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Direct Retrieval of NO_(2)Vertical Columns from UV-Vis(390-495nm)Spectral Radiances Using a Neural Network

journal of Remote Sensing 2022年第1期2022卷 200-216页

作者： Chi Li Xiaoguang Xu Xiong Liu jun Wang Kang Sun jos van Geffen Qindan Zhu jianzhong Ma junli jin Kai Qin Qin He Pinhua Xie Bo Ren Ronald C.cohen Department of Chemistry University of CaliforniaBerkeleyBerkeleyCAUSA joint Center for Earth Systems Technology University of MarylandBaltimore CountyBaltimoreMAUSA Department of Chemical and Biochemical Engineering Center for Global and Regional Environmental ResearchAnd Informatics InitiativeThe University of IowaIowa CityIAUSA harvard-Smithsonian Center for Astrophysics CambridgeMAUSA Department of Civil Structural and Environmental EngineeringUniversity at BuffaloBuffaloNYUSA Research and Education in Energy Environment and Water InstituteUniversity at BuffaloBuffaloNYUSA Satellite Observations Department Royal Netherlands Meteorological Institute(KNMI)De BiltNetherlands Department of Earth and Planetary Science University of CaliforniaBerkeleyBerkeleyCAUSA Chinese Academy of Meteorology Science China Meteorological AdministrationBeijingChina Meteorological Observation Center China Meteorological AdministrationBeijingChina School of Environment and Spatial Informatics China University of Mining and TechnologyXuzhouChina Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine MechanicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiChina

Satellite retrievals of columnar nitrogen dioxide(NO_(2))are essential for the characterization of nitrogen oxides(NO_(x))processes and *** requirements of modeled a priori profiles present an outstanding bottleneck in operational satellite NO_(2)*** this work,we instead use neural network(NN)models trained from over 360,000 radiative transfer(RT)simulations to translate satellite radiances across 390-495nm to total NO_(2)vertical column(NO_(2)C).Despite the wide variability of the many input parameters in the RT simulations,only a small number of key variables were found essential to the accurate prediction of NO_(2)C,including observing angles,surface reflectivity and altitude,and several key principal component scores of the *** addition to the NO_(2)C,the NN training and cross-validation experiments show that the wider retrieval window allows some information about the vertical distribution to be retrieved(e.g.,extending the rightmost wavelength from 465 to 495 nm decreases the root-mean-square-error by 0.75%)under high-NO_(2)C *** to four months of TROPOMI data,the trained NN model shows strong ability to reproduce the NO_(2)C observed by the ground-based Pandonia Global *** coefficient of determination(R2,0.75)and normalized mean bias(NMB,-33%)are competitive with the level 2 operational TROPOMI product(R^(2)=0:77,NMB=−29%)over clear(geometric cloud fractionhan predictions using high spatial resolution(~3 km)a priori profiles from chemical transport modeling,which is especially attractive to the handling of large volume satellite data.

关键词： Vertical attractive faster

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心理干预治疗儿童青少年焦虑症的有效性与可接受性：网络荟萃分析计划书

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英国医学杂志中文版 2016年第3期19卷 136-141页

作者：张玉清周新雨 Anthony C james 覃彬 Craig j Whittington Pim Cuijpers Cinzia Del Giovane 刘艺昀 David cohen john R. Weisz 谢鹏重庆医科大学附属第一医院神经内科中国重庆牛津大学精神科英国伦敦牛津大学Warneford医院海菲尔德家庭与青少年研究中心英国伦敦伦敦大学学院教育与健康心理学的临床研究中心英国伦敦阿姆斯特丹自由大学临床心理科荷兰阿姆斯特丹意大利摩德纳大学临床与公共卫生学的诊断科萨伯特慈善医院儿童与青少年精神中心法国巴黎哈佛大学心理学研究中心美国波士顿

