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Epidemiological and histopathological characteristics of thyroid carcinoma in a Tunisian health care center

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 37-42页

作者： Maissa ben Thayer Fatma Khanchel Imen Helal Dorra Chiboub Hedhli Raoueh Ehsen ben Brahim Raja Jouini Aschraf Chadli-Debbiche Faculty of Medicine of Tunis Tunis El Manar UniversityTunisTunisia Depatment of Pathology Habib Thameur's HospitalTunisTunisia Department of Otorhinolaryngology-Head and Neck surgery Habib Thameur's HospitalTunisTunisia

Background:Thyroid carcinoma(TC)accounts for almost 0.5%–1%of total *** incidence is increasing rapidly *** studies have drawn up the epidemiological profile of TC and its clinical and pathological ***,to date,no similar studies have been conducted in ***:To establish an epidemiological profile of TC in a Tunisian health care institute and to analyze its clinical and histopathological characteristics in our *** and Methods:We present a retrospective study reviewing the cases of TC diagnosed in our institution in a 4-year ***:We collected a sample of 192 cases of *** consisted of 31 males and 161 females(83.8%)with a sex-ratio M/F of *** mean age was 46.4 *** thyroid carcinoma was the most frequent histological *** multifocality rate was 33.8%.The mean size of TC was 2.2±1.9 cm.60.9%of TC were staged pT1 and 20.3%had nodal *** thyroid microcarcinomas were noted in 37.5%of ***:Our results were consistent with those of the literature.A high proportion of pT1 and pN0 tumors were noted in our series,suggesting that TC's diagnosis and management was performed at an early stage of the disease in our *** addition,our study enabled us to notice the impact of the Coronavirus disease 19 crisis on the management of TC in our *** studies are needed to establish the epidemiological profile of TC in Tunisia and to assess its clinical and pathological features.

关键词： coronavirus disease 19 epidemiology papillary thyroid carcinoma papillary thyroid microcarcinoma pathology thyroid carcinoma

SCALAR CURVATURE TYPE PROBLEM ON THE THREE DIMENSIONAL BOUNDED DOMAIN

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Acta Mathematica Scientia 2017年第1期37卷 139-173页

作者： Mohamed ben AYED habib FOURTI Faculte des Sciences Universite de SfaxRoute SoukraSfaxTunisie Institut Preparatoire Aux Etudes d'Ingenieurs Universite de SfaxSfaxTunisie

In this paper we prove an existence result for the nonlinear elliptic problem：-△u = Ku5,u 〉 0 in Ω,u = 0 on Ω,where Ω is a smooth bounded domain of R3 and K is a positive function in Ω.Our method relies on stud... 详细信息

关键词： scalar-curvature critical point limiting Sobolev exponent variational prob-lems with lack of compactness blow up analysis

MACS-annexin V cell sorting of semen samples with high TUNEL values decreases the concentration of cells with abnormal chromosomal content:a pilot study

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Asian Journal of Andrology 2022年第5期24卷 445-450页

作者： Sahar El Fekih Nadia Gueganic Corinne Tous habib ben Ali Mounir Ajina Nathalie Douet-Guilbert Hortense Drapier Damien Beauvillard Frédéric Morel Aurore Perrin University of Brest InsermUMR U1078Faculty of Medicine and Health SciencesBrest 29238France Laboratory of Human Cytogenetics Molecular Genetics and Reproductive BiologyFarhat Hached University HospitalSousse 4031Tunisia Departement of Medical Genetics and Reproductive Biology Brest University Regional HospitalBrest 29609France Department of Reproductive Medicine Farhat Hached Teaching HospitalSousse 4031Tunisia

