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Monascus pilosus-fermented black soybean inhibits lipid accumulation in adipocytes and in high-fat diet-induced obese mice

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Asian Pacific Journal of Tropical Medicine 2015年第4期8卷 276-282页

作者： Young-Sil lee Bong-Keun Choi hae jin lee Dong-Ryung lee jinhua Cheng Won-Keun lee Seung Hwan Yang Joo-Won Suh Center for Nutraceutical and Pharmaceutical Materials Myongji University Interdisciplinary Program of Biomodulation Myongji University Division of Bioscience and Bioinformatics College of Natural ScienceMyongji University

Objective:To explore the anti-obesity effects and the mechanism of action of Monascus pilosus(***)-fermented black soybean(MFBS)extracts(MFBSE)and MFBS powders(MFBSP)in adipocytes and high-fat diet(HFD)-induced obese mice,***:Black soybean was fermented with ***,and the main constituents in MFBS were analyzed by HPLC *** vitro,MFBSE were examined for anti-adipogenic effects using Oil-Red O *** vivo,mice were fed a normal-fat diet(NFD)control,HFD control or HFD containing 1 g/kg MFBSP for 12 weeks,and then body weight gain and tissues weight ***-time PCR and western blot assay were used to determine the mechanism of anti-adipogenic ***:MFBSE inhibited lipid accumulation in 3T3-L1 adipocytes without exerting cell *** treatment in HFD-fed mice significantly decreased the body weight gain compared with the HFD control *** and MFBSP treatment resulted in significantly lower mRNA levels of adipogenesis-related genes,such as peroxisome proliferator-activated receptorγ(PPARγ),fatty acid-binding protein 4(FABP4),and fatty acid synthase(FAS),in adipocytes and in white adipose tissue(WAT)of HFD-induced obese ***:These results suggest that the anti-obesity effects of MFBS are elicited by regulating the expression of adipogenesis-related genes in adipocytes and WAT of HFDinduced obese mice.

关键词： Monascus pilosus Black soybean Adipocytes High-fat diet-induced obese mice Anti-obesity Adipogenesis-related genes

Roots extracts of Adenophora triphylla *** improve obesity in 3T3-L1 adipocytes and high-fat diet-induced obese mice

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Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 879-886页

作者： Dong-Ryung lee Young-Sil lee Bong-Keun Choi hae jin lee Sung-Bum Park Tack-Man Kim Han jin Oh Seung Hwan Yang Joo-Won Suh NutraPham Tech Center for Nutraceutical and Pharmaceutical Materials Myongji University Interdisciplinary Program of Biomodulation Myongji University DONG IL Pharmtec Department of Family Medicine.VIEVIS NAMUH Hospital

Objective:To investigate the anti-obesity activity and the action mechanism of the roots of Adenophora triphylla *** extract(ATE) in high-fat diet(HFD)-induced obese mice and 3T3-LI ***:The roots of Ademption triphylla were extracted with 70%*** demonstrate the compounds,linoleic acid was analyzed by using gas chromatography:and the anti-obesity effects and possible mechanisms of ATE were examined in 3T3-L1 adipocytes and HFD-induced obese ***:Treatment with ATE inhibited the lipid accumulation without cytotoxicity in 3T3-L1 ***,200 and 400 mg/kg ATE treatment significantly decreased the body weight gain,white adipose tissues(WATs) weight and plasma triglyceride level,while 100 and 200 mg/kg ATE treatment increased the plasma high-density lipoprotein cholesterol level in the HFD-induced obese mice,as compared with the HFD *** with 200 and 400 mg/kg ATE also lowered the size of adipocytes in adipose tissue and reduced the lipid accumulation in *** treatment showed significantly lower expression level of adipogenesis-relatcd proteins,such as peroxisome proliferator-activated receptor y,fatty acid binding protein(aP2),fatty acid synthase in 3T3-L1 adipocytes;and furthermore,decreased peroxisome proliferatoractivated receptor γ,aP2,fatty acid synthase,sterol regulatory element binding protein-1c,and lipoprotein lipase mRNA expression levels in WAT of the HFD-induced obese ***:These results suggested that the ATE has an anti-obesity effect,which may be elicited by regulating the expression of adipogenesis and lipogenesis-related genes and proteins in adipocytes and WAT of the HFD-induced obese mice.

