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Acceleration of coasting enhances pregnancy rate in ICSI cycles at risk for ovarian hyperstimulation syndrome

Journal of Reproduction and Contraception 2016年第2期27卷 103-111页

作者： Ahmed F.Galal hadeer aly abbassy Ashraf Hany Abd Elrahman Department of Obstetrics and Gynecology Alexandria University Clinical Pathology Department Alexandria University

Objective To assess the efficacy of adding Gn-releasing hormone antagonist（GnR HA） on the day of hC G triggering in a long luteal protocol without withholding the agonist in women who are at a risk to develop ovarian hyperstimulation syndrome（OHSS）.Methods This was a retrospective cohort study conducted upon 50 women who have elevated serum estradiol（E2） level 〉4 500 ng/L at the day of ovum triggering with hC G on a long agonist luteal protocol of controlled ovarian stimulation（COS）. When an exaggerated ovarian response was observed around day 10 of stimulation, immediately the next morning at 6 a.m. gonadotropin administration was stopped or reduced, and a single dose of ganirelix acetate（antagonist） was given sc continuation of the agonist dose hC G. Another serum E2 measurement was done at 6 p.m.（after 12 h of antagonist） then hC G, sc 250 mg and choriogonadotropin α were administered 14 h later after antagonist and documented the reduction of E2 level. Oocyte retrieval was conducted after 34-36 h of hC G administration. The measured outcomes were the level of E2 on the day of hC G injection, number of oocytes and their quality, pregnancy rate and the occurrence of OHSS and its grade in case it *** The total dose for recombinant FSH was 25.3±6.4 ampoules（75 IU/ampoule） while it was 11.0±3.0 ampoules for the urinary hM G. A higher oocyte maturation rate（82.8%） and a high fertilization rate（87.8%） were observed. The mean endometrial thickness was 10.1±1.0 mm on the day of hC G triggering. The higher fertilization rate with the good endometrial thickness observed resulting in a higher pregnancy rate（78.0%, 39/50） with statistically significant（P〈0.05）. A significant reduction of E2 level was documented by a percentage around 40% before hC Ginjection. There were no reported cases of severe or moderate OHSS, however 13 cases（26%） were reported to have mild OHSS *** Acceleration of coasting in cases of OHSS through treatment with GnR HA

关键词： ovarian hyperstimulation syndrome(OHSS) coasting oocyte maturation pregnancy rate

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Predictors of thirty-day readmission in nonagenarians presenting with acute heart failure with preserved ejection fraction: a nationwide analysis

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Journal of Geriatric Cardiology 2021年第12期18卷 1008-1018页

作者： Ahmed Maraey Mahmoud Salem Nabila Dawoud Mahmoud Khalil Ahmed Elzanaty hadeer Elsharnoby Ahmed Younes Ahmed Hashim Amit Alam Department of Internal Medicine the CHI St.Alexius HealthBismarckUSA Department of Internal Medicine University of North DakotaBismarckUSA Center for Advanced Heart and Lung Diseases Baylor University Medical CenterDallasUSA Department of Internal Medicine University of KentuckyLexingtonUSA Department of Internal Medicine Lincoln Medical Center Weil Cornell UniversityBronxUSA Department of Cardiovascular Medicine Tanta UniversityTantaEgypt Department of Cardiovascular Disease University of ToledoToledoUSA Faculty of Medicine Tanta UniversityTantaEgypt Department of Internal Medicine East Carolina UniversityGreenvilleUSA Faculty of Medicine Ain Shams UniversityCairoEgypt College of Medicine Texas A&M Health Science CenterDallasUSA

BACKGROUD Acute heart failure with preserved ejection fraction(HFpEF)is a common but poorly studied cause of hospital admissions among *** study aimed to evaluate predictors of thirty-day readmission,in-hospital mortality,length of stay,and hospital charges in nonagenarians hospitalized with acute *** Patients hospitalized between January 2016 and December 2018 with a primary diagnosis of diastolic heart failure were identified using ICD-10 within the Nationwide Readmission *** excluded patients who died in index admission,and discharged in December each year to allow thirty-day *** regression was performed on each ***-ables with P-value<0.2 were included in the multivariate regression *** From a total of 45,393 index admissions,43,646 patients(96.2%)survived to discharge.A total of 7,437 patients(15.6%)had a thirty-day *** cost of readmission was 43,265 United States dollars(USD)per *** predictors of thirty-day readmission were chronic kidney disease stage III or higher[adjusted odds ratio(aOR)=1.20,95%CI:1.07−1.34,P=0.002]and diabetes mellitus(aOR=1.18,95%CI:1.07−1.29,P=0.001).Meanwhile,female(aOR=0.90,95%CI:0.82−0.99,P=0.028)and palliative care encounter(aOR=0.27,95%CI:0.21−0.34,P<0.001)were associated with lower odds of *** arrhythmia(aOR=1.46,95%CI:1.11−1.93,P=0.007)and aortic stenosis(aOR=1.36,95%CI:1.05−1.76,P=0.020)were amongst predictors of in-hospital *** In nonagenarians hospitalized with acute HFpEF,thirty-day readmission is common and *** co-morbidities predict poor *** strategies need to be developed to improve the quality of care and prevent the poor outcome in nonagenarians.

