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Vasodilator response to <i>Psidium guajave</i>leaves of mesenteric bed vessels from diabetic and non-diabetic rats

Journal of Diabetes Mellitus 2014年第1期4卷 6-11页

作者： habeib zaheri Golam Reza Farshidfar Nepton Soltani Fatemah Kharazmi Mohammad Kamalinajad Department of Biochemistery Faculty of Medicine Hormozgan University of Medical Sciences Bandar Abbas Iran Department of Biology Faculty of Science Shahid Bahonar University Kermam Iran Department of Pharmacognosy Faculty of Pharmacy Shahid Bahashti University of Medical Sciences Tehran Iran Department of Physiology Faculty of Medicine and Research Center for Molecular Medicine Hormozgan University of Medical Sciences Bandar Abbas Iran

Mortality from cardiovascular abnormalities is almost three times more prevalent in the diabetic population than that in the general population. Psidium guajave has been used traditionally for a long time as a medicinal herb to cure diabetes. Endothelial dependent vasorelaxation effect of Psidium guajave extract on normal aortic rings was observed. This study was designed to investigate the endothelium and nitric oxide roles inPGE-induced vasorelaxation in diabetic rat vessel. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Eight weeks later, superior mesenteric arteries of non-diabetic and diabetic groups were isolated and perfused according to the McGregor method. Prepared vascular beds were constricted with phenylephrine to induce 70% - 75% of maximal constriction. Psidium guajave extract at concentrations of 0.1 to 4 mg/100ml added to the medium and perfusion pressure was recorded. Baseline perfusion pressure of diabetic group was significantly higher than non-diabetic rats in both intact and denuded endothelium. Psidium guajave extract caused a significantly dose depended decrease in perfusion pressure in non-diabetic and diabetic groups in both intact and denuded endothelium. In the presence of N (ω)-nitro-L-arginine methyl ester, Psidium guajave ex-tractinduced relaxation in intact mesenteric beds of non-diabetic and diabetic animals was not suppressed. From the results of this study, it may be concluded that vasorelaxatory effect of Psidium guajave extract is not mediated by endothelium and nitric oxide in both diabetic and non-diabetic vessel and supports the use of the plant’s leaves as a natural, adjunct phytomedicine in the management of diabetes vessel complications.

关键词： Psidium guajave Linn Extract Diabetes Mellitus Mesenteric Bed Vasorelaxation Nitric Oxide

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Three-dimensional finite difference analysis of shallow sprayed concrete tunnels crossing a reverse fault or a normal fault: A parametric study

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Frontiers of Structural and Civil Engineering 2020年第4期14卷 998-1011页

作者： Masoud RANJBARNIA Milad zaheri Daniel DIAS Department of Geotechnical Engineering Faculty of Civil EngineeringUniversity of TabrizTabrizIran Schoo of Automotive and Transportation Engineering Hefei University of TechnologyHefei 230009China Universite Grenoble Alpes Grenoble F-38000France

Urban tunnels crossing faults are always at the risk of severe *** this paper,the efects of a reverse and a normal fault movement on a transversely crossing shallow shotcreted tunnel are investigated by 3D finite difference *** verifying the accuracy of the numerical simulation predictions with the centrifuge physical model results,a parametric study is then *** is,theleffects of various parameters such as the sprayed concrete thickness,the geo-mechanical properties of soil,the tunnel depth,and the fault plane dip angle are studied on the displacements of the ground surface and the tunnel structure,and on the plastic strains of the soil mass around *** results of each case of reverse and normal faulting are independently discussed and then compared with each *** is obtained that deeper tunnels show greater displacements for both types of faulting.

关键词： urban tunnel sprayed concrete reverse fault normal fault finite difference analysis

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基于ISO 26262安全要求的汽车电子电气架构优化模型

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同济大学学报（自然科学版） 2022年第S01期50卷 247-251页

作者： Dorsa zaheri Hans⁃Christian REUSS 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

在开发汽车电子电气(E/E)架构时,考虑安全要求是实现未来技术(如自动驾驶)的先决条件之一。按照ISO 26262标准,安全分析必须在产品开发生命周期的早期阶段进行,以检测设计缺陷并采取行动改善设计。本文提出了一种基于模型的方法,在汽车... 详细信息

在开发汽车电子电气(E/E)架构时,考虑安全要求是实现未来技术(如自动驾驶)的先决条件之一。按照ISO 26262标准,安全分析必须在产品开发生命周期的早期阶段进行,以检测设计缺陷并采取行动改善设计。本文提出了一种基于模型的方法,在汽车E/E架构的设计阶段解决符合ISO 26262的安全要求;同时,基于这些要求,提取了一组与安全相关的约束条件,并通过整数线性规划(ILP)模型将这些约束用于E/E架构的优化。