关键词： Roots of Adenophora triphylla var. japonica extrac

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Filling Up In Seoul

China International Business 2010年第2期 54-56页

作者： CECILIA hae-jin lee

Linking individual attributes and host specialization in brood parasitic cuckoos

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Avian Research 2022年第2期13卷 145-151页

作者： Sue-Jeong jin hae-Ni Kim Geun-Won Bae jin-Won lee Jeong-Chil Yoo Korea Institute of Ornithology Kyung Hee UniversitySeoul02447Republic of Korea Department of Biology Kyung Hee UniversitySeoul02447Republic of Korea

Generalist avian brood parasites vary considerably in their degree of host specialization(e.g.,number of hosts);some parasitize the nests of just a few host species,whereas others exploit more than 100 *** factors,including habitat range,habitat type,and geographic location,have been suggested to account for these ***,inter-specific differences in individual attributes,such as personality and plasticity,have rarely been considered as potential factors of such variation,despite their potential relationship to,for example,range *** cage experiments,we tested the hypothesis that parasitic species exploiting more host species may be more active and *** this end,we quantified behaviors exhibited by two Cuculus cuckoos(Common Cuckoo *** and Oriental Cuckoo ***)that vary greatly in their number of host ***,we evaluated exploratory behavior displayed by birds in the cage,such as the number of movements,head-turning,wing-flapping,and *** Common Cuckoo,which has a higher number of host species,tended to exhibit higher levels of exploratory behaviors than the Oriental *** study showed that the two cuckoo species exhibited different exploratory levels,as predicted by the differences in their number of *** studies regarding the causality between individual attributes and host specialization with improved experimental methodology would greatly enhance our understanding of the role of individual characteristics in the coevolution of avian brood parasites and their hosts.

关键词： Brood parasitism Common Cuckoo Individual attributes Number of hosts Oriental Cuckoo

Formation of photo-reactive heterostructure from a multicomponent amorphous alloy with atomically random distribution

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Journal of Materials Science & Technology 2022年第14期109卷 245-253页

作者： hae jin Park Hee jin lee Tae Kyung Kim Sung Hwan Hong Wei-Min Wang Taek Jib Choi Ki Buem Kim Department of Nanotechnology and Advanced Materials Engineering Sejong University209 Neung dong-roGwangjin-guSeoul 05006Republic of Korea Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China

In this study,metallic glass is designed tunable for promising functional applications via a facile and stable,one-step *** approach about alloy design and process is based on the unique properties of the Ti-Cu-Ni-Sn metallic glass that are afforded by the varying oxygen affinities of the four constituent *** metallic glass exhibits homogeneous nucleation of oxides and uniform formation of the various metal *** alloy design and hydrothermal synthesis to customize the metallic glasses are the most critical factors that determine the characteristics of the metal oxides and the resulting nanostructures and photoelectrode *** enables the desired element to be selectively grown via a facile single-step *** results provide a promising road map for the application of metallic glasses to photoelectrochemical(PEC)solar water splitting,as well as various other new possibilities.

关键词： Metallic glass Alloy design Hydrothermal synthesis Metal oxide Water splitting

A novel method to collect sperm from brood parasitic cuckoos:Urodeum stimulation(UroS)method

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Avian Research 2023年第2期14卷 298-303页

作者： Heesoo lee hae-Ni Kim Jun-Seo Go Myeong-Chan Cha Seongho Yun Sue-Jeong jin jin-Won lee Jeong-Chil Yoo Korea Institute of Ornithology Kyung Hee UniversitySeoul02447Republic of Korea Department of Biology Kyung Hee UniversitySeoul02447Republic of Korea

Sperm competition has been studied in numerous species as a representative example of postcopulatory sexual selection,where sampling sperm from male is the most basic and important *** collection can be tricky in birds,however,because unlike mammals,the genitals of birds are generally latent in the cloacal region and their characteristics vary among *** methods to collect sperm from different birds have been tested,such as cloacal massage,feces collection,and electro-stimulation,but their applicability varies depending on *** this study,we introduced the urodeum stimulation method(UroS method)to collect sperm from Cuculus cuckoos,such as the Common Cuckoo(***).These species are expected to have interesting patterns of pair bonding and sperm competition because of their unique breeding strategy called brood parasitism;however,it remains *** this study,we described the application of our new method to expel semen from male common cuckoos,measured the volume of semen collected,checked the presence of sperm in the semen sample,and finally estimated its success rate among 82 *** were successfully collected from 76 cuckoos(approximately 93%)and the colors and volumes of the samples were very *** was present in 43 of these samples(57%),showing a sperm observation rate approximately twice as high as that of the conventional cloacal massage *** believe that this novel method will contribute to a better understanding of postcopulatory sexual selection in avian brood parasites and facilitate the process of sperm collection and artificial insemination in other medium-sized birds.

关键词： Brood parasitism Cuculus cuckoos Semen collection Sexual selection Sperm competition

Effect of silicon carbide-based iron catalyst on reactor optimization for non-oxidative direct conversion of methane

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Journal of Energy Chemistry 2023年第6期81卷 519-532,I0012页

作者： Eun-hae Sim Sung Woo lee jin Ju lee Seung Ju Han Jung Ho Shin Gracia lee Sungrok Ko Kwan-Young lee Yong Tae Kim C1 Gas&Carbon Convergent Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Department of Chemical and Biological Engineering Korea University145 Anam-roSeoul 02841Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeoul 03722Republic of Korea Chemical Data-Driven Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Prospective Tech.Exploring Section Basic Chemical R&D centerLottechemical Corp.Daejeon 34059Republic of Korea Department of Advanced Materials and Chemical Engineering University of Science and Technology(UST)Gajeong-dongYuseongDaejeon 34113Republic of Korea

