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Electron beam deposition and characterization of thin film Ti-Ni for shape memory applications

Rare Metals 2006年第Z2期25卷 237-242页

作者： NOH hae-yong JEE Kwang-Koo LEE Kyu-Hwan LEE Young-Kook Department of Metallurgical System Yonsei University Seoul 120-749 KoreaAdvanced Materials Research Center Division of Materials Korea Institute of Science and Technology Cheongryang Seoul 130-650 Korea Advanced Materials Research Center Division of Materials Korea Institute of Science and Technology Cheongryang Seoul 130-650 Korea Department of Metallurgical System Yonsei University Seoul 120-749 Korea

Thin film of Ti-Ni alloy has a potential to perform the microactuation functions required in the microelectromechanical system (MEMS). It is essential, however, to have good uniformity in both chemical composition and thickness to realize its full potential as an active component of MEMS devices. Electron beam evaporation technique was employed in this study to fabricate the thin films of Ti-Ni alloy on different substrates. The targets used for the evaporation were first prepared by electron beam melting. The uniformity of composition and microstructure of the thin films were characterized by electron probe microanalysis (EPMA), Auger electron spectroscopy (AES), X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM) and transmission electron microscopy (TEM). The mechanical property of the thin films was evaluated by the nano-indentation test. The martensitic transformation temperature was measured by differential scanning calorimetry (DSC). It is confirmed that the chemical composition of deposited thin films is identical to that of the target materials. Furthermore, results from depth profiling of the chemical composition variation reveal that the electron beam evaporation process yields better compositional homogeneity than other conventional methods such as sputtering and thermal evaporation. Microstructural observation by TEM shows that nanometer size precipitates are preferentially distributed along the grain boundaries of a few micron size grains. The hardness and elastic modulus of thin films decreases with an increase in Ti contents.

关键词： electron beam evaporation TiNi SMA thin film martensitic transformation reverse martensitic transformation

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Effects of edible insect extracts on the antioxidant, physiochemical, and microbial properties of Tteokgalbi during refrigerated storage

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Food Bioscience 2023年第2期52卷 326-333页

作者： hae in yong Tae-Kyung Kim Ji Yoon Cha Jae Hoon Lee Min-Cheol Kang Samooel Jung Yun-Sang Choi Research Group of Food Processing Korea Food Research InstituteWanju55365Republic of Korea Division of Animal and Dairy Science Chungnam National UniversityDaejeon34134Republic of Korea

In this study,Tteokgalbi,a meat product,was prepared with edible insect larvae extracts and its antioxidant,physiochemical,and microbial properties were evaluated during refrigerated *** prepared with 2%*** and 2%*** showed the highest radical-scavenging activity and metal-chelating activity,but the lowest thiobarbituric acid reactive substance(TBARS)value,among the treatments(P<0.05).In addition,those antioxidant activities were the lowest and the TBARS value was the highest in control Tteokgalbi(P<0.05)during all storage *** prepared with 2%*** showed the highest brownness index,pH,and cooking yield,but the lowest shear force value(P<0.05).During all storage days,the total aerobic bacteria level did not differ significantly among the *** conclusion,*** extracts(2%)were effective as antioxidants,inhibiting lipid oxidation,and improving the quality properties of Tteokgalbi,without negatively affecting microbial *** results confirmed that the edible insect extracts have industrial value as a food additive.

关键词： Edible insect Lipid oxidation Natural antioxidant Refrigerated storage Tteokgalbi

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Hidradenocarcinoma of the Dorsum of the Hand

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Chinese Medical Journal 2017年第14期130卷 1755-1756页

作者： Wan Cheol Ryu yong hae Lee In Chang Koh Jang Sihn Sohn Se Min Jang Department of Plastic and Reconstructive Surgery Konyang University Hospital Konyang University College of Medicine Daejeon Korea Department of Pathology Konyang University Hospital Konyang University College of Medicine Daejeon Korea

Hidradenocarcinoma originates in the eccrine glands located in sun-exposed areas and accounts for approximately 6% of malignant eccrine tumors and 〈0.001% of all skin cancers.[1,2] Hidradenocarcinoma usually presents as a solitary,firm,asymptomatic intradermal nodule measuring 1-5 cm,covered by intact or occasionally ulcerated purple-,pink-,or blue-colored lesions.[1] While hidradenocarcinoma typically grows slowly over many years,it may suddenly undergo a rapid increase in *** differential diagnosis of hidradenocarcinoma is very challenging because the appearance of the lesion is benign and similar to that of other skin *** this report,we present the case of a patient with hidradenocarcinoma who was treated with wide excision and full-thickness skin grafting.

