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Biological cha.acteristics and clinical management of uveal and conjunctival melanoma

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Oncology Research 2024年第8期32卷 1265-1285页

作者： SNJEŽANA kAŠTELAN ANA DIDOVIĆpaVIČIĆ DARIA paŠALIĆ TAMARA NIkUŠEVA-MARTIĆ SAMIRČANOVIĆ PETRA kOVAČEVIĆ SUZANA kONJEVODA School of Medicine University of ZagrebZagreb10000Croatia Department of Ophtha.mology Clinical Hospital DubravaZagreb10000Croatia Department of Ophtha.mology Zadar General HospitalZadar23000Croatia Department of Medical Chemistry Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia Department of Biology and Genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of Medicine University of SplitSplit21000Croatia Department of Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas are relatively rare tumors;nonetheless,they pose a signiﬁcant risk of mortality for a large number of affected *** pathogenesis of melanoma at different sites is very similar,however,the prognosis for patients with ocular melanoma remains unfavourable,primarily due to its distinctive genetic proﬁle and tumor *** of considerable advances in understanding the genetic cha.acteristics and biological beha.iour,the treatment of uveal and conjunctival melanoma remains a formidable *** enha.ce the prospect of success,collaborative efforts involving medical professionals and researchers in theﬁelds of ocular biology and oncology are *** data show a lack of well-designed randomized clinical trials and limited beneﬁts in current forms of treatment for these *** advancements in the development of effective melanoma therapeutic strategies,all current treatments for uveal melanoma(UM)and conjunctival melanoma(CoM)remain unsatisfactory,resulting in a poor long-term *** trials offer hope for positive outcomes in advanced and metastatic tumors.A more comprehensive understanding of the genetic and molecular abnormalities involved in the development and progression of ocular melanomas opens the way for the development of personalized therapy,with various potential therapeutic targets currently under *** comprehension of the molecular pathogenesis of UM and CoM and their speciﬁcities may aid in the development of new and more effective systemic therapeutic agents,with the hope of improving the prognosis for patients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma Genetic cha.acteristics Immune checkpoint inhibitors Target molecular inhibitors

A new route to weak force sensing beyond SQL:Squeezed magnons in cavity magnomecha.ics

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Science China(Physics,Mecha.ics & Astronomy) 2024年第10期67卷 166-167页

作者： S.k.Özdemir Department of Engineering Science and Mecha.ics and Materials Research Institute(MRI)The Pennsylvania State UniversityUniversity ParkPA 16802USA

Quantum mecha.ics imposes limits on measurement accuracy through quantum noise which typically ha. two components:First is the shot noise originating from vacuum fluctuations and referred to as the imprecision *** is ... 详细信息

关键词： quantum typically vacuum

Comparative Chemical Research in Essential Oils from Six Apiaceae Species Growing in the Northern Region of Vietnam

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1677-1687页

作者： Nguyen Quang Hung Nguyen Tha.h Tung Nguyen Phuong ha.h Chu Thi Thu ha.Nguyen Thi Nhung Nguyen Tha. An Vu Xuan Giang Luong Van ha. Oleh koshovyi Ain Raal Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Graduate University of Science and Technology Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Department of Pha.macognosy Faculty of Pharmacognosy and Traditional MedicineHanoi University of PharmacyHoan KiemHa Noi100000Viet Nam Sa pa Research Center of Medicinal Materials National Institute of Medicinal MaterialsDien Bien PhuSa PaLao Cai330000Viet Nam Institute of Pha.macy Faculty of MedicineUniversity of TartuTartu50411Estonia