The conversion of methane to olefins,aromatics,and hydrogen(MTOAH)can be used to stably obtain hydrocarbons when the effect of the catalytic surface is optimized from the reaction engineering *** this study,Fe/Si C catalysts were packed into a quartz tube *** catalytic surfaces of Si C and the impregnated Fe species decreased the apparent activation energies(E_a)of methane consumption in the blank reactor between 965 and 1020℃.Consequently,the hydrocarbon yield increased by 2.4times at 1020℃.Based on the model reactions of ethane,ethylene,and acetylene mixed with hydrogen in the range of 500-1020℃,an excess amount of Fe in the reactor favored the C-C coupling reaction over the selective hydrogenation of acetylene;consequently,coke formation was favored over the hydrogenation *** gas-phase reactions and catalyst properties were optimized to increase hydrocarbon yields while reducing coke *** 0.2Fe catalyst-packed reactor(0.26 wt%Fe)resulted in a hydrocarbon yield of 7.1%and a coke selectivity of<2%when the ratio of the void space of the postcatalyst zone to the catalyst space was adjusted to be≥*** on these findings,the facile approach of decoupling the reaction zone between the catalyst surface and the gas-phase reaction can provide insights into catalytic reactor design,thereby facilitating the scale-up from the laboratory to the commercial scale.

关键词： Non-oxidative methane conversion Ethylene Aromatic Methane pyrolysis Fe/SiC Coke resistance Catalytic reactor

Influence of the electrolyte conductivity on the critical current density and the breakdown voltage

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中国化学工程学报:英文版 2023年第7期59卷 169-175页

作者： hae-Kyun Park Dong-Hyuk Park Bum-jin Chung Department of Nuclear Engineering Kyung Hee University 1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 17104Korea

The work investigates influence of the electrolyte conductivity on the onset of partial contact glow discharge electrolysis(CGDE)in a water *** current density(CCD)and breakdown voltage were measured together with in situ observation of hydrogen bubble behavior,whose influence has not been focused *** a fixed current during normal electrolysis,hydrogen coalescence adjacent to cathode surface was invigorated at a lower *** analyses elucidated the hydrogen coalescence characteristics by quantifying size and population of detached hydrogen *** CCD increased about 104% within given range of conductivity(11.50-127.48 mS·cm^(-1))due to impaired bubble coalescence,which delays hydrogen film formation on the ***,decreasing trend of breakdown voltage was measured with increased conductivity showing maximum drop of 74%.It is concluded that onset of partial CGDE is directly affected by hydrodynamic bubble behaviors,whereas the electrolyte conductivity affects the bubble formation characteristics adjacent to cathode electrode.

关键词： Water electrolysis Critical current density Breakdown voltage Electrolyte conductivity Hydrogen bubble behavior

Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function

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Neural Regeneration Research 2023年第11期18卷 2497-2503页

作者： Yeonghoon Son Hye-jin Park Ye Ji Jeong Hyung-Do Choi Nam Kim hae-June lee Division of Radiation Biomedical Research Korea Institute of Radiological&Medical SciencesSeoulKorea Department of EMF Research Team Radio and Broadcasting Technology LaboratoryElectronics and Telecommunications Research InstituteDaejonKorea School of Electrical and Computer Engineering Chungbuk National UniversityCheongjuKorea

We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,including *** examine whether this therapeutic effect is due to the regulation of activated microglia,we analyzed mic roglial gene expression profiles and the existence of microglia in the brain in this study.5xFAD mice at the age of 1.5 months were assigned to sham-and radiofrequency electromagnetic fields-exposed groups and then animals were exposed to 1950 MHz radiofrequency electromagnetic fields at a specific absorption rate of 5 W/kg for 2 hours/day and 5 days/week for 6 *** conducted behavioral tests including the object recognition and Y-maze tests and molecular and histopathological analysis of amyloid precursor protein/a myloid-beta metabolism in brain *** confirmed that radiofrequency electromagnetic field exposure for 6 months ameliorated cognitive impairment and amyloid-β*** expression levels of Iba1(pan-microglial marker)and colony-stimulating factor 1 receptor(CSF1R;regulates microglial prolife ration)in the hippocampus in 5xFAD mice treated with radiofrequency electromagnetic fields were significantly reduced compared with those of the sham-exposed ***,we analyzed the expression levels of genes related to mic rogliosis and microglial function in the radiofrequency electromagnetic fields-exposed group compared to those of a CSF1R inhibitor(PLX3397)-treated *** radiofrequency electromagnetic fields and PLX3397 suppressed the levels of genes related to microgliosis(Csf1r,CD68,and Ccl6)and pro-inflammatory cytokine interleukin-1β.N otably,the expression levels of genes related to mic roglial function,including Trem2,Fcgr1α,Ctss,and Spi1,were decreased after long-term radiofrequency electromagnetic field exposure,which was also observed in response to microglial suppression by *** res

关键词： 5×FAD Alzheimer’s disease CSF1R long term exposure microglial function neuroinflammation radiofrequency electromagnetic fields therapeutic effect