We question whether,in men with an abnormal rate of sperm DNA fragmentation,the magnetic-activated cell sorting(MACS)could select spermatozoa with lower rates of DNA fragmentation as well as spermatozoa with unbalanced chromosome *** spermatozoa from six males were separated into nonapoptotic and apoptotic *** determined the percentages of spermatozoa with(i)externalization of phosphatidylserine(EPS)by annexin V-Fluorescein isothiocyanate(FITC)labeling,(ii)DNA fragmentation by TdT-mediated-dUTP nick-end labeling(TUNEL),and(iii)numerical abnormalities for chromosomes X,Y,13,18,and 21 by fluorescence in situ hybridization(FISH),on the whole ejaculate and selected spermatozoa in the same *** to the nonapoptotic fraction,the apoptotic fraction statistically showed a higher number of spermatozoa with EPS,with DNA fragmentation,and with numerical chromosomal *** to the whole ejaculate,we found a significant decrease in the percentage of spermatozoa with EPS and decrease tendencies of the DNA fragmentation rate and the sum of disomy levels in the nonapoptotic ***,we observed statistically significant higher rates of these three parameters in the apoptotic *** may help to select spermatozoa with lower rates of DNA fragmentation and unbalanced chromosome content in men with abnormal rates of sperm DNA fragmentation.

关键词： chromosomal abnormalities DNA fragmentation externalization of phosphatidylserine magnetic-activated cell separation spermatozoa

Oxidative stress in male infertility and therapeutic approach: A mini-review

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Asian pacific Journal of Reproduction 2023年第6期12卷 249-255页

作者： Marwa Lahimer Henda Mustapha Véronique Bach Hafida Khorsi-Cauet Moncef benkhalifa Mounir Ajina habib ben Ali Service of Reproductive Medicine University Hospital Farhat HachedSousseTunisia Exercise Physiology and Physiopathology:from Integrated to Molecular“Biology Medicine and Health”(Code:LR19ES09)SousseTunisia Péritox(UMR_I 01) UPJV/INERISUPJVCURSChemin de Thil 80025 AmiensFrance ART and Reproductive Biology Laboratory University Hospital and School of MedicinePicardie University Jules VerneCHU Sud80054AmiensFrance Laboratory Histology Embryology Faculty of Medicine SousseUniversity of SousseSousseTunisia

Growing evidence suggests that oxidative stress is a major cause of male *** are highly sensitive cells due to the vulnerability of their membrane fatty acids and the diminished antioxidant *** oxygen species(ROS)impact multiple signaling pathways involved in mitochondrial dysfunction,hormonal unbalance and semen quality *** origin of ROS is diverse,including generated normal cellular metabolism,environmental exposure,advanced paternal age and *** has indicated that antioxidant supplementation can improve oxidative stress and reduce the risk of chronic ***,it is widely known that antioxidant supplementation can enhance sperm quality and increase the pregnancy rate in couples undergoing fertility *** current study highlights the deleterious effect of ROS and its impact on semen *** addition,it contributes to the development of a clinical approach for the use of antioxidants in the management of male infertility.

关键词： Oxidative stress Reactive oxygen species Mitochondria Antioxidant supplementation Spermatozoa

Cooperative Answering of Fuzzy Queries

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Journal of Computer Science & Technology 2009年第4期24卷 675-686页

作者： Narjes Hachani Mohamed Ali ben Hassine Hanene Chettaoui habib Ounelli Department of Computer Sciences Faculty of Sciences of Tunis University Campus Tunis 1060 Tunisia

The majority of existing information systems deals with crisp data through crisp database systems. Traditional Database Management Systems （DBMS） have not taken into account imprecision so one can say there is some sort of lack of flexibility. The reason is that queries retrieve only elements which precisely match to the given Boolean query. That is, an element belongs to the result if the query is true for this element; otherwise, no answers are returned to the user. The aim of this paper is to present a cooperative approach to handling empty answers of fuzzy conjunctive queries by referring to the Formal Concept Analysis （FCA） theory and fuzzy logic. We present an architecture which combines FCA and databases. The processing of fuzzy queries allows detecting the minimal reasons of empty answers. We also use concept lattice in order to provide the user with the nearest answers in the case of a query failure.