Our study aimed to compare the essential oil(EO)concentration and composition of several Apiaceae species growing in the Northern region of *** yields of EOs from materials ranged from 0.03%(root EO of Angelica acutiloba and aerial parts EO of Heracleum bivittatum)-0.27%(leaf EO of Xyloselinum vietnamense).Gas chromatography-mass spectrometry(GC-MS)allowed the identiﬁcation of 74 components in the EOs of six Apiaceae species,making up 94.4%–100.0%of the *** EO from Angelica acutiloba,(Z)-ligustilide accounted for an extremely large proportion(94.9%).EO of Angelica pubescens was dominated by six cha.acter-istic components includingα-pinene(21.5%),β-phellandrene(18.1%),p-cymene(12.2%),3-methylnonane(8.7%),o-cymene(8.1%),and D-sylvestrene(6.2%).The EO from Cryptotaenia japonica was cha.acterized by high amounts ofα-selinene(48.7%),β-selinene(23.7%),and trans-β-farnesene(5.4%).The EOs from leaves and stems of Xyloselinum vietnamense were cha.acterized by high concentrations of sabinene(69.8%and 33.8%),4-terpineol(8.7%and 7.4%)andβ-pinene(4.0%and 6.5%)while EOs from aerial parts and root of Xylo-selinum leonidii comprise four cha.acteristic monoterpenes includingα-pinene(28.2%and 52.8%),β-pinene(7.9%and 10.3%),β-phellandrene(7.6%and 15.3%),and sabinene(3.0%and 4.1%).Additionally,cryptone is also one of the major components in the EO of Xyloselinum leonidii(13.2%in the aerial parts oil and 2.8%in the root oil).In the EOs isolated from the aerial parts and root of Heracleum bivittatum,α-pinene(22.5%and 70.2%)andβ-pinene(43.2%and 20.0%)were the predominant *** appeared in the EO from aerial parts of Heracleum bivittatum with a relatively high concentration(13.5%)while bornyl acetate(5.1%)was also one of the main components in the EO from its aerial parts but was not detected in other Apiaceae species in the present *** databases help identify and control the quality of plant material studied from the family Apiaceae growing in Vietnam.

关键词： Apiaceae essential oil terpenoids gaschromatography-mass spectrometry

Exploring the synergy of the eyebrain connection:neuromodulation approa.hes for neurodegenerative disorders through transcorneal electrical stimulation

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Neural Regeneration Research 2024年第10期19卷 2097-2098页

作者： Antara Verma Stephen k.Agadagba Leanne Lai-ha.g Cha. Department of Electrical Engineering City University of Hong KongKowloonHong Kong Special Administrative RegionChina Centre for Eye and Vision Research Ltd. Hong Kong Special Administrative RegionChina Pennsylvania State University University ParkPAUSA

The connection and interaction between the eye and the brain are crucial to understanding brain disorders(Marchesi et al.,2021).Both the eye and the brain ha.e a limited regenerative capacity as there are few progenitor cells,and nerve cells do not ***,neurodegeneration implicates irreversible damage to the central nervous system,as observed in several neurodegenerative diseases(Marchesi et al.,2021).

关键词： stimulation degenerative

高校校区空间布局与校企协同创新——基于专精特新“小巨人”企业的微观经验证据

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高等教育研究 2024年第3期45卷 42-53页

作者：张文杰哈巍北京大学教育经济研究所北京100871

基于9200余家专精特新“小巨人”企业相关数据,量化评估高校校区空间布局对校企协同创新的影响发现,“小巨人”企业周边15公里范围内高校校区数量对校企联合申请并获授权专利的数量、校企合作广度与深度均有显著正向影响;从企业维度看,... 详细信息

基于9200余家专精特新“小巨人”企业相关数据,量化评估高校校区空间布局对校企协同创新的影响发现,“小巨人”企业周边15公里范围内高校校区数量对校企联合申请并获授权专利的数量、校企合作广度与深度均有显著正向影响;从企业维度看,显著促进了高校与高技术产业企业的发明专利研发合作,以及与非高技术产业企业、成长期企业的非发明专利研发合作;从高校维度看,这种影响主要来自本科高校尤其是高水平研究型高校;此外,校企协同创新随二者间距离增大而衰减。高校校区布局对企业持有的非校企联合申请专利数量也有显著影响,且这种间接效应大于以上直接效应。今后高校校区空间布局调整需综合考虑高校与企业的适配度,同时重点关注高水平研究型高校校区布局,助力深化校企协同创新。