关键词： fraction nationwide dollar

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Assessment of fibroblast growth factor 19 as a non-invasive serum marker for hepatocellular carcinoma

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World Journal of Hepatology 2022年第3期14卷 623-633页

作者： Ghada Abdelrahman Mohamed Ehab Hasan Nashaat hadeer Mohamed Fawzy Ahmed Mohamed ElGhandour Department of Internal Medicine Gastroenterology and Hepatology UnitFaculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Fibroblast growth factor 19(FGF-19)is one of the founding members of the endocrine FGF ***,it has been the subject of much interest owing to its role in various physiological processes affecting glucose and lipid metabolism and the regulation of bile acid secretion as well as cell proliferation,differentiation,and ***,FGF-19 secretion in an autocrine style has reportedly contributed to cancer progression in various types of malignancies including hepatocellular carcinoma(HCC).AIM To estimate the serum FGF-19 concentrations in HCC cases and assess its diagnostic performance for the detection of *** We recruited 90 adult participants and divided them into three equal groups:Healthy controls,cirrhosis patients,and HCC *** FGF-19 concentrations were measured using the Human FGF-19 ELISA *** We detected a high statistically significant difference in serum FGF-19 levels among the three *** highest level was observed in the HCC group,followed by the cirrhosis and control groups(236.44±40.94 vs 125.63±31.54 vs 69.60±20.90 pg/mL,respectively,P≤0.001).FGF-19 was positively correlated with alpha fetoprotein(AFP;r=0.383,P=0.003)and international normalised ratio(r=0.357,P=0.005),while it was negatively correlated with albumin(r=-0.500,P≤0.001).For the detection of HCC,receiver operating characteristic curve analysis showed that the best cut-off point of AFP was>8.2 ng/mL with an area under the curve(AUC)of 0.78,sensitivity of 63.33%,specificity of 83.33%,positive predictive value(PPV)of 79.2%,negative predictive value(NPV)of 69.4%,and total accuracy of 78%.However,FGF-19 at a cut-off point>180 pg/mL had an AUC of 0.98,sensitivity of 100%,specificity of 90.0%,PPV of 90.0%,NPV of 100%,and total accuracy of 98%.CONCLUSION FGF-19 represents a possible novel non-invasive marker for *** may improve the prognosis of HCC patients due to its utility in several aspects of HCC detection and management.

关键词： Fibroblast growth factor 19 FGF-19 Fibroblast growth factors Tumour biomarkers Hepatocellular carcinoma Detection Cirrhosis

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Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells

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World Journal of Stem Cells 2016年第3期8卷 106-117页

作者： Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem hadeer A Aglan Department Medical Research Division National Research Centre Biochemistry Department Faculty of Science Ain Shams University Clinical Biochemistry Department Faculty of Medicine King Abdulaziz University Medical Biochemistry and Molecular Biology Department Faculty of Medicine Cairo University Pathology Department Medical Research Division National Research Centre Narcotics Ergogenic aids and Poisons Department Medical Research Division National Research Centre

AIM: To explore the approaches exerted by mesenchymal stem cells (MSCs) to improve Parkinson’s disease (PD) ***: MSCs were harvested from bone marrow of femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group (1) was control, Groups (2) and (3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group (2) was left untreated, while Group (3) was treated with single intravenous dose of bone marrow derived MSCs (BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1 (TGF-β1), monocyte chemoattractant protein-1 (MCP-1) and brain derived neurotrophic factor (BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase (TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also ***: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1 (489.7 ± 13.0 vs 691.2 ± 8.0, P 0.05) expression. Finally, the brain sections showed intact histologica

关键词： Parkinson’s disease Pathophysiology Bone marrow derived mesenchymal stem cells Rotenone Anti-inflammatory action Ovariectomy Anti-apoptotic effect Neurogenic potential

