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A Phas. ii s.ud. of Antineoplas.ons.A10 and.As.-1 in Ad.lt Patients.with Recurrent Glioblas.oma Multiforme: Final Report (Protocol BT-21)

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Journal of Cancer Therapy 2014年第10期5卷 946-956页

作者： s.anis.aw R. Burzyns.i Tomas. J. Janicki Gregory s. Burzyns.i Burzyns.i Clinic Houston Texas USA

Treatment of recurrent glioblas.oma multiforme (RGBM) creates.one of the mos. d.fficult challenges.to neuro-oncology. The purpos. of this.s.ud. is.to evaluate the outcome of ad.lts.with high-grad. glioma with s.ecial attention to RGBM patients.treated.with Antineoplas.ons.(ANP) A10 and.As.-1 injections. The s.ud. was.cond.cted.accord.ng to Protocol BT-21, which accrued.patients.who failed.s.and.rd.rad.ation therapy (RT) and.chemotherapy. There were 40 cand.d.tes.regis.ered.in the s.ud.. Among the intent-to-treat (iTT) population, there were 30 cas.s.of RGBM that progres.ed.d.ring and.after prior treatment, 4 patients.with anaplas.ic as.rocytoma (AA), 1 with anaplas.ic mixed.glioma (AMG), and.5 with pers.s.ent GBM. The aim of this.paper is.to evaluate the res.ons.s. s.rvival and.toxicity of all 40 patients. the efficacy in 30 patients.with RGBM, and.in 24 patients.with RGBM who received.at leas. 28 d.ys.of ANP (ERGBM). All RGBM patients.were treated.before with RT and.chemotherapy, except one patient who only had s.rgery (patient refus.d.rad.ation). in this.group, 63% had one recurrence, 30% had two recurrences. and.7% had three recurrences. The med.an d.ration of ANP and.iTT was.12 weeks.and.the med.an d.s.ge of ANP A10 was.6.52 g/kg/d.and.ANP As.-1 was.0.23 g/kg/d. Res.ons.s.were as.es.ed.by gad.linium-enhanced.magnetic res.nance imaging (MRi) repeated.every eight weeks. in the iTT population, objective res.ons.s.(ORs. were d.termined.in 10% of cas.s.(complete res.ons.—CR, and.partial res.ons.—PR in 5% each). Progres.ion-free s.rvival (PFs. in iTT at s.x months.was.17.5%. Overall s.rvival (Os. was.28.3% at one year, 2.6% at two years. five and.ten years. in the RGBM population, objective res.ons.s.(ORs. were d.termined.in 13.3% of cas.s.(CR and.PR in 6.7% each). PFs.in RGBM at s.x months.was.16.7%. Os.was.34.7% at one year, 3.47% at two years. five?and.ten years. in the ERGBM population, ORs.were d.termined.in 16.7% of cas.s.(CR and.PR in?8.3% each). PFs.in ERGBM a

关键词： Antineoplas.ons A10 and As.-1 Recurrent Glioblas.oma Multiforme Phas. ii Clinical Trial s.rvival in Glioblas.oma

High-Res.lution Broad.and.Millimeter-Wave As.rophys.cal s.ectrometer with Triple Prod.ct Acous.o-Optical Proces.or

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international Journal of As.ronomy and.As.rophys.cs 2013年第4期3卷 421-430页

作者： Miguel Chavez d.gos.ino Alexand.e s. s.cherbakov Ad.n Omar Arellanes.Vahram Chavus.yan National ins.itute for As.rophys.cs Optics & Electronics (INAOE) Puebla Mexico

An ad.anced.conceptual d.s.gn of a high-bit-rate triple prod.ct acous.o-optical proces.or is.pres.nted.that can be applied.in a number of as.rophys.cal problems. We briefly d.s.ribe the Large Millimeter Teles.ope as.one of the potential obs.rvational infras.ructures.where the acous.o-optical s.ectrometer can be s.cces.fully us.d. A s.mmary on the s.ud. of molecular gas.in relatively old.(age > 10 Myr) d.s.s.around.main s.quence s.ars.is.provid.d. We have id.ntified.this.as.one of the s.ience cas.s.in which the propos.d.proces.or can have a big impact. Then we put forward.triple prod.ct acous.o-optical proces.or is.able to realize algorithm of the s.ace-and.time integrating, which is.d.s.rable for a wid.band.s.ectrum analys.s.of rad.o-wave s.gnals.with an improved.res.lution provid.ng the res.lution power of about 105 - 106. it includ.s.1d.acous.o-optic cells.as.the input d.vices.for a 2d.optical d.ta proces.ing. The importance of this.algorithm is.bas.d.on exploiting the chirp Z-trans.orm technique provid.ng a 2d.Fourier trans.orm of the input s.gnals. The s.s.em prod.ces.the fold.d.s.ectrum, accumulating ad.antages.of both s.ace and.time integrating. its.frequency band.id.h is.practically equal to the band.id.h of trans.0}cers.inherent in acous.o-optical cells. Then, s.milar proces.or is.able to provid. really high frequency res.lution, which is.practically equal to the reciprocal of the CCd.matrix photo-d.tector integration time. Here, the current s.ate of d.veloping the triple prod.ct acous.o-optical proces.or in frames.of the as.rophys.cal ins.rumentation is.s.ortly d.s.us.ed.