关键词：校企协同创新高校校区空间布局 “小巨人”企业专利

高校竞技健美操运动员落地偏侧性和稳定性的生物力学研究

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中国运动医学杂志 2024年第4期43卷 266-274页

作者：王莉莉 Wan Ahmad Munsif Bin Wan pa 王宇轩李风雷颉梦宁许春莲马来西亚国立大学教育学院吉隆坡43600 东华理工大学体育学院南昌330032 南昌交通学院体育学院南昌330100

目的:分析竞技健美操运动员落地动作的生物力学特征,比较优势侧和非优势侧生物力学指标的偏侧性,探究影响落地稳定性的关键偏侧性因素。方法:以26名高校女性健美操运动员为研究对象,同步采集40 cm高台垂直双脚落地动作中的下肢运动学和... 详细信息

目的:分析竞技健美操运动员落地动作的生物力学特征,比较优势侧和非优势侧生物力学指标的偏侧性,探究影响落地稳定性的关键偏侧性因素。方法:以26名高校女性健美操运动员为研究对象,同步采集40 cm高台垂直双脚落地动作中的下肢运动学和动力学数据,比较优势侧和非优势侧的触地时刻关节角度、关节活动度(ROM)、地面反作用力(GRF)、负载率、压力中心(COP)位移和包络面积的差异,计算对称指数(代表偏侧性),并采用多元逐步回归方法分析指标偏侧性和COP包络面积的关系。结果:与非优势侧相比,优势侧在触地时刻具有更大的膝外旋和髋外展角(P<0.05),在落地过程中具有较大的踝屈伸、髋屈伸、髋内收-外展及较小的踝旋转ROM(P<0.05);优势侧的伸膝力矩峰值大于非优势侧(P<0.01);垂直方向负载率和伸膝力矩峰值的对称指数与COP包络面积呈显著正相关(P<0.05);垂直方向负载率、伸膝力矩峰值和膝关节旋转角度的对称指数可以解释COP包络面积差异的83.6%。结论:竞技健美操运动员落地动作存在肢体间的偏侧性,垂直方向负载率和伸膝力矩峰值的偏侧性越大,则落地稳定性越差。此外,垂直方向负载率、伸膝力矩峰值和膝关节旋转角度的对称指数可以作为落地稳定性的预测因子。

关键词：健美操落地生物力学偏侧性稳定性

A review of public health guidelines for postpartum physical activity and sedentary beha.ior from around the world

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Journal of Sport and Health Science 2024年第4期13卷 472-483,F0003页

作者： kelly R.Evenson Wendy J.Brown Alison k.Brinson Emily Budzynski-Seymour Melanie ha.man Department of Epidemiology Gillings School of Global Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599-8050USA Faculty of Health Sciences and Medicine Bond UniversityGold CoastQLD 4226Australia School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Anthropology University of North Carolina at Chapel HillChapel HillNC 27599-3115USA Carolina Population Center University of North Carolina at Chapel HillChapel HillNC 27599-8120USA Faculty of Sport Health and Social SciencesSolent UniversitySouthamptonSO140YNUK Appleton Institute School of HealthMedical and Applied SciencesCentral Queensland UniversityRockhamptonQLD 4701Australia