关键词： cooperative system database empty answer formal concept analysis fuzzy query

Early Cretaceous Tectonostratigraphic Evolution of the Southern Tunisian Margin Based on Gravity,Seismic and Potential Field Data:New Insights into a Geodynamic Evolution in a Tethyan and Mesogean Rifting Context

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Journal of Earth Science 2023年第3期34卷 879-899页

作者： Mohamed ben Chelbi Faculty of Sciences of Tunis Laboratory of GeodynamicGeonumeric and Geomaterials(L3G)LR18ES37University of Tunis El ManarTunisTunisia

Many geophysical and geological data have been used to interpret the tectonic evolution of the south-eastern part of the Tunisian margin and to analyze the dominant structures in the *** Menzel habib Plain(MHP)and surroundings,targeted by this study,exhibits thick siliciclastic and carbonate formations attributed to the Early Cretaceous *** of seismic and gravimetric data coupled with analysis of the syndepositional faults affecting these formations prove that the Tunisian margin is dominated,during this period,by N-S to NE-SW extensional *** geodynamic evolution of the MHP is mainly due to the irregular normal movement of the N-S faults,which represents the southernmost branch of the N-S Axis(NSA)and of the NW-SE faults,which constitutes the SE segment of the South Atlasic fault corridor(SAFC).In addition,the NE-SW and E-W oriented faults contributed to this *** extensive periods,this network of faults determines horst and grabens basin geometry or tilted blocks inducing formation of several distinct areas with different subsidence ***,the normal activity of the major faults promotes the vertical mobilization of the Triassic salt resulting in the individualization of several diapiric bodies,some of which pierced their sedimentary *** dynamics reflect echoes of the sinistral drifting of Africa with respect to Europe,integrated in a long Tethyan rifting cycle,and the beginning of opening of the Mesogean Sea,respectively.

关键词： Tunisian margin Early Cretaceous extensive tectonics Tethyan and Mesogean rifting geodynamics

Metals and metalloid bioconcentrations in the tissues of Typha latifolia grown in the four interconnected ponds of a domestic landfill site

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Journal of Environmental Sciences 2017年第4期29卷 56-68页

作者： Zohra ben Salem Xavier Laffray Ahmed Al-Ashoor habib Ayadi Lotfi Aleya Bourgogne Franche-Comte University Chrono-Environnement Laboratory UMR CNRS 6249 F-25030 Besancon Cedex France Paris Est-Creteil University IPE team iEES Paris UMR 7618 F-94010 Creteil Cedex Prance Thi Qar University IQ-64001 AI Nasiriyah Iraq Sfax University LR/UR/05ES05 Biodiversity and Aquatic Ecosystem BP 1171 CP 3000 Sfax Tunisia

The uptake of metals in roots and their transfer to rhizomes and above-ground plant parts（stems, leaves） of cattails（Typha latifolia L.） were studied in leachates from a domestic landfill site（Etueffont, France） and treated in a natural lagooning system. Plant parts and corresponding water and sediment samples were taken at the inflow and outflow points of the four ponds at the beginning and at the end of the growing season. Concentrations of As, Cd, Cr, Cu, Fe, Mn, Ni and Zn in the different compartments were estimated and their removal efficiency assessed, reaching more than 90% for Fe, Mn and Ni in spring and fall as well in the water compartment. The above-and below-ground cattail biomass varied from 0.21 to 0.85, and 0.34 to 1.24 kg dry weight/m^2, respectively, the highest values being recorded in the fourth pond in spring 2011. The root system was the first site of accumulation before the rhizome, stem and leaves. The highest metal concentration was observed in roots from cattails growing at the inflow of the system＇s first pond. The trend in the average trace element concentrations in the cattail plant organs can generally be expressed as： Fe 〉 Mn 〉 As 〉 Zn 〉 Cr 〉 Cu 〉 Ni 〉 Cd for both spring and fall. While T. latifolia removes trace elements efficiently from landfill leachates, attention should also be paid to the negative effects of these elements on plant growth.