关键词：汽车电子电气电子电气架构优化模型安全要求 ISO 26262标准

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Effect of the administration of Psidium guava leaves on blood glucose, lipid profiles and sensitivity of the vascular mesenteric bed to Phenylephrine in streptozotocin-induced diabetic rats

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Journal of Diabetes Mellitus 2012年第1期2卷 138-145页

作者： Abdol Hassan Mansoori Bahrani Habib zaheri Nepton Soltani Fatemeh Kharazmi Mansoor Keshavarz Mohammad Kamalinajad Department of Physiology School of Medicine and Cardiovascular Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran

The leaf of Psidium guava is traditionally used in Asia to manage, control and treat diabetes. We designed this study to elucidate the effect of the administration of oral doses of aqueous and ethanol extract from Psidium guava leaves on plasma glucose, lipid profiles and the sensitivity of the vascular mesenteric bed to Phenylephrine in diabetic and non diabetic rats. Animals were divided into 5 groups (n = 10): two groups served as non-diabetic controls (NDC), while the other groups had diabetes induced with a single injection of streptozotocin (STZ). Psidium guava-treated chronic diabetic (PSG-CD) and Psidium guava-treated controls (PSG-C) received 1g/l of Psidium guavaadded to the drinking water for 8 weeks. The mesenteric vascular beds were prepared using the McGregor method. Administration of Psidium guava caused Ca/Mg ratio, plasma glucose, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), total cholesterol and triglyceride concentrations to return to normal levels, and was shown to decrease alteration in vascular reactivity to vasoconstrictor agents. Our results support the hypothesis that Psidium guava could play a role in the management of diabetes and the prevention of vascular complications in STZ-induced diabetic rats.

关键词： Diabetes Lipid Profile Psidium Guava Blood Glucose Mesenteric Bed Ca/Mg Ratio

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Diabetes Management, Quality of Life and Treatment Satisfaction in Adult Population in Jordan and Lebanon, Observations from the SIMPLIFY Study

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Journal of Diabetes Mellitus 2020年第2期10卷 73-87页

作者： Paola Atallah Mohamed El-zaheri Omar Abu-Hijleh Emile Andari Fares Haddad Hiba Hajar Kamal Hirbli Nadim Jarrah Rita Medlej Charles Saab Department of Endocrinology Saint George Hospital University Medical Center Beirut Lebanon Department of Endocrinology Jordan Hospital Medical Center Amman Jordan Endocrinology Department Notre Dame de Secours Hospital Byblos Lebanon Department of Endocrinology King Hussein Medical Center Amman Jordan Medical Department AstraZeneca Near East Beirut Lebanon Endocrinology Department Lebanese American University Medical Center Rizk Hospital Beirut Lebanon Department of Endocrinology Specialty Hospital Shmeisani Amman Jordan Department of Endocrinology Hotel Dieu de France Hospital Beirut Lebanon Department of Endocrinology and Metabolic Diseases Sacré Coeur Hospital Beirut Lebanon

Introduction: Type 2 Diabetes Mellitus (T2DM) has witnessed a rise in its prevalence worldwide and in the Middle East region. The overall burden associated with the disease is well characterized, but little is known about patient satisfaction in the region. The purpose of the study is to evaluate the quality of life (QoL) and treatment satisfaction of patients T2DM. Methods: The SIMPLIFY study was an observational, cross-sectional, multicenter, regional study that used patient-reported outcomes of T2DM patients in Jordan and Lebanon. Results: Patients were more satisfied when they were treated exclusively with oral medications, mainly metformin alone or combined with either sulfonylurea or dipeptidyl peptidase-4 inhibitor. Targets for glycated hemoglobin (HbA1c) values were better reached in patients treated with oral medications. Occurrence of comorbidities did not seem to be affected by oral or injectable medications or to affect patients’ satisfaction. Data highlighted a suboptimal screening for albuminuria and showed that most patients were overweight or obese and around 30% suffered from hypoglycemia episodes. Conclusion: Data shed the light on the management of T2DM in Jordan and Lebanon and suggested the need for a more comprehensive approach to T2DM management and selection of medications that would support weight control and a lower hypoglycemia incidence.

关键词： Diabetes Glycated Hemoglobin Clinical Management Patient Satisfaction Quality of Life

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