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Total estimated effective doses from radiologic imaging modalities of children with cancer:a single center experience

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World Journal of Pediatrics 2017年第3期13卷 242-247页

作者： Derya Ozyorük Suna Emir hacιahmet demir Gülsah Bayram Kabacam Bahattin Tunc Division of Pediatric Oncology Ankara Children's Hematology and Oncology Education and Research HospitalAnkaraTurkey Division of Radiology Ankara Children's Hematology and Oncology Education and Research HospitalAnkaraTurkey

Background:Recently,awareness of the cumulative radiation exposure for pediatric oncology patients has been increasing,together with increased survival rates and longer life *** aim of our study was to quantify the amount of ionising radiation from imaging modalities of pediatric oncology ***:Eighty-eight patients who were diagnosed with childhood cancer and followed up for 5 years between 2004-2014 in our center were included in the ***' medical files were reviewed retrospectively for imaging history in the first 5 years after *** estimated effective doses from radiologic imaging modalities were ***,the basic demographic data,histologic type,stage,and outcomes of disease were collected for all ***:The individual total estimated effective doses ranged from 8.73 to 167 mSv,with a median of 62.92 *** tomography was the greatest contributor of total effective *** doses ranged 21.45-113.20 mSv (median:62.92 mSv) in Hodgkin lymphoma,12.53-167.10 mSv (median:52 mSv) in non-Hodgkin lymphoma,4.13-172.98 mSv (median:52 mSv) in neuroblastoma,31-149.89 mSv (median:63.10 mSv) in Wilms' tumor,11.50-73.72 mSv (median:36.90 mSv) in germ cell tumor,26.46-125.86 mSv (median:80.90 mSv) in other solid tumor and 0.02-13.31 mSv (5.25 mSv) in brain tumor ***-two children (25%) died with progressive disease during the 5-year follow-up ***:Similar to previous studies,the total estimated effective doses in children with cancer have been found various according to diagnosis,stage and clinical *** clarify the harmfull effects of radiation burden,prospective studies should be conducted in children with cancer.

关键词： children effective dose ionizing radiation

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In vitro engineered models of neurodegenerative diseases

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BIOCELL 2024年第1期48卷 79-96页

作者： ZEHRA GÜL MORÇIMEN ŞEYMA TAŞdemir AYLIN ŞENdemir Bioengineering Department Graduate School of Natural and Applied SciencesEge UniversityIzmir35040Türkiye Bioengineering Department Faculty of Engineering and Natural ScienceCelal Bayar UniversityManisa45110Türkiye Bioengineering Department Ege UniversityIzmir35040Türkiye Department of Biomedical Technologies Graduate School of Natural and Applied SciencesEge UniversityIzmir35040Türkiye

Neurodegeneration is a catastrophic process that develops progressive damage leading to functional andstructural loss of the cells of the nervous system and is among the biggest unavoidable problems of our *** do not reflect the pathophysiology observed in humans due to distinct differences between the neuralpathways,gene expression patterns,neuronal plasticity,and other disease-related mechanisms in animals *** in vitro cell culture models are also not sufficient for pre-clinical drug testing in reflecting thecomplex pathophysiology of neurodegenerative ***,modern,engineered techniques are applied to developmulticellular,intricate in vitro models and to create the closest microenvironment simulating biological,biochemical,and mechanical characteristics of the in vivo degenerating *** THIS review,the capabilities and shortcomings ofscaffold-based and scaffold-free techniques,organoids,and microfluidic models that best reflect neurodegeneration invitro in the biomimetic framework are discussed.