关键词： Landfill leachate Lagooning Trace elements Typha latifolia Phytoremediation

Relationship between high sensitivity C-reactive protein and angiographic severity of coronary artery disease

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Journal of Geriatric Cardiology 2020年第5期17卷 256-263页

作者： Nadia Bouzidi Mejdi ben Messaoud Faouzi Maatouk habib Gamra Salima Ferchichi University of Monastir Faculty of PharmacyClinical and Molecular Biology UnitMonastirTunisia University of Monastir Cardiology A Department Fattouma Bourguiba University HospitalCardiothrombosis Research LaboratoryTunisia University of Monastir Cardiology B Department Fattouma Bourguiba University HospitalCardiothrombosis Research LaboratoryTunisia

Background Coronary artery disease(CAD)remains a leading cause of morbidity and *** play a potential role in atherosclerosis pathogenesis and *** investigated the association between high sensitive C-reactive protein(hs CRP)and severity of *** CAD patients were stratified according to hs CRP cut-off value into high levels hs CRP group(≥8.4 mg/L)and low levels hs CRP group(<8.4 mg/L).Severity of CAD was assessed according to artery stenosis degree and the number of vessel *** analysis was performed using Statistical Package for the Social Sciences(SPSS,version 23.0).Results The mean age was 60.3±11.0 *** level of hs CRP was increased and ranged from 0.2 to 1020.0 mg/*** risk factors and severity of CAD didn’t show significant differences between the two *** multivariate linear analysis,cardiac troponin I(c Tn I)and serum amyloid A(SAA)were predictors of hs *** shown in receiver operating characteristic(ROC)curve analysis performed in patients with ST-segment elevation myocardial infarction(STEMI)and compared to myonecrosis biomarkers,hs CRP(area under the curve(AUC):0.905;95%CI:0.844-0.966;P<0.001)could be a powerful predictor marker in evaluating the infarct size after myocardial infarction but not better than c Tn *** Hs CRP levels were not associated with the severity of CAD but could be useful in the evaluation of myocardial necrosis in patients with STEMI.

关键词： Coronary artery disease High sensitive C-reactive protein Severity

Specifc inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss

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Bone Research 2022年第3期10卷 548-564页

作者： Yaron Meirow Milena Jovanovic Yuval Zur Juliana habib Daniele Filippo Colombo Nira Twaik Hadas Ashkenazi-Preiser Kerem ben-Meir Ivan Mikula Jr. Or Reuven Guy Kariv Leonor Daniel Saja Baraghithy Yehuda Klein Jeroen Krijgsveld Noam Levaot Michal Baniyash The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research Israel-Canada Medical Research InstituteFaculty of MedicineThe Hebrew UniversityJerusalemIsrael Department of Physiology and Cell Biology Ben-Gurion University of the NegevBeer-ShevaIsrael Division of Proteomics of Stem Cells and Cancer German Cancer Research Center(DKFZ)HeidelbergGermany Institute for Drug Research Faculty of MedicineThe Hebrew UniversityJerusalemIsrael Hebrew University-Hadassah School of Dental Medicine JerusalemIsrael Heidelberg University Medical FacultyHeidelbergGermany

Elevated osteoclast(OC)activity is a major contributor to inflammatory bone loss(IBL)during chronic inflammatory ***,the specific OC precursors(OCPs)responding to inflammatory cues and the underlying mechanisms leading to IBL are poorly *** identified two distinct OCP subsets:Ly6C^(hi)CD11b^(hi) inflammatory OCPs(iOCPs)induced during chronic inflammation,and homeostatic Ly6C^(hi)CD11b^(lo)OCPs(hOCPs)which remained *** and proteomic characterization revealed that while iOCPs were rare and displayed low osteoclastogenic potential under normal conditions,they expanded during chronic inflammation and generated OCs with enhanced *** contrast,hOCPs were abundant and manifested high osteoclastogenic potential under normal conditions but generated OCs with low activity and were unresponsive to the inflammatory *** derived from iOCPs expressed higher levels of resorptive and metabolic proteins than those generated from hOCPs,highlighting that different osteoclast populations are formed by distinct *** further identified the TNF-αand S100A8/A9 proteins as key regulators that control the iOCP response during chronic ***,we demonstrated that the response of iOCPs but not that of hOCPs was abrogated in tnf-α^(-/-)mice,in correlation with attenuated *** findings suggest a central role for iOCPs in IBL *** can serve as potential biomarkers for IBL detection and possibly as new therapeutic targets to combat IBL in a wide range of inflammatory conditions.

关键词： inflammation inflammatory osteoclast