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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

Matter and radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion harmand Sven Toleikis Katerina Falk Libor Juha Department of radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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獐牙菜苦苷、灵仙新苷组分配伍对ra模型大鼠血清学指标及踝关节COX-2的影响

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时珍国医国药 2024年第5期35卷 1034-1040页

作者：郝倩莹高慧琴吴国泰李飒王丽明甘肃中医药大学甘肃兰州730101 中国人民解放军96604部队医院甘肃兰州730031

目的探讨獐牙菜苦苷、灵仙新苷组分配伍对类风湿关节炎(Rheumatoid arthritis,ra)模型大鼠血清学指标及踝关节COX-2的影响。方法选取SPF级SD大鼠5~6周龄36只,雌雄各半。除空白组外,均采用II型胶原诱导法复制(Collagen induced arthritis... 详细信息

目的探讨獐牙菜苦苷、灵仙新苷组分配伍对类风湿关节炎(Rheumatoid arthritis,ra)模型大鼠血清学指标及踝关节COX-2的影响。方法选取SPF级SD大鼠5~6周龄36只,雌雄各半。除空白组外,均采用II型胶原诱导法复制(Collagen induced arthritis,CIA)大鼠模型。将造模成功的30只大鼠按随机数字表法分为模型组、阳性药(正清风痛宁)组、獐牙菜苦苷组、灵仙新苷组、獐牙菜苦苷配伍灵仙新苷组(以下简称“獐-灵配伍组”),每组6只。给药组分别给予相应药液灌胃,模型组和空白组给予等量生理盐水灌胃,连续灌胃10 d。实验中对各组大鼠进行一般状态观察记录、关节炎评分(AI),苏木素-伊红(HE)染色法观察大鼠踝关节组织病理变化;酶联免疫吸附测定法(ELIsa)检测大鼠血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、类风湿因子(RF)、C反应蛋白(CRP)、抗环瓜氨酸肽抗体(anti-CCP Ab)及前列腺素E2(PGE2)含量;免疫组织化学法(Immunohistochemistry)及蛋白免疫印迹法(Western blot)检测大鼠踝关节环氧化酶-2(COX-2)蛋白表达;实时荧光定量聚合酶链式反应法(Real-time PCR)检测大鼠踝关节COX-2基因表达。结果与空白组比较,模型组大鼠一般状态较差,大鼠左后足趾AI评分及血清中TNF-α、IL-1β、RF、CRP、anti-CCP Ab、PGE2含量显著高于其他组(Pra模型大鼠能起到良好的治疗作用,其中獐-灵配伍组的治疗效果明显优于各单体给药组;獐牙菜苦苷与灵仙新苷具有明显的协同增效作用,其作用机制可能是通过降低炎性细胞因子的分泌,抑制COX-2蛋白活性而发挥作用。

关键词：獐牙菜苦苷灵仙新苷组分配伍类风湿关节炎 COX-2

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Self-powered and flexible piezo-sensors based on conductivitycontrolled GaN nanowire-arrays for mimicking rapid-and slow-adapting mechanoreceptors

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npj Flexible Electronics 2022年第1期6卷 642-652页

作者： Aadil Waseem Ameer Abdullah Indrajit V.Bagal Jun-Seok ha June Key Lee sang-Wan Ryu Department of Physics Chonnam National UniversityGwangju 61186Republic of Korea Optoelectronics Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea

Human skin contains slowly adaptive(sa)and rapidly adaptive(ra)mechanoreceptors,which respond differently to external *** on human tactile perception principles,the fabrication of a self-powered electronic skin(e-skin)that simultaneously mimics sa-and ra-mechanoreceptors is a prime need for robots and artificial prosthetics to interact with the surrounding ***,the complex process of merging multimode sensors to mimic sa-and ra-mechanoreceptors hinders their utilization in *** proposed sa-and ra-mechanoreceptors based on n-type and semi-insulating GaN nanowire *** sa-and ra-mechanoreceptors demonstrated distinguished features such as grasping of objects and detection of their surface *** on piezoelectric sensing principles,the proposed e-skin can simultaneously mimic static and dynamic pressure *** further detected several stimuli of various pressures with low and high *** response and reset times showed by sa-mechanoreceptors were 11 and 18 ms under 1-Hz frequency,which are rapid enough for practical e-skin applications.