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Preliminary Level 1 PSA Results for Sodium-Cooled Fast Reactor KALIMER-600 Conceptual Design

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Journal of Energy and Power Engineering 2011年第12期5卷 1113-1125页

作者： Tae Woon Kim Sang Hoon Han hae yong Jeong Joon Eon Yang Korea Atomic Energy Research Institute 1045 Daedeok-daero Yuseong-gu Daejeon 305-353 Korea

Core damage accident scenarios are identified for the metal-fueled, sodium-cooled fast reactor （SFR）, KALIMER-600, which is under development at KAERI. A level 1 probabilistic safety assessment （PSA） model is developed using the identified accident scenarios and the system fault tree models for the safety systems which are needed to mitigate the accidents. Using the preliminary level 1 PSA models, core damage frequency is estimated for the metal fueled KALIMER-600 conceptual design. Sensitivity studies for various design alternatives of safety systems are performed to find out optimal configurations in point of view of risk minimization.

关键词： PRA PSA SFR metallic fuel accident scenarios core damage frequency safety system configuration.

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Industrial Equipment Troubleshooting with Imaging Technique Improved Gamma-Ray Absorption Scans

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Journal of Physical Science and Application 2012年第9期2卷 359-371页

作者： Marcio Issamu Haraguchil hae yong Kim Francisco Edmundo Sprenger Wilson Aparecido Parejo Calvo Process Diagnostics Division Tricom Tecnologia Ltda. Sao Paulo 12620-000 Brazil Polytechnic School Department of Electronic Systems Engineering (LPS) Sao Paulo University (USP) Sao Paulo 05508-900Brazil Radiation Technology Centre Nuclear and Energy Research Institute National Nuclear Energy Commission (IPEN-CNEN/SP)Sao Paulo 05508-000 Brazil

Gamma scanning is one of the most common nuclear techniques on troubleshooting industrial equipments like distillation columns and reactors. With a very simple concept, the technique is easy to implement. Searching for a competitive edge the industry has been long developing solutions to achieve better results. On the last decades, significant development has been done with the advent of new equipments, electronics, portable computers and software. Continuous scanning and wireless detection systems are examples of successful field solutions, while new software aid on reporting and data presentation. However the type and quality of the results itself has not dramatically changed since its beginning. A scan profile is simple to understand, although the process to build it can be very complex as it requires a specific blend of knowledge and abilities. Process engineering, chemical engineering, internal hydraulic project, nuclear engineering and field abilities are pre requisites for of any scan specialist. Correct data gathering, interpretation and reporting are abilities often difficult to match or requires a long time of training. The industry faces a similar difficult on the customer side, as it is always necessary to train end users to understand a report and how to use its best. This paper describes our effort on developing a new approach on the gamma scan test using image reconstruction techniques that would result on a graphic image rather than a XY plot. Direct and easier to understand, a report with graphic images would be also be accessible to a wider audience, not limited to the customers experienced with gamma scan interpretation.

关键词： Industrial equipments gamma ray troubleshooting image reconstruction gamma scanning.