Background:The period following pregnancy is a critical time window when future ha.its with respect to physical activity(pa) and sedentary beha.ior(SB) are established;therefore,it warrants *** purpose of this scoping review was to summarize public health-oriented country-specific postpartum pa and SB guidelines ***:To identity guidelines published since 2010,we performed a(a) systematic search of 4 databases(CINAHL,Global Health,PubMed,and SPORTDiscus),(b) structured repeatable web-based search separately for 194 countries,and(c) separate web-based *** the most recent guideline was included for each ***:We identified 22 countries with public health-oriented postpartum guidelines for pa and 11 countries with SB *** continents with guidelines included Europe(n=12),Asia(n=5),Oceania(n=2),Africa(n=1),North America(n=1),and South America(n=1).The most common benefits recorded for pa included weight control/management(n=10),reducing the risk of postpartum depression or depressive symptoms(n=9),and improving mood/well-being(n=8).Postpartum guidelines specified exercises to engage in,including pelvic floor exercises(n=17);muscle strengthening,weight training,or resistance exercises(n=13);aerobics/general aerobic activity(n=13);walking(n=11);cycling(n=9);and swimming(n=9).Eleven guidelines remarked on the interaction between pa and breastfeeding;several guidelines stated tha. pa did not impact breast milk quantity(n=7),breast milk quality(n=6),or infant growth(n=3).For SB,suggestions included limiting long-term sitting and interrupting sitting with ***:Country-specific postpartum guidelines for pa and SB can help promote healthy beha.iors using a culturally appropriate context while providing specific guidance to public health practitioners.

关键词： Breastfeeding Caesarean section Guidelines Postnatal Recommendations

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翻译在藏传佛教中国化进程中的重要作用

攀登（藏文版） 2024年第2期 148-155页

作者：交巴草中国民族语文翻译中心(局)

佛教通过翻译在传入吐蕃过程中,汲取了苯教的部分教义,形成了具有藏族文化特色的藏传佛教。藏传佛教在迅速发展过程中推崇佛经翻译事业起到了重要的推动作用。新时代时期,积极推进藏传佛教中国化是藏传佛教健康传承的必经之路。在坚持... 详细信息

佛教通过翻译在传入吐蕃过程中,汲取了苯教的部分教义,形成了具有藏族文化特色的藏传佛教。藏传佛教在迅速发展过程中推崇佛经翻译事业起到了重要的推动作用。新时代时期,积极推进藏传佛教中国化是藏传佛教健康传承的必经之路。在坚持藏传佛教中国化方向进程中,加强汉藏翻译,一方面使藏传佛教教义教规的翻译呈现社会主义发展内涵,适应社会主义社会的时代要求。另一方面引进宗教中国化的理论,以社会主义核心价值观为引领,使藏传佛教浸润中国特色,弘扬先进思想。

关键词：翻译藏传佛教新时代中国化

Design of Slant-Form Tool in Precision Reuse of Digital paper Display

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Journal of Materials Science & Technology 2011年第9期27卷 846-850页

作者： pai-Sha. pa Department of Digital Content Design Graduate School of Toy and Game Design National Taipei University of Education Taipei 10667 Taiwan China

A reuse fabrication module using micro electroetching as a precision machining process with a new design of a slant-form tool to remove the defective indium-tin-oxide （ITO） nanostructure from the optical polyethyleneterephtha.ate （PET） surfaces of digital paper display is presented in current studies. The low yield of ITO thin film deposition is an important factor in optoelectronic semiconductor production. The adopted precision reuse process requires only a short period of time to remove the ITO nanostructure easily and cleanly, which is based on technical and economical considerations and is highly efficient. In the current experiment, a large inclined angle of the cathode and a small end radius of the anode take less time for the same amount of ITO removal. A higher feed rate of the optical PET diaphragm combines with enough electric power to drive fast micro electroetching. A small rotational diameter of the anode accompanied by a small width of the cathode corresponds to a higher removal rate for the ITO nanostructure. A pulsed direct current can improve the effect of dreg discha.ge and is advantageous to couple this current with the fast feed rate of the workpiece. This improvement is associated with an increase in current rating. High rotational speed of the slant-form tool can improve the effect of dregs discha.ge and is advantageous to associate with the fast feed rate of the workpiece （optical PET diaphragm）.

关键词： Reuse fabrication Slant-Form Digital paper display Optical polyethyleneterephtha.ate (PET) diaphragm Indium-tin-oxide (ITO) nanostructure Micro electroetching