关键词： Neurodegenerative diseases In vitro models Scaffolds Organoids Microfluidic devices

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A case of post traumatic mitral chordae rupture mimicking acute respiratory distress syndrome

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World Journal of Emergency Medicine 2024年第4期15卷 322-324页

作者： Hülya Deniz Misir Nalan demir Ferit Kasimzade Cansu Yahşi Intensive Care Department Ankara Bilkent City HospitalAnkara 06800Turkiye Intensive Care Department University of Health Sciences Ankara Bilkent City HospitalAnkara 06800Turkiye Cardiovascular Surgery Department Ankara Bilkent City HospitalAnkara 06800Turkiye Pulmonary Medicine Department University of Health Sciences Ankara Bilkent City HospitalAnkara 06800Turkiye

Traumatic mitral chordae rupture is a rare and known cause of acute mitral valve regurgitation and de novo heart *** pathologies in a trauma patient may mask the findings of de novo heart failure due to mitral chordae *** patients may also have other potential pre-diagnoses that could explain symptoms related to heart failure,such as tachycardia,circulatory shock,and acute *** possibility of traumatic chordae tendinea rupture being a preventable cause of mortality should be carefully evaluated.

关键词： rupture mitral acute

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Red cell distribution width-to-albumin ratio is a simple promising prognostic marker in acute cholangitis requiring biliary drainage

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 487-494页

作者： Fatih Acehan Hüseyin Camli Cagdas Kalkan Mesut Tez Burak Furkan demir Emin Altiparmak Ihsan Ates Department of Internal Medicine Ankara City HospitalAnkara 06800Türkiye Department of Gastroenterology Ankara City HospitalAnkara 06800Türkiye Department of General Surgery Ankara City HospitalAnkara 06800Türkiye

Background: It is crucial to assess the severity of acute cholangitis(AC). There are currently several prognostic markers. However, the accuracies of these markers are not satisfied. The present study aimed to investigate the predictive value of the red cell distribution width(RDW)-to-albumin ratio(RAR) for the prognosis of AC. Methods: We retrospectively evaluated consecutive patients diagnosed with AC between May 2019 and March 2022. RAR was calculated, and its predictive ability for in-hospital mortality, intensive care unit(ICU) admission, bacteremia, and the length of hospitalization were analyzed. Results: Out of 438 patients, 34(7.8%) died. Multivariate analysis showed that malignant etiology [odds ratio(OR) = 4.816, 95% confidence interval(CI): 1.936-11.980], creatinine(OR = 1.649, 95% CI: 1.095-2.484), and RAR(OR = 2.064, 95% CI: 1.494-2.851) were independent risk factors for mortality. When adjusted for relevant covariates, including age, sex, malignant etiology, Tokyo severity grading(TSG), Charlson comorbidity index, and creatinine, RAR significantly predicted mortality(adjusted OR = 1.833, 95% CI: 1.280-2.624). When the cut-off of RAR was set to 3.8, its sensitivity and specificity for mortality were 94.1% and 56.7%, respectively. Patients with an RAR of > 3.8 had a 20.9-fold(OR = 20.9, 95% CI: 4.9-88.6) greater risk of mortality than the remaining patients. The area under the curve value of RAR for mortality was 0.835(95% CI: 0.770-0.901), which was significantly higher than that of TSG and the other prognostic markers, such as C-reactive protein-to-albumin ratio, and procalcitonin-to-albumin ratio. Lastly, RAR was not inferior to TSG in predicting ICU admission, bacteremia, and the length of hospitalization. Conclusions: RAR successfully predicted the in-hospital mortality, ICU admission, bacteremia, and the length of hospitalization of patients with AC, especially in-hospital mortality. RAR is a promising marker that is more convenient than TSG and o

关键词： Acute cholangitis Albumin Biliary drainage Mortality Red blood cell distribution width-to-albumin ratio

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The ability of biostimulants and copper-containing fungicide to protect cotton against chilling stress

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Journal of Cotton Research 2024年第3期7卷 223-230页

作者： ERGIN Nurgül KULAN Engin Gokhan HARMANCI Pinar KAYA Mehmet demir Faculty of Agriculture and Natural Sciences Department of Field CropsBilecik Seyh Edebali UniversityBilecikTürkiye Faculty of Agriculture Department of Field CropsEskisehir Osmangazi UniversityEskisehirTürkiye