前言儿童青少年焦虑症给社会公共健康带来显著的沉重负担。认知行为治疗（CBT）是儿童青少年焦虑症中应用最为广泛的心理治疗方法，但先前的研究受限于纳入的试验数量，且试验为直接比较不同心理治疗及实施方式。因此本研究的目的为调... 详细信息

前言儿童青少年焦虑症给社会公共健康带来显著的沉重负担。认知行为治疗（CBT）是儿童青少年焦虑症中应用最为广泛的心理治疗方法，但先前的研究受限于纳入的试验数量，且试验为直接比较不同心理治疗及实施方式。因此本研究的目的为调查比较儿童青少年焦虑症患者接受不同心理治疗及同一心理治疗不同实施方式的有效性和可接受性。

关键词：心理干预治疗儿童青少年焦虑症网络荟萃分析计划书药物治疗

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The role of bitter and sweet taste receptors in upper airway innate immunity: Recent advances and future directions

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World journal of Otorhinolaryngology-Head and Neck Surgery 2018年第3期4卷 200-208页

作者： Ivy W.Maina Alan D.Workman Noam A.cohen Department of Otorhinolaryngology-Head and Neck Surgery Division of RhinologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA19104USA Corporal Michael j.Crescenz Veterans Administration Medical Center PhiladelphiaPA19104USA Monell Chemical Senses Center PhiladelphiaPA19104USA

Bitter(T2R)and sweet(T1R)taste receptors have been implicated in sinonasal innate immunity and in the pathophysiology of chronic rhinosinusitis(CRS).Taste receptors are expressed on several sinonasal cell types including ciliated epithelial cells and solitary chemosensory *** agonists released by pathogenic microbes elicit a T2R dependent signaling cascade which induces the release of bactericidal nitric oxide,increases mucociliary clearance,and promotes secretion of antimicrobial *** variation conferred by polymorphisms in T2R related genes is associated with differential CRS susceptibility,symptomatology and post-treatment *** recently,based on our understanding of T1R and T2R function,investigators have discovered novel potential therapeutics in T2R agonists and T1R *** review will discuss bitter and sweet taste receptor function in sinonasal immunity,explore the emerging diagnostic and therapeutic implications stemming from the most recent findings,and suggest directions for future research.

关键词： Chronic rhinosinusitis Taste Receptor Family 1(T1R) Taste Receptor Family 2(T2R) Sweet taste receptors Bitter taste receptors Innate immunity Solitary chemosensory cells Polymorphism

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等离子体物理中的计算

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力学进展 1986年第4期 549-558页

作者： B.I.cohen j.Killeen 唐福林

各种大大小小的计算机都有助于完善理论计算和提高精确度,并有助于设计、指导和分析实验。

关键词：磁约束等离子体不稳定性普林斯顿物理学家动力论计算机代码托卡马克气球模等离子体物理

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先进复合材料导弹结构的设计与分析

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国外导弹与航天运载器 1991年第2期 44-58页

作者： Leslie.j.cohen jaydeeW.Young 丁伟星文华

本文介绍了一种使用先进复合材料作为先进导弹的主要及辅助结构系统的初步设计方案,并论证了其制造工艺。精密安装的内部梁结构,可承受大载荷的检查口盖及各部件连接等都反映出先进复合材料的特有的设计特点。还证明了使用该材料比用金... 详细信息

本文介绍了一种使用先进复合材料作为先进导弹的主要及辅助结构系统的初步设计方案,并论证了其制造工艺。精密安装的内部梁结构,可承受大载荷的检查口盖及各部件连接等都反映出先进复合材料的特有的设计特点。还证明了使用该材料比用金属材料重量减轻了很多。

关键词：导弹复合材料航天器宇航结构

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评第三世界的认识论

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世界科学 1982年第1期 53-56页

作者： L.j.cohen 邵水浩张尧官

七十年代中期,英国著名的科学哲学家K·R·Popper提出,宇宙中除了存在物理客体的第一世界和意识状态的第二世界之外,还存在一个思想的客观内容的第三世界。第三世界是人类创造的客观知识世界,它包括理论体系、科学问题、批判论证、艺术... 详细信息

