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Surgical Science 2016年第8期7卷 357-360页

作者： Haithem Zaafouri Anis Hasnaoui Raja Jouini Dhafer Haddad Ahmed Bouhafa Anis ben Maamer Department of Surgery Habib Thameur Hospital Tunis Tunisia Department of Histopathology and Cytology Habib Thameur Hospital Tunis Tunisia

Collision tumors of adenocarcinoma and MALT (Mucosa-associated lymphoid tissue) lymphoma are often rare findings of resection specimens of gastric carcinomas. The fact that these two histological lesions are contiguous may suggest a common oncogene. As it is widely known, Helicobacter pylori (H. pylori) plays a leading role in gastric oncogenesis. Could it be responsible for these tumors? As of today, the exact mechanism is still unclear. However, some histological findings may suggest that H. pylori promotes the formation of MALT lymphoma which increases the risk of carcinomatous changes. Prognosis of collision tumors is tightly linked to the carcinoma lesion, which is generally poor due to diagnostic delay. Large scale strategies to eradicate H. pylori and detect early lesions could reduce the mortality of this disease.

关键词： Collision Tumor Gastric Lymphoma Adenocarcinoma Helicobacter pylori

Primary cancers of the small bowel: About 20 cases

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Open Journal of Gastroenterology 2014年第2期4卷 81-87页

作者： Noomen Haoues Manel Mabrouk Haithem Zaafouri Rabii Noomene Ahmed Bouhafa Anis ben Maamer Abderraouf Cherif Department of General Surgery Habib Thameur Hospital Tunis Tunisia

Background: Cancers of the small bowel are rare. Diagnosis is late and difficult because of the lack of specific signs. Treatment is surgical. Prognosis is usually poor and depends on the histological type of tumor. Aim of Study: To specify the epidemiological, clinical and therapeutic characteristics of small bowel primary cancers in order to improve their prognosis. Material and Methods: This is a retrospective study about 20 cases of malignant tumors of the small bowel, collected in the department of general surgery of habib Thameur Hospital in Tunis (Tunisia), from January 1994 through June 2011. Results: Our series involved 11 women and 9 men aged 62 on average (range: 44 - 80 years). In 45% of cases, the diagnosis was made in a patient rushed to hospital with clinical features of acute generalized peritonitis (66% of all surgical emergencies). Intestinal transit was performed in 5 patients only. Ultrasound abdominal examination was performed in 11 patients. Abdominal CT scan was performed in 7 patients, but the results were conclusive in 4 cases only (57%). Small bowel scanning was done in 5 patients only, but led to a positive diagnosis in all of them. All of our patients underwent surgery. Tumors of the small bowel were histologically divided as follows: carcinoid tumor (8 cases), leiomyosarcoma (7 cases), giant B-cell lymphoma (2 cases), malignant stromal tumor (2 cases) and malignant myxoid schwannoma (1 case). Malignant tumors of the small bowel most commonly arise in the ileum (60%) followed by the jejunum (35%). As for the long-term course, there was a recurrence at one year of a leiomyosarcoma and two recurrences of stromal tumors associated with liver metastases. Conclusion: Small bowel cancers are rare. Time to consultation is long and diagnosis is difficult and late due to the absence of typical presentation. Treatment is surgical and progression depends essentially on histological findings.

关键词： Primary Cancers Small Bowel Epidemiology Diagnosis

Multiple pyogenic liver abscess

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World Journal of Gastroenterology 2006年第18期12卷 2962-2963页

作者： Mabrouk Bahloul Anis Chaari Nadia Bouaziz-Khlaf Hatem Kallel Leila Herguefi Hedi Chelly Chokri ben Hamida Mounir Bouaziz Service de Réanimation médicale CHU habib Bourguiba Route el Ain Km 1 3029 Sfax Tunisie

多重生脓肝脓肿很少被描述了。我们报导影响要求外科的排水的一个 38 岁的女人的多重生脓肝脓肿的一个致命的案例。进化被出现标记一腐败有多器官的吃惊系统失败。病人死了在外科以后的 48 h。疾病的原因，治疗学和结果被讨论。

关键词：化脓肝脓肿病理机制临床

An Ecological Survey of Limoniastrum guyonianum： A Halophyte Native Tree in Arid Zones of Algeria

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Journal of Life Sciences 2017年第7期11卷 333-340页

作者： Chaff Mohammed El habib Selkh Chouaib bensoltane Ahmed Department of Biology Faculty of Sciences of Nature and the Life University of Ahmed Ben Bella-Oranl City of Oran 31000Algeria

Philadelphie chromosome—Positive <i>de novo</i>acute myeloid leukemia. Isolated meningeal relapse in a patient treated with imatinib mesylate

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Case Reports in Clinical Medicine 2013年第2期2卷 167-169页

作者： I. ben Amor S. Hdiji Mseddi O. Kassar S. Hdiji Mnif Ines Jdidi M. Mdhaffar L. Kammoun H. Bellaaj A. Saad M. Elloumi Cytogenetics Laboratory Farhat Hached Hospital Sousse Tunisia Hematology department Hedi Chaker Hospital Sfax Tunisia Hematology department Hedi Chaker Hospital Sfax Tunisia Hematology Laboratory habib Bourguiba Hospital Sfax Tunisia Molecular Biology Unit Institue Pasteur Tunis Tunisia

Acute myeloid leukemia philadelphie positive (Ph+ AML) is a rare aggressive acute leukemia with poor prognosis. We report a patient with ph positive AML (FAB5), the transcript bcr/abl was not performed at diagnosis. She achieved complete remission after conventional induction chemotherapy. The consolidation therapy was based on Imatinib only due to infectious complications. She was in complete hematologic and cytogenetic remission for 19 months, and after she exhibited an isolated meningeal relapse. A second remission was achieved with intrathecal chemotherapy and cranial irradiation. Imatinib was switched to second generation Tyrosine kinase Inhibitor which had better diffusion into cerebrospinal fluid. She is in complete hematologic, cytogenetic and meningeal remission after 14 months of treatment. Imatinib monotherapy affords insufficient protection from CNS relapse. Second generation Tyrosine kinase Inhibitor seems to have better efficiency. Ph+ AML with monoblastic differentiation should be considered, like Ph+ ALL, at high risk of meningeal leukemia and should receive central nervous system prophylaxis.

关键词： Acute Myeloid Leukemia Philadelphie Chromosome Meningeal Relapse