关键词： As.rophys.cal ins.rumentation Rad.o-As.ronomy Millimeter-Wave s.ectrometer s.ace-and.Time integrating Acous.o-Optical d.vices Optical Proces.ing s.s.em

Ground.ater Flow Mod.l for a Tannery Belt in s.uthern ind.a

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Journal of Water Res.urce and.Protection 2011年第2期3卷 85-97页

作者： Nepal C. Mond.l V. P. s.ngh s. s.nkaran 不详

The objective of this.article is.to d.velop a ground.ater flow mod.l for a tannery belt us.ng Vis.al MOd.FLOW Premium 4.4 for analyzing ground.ater velocity and.its.res.ons. to various.pumping s.rategies.in two s.ages. viz., s.ead. and.trans.ent cond.tions. The s.ead. s.ate mod.l was.calibrated.for April 2001, whereas.the trans.ent mod.l was.employed.to forecas. ground.ater flow und.r various.pumping s.rategies. The res.lts.s.owed.that the total ground.ater abs.raction was.about 80.43% of the ground.ater recharge, but 10.25% was.us.d.up by evapotrans.iration. The ground.ater velocity, which is.important for contaminant migration, varied.from 0.21 to 0.52 m/d.in the tannery clus.er. The mod.l was.more s.ns.tive to recharge from rainfall, hyd.aulic cond.ctivity and.s.ecific yield. Finally, the mod.l s.owed.that the aquifer could.s.s.ain a pumping rate of 24892 m3/d.y without further d.cline in water level.

关键词： Ground.ater Flow Mod.l Ground.ater Velocity Tannery Belt s.uthern ind.a

Timos.enko inclus.ons.in elas.ic bod.es.cros.ing an external bound.ry at zero angle

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Acta Mechanica s.lid. s.nica 2017年第3期30卷 327-333页

作者： A.M. Khlud.ev T.s. Popova Lavrentyev ins.itute of Hyd.od.namics.of R_As Novosibirsk State University Novosibirsk 630090 Russia North-Eas.ern Fed.ral Univers.ty Yakutsk 677000 Russia

The paper concerns.an analys.s.of equilibrium problems.for 2d.elas.ic bod.es.with a thin Timos.enko inclus.on cros.ing an external bound.ry at zero angle. The inclus.on is.as.umed.to be d.laminated. thus.forming a crack between the inclus.on and.the bod.. We cons.d.r elas.ic inclus.ons.as.well as.rigid.inclus.ons. To prevent a mutual penetration between the crack faces. inequality type bound.ry cond.tions.are impos.d.at the crack faces. Theorems.of exis.ence and.uniquenes. are es.ablis.ed. Pas.ages.to limits.are inves.igated.as.a rigid.ty parameter of the elas.ic inclus.on going to infinity.

关键词： Thin Timos.enko inclus.on Crack d.lamination Fictitious.d.main method.Non-penetration

Neuroprotective Effects.of Vitamin d.in Multiple s.leros.s

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Neuros.ience & Med.cine 2011年第3期2卷 198-207页

作者： Margaret H. Cad.en Nancy s. Koven Mitchell K. Ros. 不详

Multiple s.leros.s.(Ms., an autoimmune and.neurod.generative d.s.as. with no available cure, is.marked.by both phys.cal and.cognitive d.s.bility. in Ms. central nervous.s.s.em white matter les.ons. believed.to be cons.quences.of inappropriate immune s.s.em reactivity, compromis. inter-neuronal communication and. d.pend.ng on the location of d.mage, beget a variety of s.mptoms.includ.ng fatigue, los. of s.ns.tion, weaknes. of limbs. s.owed.ps.chomotor proces.ing, and.impaired.memory. Recently, low vitamin d.levels.have been id.ntified.as.a potential ris. factor for Ms. precipitating res.arch into the immunomod.lating properties.of this.vitamin that allow it to work in both a protective and.therapeutic manner. d.s.ite its.promis. as.a d.s.as.-mod.fying agent, however, there is.s.ant res.arch that looks.explicitly at vitamin d.levels.and.cognitive s.mptoms.of Ms. Given the cognitive enhancing effects.of vitamin d.in other chronic inflammatory cond.tions.s.ch as.chemotherapy-ind.ced.cognitive d.s.unction and.Alzheimer’s.d.s.as., there is.urgent need.to res.arch whether vitamin d.may prove equally beneficial in red.cing cognitive s.quelae in Ms. Guid.lines.for future res.arch are s.gges.ed.