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Anti-inflammatory activity of ginsenosides in LPS-stimulated RAW 264.7 cells

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Science Bulletin 2015年第8期60卷 773-784,M0003页

作者： Sungeun Ahn Muhammad Hanif Siddiqi hae-yong Noh Yu-Jin Kim Yeon-Ju Kim Chi-Gyu Jin Deok-Chun Yang Ginseng Genetic Bank Graduate School of BiotechnologyCollege of Life Science Kyung Hee University

Ginsenosides, the main active constituents of Panax ginseng Meyer （P. ginseng）, have potential therapeutic effects. All tested ginsenosides except gin- senoside F1 have previously been reported in inflammation studies using the RAW 264.7 macrophage cell line. We ex- amined the anti-inflammatory effects of single sugar moiety ginsenosides such as compound K （CK）, Rh2, Rhl, and F1 that were isolated from P. ginseng through in silico docking studies. We investigated their biological activity predictions, including absorption, distribution, metabolism, excretion, and toxicity and PASS properties, on the suppression of NF- κB, followed by in vitro validation in lipopolysaccharide （LPS）-stimulated RAW 264.7 macrophage cells. The molecular docking results of our study showed that all treated ginsenosides are non-toxic and may be drug-like molecules. The molecular binding interactions of these ginsenosides with the active residues of NF-κB noticeably support their anti-inflammatory activity. CK and Rhl sig- nificantly reduced the production of nitric oxide, cyclooxy- genase-2 （COX-2）, and pro-inflammatory cytokines such as prostaglandin E2 and tumor necrosis factor alpha （TNF-α） in a dose-dependent manner. Real-time PCR and Western blot analyses further confirmed that protopanaxadiols （PPDs） and protopanaxatriols （PPTs） inhibitory effects may have been due to the down-regulation of TNF-α, inducible nitric oxide synthase, COX2, nuclear factor kappa B （NF-κB）, and I kappa B kinase. The expression of co-stimulatory molecules such as ROS was also inhibited by CK and Rhl in a dose- dependent manner. Furthermore, activation of NF-κB in LPS-stimulated RAW 264.7 macrophages was significantly suppressed by CK and Rhl. Taken together, these results provide evidence that PPD- and PPT-type ginsenosides in- cluding CK and Rhl may exhibit strong anti-inflammatory effects by inhibiting pro-inflammatory mediators through down-regulation of NF-κB.

关键词： Ginsenosides Protopanaxadiol Protopanaxatriol Inflammation NF-κB/IKK RAW 264.7

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Status of a Sodium Cooled Fast Reactor Technology Development Program in Korea

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Journal of Energy and Power Engineering 2012年第9期6卷 1379-1397页

作者： Chungho Cho Younggyun Kim Jinwook Chang Sang-Ji Kim Chan-Bock Lee Seong-O Kim Jong-Bum Kim hae-yong Jeong yong-Bum Lee Yeong-Il. Kim Fast Reactor Technology Development Division Korea Atomic Energy Research Institute Daejeon 305-353 Republic of Korea

Korea imports about 97% of its energy resources as its available energy resources are extremely limited. Thus, the role of nuclear power in electricity generation is expected to become more important in future years. A fast reactor system is one of the most promising options for electricity generation with an efficient utilization of uranium resources and a reduction of radioactive wastes. Based on the experiences gained during the development of the conceptual designs for KALIMER （Korea advanced liquid metal reactor）, the KAERI （Korea Atomic Energy Research Institute） is currently developing advanced SFR （sodium cooled fast reactor） design concepts that can better meet the Gen IV （Generation IV） technology goals. The long-term advanced SFR development plan will be carried out toward the construction of an advanced SFR demonstration plant by 2028. Advanced concept design studies and the development of the advanced SFR technologies necessary for its commercialization and basic key technologies carried out by KAERI are included in this paper.

关键词： Sodium cooled fast reactor burner metal fuel pyroprocess.

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The expression of DNA damage checkpoint proteins and prognostic implication in metastatic brain tumors

The expression of DNA damage checkpoint proteins and prognos...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Do-Hyun Nam Ho Jun Seol hae yong Yoo Juyoun Jin Kyeung Min Joo Jung-II Lee Department of Neurosurgery Samsung Biomedical Research Instituteand Cancer Stem Cell Research CenterSamsung Medical CenterSungkyunkwan University School of Medicine