Background Cotton(Gossypium hirsutum L.),adapted to tropical and subtropical regions of the world,is highly sensitive to low temperatures throughout its life *** objective of this study was to evaluate the mitigating effects of different doses of animal-derived(0.25%,0.50%,and 1.00% Isabion■),seaweed-based(0.165%,0.330%,and 0.660% Proton■)biostimulants,as well as a copper(Cu)-containing fungicide application,on cotton cultivar Lazer seedlings at the four true leaves(V4)*** plants were exposed to a low temperature of 5℃for 48 h,and the changes in morphological(seedling fresh and dry weight,plant height,and stem diameter)and physiological parameters(leaf temperature,chlorophyll content,relative water content,electrolyte leakage,and relative injury)were *** The results revealed that chilling stress reduced plant growth,while biostimulants helped protect the plants and overcome the adverse effects of *** chilling stress,there was a considerable reduction in seedling fresh weight(SFW),seedling dry weight(SDW),plant height(PH),stem diameter(SD),leaf temperature(LT),and relative water content(RWC).Cotton seedlings treated with the animal-derived biostimulants showed significantly enhanced SFW,SDW,PH,SD,LT,chlorophyll content(Chl),electrolyte leakage(EL),and relative injury(RI),although there were no positive changes in *** significant differences in the morphological traits were observed among the doses of seaweed *** SDW,PH,EL,and RI,the best results were obtained with the application of a fungicide containing *** These results show the efficiency of the biostimulant and fungicide treatments in mitigating low-temperature stress in cotton *** a copper-containing fungicide to cotton seedlings helped to counteract the negative effects of low-temperature stress and to protect the plants from damage by maintaining electrolyte *** the biostimulant applications,all levels of animal-derive

关键词： Gossypium hirsutum L. Cold stress Electrolyte leakage

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Investigation of the Acceptability of Cultured Meat in University Students

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Food and Nutrition Sciences 2024年第2期15卷 151-169页

作者： Merve Kumru Hulya demir Nutrition and Dietetic Department Health Science Faculty Yeditepe University Istanbul Türkiye

Background: Over the past 20 years, cultured meat has drawn a lot of public attention as a potential solution to issues with animal husbandry, including inadequate use of natural sources, improper animal welfare practices, and possible risks to public health and safety. The novel method of producing meat through culture reduces the need for animals to produce muscle fiber, thereby obviating the necessity for animal slaughter. Apart from its ethical advantages, cultured meat presents a possible way to fulfill the expanding need for food among growing populations. The purpose of this research was to find out whether Turkish students would be willing to pay for and accept cultured meat. Technique: Method: 371 university students who willingly consented to fill out a questionnaire and provide demographic data make up the research sample. Questions from previous studies on the acceptability of cultured meat were compiled to create the survey. The research’s data collection took place in March and April of 2022. The research was completed in June 2022 after the data had been processed and analyzed. Results: The results showed that the majority of participants were female and had omnivorous eating habits. Based on the results of the Bonferroni correction test, students with a higher intention to purchase and consume cultured meat were those who received economics and business education. Students with two years of university education had a higher overall survey score than those with four years of education (p < 0.05). Furthermore, it is discovered that there is a negative correlation between the participants’ ages and their Factor 2 (using cultured meat as an alternative to industrial meat) and Factor 3 (consuming and purchasing it) section points (r = -109, p = 0.036) (r = -0.121, p = 0.019). In conclusion, university students generally have a negative outlook on health-related issues, such as eating cultured meat as an alternative.

