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Association of a genetic variant in AKT1 gene with features of the metabolic syndrome

Genes & Diseases 2019年第3期6卷 290-295页

作者： Fateme Sadat Eshaghi Hamideh Ghazizadeh Sakine Kazami-Nooreini Ameneh Timar habibollah esmaeily Mehrane Mehramiz Amir Avan Majid Ghayour-Mobarhan Dept.Biology Faculty of Basic SciencesHakim Sabzevari UniversityP.O.Box:397SabzevarIran Student Research Committee Faculty of MedicineMashhad University of Medical SciencesMashhadIran Metabolic Syndrome Research Center Mashhad University of Medical SciencesMashhadIran Social Department of Health Research Center Mashhad University of Medical SciencesMashhadIran

Metabolic syndrome(MetS)is a clustering of metabolic abnormalities that is associated with increased risk of developing cardiovascular disease and type 2 *** is growing body of data showing the associations of genetic variants of the genes involved in the PI3K/AKT/mTOR pathway with diabetes and *** aimed to investigate the association between MetS and its components with the genetic polymorphism in AKT1,rs1130233(T>C).Total of 618 participants,recruited from Mashhad stroke and heart atherosclerosis disorder cohort(MASHAD study).Patients with MetS were defined by using international diabetes federation(IDF)criteria(n Z 326)and those without MetS(n Z 261)were *** and biochemical parameters were measured in all *** analysis for the rs1130233 polymorphism was performed,using the ABI-StepOne instruments with SDS version-2.0 *** with MetS had a significantly higher levels of BMI,waistcircumference,total cholesterol,triglyceride,high sensitivity-c reactive protein(hs-CRP)and blood-pressure,and lower concentrations of high density lipoprotein(HDL-C),compared to non-MetS individuals(PC)polymorphism was associated with major components of MetS such as hs-CRP,and BMI,indicating further investigation in a multi-center setting to explore its value as an emerging biomarker of risk stratification marker.

关键词： AKT1 CRP Genetic variant MetS PI3K/AKT/mTOR pathway rs1130233

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Anxiety, Depression and Coronary Artery Disease among Patients Undergoing Angiography in Ghaem Hospital, Mashhad, Iran

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Health 2014年第11期6卷 1108-1115页

作者： Mohammad Tajfard Majid Ghayour-Mobarhan Hamid Reza Rahimi Mohsen Mouhebati habibollah esmaeily Gordon A. A. Ferns Latiffah A. Latiff Farzaneh Tajfiroozeh Nagmeh Mokhber Ramin Nazeminezhad Homa Falsoleyman Ali Taghipour Ahmad Fazli Abdul Aziz Rosliza A. Manaf Zahra Saghiri Parichehr Hanachi Brighton & Sussex Medical School Falmer Brighton UK Cardiovascular Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran Departemet of Psychiatry School of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Biology-Biochemistry Faculty of Science Payame Noor University of Mashhad Mashhad Iran Department of Cardiology School of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Community Health Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Selangor Malaysia Department of Medicine Faculty of Medicine and Health Sciences University Putra Malaysia Serdang Selangor Malaysia Faculty of Science Biology Department Biochemistry Unit Alzahra University Tehran Iran Health Sciences Research Center Department of Biostatistics School of Health Mashhad University of Medical Sciences Mashhad Iran Health Sciences Research Center Department of Health and management School of Health Mashhad University of Medical Sciences Mashhad Iran Student Research Committee Department of Modern Sciences & Technologies School of Medicine Mashhad University of Medical Sciences Mashhad Iran

The prevalence of coronary artery disease (CAD) is increasing in Iran. Patients with depression who have a myocardial infarction are more likely to die and patients who have depressive symptoms during hospitalization may have increased cardiovascular events. This study aimed to determine the relationship between anxiety, depression and coronary artery disease among patients undergoing angiography in Ghaem Hospital, Mashhad. This was a case-control study conducted between September 2011 and August 2012 among patients undergoing coronary angiography in Ghaem Hospital, Mashhad, Iran. There were 486 cases that were found to have one or more coronary stenoses, with a stenosis of equal or more than 50% of the diameter of at least one major coronary artery. The other patient group consisted of the patients in whom the coronary artery stenosis was less than 50% in diameter which was classified as angiography negative, and a control group that consisted of 440 healthy adults aged 18 years old and above who were selected among people who attended for routine medical checkup and medical examination of employment. The dependent variables were Beck Anxiety and Depression Inventory scores and the independent factors were coronary artery disease, and socioeconomic profiles. Validated and reliability-tested questionnaires were used for data collection. The mean age of patients was 55.75 ± 10.64 years and in the healthy group was 55.83 ± 8.55 years;there was no significant difference in age between subject groups (p = 0.897) nor a significant difference in the gender frequency distribution of subjects (p = 0.610). There was a significant difference in anxiety score between the Angio positive and Angio negative patients and healthy control subjects

关键词： Coronary Artery Disease Anxiety Depression Angiography

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