Resistance to radiation is a possible cause of recurrence or treatment failure in brain *** expression of the DNA damage checkpoint pathway components was investigated in cell lines and metastatic brain tumor（MBT） *** association between the expression levels and survival outcome were evaluated to find out possible therapeutic targets in brain *** of human non-small cell lung cancer cell lines was determined by checking their viability after treatment with varying doses of ionizing radiation（IR）.The expression of DNA checkpoint proteins were analyzed by Western blots and *** the basis of the clinical data for the MBT patients,the association between the expression of the components and patients’ survival was *** expression levels of TopBP1 and Chk1 protein were higher in radioresistant lung cancer cell line compared to radiosensitive cell *** activity of Chk1 in response to IR was also higher in radioresistant cell lines than in radiosensitive cell *** assessed radiation survival of lung cancer cell lines after treating them with Chk1 inhibitor,***7762 significantly sensitized both radioresistant and radiosensitive cells to *** also observed a strong inverse relationship between progression-free survival（PFS） and expression level of phosphorylated Chk1（P-Chk1） and *** association between the PFS and the expression of TopBP1 and P-Chk1 was observed for the first *** further investigation for understanding the role of these proteins are necessary,these two DNA damage checkpoints proteins can be promising targets for enhancing therapeutic potentials in the MBTs.

关键词： DNA damage checkpoint metastatic brain tumor P-Chk1 radioresistance TopBP1

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基于上限法的闭式冷正挤压棒料脱膜状态分析

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塑性工程学报 2023年第5期30卷 21-26页

作者：金城旭任靖日赵海龙忠北大学工学院精密机械科忠清北道清州28644 鲜一汽车配件有限公司技术研究所忠清北道镇川郡27807 延边大学机械工程系吉林延吉133002

考虑一种非磷系润滑膜的脱膜长度,通过上限法分析模型对棒料的闭式冷正挤压工艺进行了分析。通过实验获得了脱膜长度随锥模半角和断面收缩率的变化规律。实验结果表明,随断面收缩率的增长,脱膜长度快速增长。随着锥模半角的增长,脱膜长... 详细信息

考虑一种非磷系润滑膜的脱膜长度,通过上限法分析模型对棒料的闭式冷正挤压工艺进行了分析。通过实验获得了脱膜长度随锥模半角和断面收缩率的变化规律。实验结果表明,随断面收缩率的增长,脱膜长度快速增长。随着锥模半角的增长,脱膜长度也在增长,但是锥模半角增大到一定程度后,脱膜长度的增长幅度减小。求得总功率为最小时的最佳锥模半角,范围是15°~28°,最佳锥模半角随脱膜长度的增加而增加。在成形载荷方面,与DEFORM商用有限元分析软件的仿真结果进行了比较,上限法算得的成形载荷略大于有限元仿真结果,而且两者的载荷曲线较为相近,证明了该上限法分析模型的合理性,也表明上限法更有利于成形设备的选型。

关键词：脱膜长度闭式冷正挤压上限法锥模半角断面收缩率

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基于仿真金属流线的冷锻表面粗糙带预测及改进

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塑性工程学报 2019年第4期26卷 55-60页

作者：宋寅哲金城旭任靖日赵海龙忠北大学校机械工学部忠清北道清州28644 鲜一汽车配件有限公司技术研究所忠清北道镇川郡27807 延边大学机械工程系吉林延吉133002

采用仿真金属流线的形态特征解释了某螺栓的法兰平面产生粗糙带的原因,通过理论分析,提出了一种改善粗糙度的预成形设计方法。仿真结果表明,仿真金属流线可以预测冷锻件表面的粗糙位置,相比于法兰平面与模具接触面间产生的剪切应力,金... 详细信息

采用仿真金属流线的形态特征解释了某螺栓的法兰平面产生粗糙带的原因,通过理论分析,提出了一种改善粗糙度的预成形设计方法。仿真结果表明,仿真金属流线可以预测冷锻件表面的粗糙位置,相比于法兰平面与模具接触面间产生的剪切应力,金属流线的局部凸起对表面粗糙度影响较大。依据改进后的方法进行了试验,结果表明,试验结果与仿真结果基本一致,改进后的金属流线细密,法兰平面周围组织呈颗粒状均匀分布。法兰量产结果表明,改进后的设计方法不仅消除了粗糙带,同时提高了模具的使用寿命。

关键词：金属流线冷锻表面预成形粗糙带螺栓法兰平面粗糙度

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