关键词： arrays rapid conductivity

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Senescent mesenchymal stem/stromal cells in pre-metastatic bone marrow of untreated advanced breast cancer patients

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Oncology Research 2023年第3期31卷 361-374页

作者： FraNCISCO raÚL BORZONE MARÍA BELÉN GIORELLO LEANDRO MARCELO MARTINEZ MARÍA CECILIA saNMARTIN LEONARDO FELDMAN FEDERICO DIMASE EMILIO BATAGELJ GUSTAVO YANNARELLI NORMA ALEJANDra ChaSSEING Laboratorio de Inmunohematología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Buenos AiresArgentina Division of Hematology and Medical Oncology Department of MedicineWeill Cornell Medical CollegeNew YorkUSA Laboratorio de Regulación Génica y Células Madre Instituto de Medicina TraslacionalTrasplante y Bioingeniería(IMeTTyB)Universidad Favaloro-CONICETBuenos AiresArgentina Facultad de Ciencias de la salud Universidad Nacional del Centro de la Provincia de Buenos Aires(UNCPB)TandilBuenos AiresArgentina Servicio de Hematología Hospital Militar CentralBuenos AiresArgentina Servicio de Oncología Hospital Militar CentralBuenos AiresArgentina

Breast cancer is the predominant form of carcinoma among women worldwide,with 70%of advanced patients developing bone metastases,with a high mortality *** this sense,the bone marrow(BM)mesenchymal stem/stromal cells(MSCs)are critical for BM/bone homeostasis,and failures in their functionality,transform the BM into a premetastatic niche(PMN).We previously found that BM-MSCs from advanced breast cancer patients(BCPs,infiltrative ductal carcinoma,stage III-B)have an abnormal *** work aims to study some of the metabolic and molecular mechanisms underlying MSCs shift from a normal to an abnormal profile in this group of patients.A comparative analysis was undertaken,which included self-renewal capacity,morphology,proliferation capacity,cell cycle,reactive oxygen species(ROS)levels,and senescence-associatedβ‑galactosidase(sa‑β‑gal)staining of BMderived MSCs isolated from 14 BCPs and 9 healthy volunteers(HVs).Additionally,the expression and activity of the telomerase subunit TERT,as well as telomere length,were *** levels of pluripotency,osteogenic,and osteoclastogenic genes(OCT-4,SOX-2,M-CAM,RUNX-2,BMP-2,CCL-2,M-CSF,and IL-6)were also *** results showed that MSCs from BCPs had reduced,self-renewal and proliferation *** cells also exhibited inhibited cell cycle progression and phenotypic changes,such as an enlarged and flattened ***,there was an increase in ROS and senescence levels and a decrease in the functional capacity of TERT to preserve telomere *** also found an increase in pro-inflammatory/pro-osteoclastogenic gene expression and a decrease in pluripotency gene *** conclude that these changes could be responsible for the abnormal functional profile that MSCs show in this group of patients.

关键词： Mesenchymal stem/stromal cells Senescence Breast cancer Bone marrow Pre-metastatic niche Bone metastasis

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The evolution of available pharmacological treatments for variceal bleeding secondary to portal hypertension: A scope review

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iLIVER 2023年第3期2卷 170-176页

作者： Eduarda raisa Coser raphael Bernardo Neto Izabel Cristina Meister Martins Coelho Norma Possa Marroni Claudio Augusto Marroni Camila Moraes Marques Faculdades Pequeno Principe Brazil Universidade Federal de Ciencias da saude de Porto Alegre Brazil

The texts analyzed in full totaled 110,of which 36 articles published between 2001 and 2020 were selected,with quantitative approaches,case reviews,liter-ature reviews,meta-analyses,and *** is concluded that beta-blockers are the drugs of choice for primary prophylaxis of variceal *** for secondary prophylaxis,there is an association of these with nitrates and endoscopic *** regard to acute bleeding,the use of vasoactive drugs is chosen,especially ***,it is important to emphasize that there is a shortage of clinical studies and a need for investment in new therapies.

关键词： Portal hypertension Clinical treatment pharmacology and variceal bleeding

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The influence of porosity on tablet subdivision

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Particuology 2020年第6期18卷 192-196页

作者： Maira T.Teixeira Livia L.sa-Barreto Izabel C.Silva Tais Gratieri Guilherme M.Gelfuso Ricardo N.Marreto Mariana Landin Marcilio Cunha-Filho Laboratory of Food Drugs and Cosmetics(LTMAC)University of Brasilia(UnB)70910-900 BrasiliaDFBrazil Laboratory of Nanosystems and Drug Delivery Devices(NanoSYS) Federal University of GoiasGoianiaGO.Brazil Departamento de Farmacologia Farmacia y Tecnologia Farmaceutica1+D Farma Group(Gl-1645)Universidade de Santiago de CompostelaSpain

A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical ***,tablet subdivisions were studied as a functi on of tablet *** tablets were manufactured in the presenee of different diluents,namely microcrystalline cellulose,LudipressR,or lactose ***,the add让ion of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of *** assays were corre lated to the subdivision performs *** increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the *** all the excipients,an increase in relative porosity>90%represented the threshold level from which an inadequate subdivision *** in crease in tablet porosity led to a reduction in mechanical resista nee,which,combined with a heterogeneous and disc on tinuous distribution of pores within the matrix,resulted in poor subdivision *** trolling tablet porosity is an important consideration when designing tablets having a subdivision purpose.