七十年代中期,英国著名的科学哲学家K·R·Popper提出,宇宙中除了存在物理客体的第一世界和意识状态的第二世界之外,还存在一个思想的客观内容的第三世界。第三世界是人类创造的客观知识世界,它包括理论体系、科学问题、批判论证、艺术作品以及书籍杂志的内容等。第三世界是客观的,并不是人类有意创造的;它又是自主的,有自己的发展规律。而且,第三世界通过人的干预能够反馈于第一、二世界。Popper提出的第三世界理论,在西方科学哲学界引起了强烈的反响。本文作者就Popper的第三世界理论阐述了几点评论性看法,颇有启发,值得一读。

关键词：第三世界三个世界理论认识论辩证唯物主义

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j-F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS jET QUARK GLUON TAGGING

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A phase I radiation dose escalation of stereotactic body radiotherapy for malignant lung tumors

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journal of Biomedical Science and Engineering 2010年第4期3卷 351-358页

作者： Randi j. cohen Navesh K. Sharma jian Q. (Michael) Yu Lu Wang Mark K. Buyyounouski Michael Unger Hossein Borghaei Earl King Walter Scott Elaine Callahan Benjamin j. Movsas Steven j. Feigenberg 不详

Objectives: This Phase I study determines the maximum tolerated dose (MTD) of stereotactic body radiotherapy (SBRT) for lung tumors. Methods: Eli- gible patients had biopsy proven cancer with a maxi- mum tumor size ≤ 5 cm. Total doses were escalated from 40 to 48, then to 56 Gy, delivered in 4 equal fractions administered 2 to 3 times per week on an IRB approved protocol. SBRT was administered us- ing 5 to 9 fixed beam arrangements with CT loca- lization. Internal target volumes (ITV) were based on breath hold scans or 4D CT simulation. The planning target volume (PTV) was defined as the ITV with a uniform 5 mm expansion. Dose limiting toxicity (DLT) was defined as any grade 3 or higher toxicity using the Radiation Therapy Oncology Group (RTOG) common toxicity criteria (CTC). Results: Between April 2004 and February 2008, 18 patients received the prescribed treatment (40 Gy n = 6, 48 Gy n = 7, 56 Gy n = 5). Seventeen of 18 patients had non-small cell lung cancer (1 with rectal cancer), four of whom were treated for an oligometastasis. The median age of the patients was 68, while the median Karnofsky performance status was 90. The mean tumor size was 2.6 cm (range 0.9 to 4.5 cm). One grade 3 pulmonary event occurred (at 48 Gy dose level) immediately following treatment with the onset of fever and shortness of breath that responded to antibiotics. No other DLTs occurred. Conclusions: SBRT utilizing patient specific target volumes without gating appears safe. The maximum tolerated dose was not reached.

关键词： Stereotactic Body Radiotherapy Phase I Dose Escalation Prospective Lung Cancer

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Retrospective evaluation of frozen section use for thyroid nodules with a prior fine needle aspiration diagnosis of Bethesda Ⅱ-Ⅵ: The Weill Cornell Medical College experience

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World journal of Otorhinolaryngology-Head and Neck Surgery 2015年第1期1卷 -页

作者： Marc A.cohen Krupa R.Patel jonathan Gromis David I.Kutler William I.Kuhel Brian j.Stater Aaron Schulman Department of Otolaryngology-Head and Neck Surgery New York Presbyterian Hospital/Weill Cornell Medical Center New York NY 10065 USA Weill Cornell Medical College New York NY 10065 USA Department of Endocrinology New York Presbyterian Hospital/Weill Cornell Medical CenterNew York NY 10065 USA

