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Modelling of dust emissions induced by flow over stockpiles and through packed beds

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Particuology 2021年第6期19卷 55-63页

作者： daniel Schulz Nadja Schwindt Eberhard Schmidt ha.a.d kruggel-emden Technische Universitat Berlin Chair of Mechanical Process Engineering and Solids ProcessingEmst-Reuter-Platz 1D-10587 BerlinGermany University of Wuppertal Institute of Particle TechnologyRainer-Gruenter-StrGeb.FFD-42119 WuppertalGermany

dust emissions during storage of non-moving bulk materials are studied with a numerical *** model relies on a contact-model-free discrete Element Method(dEM)to model the bulk particle-fluid interaction and the dust removal coupled with Computational Fluid dynamics(CFd)to model the gas and the dust phase in a multiphase ***,two storage scenarios are considered:a flown through packed bed and a flown over *** the first,the performed simulations reveal that the dust discharge can be correlated with the passing fluid pressure *** the second,a parameter study of factors influencing the dust emissions is *** parameters discussed are the stockpile size,the gas velocity,the slope angle,the particle diameter and the shape of the stockpile,taking into account conical and truncated conical *** release correlations are obtained for both scenarios,which reflect very well the obtained numerical results.

关键词： Computational Fluid dynamics(CFd) discrete Element Method(dEM) dust release correlations Stockpile emissions Packed bed emissions

The Effect of Moisture in different Altitude Layers on the Eastward Propagation of MJO

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Journal of Meteorological Research 2024年第3期38卷 437-452页

作者： Xiaoyu ZHU Zhong ZHONG Yimin ZHU Yunying LI Yijia HU Yao ha College of Meteorology and Oceanography National University of Defense TechnologyChangsha410000China Key Laboratory for Virtual Geographic Environment School of Geography ScienceNanjing Normal UniversityNanjing210023China Jiangsu Collaborative Innovation Center for Climate Change School of Atmospheric SciencesNanjing UniversityNanjing210000China

In this study,driven by ERA5 reanalysis data,the Weather Research and Forecasting(WRF)version 4.0 was used to investigate the eastward propagation of the Madden-Julian oscillation(MJO)in the tropical atmosphere during december-February(dJF)of 2007/*** experiment with 11 cumulus parameterization schemes respectively shows that the Grell 3d scheme is one of several worse ones in describing MJO *** addition,still by use of the Grell 3d scheme,four nudging assimilation experiments for water vapor in all model vertical layers(Ndg_all),lower layers(Ndg_low),middle layers(Ndg_mid),and upper layers(Ndg_upp)were *** is found that when the water vapor in the model approaches to the observed value,the model performance for MJO activities is improved *** the four nudging simulations,Ndg_all certainly performs *** Ndg_mid is important for the MJO-filtered profiles related to moisture,Ndg_low and Ndg_upp exhibit superiority to Ndg_mid in simulating MJO eastward ***_low has advantages when MJO features are represented by zonal wind at 850 hPa and precipitation because the lower-level MJO-filtered moisture is conducive to the existence of lower-level condensational heating to the east of the MJO convective ***_upp performs better when describing the MJO eastward propagation features by outgoing longwave radiation(OLR)since it can capture the moisture and cloud top temperature of deep convection associated with MJO,as well as front Walker *** results suggest that the lower-level moisture is more important in regulating the MJO eastward propagation,and the observed maximum MJO-filtered moisture in the middle troposphere might be a phenomenon accompanying the MJO deep convection,but not a factor controlling its eastward propagation.

关键词： Madden-Julian oscillation(MJO) nudging technique Weather Research and Forecasting(WRF)model vertical moisture structure

CYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer

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Genes & diseases 2024年第4期11卷 381-399页

作者： Ming Shao Qingfei Pan haiyan Tan Jing Wu ha Won Lee Andrew d.Huber William C.Wright Ji-Hoon Cho Jiyang Yu Junmin Peng Taosheng Chen department of Chemical Biology and Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA department of Computational Biology St.Jude Children's Research HospitalMemphisTN 38105USA Center for Proteomics and Metabolomics St.Jude Children's Research HospitalMemphisTN 38105USA department of Structural Biology St.Jude Children's Research HospitalMemphisTN 38105USA department of developmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

CYP3A5 is a cytochrome P450(CYP)enzyme that metabolizes drugs and contributes to drug resistance in ***,it remains unclear whether CYP3A5 directly influences cancer *** this report,we demonstrate that CYP3A5 regulates glucose metabolism in pancreatic ductal ***-omics analysis showed that CYP3A5 knockdown re-sults in a decrease in various glucose-related metabolites through its effect on glucose trans-port.A mechanistic study revealed that CYP3A5 enriches the glucose transporter GLUT1 at the plasma membrane by restricting the translation of TXNIP,a negative regulator of ***,CYP3A5-generated reactive oxygen species were proved to be responsible for atten-uating the AKT-4EBP1-TXNIP signaling ***3A5 contributes to cell migration by maintaining high glucose uptake in pancreatic *** together,our results,for the first time,reveal a role of CYP3A5 in glucose metabolism in pancreatic ductal adenocarcinoma and identify a novel mechanism that is a potential therapeutic target.

