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Discovery of Novel Anthranilic Diamide Derivatives Bearing Sulfoximine Group as Potent Insecticide Candidates

Chemical Research in Chinese Universities 2024年第1期40卷 96-108页

作者： ZHANG Hongyuan PENG Jinmin ZHONG Yuanhan CHEN Yue WANG Qing haditullah hadiatullah XIE Weibin XIONG Lixia YUCHI Zhiguang LIU Jingbo LI Yuxin State Key Laboratory of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin300071P.R.China Nankai University&Cangzhou Bohai New Area Institute of Green Chemical Engineering Changzhou062550P.R.China College of Horticulture and Landscape Architecture Tianjin Agricultural UniversityTianjin300392P.R.China Tianjin Key Laboratory for Modern Drug Delivery and High-efficiency Collaborative Innovation Center of Chemical Science and EngineeringSchool of Pharmaceutical Science and TechnologyTianjin UniversityTianjin300072P.R.China

The fall armyworm,Spodoptera frugiperda(***),represents the most resistant insect species and poses serious threat to grain ***(CHL),which targets the ryanodine receptors(RyRs)in insects,has demonstrated the efficacy in controlling ***,this has led to emerging resistance in several *** counter this resistance,a viable approach involves the development of novel compounds that bind against RyRs via distinct binding sites or *** this study,a series of 22 novel anthranilic diamide derivatives was designed and synthesized,and their insecticidal activities were *** of these derivatives showed moderate to good insecticidal activity against *** and Mythimna ***-lapse fluorescence measurements of endoplasmic reticulum luminal calcium revealed that most derivatives elicited cellular responses similar as CHL when assessed on HEK293 cells expressing *** ryanodine receptors(SfRyRs).The mode of action of compound 13a was studied and verified on the isolated neurons by calcium imaging ***,molecular docking analysis was employed to predict the binding mechanism of compound 13a against ***,these novel diamide derivatives hold promise as a valuable resource for guiding the future design of insecticidal compounds targeting RyRs.

关键词： Anthranilic diamide derivative Sulfoximine Spodoptera frugiperda Mode of action Molecular docking

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