Objective: To evaluate the Weill Cornell Medical CoLlege (WCMC)/New York Presbyterian Hospital (NYPH) experience with intraoperative frozen (IOF) section in the management of thyroid nodules with a fine needle aspiration (FNA) diagnosis of Bethesda Ⅱ-Ⅵ and to analyze the cost and pathology benefit it ***: The surgical and cytopathology files at WCMC/NYPH were searched within the time period of january 2008 to May 2013.A total of 435 thyroid specimens were identified for which both an FNA and subsequent IOF section was *** FNA was correlated with the locations of the resected nodule and the nodule frozen for intraoperative *** results of the FNA were compared to the IOF section diagnosis and final diagnosis (FD).Results: Among 435 cases, the FNA diagnosis was Bethesda Ⅱ:149 cases, Bethesda Ⅲ:170 cases, Bethesda Ⅳ: 91 cases, Bethesda Ⅴ: 19 cases, and Bethesda Ⅵ: 6 *** were a total of 83 carcinomas identified on FD, which included 69 papillary thyroid carcinomas (PTCs), 12 follicular carcinomas, and 2 poorly differentiated *** preoperative FNA diagnosis for these carcinomas was as follows: Bethesda Ⅱ, 11/149 (7.4％), Bethesda Ⅲ, 24/170 (14％), Bethesda Ⅳ, 26/91 (29％), Bethesda Ⅴ, 16/19 (84％), and Bethesda Ⅵ, 6/6 (100％).IOF section contributed to the diagnosis of malignancy in 16/429 (4％) cases: 1/149 (0.7％) Bethesda Ⅱ, 5/170 (3％) Bethesda Ⅲ, 2/91 (1.1％) Bethesda Ⅳ, and 8/19 (42％) Bethesda Ⅴ.The diagnosis of malignancy was confirmed in the 6 Bethesda Ⅵl cases by IOF *** were no false positives on IOF *** had a sensitivity and specificity of 26％ and 100％, ***: The role of IOF section is limited in the evaluation of thyroid *** section is most useful for nodules with an FNA diagnosis of Bethesda V *** diagnosis of follicular variant of PTC remains difficult on frozen section.

关键词： Thyroid Nodule Frozen section Fine-needle aspiration Sensitivity Specificity

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胎儿外科手术产生的急性心血管效应

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世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 25-26页

作者： Rychik j. cohen M.S. 郝广华 Fetal Heart Program Children's Hospital of Philadelphia 34th St and Civic Center Blvd Philadelphia PA 19104 United States Dr.

Background-Prenatal surgery for congenital anomalies can prevent fetal demise or alter the course of organ development, resulting in a more favorable condition at birth. The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system. Methods and Results-Echocar-diography was used to evaluate the heart before, during, and early after fetal surgery for congenital anomalies, including repair of myelomeningocele(MMC, n=51), resection of intrathoracic masses (ITM, n=15), tracheal occlusion for congenital diaphragmatic hernia (CDH, n=13), and resection of sacrococcygeal teratoma (SCT, n=4). Fetuses with MMC all had normal cardiovascular systems entering into fetal surgery,whereas those with ITM, CDH, and SCT all exhibited secondary cardiovascular sequelae of the anomaly present. At fetal surgery, heart rate increased acutely, and combined cardiac output diminished at the time of fetal incision for all groups including thzose with MMC, which suggests diminished stroke volume. Ventricular dysfunction and valvular dysfunction were identified in all groups, as was acute constriction of the ductus arteriosus. Fetuses with ITM and SCT had the most significant changes at surgery. Conclusions-Acute cardiovascular changes take place during fetal surgery that are likely a consequence of the physiology of the anomaly and the general effects of surgical stress, tocolytic agents, and anesthesia. Echocardiographicmonitoring during fetal surgery is an important adjunct in the management of these patients.

关键词：胎儿外科心血管效应肿块切除术胎儿心率骶尾部畸胎瘤先天性膈疝先天异常脊膜膨出超声心动图动脉导管

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