关键词： Cultured Meat University Students

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Exploration of Green Alternatives to 6PPD (P-Phenylenediamine) Used as Antiozonant and Antioxidant in the Rubber Industry

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Materials Sciences and Applications 2024年第4期15卷 87-100页

作者： Emine demir Husnu Gerengi Kerem Savcı Gasim Altundal Canan Yüksel Doğaç Çağıl Anlas Tyre Company R&D Center D&#252zce T&#252rkiye Department of Mechanical Engineering Faculty of Engineering D&#252zce University D&#252zce T&#252rkiye The Koc High School &#304stanbul T&#252rkiye

Antiozonants and antioxidants are additives commonly used in the rubber industry to enhance the durability and performance of rubber products. Ozone, present in the atmosphere, can cause rubber to degrade over time through a process known as ozone cracking. These rubber additives are added to rubber compounds to protect against this degradation. They work by reacting with ozone, preventing it from attacking and breaking the molecular chains in the rubber, helping to maintain the structural integrity of the rubber product. It is now well known that 6PPD contributes to the extension of the service life of rubber products. However, recent studies have shown that 6PPD can be harmful to the environment, especially when end-of-life tyres (ELTs) are contaminated with the water. With the effect of ozone, 6PPD is converted to 6PPD quinone, which is toxic enough to kill some sensitive fish species such as Coho Salmon (Oncorhynchus kisutch). This study drew attention to new chemical compounds and natural products that can be used as antiozonants and antioxidants in the rubber industry instead of 6PPD. Although the scientific studies are promising, the fact that 6PPD is still used in production shows that more scientific studies and social awareness need to be developed in this area.

关键词： 6PPD Coho Salmon Antiozonant Antioxidant

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Polariton lasing in Mie-resonant perovskite nanocavity

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Opto-Electronic Advances 2024年第4期7卷 27-42页

作者： Mikhail A.Masharin Daria Khmelevskaia Valeriy I.Kondratiev Daria I.Markina Anton D.Utyushev Dmitriy M.Dolgintsev Alexey D.Dmitriev Vanik A.Shahnazaryan Anatoly P.Pushkarev Furkan Isik Ivan V.Iorsh Ivan A.Shelykh Hilmi V.demir Anton K.Samusev Sergey V.Makarov UNAM-Institute of Materials Science and Nanotechnology National Nanotechnology Research CenterDepartment of Electrical and Electronics EngineeringDepartment of PhysicsBilkent UniversityAnkara 06800Turkey ITMO University School of Physics and EngineeringSt.Petersburg 197101Russia Abrikosov Center for Theoretical Physics MIPTDolgoprudnyiMoscow Region 141701Russia LUMINOUS!Center of Excellence for Semiconductor Lighting and Displays School of Electrical and Electronic EngineeringSchool of Physical and Mathematical SciencesSchool of Materials Science and EngineeringNanyang Technological UniversitySingapore 639798Singapore Department of Physics Engineering Physics and AstronomyQueen’s UniversityKingstonOntario K7L 3N6Canada Science Institute University of IcelandDunhagi 3IS-107ReykjavikIceland Experimentelle Physik 2 Technische Universität DortmundDortmund 44227Germany Qingdao Innovation and Development Center Harbin Engineering UniversityQingdao 266000China

Deeply subwavelength lasers(or nanolasers)are highly demanded for compact on-chip bioimaging and sensing at the *** of the main obstacles for the development of single-particle nanolasers with all three dimensions shorter than the emitting wavelength in the visible range is the high lasing thresholds and the resulting *** we ex-ploit exciton-polariton condensation and mirror-image Mie modes in a cuboid CsPbBr3 nanoparticle to achieve coherent emission at the visible wavelength of around 0.53μm from its ultra-small(≈0.007μm3 or≈λ3/20)semiconductor *** polaritonic nature of the emission from the nanocavity localized in all three dimensions is proven by direct com-parison with corresponding one-dimensional and two-dimensional waveguiding systems with similar material *** a deeply subwavelength nanolaser is enabled not only by the high values for exciton binding energy(≈35 meV),re-fractive index(>2.5 at low temperature),and luminescence quantum yield of CsPbBr3,but also by the optimization of po-laritons condensation on the Mie resonances with quality factors improved by the metallic ***,the key parameters for optimal lasing conditions are intermode free spectral range and phonons spectrum in CsPbBr3,which govern polaritons condensation *** chemically synthesized colloidal CsPbBr3 nanolasers can be potentially de-posited on arbitrary surfaces,which makes them a versatile tool for integration with various on-chip systems.