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Influence of bioactive sulphated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1175-1186页

作者： Azza A.Matloub hadeer A.Aglan Sahar Salah Mohamed El Souda Mona Elsayed Aboutabl Amany Sayed Maghraby Hanaa H.Ahmed Pharmacognosy Department National Research Centre Hormones Department National Research Centre Chemistry of Natural Compounds Department National Research Centre Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group) National Research Centre Therapeutical Chemistry Department National Research Centre Laboratory of Immune and Biomarkers for Infection the Center of Excellence for Advanced SciencesNational Research Centre

Objective:To explore the in vivo anticancer,anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens(JCEM) and Pterocladia capillacea(PCEM) as well as hot aqueous extract of Enteromorpha intestinalis(EHEM) against hepatocellular carcinoma rat model(HCC) and to study their chemical ***:The sugars and amino acids composition of the bioactive polysaccharides of JCEM,PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer,*** polysaccharide extracts(20 mg/kg *** 5 weeks) were assessed on hepatocarcinogenesis in rats and α-fetoprotein(AFP),carcinoembryonic antigen(CEA),glypican-3(GPC-3),hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) and Ig G levels were ***:The GLC analysis of JCEM,PCEM and EHEM polysaccharide revealed the presence of 10,9 and10 sugars,in addition the amino acid analyser enable identification of 16,15 and 15 amino acids,*** polysaccharide extracts of JCEM,PCEM and EHEM produced significant decrease in serum AFP,CEA,GPC-3,HGF and VEGF compared with untreated HCC ***,PCEM and EHEM had an immunostimulatory responses by increasing the IgG levels as compared by naive value(1.23,1.53 and 1.17 folds),*** bioactive polysaccharides in HCC induced rats improved the humoral immune *** photomicrographs of liver tissue sections of the groups of HCC treated with polysaccharide extracts of Jania rubens and Enteromorpha intestinalis showed intact histological ***,fractions HE1,HE4,HE7 obtained from polysaccharide of EHEM showed moderate cytotoxic activity against Hep G2 in vitro with IC_(50) 73.1,42.6,76.2 μg/***,fractions of PCEM and JCEM show no or weak cytotoxicity against Hep G2 in vitro where the cytotoxic activity of their crude polysaccharide extract proved synergetic ***:The pronounced antitumor activi

关键词： Jania rubens Pterocladia capillacea Enteromorpha intestinalis Polysaccharide-protein complexes Anti-tumor activity Anti-angiogenesis

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埃及汉语教学中的师生文化差异案例分析

埃及汉语教学中的师生文化差异案例分析

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作者： hadeer ZAINELABEDEN MOHAMED MOUSTFA（杨洁）上海外国语大学

学位级别：硕士

埃及和中国都是历史悠久的文明古国,各自拥有其独特的民族传承与文化内涵。随着两国之间的经济交流日益密切,汉语学习在埃及学生群体中逐渐普及,前来授学的汉语教师也随之增多。但因为地理位置、历史进程和和宗教信仰等原因,两国的风土... 详细信息

埃及和中国都是历史悠久的文明古国,各自拥有其独特的民族传承与文化内涵。随着两国之间的经济交流日益密切,汉语学习在埃及学生群体中逐渐普及,前来授学的汉语教师也随之增多。但因为地理位置、历史进程和和宗教信仰等原因,两国的风土民俗存在着诸多差异,导致在教学中,师生之间时常会出现许多跨文化沟通上的壁垒,甚至发生一些本不必要的误解与误会。本论文主要立足于研究和分析在埃及汉语教学过程中中国教师和埃及学生之间最容易发生的交流障碍。全文主要以“案例分析”的研究方式,客观生动地展示几则常见案例,并逐一说明其产生的背景、情境、原因分析及解决方法。本文主要从语言、非语言和社会文化等方面追因溯源,最后结合实际情况来对埃及学生、中国教师和埃及学校提出一些建议,以致力于使两国师生在能够在今后更加顺畅的开展语言课程及文化交流。

关键词：埃及学生中国教师汉语教学文化差异案例分析

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尼罗河三角洲早-中全新世气候-环境变化对早期农业发展的影响

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湖泊科学 2018年第3期30卷 857-864页

作者： hadeer Sheashaa 赵小双 Alaa Salem 刘演赖晓鹤陈中原华东师范大学河口海岸国家重点实验室上海200062 Faculty of Science Kafrelsheikh UniversityKafrelsheikhEgypt

