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Diabetes onset before or after the age of 65 does it affect the progression of renal and cardiovascular diseases in the elderly patient？

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Journal of Geriatric Cardiology 2016年第3期13卷 267-269页

作者： Yassamine Bentata haddiya intissar Karimi Ilham Benabdellah Nawal Chemlal Abdeljalil Redouane Abouqal Department of Nephrology Medical Sehool of Oujda University Mohammed the First Oujda Morocco Medical Emergency Department lbn Sina University Hospital Rabat Morocco Laboratory of Biostattics Clinical and Epidemiological Research Medical School University Mohamed V SouissL Rabat Morocco

Type 2 diabetes （T2D） is common in the elderly and more than half of the people with diabetes are over 65 years old. Elderly diabetic patients have a higher frequency of hypertension, coronary artery disease and chronic kidney disease than non-diabetic elderly patients and the risk of these complications increases with patient age, duration of the dia- betes and glycated hemoglobin values. Besides the known classical factors of renal disease progression,

关键词： Cardiovascular disease Diabetes Elderly patients Renal disease

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Novel StAR Gene Mutation Identified in a Moroccan Patient with Lipoid Congenital Adrenal Hyperplasia

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Journal of Endocrinology Research 2019年第2期1卷 19-23页

作者： Hanane Zaddouq Althel Pharel Opoko Khadija Belhassan intissar haddiya Ahmed Gaouzi Endocrinology diabetology department Rabat child HospitalRabatMorocco Endocrinology diabetology department General Hospital of LoandjiliPointe NoireRepublic of Congo Hassan Ⅱ University Medical Center-Genetic Department-Fes Medical School Department of Nephrology Faculty of medicine of OujdaMorocco

Congenital Adrenal Hyperplasia(CAH)is an autosomal recessive condition that results from the deficiency of one of the steroidogenesis enzymes responsible for cortisol *** the majority of cases,CAH is caused by 21-hydroxylase *** rarely,the deficiency concerns 11b-hydroxylase,3b-hydroxysteroid dehydrogenase,17hydroxylase,or exceptionally StAR and P450 ***,we report the case of a 3 year and 4 months old male child,born from a consanguineous marriage who presented at 15 months old with the salt-loss *** examination found generalized melanoderma,micropenis and bilateral *** assessment at the time of diagnosis revealed hyponatremia,hyperkalemia,functional renal failure,hypoglycemia,low blood cortisol level,and high blood level of ACTH,suggesting primary adrenal *** patient presented also with the abnormality of sexual differentiation with a 46 XY karyotype,testosteronemia level was low at the baseline and after HCG stimulation,pelvic ultrasound and Magnetic Raisonance Imaging(MRI)showed bilateral testicular atrophy in the inguinal *** genetic study revealed a likely pathogenic homozygous variant in the StAR(steroidogenic acute regulatory)***,our patient was hydrated by saline solution and treated with hydrocortisone and fludrocortisone,then benefited from a surgical testicular correction marked by a favorable *** mutations in StAR gene are rare,they can be responsible for the defect in the early stage of steroidogenesis and therefore cause a deficiency in adrenal and sexual hormones biosynthesis.

关键词： StAR gene Mutation Congenital adrenal hyperplasia Disorders of sex development

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