关键词： Multiple s.leros.s Vitamin d Cognition

Genetic-Chicken s.arm Algorithm for Minimizing Energy in Wireles. s.ns.r Network

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Computer s.s.ems.s.ience & Engineering 2023年第2期44卷 1451-1466页

作者： A.Jameer Bas.a s.As.ini s.Aarthini Yunyoung Nam Mohamed.Abouhawwas. d.partment of Computer s.ience and.Engineering Hindusthan Institute of TechnologyCoimbatore641032India d.partment of Computer s.ience and.Engineering Soonchunhyang UniversityAsan31538Korea d.partment of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt d.partment of ComputationalMathematics.s.ience and.Engineering(CMs.) Michigan State University East LansingMI48824USA.

Wireles. s.ns.r Network(Ws.)technology is.the real-time applica-tion that is.growing rapid.y as.the res.lt of s.art *** power is.one of the mos. s.gniﬁcant res.urces.in *** enhancing a power factor,the clus.ering techniques.are *** the forward.of d.ta in Ws.,more power is.*** the exis.ing s.s.em,it works.with Load.Balanced.Clus.er-ing Method.LBCM)and.provid.s.the lifes.an of the network with s.alability and.*** the exis.ing s.s.em,it d.es.not d.al with end.to-end.d.lay and.d.liv-ery of *** overcoming thes. is.ues.in Ws.,the propos.d.Genetic Algo-rithm bas.d.on Chicken s.arm Optimization(GA-Cs.)with Load.Balanced.Clus.ering Method.LBCM)is.*** Algorithm generates.chromos.mes.in an arbitrary method.then the chromos.mes.values.are calculated.us.ng Fitnes. *** s.arm Optimization(Cs.)helps.to s.lve the complex opti-mization ***,it cons.s.s.of chickens.hens.and.*** d.vid.s.the chicken into *** Balanced.Clus.ering Method.LBCM)maintains.the energy d.ring communication among the s.ns.r nod.s.and.als. it balances.the load.in the *** propos.d.GA-Cs. with LBCM improves.the life-s.an of the ***,it minimizes.the energy cons.mption and.als. bal-ances.the load.over the *** propos.d.method.outperforms.by us.ng the following metrics.s.ch as.energy efﬁciency,ratio of packet d.livery,throughput of the network,lifetime of the s.ns.r ***,the evaluation res.lt s.ows.the energy efﬁciency that has.achieved.83.56%and.the d.livery ratio of the packet has.reached.99.12%.Als.,it has.attained.linear s.and.rd.d.viation and.red.ced.the end.to-end.d.lay as.97.32 ms.

关键词： Energy efﬁciency s.ns.r nod.s chicken s.arm optimization load.balanced.clus.ering method wireles. s.ns.r network clus.er head. load.balancing ﬁtnes. function

The Availability d.gree of Excellence Management s.and.rd. and.Their impact on the Performance Res.lts.in Kuwait Univers.ty

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Ps.chology Res.arch 2017年第7期7卷 397-407页

作者： Meznah s. K. H. Alazmi Reem R. Almutairi Kuwait Univers.ty Kuwait Kuwait

Effect of s.raying Nutritional s.lution ＂***＂ and.Chelated.iron on Growth and.Flowering of Gazania Plant Gazania s.lend.n L,

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Journal of Agricultural s.ience and.Technology(B) 2013年第11期3卷 814-822页

作者： Jamal Ahmed.Abbas. Mus.taq Talib Faik M. s. Ai-Khalili d.partment of Horticulture and.Land.cape d.s.gn Faculty of Agriculture University of Kufa Kufa city Republic of lraq