关键词： Tablet subdivision Porosity Mass variation Mass loss Friability hardness

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“三法三穴”推拿手法干预早期对Minor CCI模型大鼠脊髓背角IL-17A/ra、C/EBPβ信号通路影响的研究

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环球中医药 2024年第3期17卷 401-406页

作者：陈金平刘志凤于天源王厚融张英琦杨震杰萨出拉官乾徐亚静张润龙张汉钰刘家玥孙佳伟北京中医药大学针灸推拿学院 100029 北京中医药大学东直门医院推拿疼痛科北京医院针灸按摩科

目的通过观察“三法三穴”推拿手法干预早期对轻度坐骨神经慢性压迫性损伤(Minor chronic compression injury of sciatic nerve, Minor CCI)模型大鼠脊髓背角中白介素-17A(interleukin-17A,IL-17A)、白介素-17A受体(interleukin-17A receptor, IL-17ra)、转录因子CCAAT增强子结合蛋白β(transcription factor CCAAT/enhancer binding protein β, C/EBPβ)表达的影响,明确推拿对周围神经病理性疼痛(peripherally neuropathic pain, pNP)的即刻镇痛机制。方法 SD大鼠随机分为假手术组、模型组、推拿组,8只/组,模型组、推拿组复制Minor CCI模型。使用按摩推拿手法模拟仪模拟点法、拨法、揉法,对推拿组大鼠患侧殷门、承山、阳陵泉进行定时、定性、定量干预1次,通过机械缩足反射阈值(paw mechanical withdraw threshold, PMWT)与冷敏阈值(cold sensitivity threshold, CST)评价干预后即刻对大鼠机械痛觉、温度觉敏化情况变化;通过蛋白免疫印迹法(Western Bolt, WB)检测脊髓背角中IL-17A、C/EBPβ表达;通过荧光定量聚合酶链式反应(real time-polymerase chain reaction, RT-PCR)检测脊髓背角中IL-17A、IL-17ra、C/EBPβ表达。结果与假手术组、模型组相比,推拿干预1次后可提高Minor CCI模型大鼠PMWT与CST(Pra、C/EBPβ在脊髓背角中mRNA的表达(Pra、C/EBPβ信号通路的表达,改善机械痛觉及冷刺激敏化情况,从而实现即刻镇痛的作用。

关键词：推拿周围神经病理性疼痛脊髓背角白介素-17A 白介素-17A受体转录因子CCAAT增强子结合蛋白β

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The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis

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Cellular & Molecular Immunology 2021年第12期18卷 2648-2659页

作者： Heng Lin Lu Feng Kai-sa Cui Lin-Wen Zeng Deng Gao Long-Xiang Zhang Wen-Hua Xu Yu-hao Sun Hong-Bing Shu Shu Li Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityMedical Research InstituteFrontier Science Center for Immunology and MetabolismResearch Unit of Innate Immune and Inflammatory DiseasesChinese Academy of Medical SciencesWuhan UniversityWuhan430071China Wuxi Cancer Institute Affiliated Hospital of Jiangnan UniversityWuxi214062JiangsuChina

The IL-6-STAT3 axis is critically involved in inflammation-associated carcinogenesis(IAC).How this axis is regulated to modulate IAC remains ***,we show that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates STAT3 activation triggered by IL-6,as well as another IL-6 subfamily member,Oncostatin M(OSM).MARCH3 is associated with the IL-6 receptorα-chain(IL-6Rα)and its coreceptor *** experiments indicated that MARCH3 mediates the polyubiquitination of IL-6Rαat K401 and gp130 at K849 following IL-6 stimulation,leading to their translocation to and degradation in ***3 deficiency increases IL-6-and OSM-triggered activation of STAT3 and induction of downstream effector genes in various cell ***3 deficiency enhances dextran sulfate sodium(DSS)-induced STAT3 activation,increases the expression of inflammatory cytokines,and exacerbates colitis,as well as azoxymethane(AOM)/DSS-induced colitis-associated cancer in *** addition,MARCH3 is downregulated in human colorectal cancer tissues and associated with poor survival across different cancer *** findings suggest that MARCH3 is a pivotal negative regulator of IL-6-induced STAT3 activation,inflammation,and inflammation-associated carcinogenesis.