关键词： Cell migration CYP3A5 Glucose metabolism GLUT1 Pancreatic cancer TXNIP

Sandwich structures with tapered tubes as core:A quasi-static investigation

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defence Technology（防务技术） 2024年第3期33卷 447-462页

作者： Xinmei Xiang dehua Shao Xin Zhang Umer Sharif Ngoc San ha Li Xiang Jing Zhang Jiang Yi School of Civil Engineering Guangzhou UniversityGuangzhouChina department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhenGuangdongChina School of Engineering Centre for Innovative Structures and MaterialsRMIT UniversityMelbourneAustralia China Southern Airlines Co. LtdShenzhen BranchShenzhen518000China

In this article,the experimental and finite element analysis is utilized to investigate the quasi-static compression features of sandwich constructions built with tapered tubes.3d printing technology was utilized to create the hollow centers of the tapering tubes,with and without *** results demonstrate that the energy absorption(EA)and specific energy absorption(SEA)of the single corrugated tapered tube sandwich are 51.6% and 19.8% higher,respectively,than those of the conical tube ***,the results demonstrate that energy absorbers can benefit from corrugation in order to increase their ***,the tapered corrugated tubes'resistance to oblique impacts was *** to a straight tube,the tapered tube is more resistant to oblique loads and has a lower initial peak crushing force(PCF),according to numerical *** conducting a parametric study,it was discovered that the energy absorption performance of the sandwich construction is significantly affected by the amplitude,number of corrugations,and wall *** and SEA of dTS with corrugation number of 8 increased by 17.4%and 29.6%,respectively,while PCF decreased by 9.2% compared to dTS with corrugation number of 10.

关键词： Sandwich structure Corrugated tube Tapered tube Quasi-static Energy absorption

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-ha Lee Kyoungho Suk department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Probiotics intervention in colorectal cancer:From traditional approaches to novel strategies

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Chinese Medical Journal 2024年第1期137卷 8-20页

作者： Suki ha Xiang Zhang Jun Yu Institute of digestive disease and department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina

The intestine harbors a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological *** intestinal microbiota engage in the fermentation of non-digestible nutrients and produce beneficial metabolites to regulate host homeostasis,metabolism,and immune *** disruption of microbiota,known as dysbiosis,has been implicated in many intestinal diseases,including colorectal cancer(CRC).As the third most common cancer and the second leading cause of cancer-related death worldwide,CRC poses a significant health *** is an urgent need for novel interventions to reduce CRC incidence and improve clinical *** the intestinal microbiota has emerged as a promising approach for CRC prevention and *** research efforts in CRC probiotics primarily focus on reducing the incidence of CRC,alleviating treatment-related side effects,and potentiating the efficacy of anticancer therapy,which is the key to successful translation to clinical *** paper aims to review the traditional probiotics and new interventions,such as next-generation probiotics and postbiotics,in the context of *** underlying mechanisms of probiotic anti-cancer effects are also discussed,including the restoration of microbial composition,reinforcement of gut barrier integrity,induction of cancer cell apoptosis,inactivation of carcinogens,and modulation of host immune *** paper further evaluates the novel strategy of probiotics as an adjuvant therapy in boosting the efficacy of chemotherapy and *** all the promising findings presented in studies,the evaluation of potential risks,optimization of delivery methods,and consideration of intra-patient variability of gut microbial baseline must be thoroughly interpreted before bench-to-bedside translation.

关键词： colorectal cancer probiotics gut microbiota dysbiosis adjuvant therapy immune modulation gut barrrier

Predicting 3d Radiotherapy dose-Volume Based on deep Learning

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Intelligent Automation & Soft Computing 2024年第2期39卷 319-335页

作者： do Nang Toan Lam Thanh Hien ha Manh Toan Nguyen Trong Vinh Pham Trung Hieu Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam

Cancer is one of the most dangerous diseaseswith *** of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and *** our study,we focused on the 3d dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer *** image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3d dose prediction *** proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and *** strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the *** output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation *** experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation *** results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the dose-score and the dose-volume histogram score(dVH-score).In the best training cases,the dose-score is 3.08 and the dVH-score is *** addition,we also conducted a comparison with the results of another study in the same context of using the loss function.

关键词： CT image 3d dose prediction data preprocessing augmentation

Advancing Wound Filling Extraction on 3d Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： duong Q.Nguyen Thinh d.Le Phuong d.Nguyen Nga T.K.Le H.Nguyen-Xuan department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and Technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3d facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3d-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3d facial ***,based on the segmentation model,we propose an improved approach for extracting 3d facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3d printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3d bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3d.

关键词： 3d printing technology face reconstruction 3d segmentation 3d printed model

Surface engineering of ZnO electrocatalyst by N doping towards electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini Subhash Kanase Getasew Mulualem Zewdie Maheswari Arunachalam Jyoti Badiger Suzan Abdelfattah Sayed Kwang-Soon Ahn Jun-Seok ha Uk Sim Hyeyoung Shin Soon Hyung Kang department of Interdisciplinary Program for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea department of Chemistry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea department of Advanced Chemicals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea department of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GdE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2d nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 M KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RdS),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO Selectivity Electrochemical CO_(2)reduction