragalus membranaceus polysaccharide Spleen dendritic cell Human peripheral blood dendritic cell

Linking individual attributes and host specialization in brood parasitic cuckoos

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Avian Research 2022年第2期13卷 145-151页

作者： Sue-Jeong jin hae-Ni k.m Geun-Won Bae jin-Won Lee Jeong-Chil Yoo korea Institute of Ornithology Kyung Hee UniversitySeoul02447Republic of Korea Department of Biology Kyung Hee UniversitySeoul02447Republic of Korea

Generalist avian brood parasites vary considerably in their degree of host specialization(e.g.,number of hosts);some parasitize the nests of just a few host species,whereas others exploit more than 100 *** factors,including habitat range,habitat type,and geographic location,have been suggested to account for these ***,inter-specific differences in individual attributes,such as personality and plasticity,have rarely been considered as potential factors of such variation,despite their potential relationship to,for example,range *** cage experiments,we tested the hypothesis that parasitic species exploiting more host species may be more active and *** this end,we quantified behaviors exhibited by two Cuculus cuckoos(Common Cuckoo *** and Oriental Cuckoo ***)that vary greatly in their number of host ***,we evaluated exploratory behavior displayed by birds in the cage,such as the number of movements,head-turning,wing-flapping,and *** Common Cuckoo,which has a higher number of host species,tended to exhibit higher levels of exploratory behaviors than the Oriental *** study showed that the two cuckoo species exhibited different exploratory levels,as predicted by the differences in their number of *** studies regarding the causality between individual attributes and host specialization with improved experimental methodology would greatly enhance our understanding of the role of individual characteristics in the coevolution of avian brood parasites and their hosts.

关键词： Brood parasitism Common Cuckoo Individual attributes Number of hosts Oriental Cuckoo

Adaptive immunity of materials: Implications for tissue healing and regeneration

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Bioactive materials 2024年第11期41卷 499-522页

作者： Jung-Hwan Lee Seong-jin Shin Jun Hee Lee Jonathan Cknowles hae-Hyoung Lee hae-Won k.m Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science College of DentistryDankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science and Bk21 NBm Global Research Center for Regenerative medicine Dankook UniversityCheonan 31116Republic of Korea Cell&matter Institute Dankook UniversityCheonan 31116Republic of Korea mechanobiology Dental medicine Research Center Dankook UniversityCheonan 31116Republic of Korea UCL Eastman-korea Dental medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea UCL Eastman Dental Institute University College LondonLondon NW32PXUnited Kingdom

Recent cumulative findings signify the adaptive immunity of materials as a key agenda in tissue healing that can improve regenerative events and outcomes. modulating immune responses, mainly the recruitment and functions of T and B cells and their further interplay with innate immune cells (e.g., dendritic cells, macrophages) can be orchestrated by materials. For instance, decellularized matrices have been shown to promote muscle healing by inducing T helper 2 (Th2) cell immunity, while synthetic biopolymers exhibit differential effects on B cell responses and fibrosis compared decellularized matrices. We discuss the recent findings on how implantable materials instruct the adaptive immune events and the subsequent tissue healing process. In particular, we dissect the materials’ physicochemical properties (shape, size, topology, degradation, rigidity, and matrix dynamic mechanics) to demonstrate the relations of these parameters with the adaptive immune responses in vitro and the underlying biological mechanisms. Furthermore, we present evidence of recent in vivo phenomena, including tissue healing, cancer progression, and fibrosis, wherein biomaterials potentially shape adaptive immune cell functions and in vivo outcomes. Our discussion will help understand the materials-regulated immunology events more deeply, and offer the design rationale of materials with tunable matrix properties for accelerated tissue repair and regeneration.

关键词： Adaptive immunity materials interactions Tissue healing Physicochemical properties Immune cell interplay

Association of erectile dysfunction with depression in patients with chronic viral hepatitis

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World Journal of Gastroenterology 2015年第18期21卷 5641-5646页

作者： Bong Oh ma Sang Goon Shim hae jin Yang Department of medicine Samsung Changwon Hospital Sungkyunkwan University School of medicine Changwon-si 630-723 South Korea

AIm: To investigate the prevalence of erectile dysfunction(ED) and its association with depression in patients with chronic viral ***: This single center cross-sectional study was conducted from August 2013 through January 2014. All outpatients with chronic viral hepatitis in our liver clinic between 18 and 80 years of age were considered eligible for this study. The exclusion criteria included well-established causes of ED, such as diabetes, hypertension, hyperlipidemia, alcohol abuse, liver cirrhosis, ischemic heart disease, renal disease, neurologic disease, and malignancy. We also excluded the patients who had incompletely answered the questionnaires. ED was assessed using the validated korean version of the International Index of Erectile Function(IIEF-5) scale. The korean version of the self-administered Beck Depression Inventory(BDI) scale was used to assess depression in the patients. Demographic and medical data were obtained from the patients' medical records. Current or past history of psychiatric diagnosis and drug history including the use of an antiviral agent and an antidepressant were also recorded. RESULTS: A total of 727 patients met the initial eligibility criteria. Six hundred seventeen patients were excluded because their medical records contained one or more of the previously determined exclusion criteria. The remaining 110 patients were assessed based on the BDI and IIEF-5 questionnaires. Based on the IIEF-5 scale, the prevalence of ED among patients with chronic viral hepatitis was 40%. Compared with the non-ED group, patients in the ED group were older. The proportion of patients in the ED group who had a job or who were na?ve peg-interferon users was lower than that in patients in the non-ED group. Patients with ED had significantly lower scores on the IIEF-5 scale than patients without ED(11.75 ± 4.88 vs 21.33 ± 1.86, P = 0.000). Patients with ED rated significantly higher scores on the BDI scale compared with patients withou

关键词： Beck depression inventory Chronic viral hepatitis Depression Erectile dysfunction International Index of Erectile Function-5

Do brood parasitic Common Cuckoos develop brood patches during the breeding season?

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Avian Research 2024年第3期15卷 363-368页

作者： Jun-Seo Go hae-Ni k.m Sue-Jeong jin myeong-Chan Cha Heesoo Lee jin-Won Lee korea Institute of Ornithology&Department of Biology Kyung Hee University02447SeoulRepublic of Korea Bird Research SaeZiP 12504YangpyeongRepublic of Korea

many birds develop brood patches on their ventral apterium under hormonal regulation to effectively transmit body heat to eggs during *** developed patch has several characteristics,including de-feathering,vascularization,and ***,little is known about whether avian brood parasites that do not incubate their eggs exhibit brood patch development during the breeding *** this study,we measured the size of the ventral apterium in 114 Common Cuckoos(Cuculus canorus)captured in the field throughout the breeding season and examined the appearance of the ventral apterium to confirm the development of brood *** also examined whether morphological traits and various factors correlated with the size of the ventral apterium(sternal apterium and abdominal apterium)and how it changed during the breeding *** found no clear signs of brood patch development in Common Cuckoos captured throughout the breeding season,indicating that they likely did not develop brood patches on the ventral apterium during this *** also found that ventral apterium size was positively correlated with wing length and body *** addition,Common Cuckoos with newly growing feathers on the boundary of the ventral apterium with pteryla were frequently observed as seasons progressed to the *** conclusion,Common Cuckoos exhibit neither brood patch development nor the vestigial characteristics of ancestral brood patches,except for the growth of feathers on boundary the ventral *** studies examining brood patches across different groups of avian brood parasites are valuable for enhancing our understanding of the developmental and physiological adaptations of avian brood parasites.

关键词： Brood parasitism Brood patch Common Cuckoo Pterylosis Re-feathering Ventral apterium