关键词： nanolaser perovskite polariton Mie resonance exciton-polariton

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Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer

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World Journal of Gastroenterology 2007年第33期13卷 4437-4444页

作者： Sibel Erdamar Esra Ucaryilmaz Gokhan demir Tayfun Karahasanoglu Gulen Dogusoy ahmet Dirican Suha Goksel Department of Pathology Cerrahpasa Medical CollegeIstanbul University Cerrahpasa 34303 Istanbul Turkey Department of Oncology Cerrahpasa Medical College Istanbul University Cerrahpasa 34303 Istanbul Turkey Department of General Surgery Cerrahpasa Medical College Istanbul University Cerrahpas34303 Istanbul Turkey Department of Statistics Cerrahpasa Medical College Istanbul University Cerrahpasa 34303 Istanbul Turkey

AIM： To assess the incidence of MLH1 （the human MutL homologue） and MSH2 （the human MutS homologue） protein expression in Turkish patients with sporadic colorectal cancers and to compare their survival and clinicopathological features. METHODS： We validated the tissue microarray technology in 77 colorectal carcinomas by analyzing the immunohistochemical expression of proteins involved in two main pathways of colorectal carcinogenesis： p53 protein for loss of heterozygosity tumors; MLH1 and MSH2 proteins for microsatellite instability （MSI）. RESULTS： Our analysis showed that 29 （39.2%） had loss of MLH1 expression, 5 （6.8%） had loss of MSH2 expression and 2 cases had loss of expression of both proteins. We found that 60% of MSH2-negative tumors were located in the right side of the colon; all MSH2-negative cases were women. In addition, the loss of MSH2 expression was correlated with low p53 expression. Neither MLH1 nor MSH2 expressions were associated with prognosis, although there seemed a tendency of longer survival （71.7 ± 8.65 mo vs 47.08± 5.26 too） for the patients with MLHl-negative versus MLHl-positive carcinomas. There were not significant differences in overall and recurrence-free survival among MLH1/MSH2-positive and -negative cases.CONCLUSION： Our data supports that Turkish patients with MLH1- and MSH2-defective tumors have some distinct features from each other. Although prognostic importance remains controversial, immunohistochemical analysis of mismatch repair genes may be used as a routine histopathological examination of sporadic colorectal carcinomas.

关键词： Colorectal carcinoma MLH1 MSH2 Immunohistochemistry Prognosis

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Acute appendicitis presenting with abdominal wall and right groin abscess:A case report

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World Journal of Gastroenterology 2007年第26期13卷 3631-3633页

作者： Mustafa Yildiz ahmet Sevki Karakayali Saadet Ozer Hilal Ozer Aydin demir Bugra Kaptanoglu Department of General Surgery Ministry of Health Ankara Training and Research Hospital UlucanlarAnkaraTurkey

We report a case of right lower abdominal wall and groin abscess resulting from acute appendicitis. The patient was an 27-year-old man who had no apparent abdominal signs and was brought to the hospital due to progressive painful swelling of right lower abdomen and the groin for 10 d. Significant inflammatory changes of soft tissue involving the right lower trunk were noted without any apparent signs of peritonitis. Laboratory results revealed leukocytosis. Abdominal ultrasonography described the presence of abscess at right inguinal site also communicating with the intraabdominal region. Right inguinal exploration and laparotomy were performed and about 250 mL of pus was drained from the subcutaneous tissue and preperitoneal space. No collection of pus was found intraabdominally and subserous acute appendicitis was the cause of the abscess. The patient fully recovered at the end of the second post-operation week. This case reminds us that acute appendicitis may have an atypical clinical presentation and should be treated carefully on an emergency basis to avoid serious complications.

关键词： Acute appendicitis Groin abscess Inguinalabscess Complication Thigh abscess

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