关键词： MARCH3 IL-6 IL-6ra colitis-associated carcinogenesis polyubiquitination

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Laser produced electromagnetic pulses: generation, detection and mitigation

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High Power Laser Science and Engineering 2020年第2期8卷 88-146页

作者： Fabrizio Consoli Vladimir TTikhonchuk Matthieu Bardon Philip Bradford David CCarroll Jakub Cikhardt Mattia Cipriani Robert JClarke Thomas ECowan Colin NDanson Riccardo De Angelis Massimo De Marco Jean-Luc Dubois Bertr Etchessahar Alejro Laso Garcia David IHillier Ales Honsa Weiman Jiang Viliam Kmetik Josef Krása Yutong Li FredériéLubrano Paul McKenna Josefine Metzkes-Ng Alexre Poyé Irene Prencipe Piotr ra¸czka Rol ASmith Roman Vrana Nigel CWoolsey Egle Zemaityte Yihang Zhang Zhe Zhang Bernhard Zielbauer David Neely ENEA Fusion and Technologies for Nuclear Safety DepartmentC.R.Frascati00044 FrascatiItaly CELIA University of BordeauxCNRSCEA33405 TalenceFrance ELI Beamlines Institute of PhysicsCzech Academy of Sciences25241 Dolni BrezanyCzech Republic CEA DAMCESTA33116 Le BarpFrance Department of Physics York Plasma InstituteUniversity of YorkHeslingtonYork YO105DDUK Central Laser Facility Rutherford Appleton LaboratorySTFCUKRIChiltonDidcotOxfordshire OX110QXUK Czech Technical University in Prague Faculty of Electrical Engineering16627 Prague 6Czech Republic Institute of Plasma Physics of the Czech Academy of Sciences Za Slovankou 318200 PragueCzech Republic Helmholtz-Zentrum Dresden-Rossendorf Institut fur Strahlenphysik01328 DresdenGermany AWE plc AldermastonReadingBerkshire RG74PRUK OxCHEDS Clarendon LaboratoryDepartment of PhysicsUniversity of OxfordOxford OX13PUUK CIFS The Blackett LaboratoryImperial College LondonLondon SW72AZUK Centro de Laseres Pulsados(CLPU) 37185 VillamayorSalamancaSpain Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Institute of Physics of the Czech Academy of Sciences Na Slovance 218221 PragueCzech Republic School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Physics Scottish Universities Physics Alliance(SUPA)University of StrathclydeGlasgow G40NGUK Laboratory PIIM University Aix-Marseille-CNRS13397 MarseilleFrance Institute of Plasma Physics and Laser Microfusion 01-497 WarsawPoland The Blackett Laboratory Imperial College LondonLondon SW72AZUK PHELIX Group GSI Helmholtzzentrum fur SchwerionenforschungD-64291 DarmstadtGermany

This paper provides an up-to-date review of the problems related to the generation,detection and mitigation of strong electromagnetic pulses created in the interaction of high-power,high-energy laser pulses with different types of solid *** includes new experimental data obtained independently at several international *** mechanisms of electromagnetic field generation are analyzed and considered as a function of the intensity and the spectral range of emissions they *** major emphasis is put on the GHz frequency domain,which is the most damaging for electronics and may have important *** physics of electromagnetic emissions in other spectral domains,in particular THz and MHz,is also *** theoretical models and numerical simulations are compared with the results of experimental measurements,with special attention to the methodology of measurements and complementary *** the underlying physical processes is the basis for developing techniques to mitigate the electromagnetic threat and to harness electromagnetic emissions,which may have promising applications.

关键词： electromagnetic pulses high-power lasers diagnostics mitigation techniques

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Characterization and Utilization of Starches Extracted from Florencia and Waxy Maize Hybrids for Tablet Formulation: Compaction Behaviour and Tablet Properties

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American Journal of Plant Sciences 2014年第6期5卷 787-798页

作者： Anikó Szepes Piroska Szabó-Révész János Bajdik Péter Kása Jr. Miklós Neményi Roland Pap Attila József Kovács Klára Pintye-Hódi Martin Luther University halle-Wittenberg Center for Engineering Thermal Process Technology Halle (Saale) Germany Department of Pharmaceutical Technology University of Szeged Szeged Hungary Faculty for Agricultural and Food Sciences Institut of Biosystems Engineering University of West Hungary Mosonmagyaróvár Hungary

The aim of this work is to analyze the particle characteristics, such as shape, roundness and size, of starches extracted from Florencia and waxy maize hybrids. The micromeritics and structural properties of the samples were examined. The evaluation of flow properties, densification and compression behaviour of the powders was carried out. Physical parameters and swelling characteristics of tablets containing Florencia and waxy maize starch were also studied. Starch samples were compared with respect to their applicability as excipients in tablet formulation. The samples exhibited identical structure and similar particle characteristics. Maize starch extracted from the Florencia dent hybrid showed better flowability and compressibility in tableting experiments, which resulted in better mechanical tablet properties. With regard to utilization as a disintegrant, Florencia starch indicated rapid and intensive swelling and proved to act more effectively in the swelling process than waxy maize starch.

关键词： Maize Starch Micromeritics X-ray Diffraction Compression Behaviour Tablets

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