对尼罗河三角洲平原东北部一个古埃及文化遗址(Kom El-Khilgan)1.5 m长的沉积物剖面KH1开展14C测年、沉积物粒度和孢粉分析.根据岩性、粒度和测年等结果综合判定:剖面150~100 cm地层为早全新世河流相沉积;100~27 cm地层为早、中全新世(8... 详细信息

对尼罗河三角洲平原东北部一个古埃及文化遗址(Kom El-Khilgan)1.5 m长的沉积物剖面KH1开展14C测年、沉积物粒度和孢粉分析.根据岩性、粒度和测年等结果综合判定:剖面150~100 cm地层为早全新世河流相沉积;100~27 cm地层为早、中全新世(8000—4000 cal a BP)三角洲冲积平原沉积,其中涵盖了古埃及前王朝至古王国时期(6500—4131cal a BP)的人类活动信息;27~0 cm为现代表土层.孢粉分析结果反映了在距今8000~4000 a期间:1)研究区气候由湿润过渡为温和,最后趋于干旱;2)随着气候变干,尼罗河上游水文变化对三角洲环境影响减小,研究区由沼泽湿地逐渐过渡为干草甸环境,更多的土地可以被人类利用;3)常被用来指示农业活动的>35μm禾本科、陶器碎片和炭屑的出现并逐渐增加,表明该遗址附近的人类农业活动始于距今6500 a左右,并持续至距今4000 a前后.上述证据表明尼罗河三角洲全新世早—中期湿润向干旱过渡的气候驱动了人类农业活动的开展.本研究为进一步探讨尼罗河三角洲古文明对环境适应性研究提供了科学依据.

关键词：全新世气候早期农业活动尼罗河三角洲

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家庭亲密度与留守儿童学校适应的关系

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心理学进展 2024年第3期14卷 474-477页

作者： hadeer Mierjiang 重庆大学公共管理学院重庆

本研究拟探讨家庭亲密度对留守儿童学校适应的影响。采用家庭亲密度量表和学校适应量表对196名留守儿童进行施测。结果:1) 家庭亲密度与学校适应呈显著正相关预测;2) 家庭亲密度正向预测留守儿童的学校适应。结论:家庭亲密度对留守儿童... 详细信息

本研究拟探讨家庭亲密度对留守儿童学校适应的影响。采用家庭亲密度量表和学校适应量表对196名留守儿童进行施测。结果:1) 家庭亲密度与学校适应呈显著正相关预测;2) 家庭亲密度正向预测留守儿童的学校适应。结论:家庭亲密度对留守儿童的学校适应有积极的预测作用。

关键词：留守儿童家庭亲密度学校适应

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ICU and Aerosol-Generating Procedures in COVID Patients

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Journal of Clinical and Nursing Research 2022年第4期6卷 12-16页

作者： Haitham Saeed hadeer S Harb Yasmin M Madney Mohamed EA Abdelrahim Clinical Pharmacy Department Faculty of PharmacyBeni-Suef UniversityBeni-SuefEgypt

Some of the COVID-19 patients required an intensive care unit admission,additionally an aerosol delivery is an important treatment method in this type of *** present mini-review describes the best aerosol delivery method in this type of ***,the different delivery methods of aerosol,and the best placement of the aerosol which allows the best delivery was discussed in this paper.

关键词： COVID-19 ICU Mutation Aerosol

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Solitary fibrous tumor:A case report of this multifaceted tumor

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World Journal of Clinical Cases 2024年第25期12卷 5791-5797页

作者： Hani Maalouf Ribal Aby hadeer Souad Ghattas Omar Tabbikha Hasan Numan Raja Wakim Department of General Surgery University of BalamandBeirut 100Lebanon Department of General Surgery Mount Lebanon Hospital University Medical CenterBeirut 7031Lebanon

BACKGROUND Solitary fibrous tumor(SFT)is a remarkably uncommon mesenchymal ***6 level and a combination of clinical,pathological,and molecular features are required to arrive at a proper *** SUMMARY In this report,we present an intriguing case involving a 43-year-old woman who initially exhibited symptoms of a bleeding retroperitoneal tumor,initially resembling a gastrointestinal stromal tumor,but later confirmed as an ***,a year later,what was initially believed to be a recurrence of her SFT was instead identified as a desmoid *** Distinguishing SFT from other tumors was *** misdiagnoses of tumor type initially and of recurrence later was necessary for appropriate treatment of the correct desmoid type.

关键词： Solitary fibrous tumor Retroperitoneal tumor Soft tissue neoplasms Sarcoma NAB2-STAT6 Case report

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