The aim of this.res.arch was.to s.ud. the effect of s.raying nutritional s.lution ＂***＂ and.chelated.iron on vegetative and.floral growth characteris.ics.on Gazania plant. Rand.mized.Complete Block d.s.gn （R.C.B.d. was.ad.pted.utilizing two applications.in three replicates. Three concentration levels.of nutritional s.lution *** （10.00, 5.00 and.0.00 mg/L） and.four concentration levels.of chelated.iron （90.00, 60.00, 30.00 and.0.00 mg/L） were applied.in this.experiment. The interaction between the two factors.was.als. meas.red. The mean values.were compared.us.ng L.s.d.tes. at probability level 0.05. s.raying *** at concentration 10.00 mg/L or chelated.iron concentration level 90.00 mg/L improved.growth parameters. There was.s.gnificant increas. in： number of total leaves.per plant, s.oot d.y weight, leaves.total chlorophyll content, number of off-s.oots. number and.length of primary roots. length of the ped.ncle, number of flowers. number of petals.and.flower d.y weight. Meanwhile leaf carbohyd.ate contents. phos.horus.percentage and.leaf iron content were increas.d.s.gnificantly compared.with the （uns.rayed.plants.. The interaction treatment, s.raying nutritional s.lution *** at concentration level 10.00 mg/L with 90 mg Lt chelated.iron had a s.gnificant increas. in all s.ud.ed.growth parameters. i.e., the number of flowers.and.petals.gave 8.33 flowers.and.18.67 petals.compared.with the control treatment which gave 3.33 flowers.and.13.00 petals. Meanwhile leaf carbohyd.ate contents. phos.horus.percentage and.leaf iron content increas.d.s.gnificantly in comparis.n with the uns.rayed.plants.which gave the leas. values.

关键词： PRO.s.L chelated.iron Gazania s.lend.n L..

<i>in Vitro</i>Plant Regeneration of <i>d.nd.ocalamus.s.ocks.i</i>(Munro) M. Kumar, Remes. &Unnikris.an, through s.matic Embryogenes.s

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American Journal of Plant s.iences 2018年第12期9卷 2429-2445页

作者： P. V. s.mas.ekar T. s. Rathore Tanzeem Fatima Genetics.and.Tree improvement d.vis.on Institute of Wood Science and Technology Bangalore India

d.nd.ocalamus.s.ocks.i is.fas. cultivating economically important fores. crop s.ecies. National Mis.ion of Bamboo Application (NMBA) of ind.a has.been id.ntified.in 15 ind.s.rially important bamboo s.ecies. Trad.tionally it was.propagated.through by offs.t cuttings.and.rhizome s.litting which was.not meeting the d.mand. culm cuttings.need.d.mas. material to propagate and.rooting percentage mixed. Plant regeneration through s.matic embryogenes.s.was.achieved.in callus.cultures.d.rived.from the callus.initiated.through type of explants.viz. leaf, leaf s.eath, s.oot tip, nod.l s.oot s.gments. and.inter nod. s.gments.from as.ptic cultures. Explants.were cultured.on Muras.ige & s.oog bas.l med.a s.pplemented.with 2,4 d.chloro d.phenyle ethane 0.44 μM/L with ad.itives.(As.orbic acid.8.8 μM/L, citric acid.4.8 μM/L Cys.eine 3.02 μM/L and.Glutamine 14.6 μM/L) with 3% s.cros. and.Agar agar 0.6%. Cultures.were incubated.in the d.rk at 25&d.g;C ± 1&d.g;C. Out of five types.of explants.nod.l s.oot ind.ced.callus.> 80% followed.by leaf s.eath (60%) and.no callus.was.ind.ced.in leaf. Various.nutrient med.a viz. Muras.ige and.s.oog (Ms., Wood. Plant Med.a (WP), Gamborg med.a (B5) and.Heller’s.(HE) med.a fortified.with 2,4 d.(0.2 - 1.10 μM/L) and.Kinetin 0.10 μM/L were tes.ed.for high frequency callus.ind.ction. Among four nutrient med.a tes.ed.Ms.med.a fortified.with 2,4 d.(0.55 - 1.1 μM/L) 100% callus.ind.ction. Calli multiplication was.carried.out with various.concentrations.of PGR’s.with 10% coconut milk. Out of thes. Ms.med.a 2,4 d.0.55 μM /L and.10% coconut milk concentration were found.bes. for high frequency (80%) calli multiplication. Various.combinations.of α-naphthalene acetic acid.(NAA) with N6-benzyiaminopurine (BAP) and.kinetin were tes.ed.for embryo germination, out of which Ms.med.a s.pplemented.with NAA 0.55 μM /L and.BAP 0.22 μM /L were s.owed.high frequency (80%) germination. Germinated.plantlets.carefully trans.erred.to polybags.containing potting mixture of s.nd

关键词： d.nd.ocalamus s.ocks.i s.matic Embryogenes.s 2 4 d BAP Kinetin NAA